A cross-sectional assessment of metabolic syndrome in HIV-infected people of low socio-economic status receiving antiretroviral therapy

Eduard Tiozzo, Janet Konefal, Sarah Adwan, Lynell A. Martinez, Juan Villabona, Johanna Lopez, Stacy Cutrono, Syed Muhammad Ahsan Mehdi, Allan Rodriguez, Judi M. Woolger, John E. Lewis

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Background: Metabolic syndrome (MetS) is a constellation of symptoms used as a measure to identify patients at increased risk for cardiovascular disease, type 2 diabetes, and all-cause mortality. The results of prolonged life expectancy and cumulative toxic effects of antiretroviral therapy increase the chance that HIV can cause clinical abnormalities, including MetS. Methods: We evaluated 89 people living with HIV (PLWH; mean age 48∈±∈7 years; mean duration of HIV infection 17∈±∈12 years; 47% men; 66% African-American, 22% Hispanic, and 10% non-Hispanic white; and 84% unemployed) enrolled in a community-based exercise training and nutrition education program targeting individuals of low socio-economic status (SES). The prevalence of MetS characteristics and the factors associated with the presence of MetS were analyzed. Results: One in three (33%; 12 men and 17 women) PLWH met ATPIII criteria for MetS. In our cohort, MetS was driven by high waist circumference and elevated blood pressure. In addition, higher use of protease inhibitors, elevated hemoglobin A1c (HbA1c), greater self-reported daily caloric intake and consumption of carbohydrates, sugar, added sugar, and higher glycemic load were found among the individuals with MetS, compared to those without it. Elevated HbA1c and high total sugar consumption were the strongest predictors and accounted for 30% of the occurrence of MetS. Conclusions: The overall prevalence of MetS in our PLWH cohort receiving antiretroviral therapy is higher than previously reported in the general population and in other PLWH cohorts. Additional work is needed to determine whether MetS is a more disease dependent or lifestyle dependent condition in PLWH.

Original languageEnglish (US)
Article number15
JournalDiabetology and Metabolic Syndrome
Issue number1
StatePublished - Dec 14 2015
Externally publishedYes


  • HIV
  • HbA1c
  • Low SES
  • Metabolic syndrome
  • Sugar consumption

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


Dive into the research topics of 'A cross-sectional assessment of metabolic syndrome in HIV-infected people of low socio-economic status receiving antiretroviral therapy'. Together they form a unique fingerprint.

Cite this