A critical appraisal of the literature on local ablative therapies for hepatocellular carcinoma

Riccardo Lencioni, Laura Crocetti

Research output: Contribution to journalArticle

51 Scopus citations


HCC is one of the most common malignancies worldwide. Only a minority of the patients can be treated by surgical resection or liver transplantation. Several minimally invasive percutaneous techniques have been developed to treat nonsurgical patients with early-stage tumors. PEI is the seminal technique for local tumor treatment, and may achieve a 5-year survival rate of 50% in selected Child A patients. RF ablation constitutes the most assessed alternative technique. On the basis of the identified evidence, RF ablation seems to reach higher recurrence-free survival rates compared with PEI. Further randomized trials are needed to establish the clinical efficacy of RF ablation with respect to other percutaneous treatments and to devise an unbiased therapeutic strategy.

Original languageEnglish (US)
Pages (from-to)301-314
Number of pages14
JournalClinics in liver disease
Issue number2
StatePublished - May 2005


ASJC Scopus subject areas

  • Hepatology

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