A critical appraisal of the literature on local ablative therapies for hepatocellular carcinoma

Riccardo Lencioni, Laura Crocetti

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

HCC is one of the most common malignancies worldwide. Only a minority of the patients can be treated by surgical resection or liver transplantation. Several minimally invasive percutaneous techniques have been developed to treat nonsurgical patients with early-stage tumors. PEI is the seminal technique for local tumor treatment, and may achieve a 5-year survival rate of 50% in selected Child A patients. RF ablation constitutes the most assessed alternative technique. On the basis of the identified evidence, RF ablation seems to reach higher recurrence-free survival rates compared with PEI. Further randomized trials are needed to establish the clinical efficacy of RF ablation with respect to other percutaneous treatments and to devise an unbiased therapeutic strategy.

Original languageEnglish (US)
Pages (from-to)301-314
Number of pages14
JournalClinics in Liver Disease
Volume9
Issue number2
DOIs
StatePublished - May 2005
Externally publishedYes

Fingerprint

Hepatocellular Carcinoma
Survival Rate
Neoplasms
Liver Transplantation
Therapeutics
Recurrence

ASJC Scopus subject areas

  • Hepatology

Cite this

A critical appraisal of the literature on local ablative therapies for hepatocellular carcinoma. / Lencioni, Riccardo; Crocetti, Laura.

In: Clinics in Liver Disease, Vol. 9, No. 2, 05.2005, p. 301-314.

Research output: Contribution to journalArticle

Lencioni, Riccardo ; Crocetti, Laura. / A critical appraisal of the literature on local ablative therapies for hepatocellular carcinoma. In: Clinics in Liver Disease. 2005 ; Vol. 9, No. 2. pp. 301-314.
@article{614f792bcc49487782a9ab265d7db5f1,
title = "A critical appraisal of the literature on local ablative therapies for hepatocellular carcinoma",
abstract = "HCC is one of the most common malignancies worldwide. Only a minority of the patients can be treated by surgical resection or liver transplantation. Several minimally invasive percutaneous techniques have been developed to treat nonsurgical patients with early-stage tumors. PEI is the seminal technique for local tumor treatment, and may achieve a 5-year survival rate of 50{\%} in selected Child A patients. RF ablation constitutes the most assessed alternative technique. On the basis of the identified evidence, RF ablation seems to reach higher recurrence-free survival rates compared with PEI. Further randomized trials are needed to establish the clinical efficacy of RF ablation with respect to other percutaneous treatments and to devise an unbiased therapeutic strategy.",
author = "Riccardo Lencioni and Laura Crocetti",
year = "2005",
month = "5",
doi = "10.1016/j.cld.2004.12.002",
language = "English (US)",
volume = "9",
pages = "301--314",
journal = "Clinics in Liver Disease",
issn = "1089-3261",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - A critical appraisal of the literature on local ablative therapies for hepatocellular carcinoma

AU - Lencioni, Riccardo

AU - Crocetti, Laura

PY - 2005/5

Y1 - 2005/5

N2 - HCC is one of the most common malignancies worldwide. Only a minority of the patients can be treated by surgical resection or liver transplantation. Several minimally invasive percutaneous techniques have been developed to treat nonsurgical patients with early-stage tumors. PEI is the seminal technique for local tumor treatment, and may achieve a 5-year survival rate of 50% in selected Child A patients. RF ablation constitutes the most assessed alternative technique. On the basis of the identified evidence, RF ablation seems to reach higher recurrence-free survival rates compared with PEI. Further randomized trials are needed to establish the clinical efficacy of RF ablation with respect to other percutaneous treatments and to devise an unbiased therapeutic strategy.

AB - HCC is one of the most common malignancies worldwide. Only a minority of the patients can be treated by surgical resection or liver transplantation. Several minimally invasive percutaneous techniques have been developed to treat nonsurgical patients with early-stage tumors. PEI is the seminal technique for local tumor treatment, and may achieve a 5-year survival rate of 50% in selected Child A patients. RF ablation constitutes the most assessed alternative technique. On the basis of the identified evidence, RF ablation seems to reach higher recurrence-free survival rates compared with PEI. Further randomized trials are needed to establish the clinical efficacy of RF ablation with respect to other percutaneous treatments and to devise an unbiased therapeutic strategy.

UR - http://www.scopus.com/inward/record.url?scp=17044368307&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17044368307&partnerID=8YFLogxK

U2 - 10.1016/j.cld.2004.12.002

DO - 10.1016/j.cld.2004.12.002

M3 - Article

VL - 9

SP - 301

EP - 314

JO - Clinics in Liver Disease

JF - Clinics in Liver Disease

SN - 1089-3261

IS - 2

ER -