A convolutional neural network to filter artifacts in spectroscopic MRI

Saumya S. Gurbani, Eduard Schreibmann, Andrew A. Maudsley, James Scott Cordova, Brian J. Soher, Harish Poptani, Gaurav Verma, Peter B. Barker, Hyunsuk Shim, Lee A.D. Cooper

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Purpose: Proton MRSI is a noninvasive modality capable of generating volumetric maps of in vivo tissue metabolism without the need for ionizing radiation or injected contrast agent. Magnetic resonance spectroscopic imaging has been shown to be a viable imaging modality for studying several neuropathologies. However, a key hurdle in the routine clinical adoption of MRSI is the presence of spectral artifacts that can arise from a number of sources, possibly leading to false information. Methods: A deep learning model was developed that was capable of identifying and filtering out poor quality spectra. The core of the model used a tiled convolutional neural network that analyzed frequency-domain spectra to detect artifacts. Results: When compared with a panel of MRS experts, our convolutional neural network achieved high sensitivity and specificity with an area under the curve of 0.95. A visualization scheme was implemented to better understand how the convolutional neural network made its judgement on single-voxel or multivoxel MRSI, and the convolutional neural network was embedded into a pipeline capable of producing whole-brain spectroscopic MRI volumes in real time. Conclusion: The fully automated method for assessment of spectral quality provides a valuable tool to support clinical MRSI or spectroscopic MRI studies for use in fields such as adaptive radiation therapy planning.

Original languageEnglish (US)
Pages (from-to)1765-1775
Number of pages11
JournalMagnetic Resonance in Medicine
Volume80
Issue number5
DOIs
StatePublished - Nov 2018

Keywords

  • MR spectroscopic imaging
  • deep learning
  • machine learning
  • spectroscopic MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Gurbani, S. S., Schreibmann, E., Maudsley, A. A., Cordova, J. S., Soher, B. J., Poptani, H., Verma, G., Barker, P. B., Shim, H., & Cooper, L. A. D. (2018). A convolutional neural network to filter artifacts in spectroscopic MRI. Magnetic Resonance in Medicine, 80(5), 1765-1775. https://doi.org/10.1002/mrm.27166