A computer model of denervation-reinnervation in skeletal muscle

M. H. Cohen, J. M. Lester, Walter G Bradley, J. F. Brenner, R. P. Hirsch, D. I. Silber, D. Ziegelmiller

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A computer model of the process denervation and complete reinnervation of skeletal muscle has been developed for the purpose of exploring underlying mechanisms and for use in the development of new clinical and research tools for evaluating neuromuscular disease. Progressive motor neuron death and reinnervation in this model reproduces the fiber-type grouping, increased fiber density, and minimal increase of motor unit size seen in human chronic denervating diseases. Studies using the model suggest that (1) preferential involvement of motor units of one type could account for the abnormal fibre-type proportions observed in some diseases, (2) reinnervation by axons innervating adjacent fibers is compatible with single fiber multielectrode study results in that it does not produce a large increase in motor unit area, and (3) such reinnervation is sufficient to account for the increases in motor unit density that have been observed. The model has also been used in the development and testing of the Codispersion Index, a measure of the codistribution of two fiber types, which is useful in detecting fibre-type grouping.

Original languageEnglish
Pages (from-to)826-836
Number of pages11
JournalMuscle and Nerve
Volume10
Issue number9
StatePublished - Dec 1 1987
Externally publishedYes

Fingerprint

Neuromuscular Diseases
Motor Cortex
Motor Neurons
Denervation
Computer Simulation
Axons
Skeletal Muscle
Chronic Disease
Research

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Cohen, M. H., Lester, J. M., Bradley, W. G., Brenner, J. F., Hirsch, R. P., Silber, D. I., & Ziegelmiller, D. (1987). A computer model of denervation-reinnervation in skeletal muscle. Muscle and Nerve, 10(9), 826-836.

A computer model of denervation-reinnervation in skeletal muscle. / Cohen, M. H.; Lester, J. M.; Bradley, Walter G; Brenner, J. F.; Hirsch, R. P.; Silber, D. I.; Ziegelmiller, D.

In: Muscle and Nerve, Vol. 10, No. 9, 01.12.1987, p. 826-836.

Research output: Contribution to journalArticle

Cohen, MH, Lester, JM, Bradley, WG, Brenner, JF, Hirsch, RP, Silber, DI & Ziegelmiller, D 1987, 'A computer model of denervation-reinnervation in skeletal muscle', Muscle and Nerve, vol. 10, no. 9, pp. 826-836.
Cohen MH, Lester JM, Bradley WG, Brenner JF, Hirsch RP, Silber DI et al. A computer model of denervation-reinnervation in skeletal muscle. Muscle and Nerve. 1987 Dec 1;10(9):826-836.
Cohen, M. H. ; Lester, J. M. ; Bradley, Walter G ; Brenner, J. F. ; Hirsch, R. P. ; Silber, D. I. ; Ziegelmiller, D. / A computer model of denervation-reinnervation in skeletal muscle. In: Muscle and Nerve. 1987 ; Vol. 10, No. 9. pp. 826-836.
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