A comprehensive pathophysiology of dandruff and seborrheic dermatitis - Towards a more precise definition of scalp health

James R. Schwartz, Andrew G. Mesenger, Antonella Tosti, Gail Todd, Maria Hordinsky, Roderick J. Hay, Xuemin Wang, Claus Zachariae, Kathy M. Ker, James P. Henry, Rene C. Rust, Michael K. Robinson

Research output: Contribution to journalReview article

44 Scopus citations

Abstract

Despite an increasing knowledge of dandruff and seborrheic dermatitis (D/SD), the pathophysiological understanding is still incomplete but suggests a role of Malassezia yeasts in triggering inflammatory and hyper- proliferative epidermal responses. The objective of this report is to review published literature from in vivo studies of D/SD populations to provide a more complete description of overall scalp health. New biomolecular capabilities establish a depth of pathophysiological understanding not previously achievable with traditional means of investigation. Biomarkers representing inflammation, hyper-proliferation and barrier function are all perturbed by the D/SD condition and robustly respond to therapeutic resolution. These biomarkers can be sampled noninvasively, enabling their use in routine clinical evaluations as either surrogate endpoints or complementary ones to classical signs/symptoms to broaden the etiological learning.

Original languageEnglish (US)
Pages (from-to)131-137
Number of pages7
JournalActa dermato-venereologica
Volume93
Issue number2
DOIs
StatePublished - Mar 1 2013

Keywords

  • Biomarkers
  • Dandruff
  • Hyper-proliferation
  • Inflammation
  • Scalp health
  • Seborrheic dermatitis
  • Skin barrier

ASJC Scopus subject areas

  • Dermatology

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    Schwartz, J. R., Mesenger, A. G., Tosti, A., Todd, G., Hordinsky, M., Hay, R. J., Wang, X., Zachariae, C., Ker, K. M., Henry, J. P., Rust, R. C., & Robinson, M. K. (2013). A comprehensive pathophysiology of dandruff and seborrheic dermatitis - Towards a more precise definition of scalp health. Acta dermato-venereologica, 93(2), 131-137. https://doi.org/10.2340/00015555-1382