A comprehensive analysis of parotid and salivary gland cancer: Worse outcomes for male gender

Michael C. Cheung, Elizabeth J Franzmann, Juan E Sola, David J. Pincus, Leonidas G. Koniaris

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: To determine the effects of patient demographics, socioeconomic status (SES) and clinical variables on outcomes for patients with salivary and parotid gland tumors. Methods: Florida cancer registry and inpatient hospital data were queried for cancer of the salivary glands diagnosed between 1998 - 2002. Results: A total of 1573 patients were identified. Women were diagnosed at a younger age (median age (years): women 60.8 versus men 64.3, P = 0.003). Men were more often diagnosed with high grade tumors (65.1% versus 41.9% for women, P < 0.001) and advanced disease stage (>stage III: 60.2 versus 49.4%, P < 0.001), but underwent surgical extirpation and received radiation at equal rates compared with women. Overall 5-year survival rates was superior in women (67.4% versus 55.6%, P = 0.001). By multivariate analysis, adjusted for patient comorbidities, age over 65 (HR 3.43 P = 0.008), advanced disease stage (HR 8.05 P < 0.001), and high tumor grade (HR 2.33, P < 0.001) were independent predictors of worse prognosis. Improved outcomes were observed for female gender (HR 0.68, P = 0.011). Tumors located in the parotid gland (HR 0.631 P = 0.003) and receiving both surgical extirpation and radiation were predictors of improved survival. Conclusion: Salivary gland tumors carry a worse prognosis than tumors of the parotid. Male patients have worse outcomes.

Original languageEnglish
Pages (from-to)151-158
Number of pages8
JournalJournal of Surgical Research
Volume171
Issue number1
DOIs
StatePublished - Nov 1 2011

Fingerprint

Salivary Gland Neoplasms
Parotid Gland
Neoplasms
Radiation
Glandular and Epithelial Neoplasms
Salivary Glands
Social Class
Registries
Comorbidity
Inpatients
Multivariate Analysis
Survival Rate
Demography
Survival

Keywords

  • gender disparities
  • outcomes
  • parotid
  • salivary gland

ASJC Scopus subject areas

  • Surgery

Cite this

A comprehensive analysis of parotid and salivary gland cancer : Worse outcomes for male gender. / Cheung, Michael C.; Franzmann, Elizabeth J; Sola, Juan E; Pincus, David J.; Koniaris, Leonidas G.

In: Journal of Surgical Research, Vol. 171, No. 1, 01.11.2011, p. 151-158.

Research output: Contribution to journalArticle

Cheung, Michael C. ; Franzmann, Elizabeth J ; Sola, Juan E ; Pincus, David J. ; Koniaris, Leonidas G. / A comprehensive analysis of parotid and salivary gland cancer : Worse outcomes for male gender. In: Journal of Surgical Research. 2011 ; Vol. 171, No. 1. pp. 151-158.
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