A Comparison of Fentanyl and Flurbiprofen Axetil on Serum VEGF-C, TNF-α, and IL-1ß Concentrations in Women Undergoing Surgery for Breast Cancer

Yiyun Wen; Mingde Wang; Jinfeng Yang; Yichun Wang; Huiping Sun; Jianghong Zhao; Weizhen Liu; Zhengyu Zhou; Hongwu Deng; Catalina Castillo-Pedraza; Yi Zhang; Keith A. Candiotti

doi:10.1111/papr.12206

A Comparison of Fentanyl and Flurbiprofen Axetil on Serum VEGF-C, TNF-α, and IL-1ß Concentrations in Women Undergoing Surgery for Breast Cancer

Yiyun Wen, Mingde Wang, Jinfeng Yang, Yichun Wang, Huiping Sun, Jianghong Zhao, Weizhen Liu, Zhengyu Zhou, Hongwu Deng, Catalina Castillo-Pedraza, Yi Zhang, Keith A. Candiotti

Anesthesiology

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Background: Vascular endothelial growth factor-C (VEGF-C), tumor necrosis factor-α (TNF-α), and interleukin-1ß(IL-1ß) have been shown to be associated with the recurrence and metastasis of breast cancer after surgery. This study tested the hypothesis that patients undergoing surgery for breast cancer, who received postoperative analgesia with flurbiprofen axetil combined with small doses of fentanyl (FA), exhibited reduced levels of VEGF-C, TNF-α, and IL-1ß compared with those patients receiving fentanyl alone (F).

Original language	English (US)
Pages (from-to)	530-537
Number of pages	8
Journal	Pain Practice
Volume	15
Issue number	6
DOIs	https://doi.org/10.1111/papr.12206
State	Published - Jul 1 2015

Keywords

Analgesia
Immunologic factors
Postoperative pain

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

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A Comparison of Fentanyl and Flurbiprofen Axetil on Serum VEGF-C, TNF-α, and IL-1ß Concentrations in Women Undergoing Surgery for Breast Cancer. / Wen, Yiyun; Wang, Mingde; Yang, Jinfeng; Wang, Yichun; Sun, Huiping; Zhao, Jianghong; Liu, Weizhen; Zhou, Zhengyu; Deng, Hongwu; Castillo-Pedraza, Catalina; Zhang, Yi; Candiotti, Keith A.

In: Pain Practice, Vol. 15, No. 6, 01.07.2015, p. 530-537.

Research output: Contribution to journal › Article › peer-review

Wen, Yiyun ; Wang, Mingde ; Yang, Jinfeng ; Wang, Yichun ; Sun, Huiping ; Zhao, Jianghong ; Liu, Weizhen ; Zhou, Zhengyu ; Deng, Hongwu ; Castillo-Pedraza, Catalina ; Zhang, Yi ; Candiotti, Keith A. / A Comparison of Fentanyl and Flurbiprofen Axetil on Serum VEGF-C, TNF-α, and IL-1ß Concentrations in Women Undergoing Surgery for Breast Cancer. In: Pain Practice. 2015 ; Vol. 15, No. 6. pp. 530-537.

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abstract = "Background: Vascular endothelial growth factor-C (VEGF-C), tumor necrosis factor-α (TNF-α), and interleukin-1{\ss}(IL-1{\ss}) have been shown to be associated with the recurrence and metastasis of breast cancer after surgery. This study tested the hypothesis that patients undergoing surgery for breast cancer, who received postoperative analgesia with flurbiprofen axetil combined with small doses of fentanyl (FA), exhibited reduced levels of VEGF-C, TNF-α, and IL-1{\ss} compared with those patients receiving fentanyl alone (F).",

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AU - Yang, Jinfeng

AU - Wang, Yichun

AU - Sun, Huiping

AU - Zhao, Jianghong

AU - Liu, Weizhen

AU - Zhou, Zhengyu

AU - Deng, Hongwu

AU - Castillo-Pedraza, Catalina

AU - Zhang, Yi

AU - Candiotti, Keith A.

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AB - Background: Vascular endothelial growth factor-C (VEGF-C), tumor necrosis factor-α (TNF-α), and interleukin-1ß(IL-1ß) have been shown to be associated with the recurrence and metastasis of breast cancer after surgery. This study tested the hypothesis that patients undergoing surgery for breast cancer, who received postoperative analgesia with flurbiprofen axetil combined with small doses of fentanyl (FA), exhibited reduced levels of VEGF-C, TNF-α, and IL-1ß compared with those patients receiving fentanyl alone (F).

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A Comparison of Fentanyl and Flurbiprofen Axetil on Serum VEGF-C, TNF-α, and IL-1ß Concentrations in Women Undergoing Surgery for Breast Cancer

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Keywords

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