A Comparison of Fentanyl and Flurbiprofen Axetil on Serum VEGF-C, TNF-α, and IL-1ß Concentrations in Women Undergoing Surgery for Breast Cancer

Yiyun Wen, Mingde Wang, Jinfeng Yang, Yichun Wang, Huiping Sun, Jianghong Zhao, Weizhen Liu, Zhengyu Zhou, Hongwu Deng, Catalina Castillo-Pedraza, Yi Zhang, Keith A Candiotti

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Background: Vascular endothelial growth factor-C (VEGF-C), tumor necrosis factor-α (TNF-α), and interleukin-1ß(IL-1ß) have been shown to be associated with the recurrence and metastasis of breast cancer after surgery. This study tested the hypothesis that patients undergoing surgery for breast cancer, who received postoperative analgesia with flurbiprofen axetil combined with small doses of fentanyl (FA), exhibited reduced levels of VEGF-C, TNF-α, and IL-1ß compared with those patients receiving fentanyl alone (F).

Original languageEnglish (US)
Pages (from-to)530-537
Number of pages8
JournalPain Practice
Volume15
Issue number6
DOIs
StatePublished - Jul 1 2015

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Keywords

  • Analgesia
  • Immunologic factors
  • Postoperative pain

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Wen, Y., Wang, M., Yang, J., Wang, Y., Sun, H., Zhao, J., Liu, W., Zhou, Z., Deng, H., Castillo-Pedraza, C., Zhang, Y., & Candiotti, K. A. (2015). A Comparison of Fentanyl and Flurbiprofen Axetil on Serum VEGF-C, TNF-α, and IL-1ß Concentrations in Women Undergoing Surgery for Breast Cancer. Pain Practice, 15(6), 530-537. https://doi.org/10.1111/papr.12206