A comparison of familial and sporadic Alzheimer's disease

R. Duara, Roberto Lopez Alberola, W. W. Barker, David Loewenstein, M. Zatinsky, C. E. Eisdorfer, G. B. Weinberg

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Abstract

Using a liberal criterion, a conservative probability-based criterion, and a criterion for autosomal dominant inheritance, we classified 36%, 13.5%, and 6.4% of 311 patients, respectively, as having familial Alzheimer's disease (FAD). The mean age of onset was over 70 years for all three categories of FAD. FAD and sporadic Alzheimer's disease (SAD) cases did not differ in clinical features, incidence of risk factors for dementia, or MRI or PET features. We observed earlier age of onset of AD to be related positively to longer duration of disease. Except for the autosomal dominant AD group, there was an earlier age of onset in FAD probands. The inheritance of AD from mothers was from 1.7 to 3.6 times more frequent than from fathers. Among SAD patients only, we found a preponderance of women, who were more frequently affected than would be expected from the male/female ratio in the general population of the same average age. Language performance tended to be less affected in FAD than in SAD patients, contrary to some previous reports.

Original languageEnglish
Pages (from-to)1377-1384
Number of pages8
JournalNeurology
Volume43
Issue number7
StatePublished - Jul 1 1993

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Alzheimer Disease
Age of Onset
Fathers
Dementia
Language
Mothers
Incidence
Population

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Duara, R., Lopez Alberola, R., Barker, W. W., Loewenstein, D., Zatinsky, M., Eisdorfer, C. E., & Weinberg, G. B. (1993). A comparison of familial and sporadic Alzheimer's disease. Neurology, 43(7), 1377-1384.

A comparison of familial and sporadic Alzheimer's disease. / Duara, R.; Lopez Alberola, Roberto; Barker, W. W.; Loewenstein, David; Zatinsky, M.; Eisdorfer, C. E.; Weinberg, G. B.

In: Neurology, Vol. 43, No. 7, 01.07.1993, p. 1377-1384.

Research output: Contribution to journalArticle

Duara, R, Lopez Alberola, R, Barker, WW, Loewenstein, D, Zatinsky, M, Eisdorfer, CE & Weinberg, GB 1993, 'A comparison of familial and sporadic Alzheimer's disease', Neurology, vol. 43, no. 7, pp. 1377-1384.
Duara R, Lopez Alberola R, Barker WW, Loewenstein D, Zatinsky M, Eisdorfer CE et al. A comparison of familial and sporadic Alzheimer's disease. Neurology. 1993 Jul 1;43(7):1377-1384.
Duara, R. ; Lopez Alberola, Roberto ; Barker, W. W. ; Loewenstein, David ; Zatinsky, M. ; Eisdorfer, C. E. ; Weinberg, G. B. / A comparison of familial and sporadic Alzheimer's disease. In: Neurology. 1993 ; Vol. 43, No. 7. pp. 1377-1384.
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