In an ongoing prospective randomized study, 113 evaluable patients have received either a three-drug combination that included cyclophosphamide, adriamycin and 5-fluorouracil (CAF) or a five-drug combination including cyclophosphamide, methotrexate, 5-fluorouracil, vincristine and prednisone (CMFVP) given intermittently 1 week out of 4. Responses (64%), median duration of response (32 weeks), and median duration of disease control (32 weeks) achieved with CAF were superior to those achieved with CMFVP (37%, 22 weeks, 17 weeks, respectively). Morbidity secondary to CAF was significant, with nausea and vomiting, malaise, total alopecia, and granulocytopenia being the main features.
|Original language||English (US)|
|Number of pages||8|
|State||Published - Aug 1977|
ASJC Scopus subject areas
- Cancer Research