A comparison of cocaine and its metabolite norcocaine: Effects on locomotor activity

Peter J. Elliott, Gerald M. Rosen, Charles Nemeroff

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Intraventricular and intraperitoneal administration of cocaine and its metabolite norcocaine were studied in adult male rats. Norcocaine (10-100 μm) had no behavioral activity following central infusiion but proved to be toxic at high doses (50-100 mg/kg) when given peripherally. Cocaine at high doses (100 μm), produced possible hypoactivity after central injections but produced significant hyperactivity after peripheral administration (20 mg/kg).

Original languageEnglish
Pages (from-to)573-575
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Volume26
Issue number3
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

Fingerprint

Locomotion
Metabolites
Cocaine
Poisons
Rats
Injections
norcocaine

Keywords

  • Cocaine
  • Dopamine
  • Locomotor activity
  • Norcocaine

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

A comparison of cocaine and its metabolite norcocaine : Effects on locomotor activity. / Elliott, Peter J.; Rosen, Gerald M.; Nemeroff, Charles.

In: Pharmacology, Biochemistry and Behavior, Vol. 26, No. 3, 01.01.1987, p. 573-575.

Research output: Contribution to journalArticle

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