A comparison of cocaine and its metabolite norcocaine: Effects on locomotor activity

Peter J. Elliott, Gerald M. Rosen, Charles B. Nemeroff

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Intraventricular and intraperitoneal administration of cocaine and its metabolite norcocaine were studied in adult male rats. Norcocaine (10-100 μm) had no behavioral activity following central infusiion but proved to be toxic at high doses (50-100 mg/kg) when given peripherally. Cocaine at high doses (100 μm), produced possible hypoactivity after central injections but produced significant hyperactivity after peripheral administration (20 mg/kg).

Original languageEnglish (US)
Pages (from-to)573-575
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Volume26
Issue number3
DOIs
StatePublished - Mar 1987

Keywords

  • Cocaine
  • Dopamine
  • Locomotor activity
  • Norcocaine

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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