A comparison of cisplatin and the combination of cisplatin and cyclophosphamide in advanced urothelial cancer. A national bladder cancer collaborative group a study

Mark S. Soloway, Albert Einstein, Michael P. Corder, William Bonney, George R. Prout, Jean Coombs

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

A prospective multi-institutional randomized trial compared the use of cisplatin (DDP) alone to the combination of DDP and cyclophosphamide in patients with advanced urothelial cancer. Patients were stratified according to measurable or evaluable tumor and performance status. The dose of DDP was 70 mg/m2 and the initial dose of cyclophosphamide was 750 mg/m2. There were 10 objective responders (20%), including 5 complete responders, among the 50 evaluable patients who received DDP alone, and 7 responders (11.9%), 3 complete, among the 59 receiving the combination therapy. Approximately one third of the patients in each treatment arm were stable at the 9-week evaluation. There was no statistical significance between the response rates in the two treatment arms.

Original languageEnglish (US)
Pages (from-to)767-772
Number of pages6
JournalCancer
Volume52
Issue number5
DOIs
StatePublished - Sep 1 1983

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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