A Comparison of Adherence Timeframes Using Missed Dose Items and Their Associations with Viral Load in Routine Clinical Care: Is Longer Better?

H. M. Crane, R. M. Nance, J. A C Delaney, R. J. Fredericksen, A. Church, J. M. Simoni, R. D. Harrington, S. Dhanireddy, Steven Safren, M. E. McCaul, W. B. Lober, P. K. Crane, I. B. Wilson, M. J. Mugavero, M. M. Kitahata

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Questions remain regarding optimal timeframes for asking about adherence in clinical care. We compared 4-, 7-, 14-, 30-, and 60-day timeframe missed dose items with viral load levels among 1099 patients on antiretroviral therapy in routine care. We conducted logistic and linear regression analyses examining associations between different timeframes and viral load using Bayesian model averaging (BMA). We conducted sensitivity analyses with subgroups at increased risk for suboptimal adherence (e.g. patients with depression, substance use). The 14-day timeframe had the largest mean difference in adherence levels among those with detectable and undetectable viral loads. BMA estimates suggested the 14-day timeframe was strongest overall and for most subgroups although findings differed somewhat for hazardous alcohol users and those with current depression. Adherence measured by all missed dose timeframes correlated with viral load. Adherence calculated from intermediate timeframes (e.g. 14-day) appeared best able to capture adherence behavior as measured by viral load.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalAIDS and Behavior
DOIs
StateAccepted/In press - Oct 6 2016

Fingerprint

Viral Load
Depression
Patient Compliance
Linear Models
Logistic Models
Regression Analysis
Alcohols
Therapeutics

Keywords

  • Adherence
  • Depression
  • Hazardous alcohol use
  • Substance use
  • Viral load

ASJC Scopus subject areas

  • Social Psychology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Crane, H. M., Nance, R. M., Delaney, J. A. C., Fredericksen, R. J., Church, A., Simoni, J. M., ... Kitahata, M. M. (Accepted/In press). A Comparison of Adherence Timeframes Using Missed Dose Items and Their Associations with Viral Load in Routine Clinical Care: Is Longer Better? AIDS and Behavior, 1-11. https://doi.org/10.1007/s10461-016-1566-8

A Comparison of Adherence Timeframes Using Missed Dose Items and Their Associations with Viral Load in Routine Clinical Care : Is Longer Better? / Crane, H. M.; Nance, R. M.; Delaney, J. A C; Fredericksen, R. J.; Church, A.; Simoni, J. M.; Harrington, R. D.; Dhanireddy, S.; Safren, Steven; McCaul, M. E.; Lober, W. B.; Crane, P. K.; Wilson, I. B.; Mugavero, M. J.; Kitahata, M. M.

In: AIDS and Behavior, 06.10.2016, p. 1-11.

Research output: Contribution to journalArticle

Crane, HM, Nance, RM, Delaney, JAC, Fredericksen, RJ, Church, A, Simoni, JM, Harrington, RD, Dhanireddy, S, Safren, S, McCaul, ME, Lober, WB, Crane, PK, Wilson, IB, Mugavero, MJ & Kitahata, MM 2016, 'A Comparison of Adherence Timeframes Using Missed Dose Items and Their Associations with Viral Load in Routine Clinical Care: Is Longer Better?', AIDS and Behavior, pp. 1-11. https://doi.org/10.1007/s10461-016-1566-8
Crane, H. M. ; Nance, R. M. ; Delaney, J. A C ; Fredericksen, R. J. ; Church, A. ; Simoni, J. M. ; Harrington, R. D. ; Dhanireddy, S. ; Safren, Steven ; McCaul, M. E. ; Lober, W. B. ; Crane, P. K. ; Wilson, I. B. ; Mugavero, M. J. ; Kitahata, M. M. / A Comparison of Adherence Timeframes Using Missed Dose Items and Their Associations with Viral Load in Routine Clinical Care : Is Longer Better?. In: AIDS and Behavior. 2016 ; pp. 1-11.
@article{7e306b3fb80d458fbf50670b8c3aa6b2,
title = "A Comparison of Adherence Timeframes Using Missed Dose Items and Their Associations with Viral Load in Routine Clinical Care: Is Longer Better?",
abstract = "Questions remain regarding optimal timeframes for asking about adherence in clinical care. We compared 4-, 7-, 14-, 30-, and 60-day timeframe missed dose items with viral load levels among 1099 patients on antiretroviral therapy in routine care. We conducted logistic and linear regression analyses examining associations between different timeframes and viral load using Bayesian model averaging (BMA). We conducted sensitivity analyses with subgroups at increased risk for suboptimal adherence (e.g. patients with depression, substance use). The 14-day timeframe had the largest mean difference in adherence levels among those with detectable and undetectable viral loads. BMA estimates suggested the 14-day timeframe was strongest overall and for most subgroups although findings differed somewhat for hazardous alcohol users and those with current depression. Adherence measured by all missed dose timeframes correlated with viral load. Adherence calculated from intermediate timeframes (e.g. 14-day) appeared best able to capture adherence behavior as measured by viral load.",
keywords = "Adherence, Depression, Hazardous alcohol use, Substance use, Viral load",
author = "Crane, {H. M.} and Nance, {R. M.} and Delaney, {J. A C} and Fredericksen, {R. J.} and A. Church and Simoni, {J. M.} and Harrington, {R. D.} and S. Dhanireddy and Steven Safren and McCaul, {M. E.} and Lober, {W. B.} and Crane, {P. K.} and Wilson, {I. B.} and Mugavero, {M. J.} and Kitahata, {M. M.}",
year = "2016",
month = "10",
day = "6",
doi = "10.1007/s10461-016-1566-8",
language = "English (US)",
pages = "1--11",
journal = "AIDS and Behavior",
issn = "1090-7165",
publisher = "Springer New York",

}

TY - JOUR

T1 - A Comparison of Adherence Timeframes Using Missed Dose Items and Their Associations with Viral Load in Routine Clinical Care

T2 - Is Longer Better?

AU - Crane, H. M.

AU - Nance, R. M.

AU - Delaney, J. A C

AU - Fredericksen, R. J.

AU - Church, A.

AU - Simoni, J. M.

AU - Harrington, R. D.

AU - Dhanireddy, S.

AU - Safren, Steven

AU - McCaul, M. E.

AU - Lober, W. B.

AU - Crane, P. K.

AU - Wilson, I. B.

AU - Mugavero, M. J.

AU - Kitahata, M. M.

PY - 2016/10/6

Y1 - 2016/10/6

N2 - Questions remain regarding optimal timeframes for asking about adherence in clinical care. We compared 4-, 7-, 14-, 30-, and 60-day timeframe missed dose items with viral load levels among 1099 patients on antiretroviral therapy in routine care. We conducted logistic and linear regression analyses examining associations between different timeframes and viral load using Bayesian model averaging (BMA). We conducted sensitivity analyses with subgroups at increased risk for suboptimal adherence (e.g. patients with depression, substance use). The 14-day timeframe had the largest mean difference in adherence levels among those with detectable and undetectable viral loads. BMA estimates suggested the 14-day timeframe was strongest overall and for most subgroups although findings differed somewhat for hazardous alcohol users and those with current depression. Adherence measured by all missed dose timeframes correlated with viral load. Adherence calculated from intermediate timeframes (e.g. 14-day) appeared best able to capture adherence behavior as measured by viral load.

AB - Questions remain regarding optimal timeframes for asking about adherence in clinical care. We compared 4-, 7-, 14-, 30-, and 60-day timeframe missed dose items with viral load levels among 1099 patients on antiretroviral therapy in routine care. We conducted logistic and linear regression analyses examining associations between different timeframes and viral load using Bayesian model averaging (BMA). We conducted sensitivity analyses with subgroups at increased risk for suboptimal adherence (e.g. patients with depression, substance use). The 14-day timeframe had the largest mean difference in adherence levels among those with detectable and undetectable viral loads. BMA estimates suggested the 14-day timeframe was strongest overall and for most subgroups although findings differed somewhat for hazardous alcohol users and those with current depression. Adherence measured by all missed dose timeframes correlated with viral load. Adherence calculated from intermediate timeframes (e.g. 14-day) appeared best able to capture adherence behavior as measured by viral load.

KW - Adherence

KW - Depression

KW - Hazardous alcohol use

KW - Substance use

KW - Viral load

UR - http://www.scopus.com/inward/record.url?scp=84990842054&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84990842054&partnerID=8YFLogxK

U2 - 10.1007/s10461-016-1566-8

DO - 10.1007/s10461-016-1566-8

M3 - Article

C2 - 27714525

AN - SCOPUS:84990842054

SP - 1

EP - 11

JO - AIDS and Behavior

JF - AIDS and Behavior

SN - 1090-7165

ER -