Abstract
In the context of investigations on drug diffusion into human skin, first examples of using porous filters as model bio-membranes to understand the role of physical and chemical parameters on the penetration of chromophores. The diffusion of small molecules has been investigated in porous filters of different pore sizes by using pulsed photoacoustic spectroscopy. An analogy is made between the model membranes and human skin concerning the influence of the filter structure and the hydrophilic nature of the matrix support material. Finally, first data are presented on the effect of a modified surface filter structure on the diffusion pattern, thus opening the field to the potential use of these filters as model membrane of adjustable structural and chemical parameters.
| Original language | English |
|---|---|
| Pages (from-to) | 213-228 |
| Number of pages | 16 |
| Journal | Journal of Membrane Science |
| Volume | 119 |
| Issue number | 2 |
| DOIs | |
| State | Published - Oct 16 1996 |
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Keywords
- Diffusion
- Drug permeability
- Microporous and porous membranes
- Photoacoustic spectroscopy
- Skin
ASJC Scopus subject areas
- Filtration and Separation
- Polymers and Plastics
Cite this
A comparative study on chromophore diffusion inside porous filters by pulsed photoacoustic spectroscopy. / Puccetti, Germain; Leblanc, Roger.
In: Journal of Membrane Science, Vol. 119, No. 2, 16.10.1996, p. 213-228.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A comparative study on chromophore diffusion inside porous filters by pulsed photoacoustic spectroscopy
AU - Puccetti, Germain
AU - Leblanc, Roger
PY - 1996/10/16
Y1 - 1996/10/16
N2 - In the context of investigations on drug diffusion into human skin, first examples of using porous filters as model bio-membranes to understand the role of physical and chemical parameters on the penetration of chromophores. The diffusion of small molecules has been investigated in porous filters of different pore sizes by using pulsed photoacoustic spectroscopy. An analogy is made between the model membranes and human skin concerning the influence of the filter structure and the hydrophilic nature of the matrix support material. Finally, first data are presented on the effect of a modified surface filter structure on the diffusion pattern, thus opening the field to the potential use of these filters as model membrane of adjustable structural and chemical parameters.
AB - In the context of investigations on drug diffusion into human skin, first examples of using porous filters as model bio-membranes to understand the role of physical and chemical parameters on the penetration of chromophores. The diffusion of small molecules has been investigated in porous filters of different pore sizes by using pulsed photoacoustic spectroscopy. An analogy is made between the model membranes and human skin concerning the influence of the filter structure and the hydrophilic nature of the matrix support material. Finally, first data are presented on the effect of a modified surface filter structure on the diffusion pattern, thus opening the field to the potential use of these filters as model membrane of adjustable structural and chemical parameters.
KW - Diffusion
KW - Drug permeability
KW - Microporous and porous membranes
KW - Photoacoustic spectroscopy
KW - Skin
UR - http://www.scopus.com/inward/record.url?scp=0030590545&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030590545&partnerID=8YFLogxK
U2 - 10.1016/0376-7388(96)00126-3
DO - 10.1016/0376-7388(96)00126-3
M3 - Article
VL - 119
SP - 213
EP - 228
JO - Jornal of Membrane Science
JF - Jornal of Membrane Science
SN - 0376-7388
IS - 2
ER -