A comparative study of effects of sex hormones and β-adrenergic agents on sialic acid content of submandibular gland of male albino rat, rattus norvagicus albinus

S. J. Killedar, Ami Raval, P. M. Ambadkar

Research output: Contribution to journalArticle

Abstract

Rapid effects of testosterone propionate (TP) and 17 β - estradiol on the sialic acid (SA) content of submandibular gland of male albino rats were assayed after 1,2 and 4 h of administration to normal intact as well as 48 h castrates. Replacement with TP was seen to counteract castration effect but only slightly and transitorily. Administration of 17β - estradiol (E2) to intact rats led to a steady time-dependent increase but the variation pattern in 48 h castrate exhibited similar trend as was obtainable after TP administration, but the magnitude was remarkably high. Since it is known that autonomic nerve supply maintains the structural and functional integrity of salivary glands, the effects of isoproterenol (IPR) and propranolol (PPN) on submandibular gland functions were also studied. IPR was found to lower SA content within 60 min whereas PPN significantly increased the SA content. From this it may be suggested that normal levels of testosterone may have complementary influence on usual β-adrenergic regulation of SA of submandibular gland of male rat.

Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalJournal of Advanced Zoology
Volume19
Issue number1
StatePublished - Jun 1 1998
Externally publishedYes

Fingerprint

adrenergic agents
Rattus
sialic acids
sex hormones
albino
testosterone
propionates
propranolol
rats
estradiol
castration
salivary glands
nerve tissue

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

@article{79fce2e4521747c3aea8640613509a17,
title = "A comparative study of effects of sex hormones and β-adrenergic agents on sialic acid content of submandibular gland of male albino rat, rattus norvagicus albinus",
abstract = "Rapid effects of testosterone propionate (TP) and 17 β - estradiol on the sialic acid (SA) content of submandibular gland of male albino rats were assayed after 1,2 and 4 h of administration to normal intact as well as 48 h castrates. Replacement with TP was seen to counteract castration effect but only slightly and transitorily. Administration of 17β - estradiol (E2) to intact rats led to a steady time-dependent increase but the variation pattern in 48 h castrate exhibited similar trend as was obtainable after TP administration, but the magnitude was remarkably high. Since it is known that autonomic nerve supply maintains the structural and functional integrity of salivary glands, the effects of isoproterenol (IPR) and propranolol (PPN) on submandibular gland functions were also studied. IPR was found to lower SA content within 60 min whereas PPN significantly increased the SA content. From this it may be suggested that normal levels of testosterone may have complementary influence on usual β-adrenergic regulation of SA of submandibular gland of male rat.",
author = "Killedar, {S. J.} and Ami Raval and Ambadkar, {P. M.}",
year = "1998",
month = "6",
day = "1",
language = "English",
volume = "19",
pages = "27--32",
journal = "Journal of Advanced Zoology",
issn = "0253-7214",
publisher = "INSIO Scientific Books and Periodicals",
number = "1",

}

TY - JOUR

T1 - A comparative study of effects of sex hormones and β-adrenergic agents on sialic acid content of submandibular gland of male albino rat, rattus norvagicus albinus

AU - Killedar, S. J.

AU - Raval, Ami

AU - Ambadkar, P. M.

PY - 1998/6/1

Y1 - 1998/6/1

N2 - Rapid effects of testosterone propionate (TP) and 17 β - estradiol on the sialic acid (SA) content of submandibular gland of male albino rats were assayed after 1,2 and 4 h of administration to normal intact as well as 48 h castrates. Replacement with TP was seen to counteract castration effect but only slightly and transitorily. Administration of 17β - estradiol (E2) to intact rats led to a steady time-dependent increase but the variation pattern in 48 h castrate exhibited similar trend as was obtainable after TP administration, but the magnitude was remarkably high. Since it is known that autonomic nerve supply maintains the structural and functional integrity of salivary glands, the effects of isoproterenol (IPR) and propranolol (PPN) on submandibular gland functions were also studied. IPR was found to lower SA content within 60 min whereas PPN significantly increased the SA content. From this it may be suggested that normal levels of testosterone may have complementary influence on usual β-adrenergic regulation of SA of submandibular gland of male rat.

AB - Rapid effects of testosterone propionate (TP) and 17 β - estradiol on the sialic acid (SA) content of submandibular gland of male albino rats were assayed after 1,2 and 4 h of administration to normal intact as well as 48 h castrates. Replacement with TP was seen to counteract castration effect but only slightly and transitorily. Administration of 17β - estradiol (E2) to intact rats led to a steady time-dependent increase but the variation pattern in 48 h castrate exhibited similar trend as was obtainable after TP administration, but the magnitude was remarkably high. Since it is known that autonomic nerve supply maintains the structural and functional integrity of salivary glands, the effects of isoproterenol (IPR) and propranolol (PPN) on submandibular gland functions were also studied. IPR was found to lower SA content within 60 min whereas PPN significantly increased the SA content. From this it may be suggested that normal levels of testosterone may have complementary influence on usual β-adrenergic regulation of SA of submandibular gland of male rat.

UR - http://www.scopus.com/inward/record.url?scp=3042861396&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042861396&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:3042861396

VL - 19

SP - 27

EP - 32

JO - Journal of Advanced Zoology

JF - Journal of Advanced Zoology

SN - 0253-7214

IS - 1

ER -