Rapid effects of testosterone propionate (TP) and 17 β - estradiol on the sialic acid (SA) content of submandibular gland of male albino rats were assayed after 1,2 and 4 h of administration to normal intact as well as 48 h castrates. Replacement with TP was seen to counteract castration effect but only slightly and transitorily. Administration of 17β - estradiol (E2) to intact rats led to a steady time-dependent increase but the variation pattern in 48 h castrate exhibited similar trend as was obtainable after TP administration, but the magnitude was remarkably high. Since it is known that autonomic nerve supply maintains the structural and functional integrity of salivary glands, the effects of isoproterenol (IPR) and propranolol (PPN) on submandibular gland functions were also studied. IPR was found to lower SA content within 60 min whereas PPN significantly increased the SA content. From this it may be suggested that normal levels of testosterone may have complementary influence on usual β-adrenergic regulation of SA of submandibular gland of male rat.
|Original language||English (US)|
|Number of pages||6|
|Journal||Journal of Advanced Zoology|
|State||Published - Jun 1 1998|
ASJC Scopus subject areas
- Animal Science and Zoology