A comparative review of aging and B cell function in mice and humans

Jean L. Scholz, Alain Diaz, Richard L Riley, Michael P. Cancro, Daniela Frasca

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Immune system function declines with age. Here we review and compare age-associated changes in murine and human B cell pools and humoral immune responses. We summarize changes in B cell generation and homeostasis, as well as notable changes at the subcellular level; then discuss how these changes help to explain alterations in immune responses across the adult lifespan of the animal. In each section we compare and contrast findings in the mouse, arguably the best animal model of the aging immune system, with current understanding of B cell immunity in humans.

Original languageEnglish
Pages (from-to)504-510
Number of pages7
JournalCurrent Opinion in Immunology
Volume25
Issue number4
DOIs
StatePublished - Aug 1 2013

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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