A collagen matrix derived from bladder can be used to engineer smooth muscle tissue

Byung Soo Kim, Anthony Atala, James J. Yoo

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We have previously demonstrated that a collagen matrix derived from lamina propria, commonly known as bladder submucosa (BSM matrix), is a suitable biomaterial for several urologic applications, including reconstruction of the bladder and urethra in experimental models and clinical trials. In the present study, we evaluated the physical properties of BSM as well as its biocompatibility, cellular interactions, and ability to support the formation of functional tissue in order to determine whether this biomaterial could serve as a matrix for urinary smooth muscle tissue engineering. BSM matrix resembles the extracellular matrix of bladder submucosa in its native structure, composition, and mechanical properties. BSM matrix supported normal mitochondrial metabolic and proliferative functions of human urinary smooth muscle cells and did not induce cytotoxic effects in vitro. When implanted in vivo, BSM matrix promoted the regeneration of urinary smooth muscle tissues with contractility, which is a smooth muscle-specific tissue function. These results suggest that BSM matrix would be a useful biomaterial for urinary smooth muscle reconstruction.

Original languageEnglish
Pages (from-to)307-314
Number of pages8
JournalWorld Journal of Urology
Volume26
Issue number4
DOIs
StatePublished - Jul 2 2008
Externally publishedYes

Fingerprint

Smooth Muscle
Urinary Bladder
Biocompatible Materials
Collagen
Muscles
Urethra
Tissue Engineering
Smooth Muscle Myocytes
Extracellular Matrix
Regeneration
Mucous Membrane
Theoretical Models
Clinical Trials

Keywords

  • Bladder submucosa
  • Collagen matrix
  • Smooth muscle

ASJC Scopus subject areas

  • Urology

Cite this

A collagen matrix derived from bladder can be used to engineer smooth muscle tissue. / Kim, Byung Soo; Atala, Anthony; Yoo, James J.

In: World Journal of Urology, Vol. 26, No. 4, 02.07.2008, p. 307-314.

Research output: Contribution to journalArticle

Kim, Byung Soo ; Atala, Anthony ; Yoo, James J. / A collagen matrix derived from bladder can be used to engineer smooth muscle tissue. In: World Journal of Urology. 2008 ; Vol. 26, No. 4. pp. 307-314.
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