A cognitive stress test for prodromal Alzheimer's disease: Multiethnic generalizability

Rosie E. Curiel Cid, David A. Loewenstein, Monica Rosselli, Jordi A. Matias-Guiu, D. Piña, M. Adjouadi, Mercedes Cabrerizo, Russell M. Bauer, Aldrich Chan, Steven T. DeKosky, Todd Golde, Maria T. Greig-Custo, Gabriel Lizarraga, A. Peñate, Ranjan Duara

Research output: Contribution to journalArticle

Abstract

Introduction: Culturally fair cognitive assessments sensitive to detecting changes associated with prodromal Alzheimer's disease are needed. Methods: Performance of Hispanic and non-Hispanic older adults on the Loewenstein-Acevedo Scale of Semantic Interference and Learning (LASSI-L) was examined in persons with amnestic mild cognitive impairment (aMCI) or normal cognition. The association between a novel cognitive marker, the failure to recover from proactive semantic interference (frPSI), and cortical thinning was explored. Results: English-speaking aMCI participants scored lower than cognitively normal participants on all LASSI-L indices, while Spanish-speaking aMCI participants scored lower in learning, frPSI, and delayed recall. Healthy controls obtained equivalent scores on all indices except retroactive semantic interference. English-speaking and Spanish-speaking aMCI participants had equivalent scores except English speaker's greater vulnerability to frPSI. Across aMCI groups, frPSI was associated with cortical thinning of the entorhinal cortex and precuneus (r = −0.45 to r = 0.52; P < .005). Discussion: In diverse populations, LASSI-L performance differentiated patients with aMCI from cognitively normal older adults and was associated with thinning in Alzheimer's disease–prone regions, suggesting its clinical utility.

Original languageEnglish (US)
Pages (from-to)550-559
Number of pages10
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume11
DOIs
StatePublished - Dec 2019

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Exercise Test
Semantics
Alzheimer Disease
Learning
Entorhinal Cortex
Parietal Lobe
Hispanic Americans
Cognition
Cognitive Dysfunction
Population

Keywords

  • Cognitive assessment
  • Diversity
  • Mild cognitive impairment
  • Prodromal Alzheimer's disease
  • Semantic interference

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

A cognitive stress test for prodromal Alzheimer's disease : Multiethnic generalizability. / Curiel Cid, Rosie E.; Loewenstein, David A.; Rosselli, Monica; Matias-Guiu, Jordi A.; Piña, D.; Adjouadi, M.; Cabrerizo, Mercedes; Bauer, Russell M.; Chan, Aldrich; DeKosky, Steven T.; Golde, Todd; Greig-Custo, Maria T.; Lizarraga, Gabriel; Peñate, A.; Duara, Ranjan.

In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 11, 12.2019, p. 550-559.

Research output: Contribution to journalArticle

Curiel Cid, RE, Loewenstein, DA, Rosselli, M, Matias-Guiu, JA, Piña, D, Adjouadi, M, Cabrerizo, M, Bauer, RM, Chan, A, DeKosky, ST, Golde, T, Greig-Custo, MT, Lizarraga, G, Peñate, A & Duara, R 2019, 'A cognitive stress test for prodromal Alzheimer's disease: Multiethnic generalizability', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 11, pp. 550-559. https://doi.org/10.1016/j.dadm.2019.05.003
Curiel Cid, Rosie E. ; Loewenstein, David A. ; Rosselli, Monica ; Matias-Guiu, Jordi A. ; Piña, D. ; Adjouadi, M. ; Cabrerizo, Mercedes ; Bauer, Russell M. ; Chan, Aldrich ; DeKosky, Steven T. ; Golde, Todd ; Greig-Custo, Maria T. ; Lizarraga, Gabriel ; Peñate, A. ; Duara, Ranjan. / A cognitive stress test for prodromal Alzheimer's disease : Multiethnic generalizability. In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2019 ; Vol. 11. pp. 550-559.
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AU - Loewenstein, David A.

AU - Rosselli, Monica

AU - Matias-Guiu, Jordi A.

AU - Piña, D.

AU - Adjouadi, M.

AU - Cabrerizo, Mercedes

AU - Bauer, Russell M.

AU - Chan, Aldrich

AU - DeKosky, Steven T.

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AU - Duara, Ranjan

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