A cognitive stress test for prodromal Alzheimer's disease: Multiethnic generalizability

Rosie E. Curiel Cid, David A. Loewenstein, Monica Rosselli, Jordi A. Matias-Guiu, D. Piña, M. Adjouadi, Mercedes Cabrerizo, Russell M. Bauer, Aldrich Chan, Steven T. DeKosky, Todd Golde, Maria T. Greig-Custo, Gabriel Lizarraga, A. Peñate, Ranjan Duara

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Introduction: Culturally fair cognitive assessments sensitive to detecting changes associated with prodromal Alzheimer's disease are needed. Methods: Performance of Hispanic and non-Hispanic older adults on the Loewenstein-Acevedo Scale of Semantic Interference and Learning (LASSI-L) was examined in persons with amnestic mild cognitive impairment (aMCI) or normal cognition. The association between a novel cognitive marker, the failure to recover from proactive semantic interference (frPSI), and cortical thinning was explored. Results: English-speaking aMCI participants scored lower than cognitively normal participants on all LASSI-L indices, while Spanish-speaking aMCI participants scored lower in learning, frPSI, and delayed recall. Healthy controls obtained equivalent scores on all indices except retroactive semantic interference. English-speaking and Spanish-speaking aMCI participants had equivalent scores except English speaker's greater vulnerability to frPSI. Across aMCI groups, frPSI was associated with cortical thinning of the entorhinal cortex and precuneus (r = −0.45 to r = 0.52; P < .005). Discussion: In diverse populations, LASSI-L performance differentiated patients with aMCI from cognitively normal older adults and was associated with thinning in Alzheimer's disease–prone regions, suggesting its clinical utility.

Original languageEnglish (US)
Pages (from-to)550-559
Number of pages10
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
StatePublished - Dec 2019


  • Cognitive assessment
  • Diversity
  • Mild cognitive impairment
  • Prodromal Alzheimer's disease
  • Semantic interference

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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