Abstract
Persistence of vaccine-induced immune responses, not the initial magnitude, best correlates with protective antitumor immunity. In mice, oligonucleotide aptamer-targeted siRNA inhibition of mammalian target of rapamycin (mTOR) activity in activated CD8+ T cells promotes their differentiation into functionally competent memory cells leading to enhanced antitumor immunity, a protective effect superior to that of non-targeted administration of the mTOR inhibitor rapamycin.
Original language | English (US) |
---|---|
Article number | e28811 |
Journal | OncoImmunology |
Volume | 3 |
Issue number | 5 |
DOIs | |
State | Published - 2014 |
Keywords
- 4-1BB costimulation
- Aptamers
- MTOR
- T cell memory
- Tumor immunity
ASJC Scopus subject areas
- Immunology and Allergy
- Oncology
- Immunology