A clinically useful approach to enhance immunological memory and antitumor immunity

Alex Berezhnoy; Anugraha Rajagopalan; Eli Gilboa

doi:10.4161/onci.28811

A clinically useful approach to enhance immunological memory and antitumor immunity

Alex Berezhnoy, Anugraha Rajagopalan, Eli Gilboa

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Persistence of vaccine-induced immune responses, not the initial magnitude, best correlates with protective antitumor immunity. In mice, oligonucleotide aptamer-targeted siRNA inhibition of mammalian target of rapamycin (mTOR) activity in activated CD8+ T cells promotes their differentiation into functionally competent memory cells leading to enhanced antitumor immunity, a protective effect superior to that of non-targeted administration of the mTOR inhibitor rapamycin.

Original language	English (US)
Article number	e28811
Journal	OncoImmunology
Volume	3
Issue number	5
DOIs	https://doi.org/10.4161/onci.28811
State	Published - 2014

Keywords

4-1BB costimulation
Aptamers
MTOR
T cell memory
Tumor immunity

ASJC Scopus subject areas

Immunology and Allergy
Oncology
Immunology

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title = "A clinically useful approach to enhance immunological memory and antitumor immunity",

abstract = "Persistence of vaccine-induced immune responses, not the initial magnitude, best correlates with protective antitumor immunity. In mice, oligonucleotide aptamer-targeted siRNA inhibition of mammalian target of rapamycin (mTOR) activity in activated CD8+ T cells promotes their differentiation into functionally competent memory cells leading to enhanced antitumor immunity, a protective effect superior to that of non-targeted administration of the mTOR inhibitor rapamycin.",

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AU - Berezhnoy, Alex

AU - Rajagopalan, Anugraha

AU - Gilboa, Eli

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AB - Persistence of vaccine-induced immune responses, not the initial magnitude, best correlates with protective antitumor immunity. In mice, oligonucleotide aptamer-targeted siRNA inhibition of mammalian target of rapamycin (mTOR) activity in activated CD8+ T cells promotes their differentiation into functionally competent memory cells leading to enhanced antitumor immunity, a protective effect superior to that of non-targeted administration of the mTOR inhibitor rapamycin.

KW - 4-1BB costimulation

KW - Aptamers

KW - MTOR

KW - T cell memory

KW - Tumor immunity

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A clinically useful approach to enhance immunological memory and antitumor immunity

Abstract

Keywords

ASJC Scopus subject areas

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