Abstract
Persistence of vaccine-induced immune responses, not the initial magnitude, best correlates with protective antitumor immunity. In mice, oligonucleotide aptamer-targeted siRNA inhibition of mammalian target of rapamycin (mTOR) activity in activated CD8+ T cells promotes their differentiation into functionally competent memory cells leading to enhanced antitumor immunity, a protective effect superior to that of non-targeted administration of the mTOR inhibitor rapamycin.
| Original language | English (US) |
|---|---|
| Article number | e28811 |
| Journal | OncoImmunology |
| Volume | 3 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 2014 |
Keywords
- 4-1BB costimulation
- Aptamers
- MTOR
- T cell memory
- Tumor immunity
ASJC Scopus subject areas
- Immunology and Allergy
- Oncology
- Immunology
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Cite this
Berezhnoy, A., Rajagopalan, A., & Gilboa, E. (2014). A clinically useful approach to enhance immunological memory and antitumor immunity. OncoImmunology, 3(5), [e28811]. https://doi.org/10.4161/onci.28811