A clinically useful approach to enhance immunological memory and antitumor immunity

Alex Berezhnoy, Anugraha Rajagopalan, Eli Gilboa

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Persistence of vaccine-induced immune responses, not the initial magnitude, best correlates with protective antitumor immunity. In mice, oligonucleotide aptamer-targeted siRNA inhibition of mammalian target of rapamycin (mTOR) activity in activated CD8+ T cells promotes their differentiation into functionally competent memory cells leading to enhanced antitumor immunity, a protective effect superior to that of non-targeted administration of the mTOR inhibitor rapamycin.

Original languageEnglish (US)
Article numbere28811
JournalOncoImmunology
Volume3
Issue number5
DOIs
StatePublished - 2014

Keywords

  • 4-1BB costimulation
  • Aptamers
  • MTOR
  • T cell memory
  • Tumor immunity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

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