TY - JOUR
T1 - A clinical perspective of mild cognitive impairment
T2 - What radiologists should know
AU - Duara, Ranjan
AU - Loewenstein, David
AU - Barker, Warren W.
AU - Isaacson, Richard S.
AU - Greig-Custo, Maria
PY - 2005/11/1
Y1 - 2005/11/1
N2 - Mild cognitive impairment (MCI), a major risk factor for dementia, has an amnestic subtype that has a high probability of progressing to Alzheimer's disease. The rate of progression may be predicted by the severity of memory impairment at baseline, the severity of hippocampal atrophy, and, possibly, the presence of an ε4 allele of the apolipoprotein E gene. MCI can be diagnosed using purely clinical or a combination of clinical and neuropsychologic criteria. Treatment trials show no disease-modifying effect. The radiologists' role is to determine whether or not the hallmarks of degenerative and vascular disease of the brain are present, aiding in the diagnosis of the cause of MCI.
AB - Mild cognitive impairment (MCI), a major risk factor for dementia, has an amnestic subtype that has a high probability of progressing to Alzheimer's disease. The rate of progression may be predicted by the severity of memory impairment at baseline, the severity of hippocampal atrophy, and, possibly, the presence of an ε4 allele of the apolipoprotein E gene. MCI can be diagnosed using purely clinical or a combination of clinical and neuropsychologic criteria. Treatment trials show no disease-modifying effect. The radiologists' role is to determine whether or not the hallmarks of degenerative and vascular disease of the brain are present, aiding in the diagnosis of the cause of MCI.
UR - http://www.scopus.com/inward/record.url?scp=31544437734&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=31544437734&partnerID=8YFLogxK
U2 - 10.1016/j.nic.2005.09.010
DO - 10.1016/j.nic.2005.09.010
M3 - Review article
C2 - 16443490
AN - SCOPUS:31544437734
VL - 15
SP - 779
EP - 788
JO - Neuroimaging Clinics of North America
JF - Neuroimaging Clinics of North America
SN - 1052-5149
IS - 4
ER -