A clinical, histopathologic, and molecular biologic investigation of vulvar intraepithelial neoplasia

Leo B. Twiggs, Takashi Okagaki, Barbara Clark, Michio Fukushima, Ronald Ostrow, Anthony Faras

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

The spectrum of vulvar intraepithelial neoplasia (VIN) was investigated with human papillomavirus (HPV) DNA probes by Southern blot hybridization technique. The results of vulvar tissue examinations from 25 patients were compared to prior genital and systemic diseases, clinical presentation, and histopathologic manifestations. The presence of HPV DNA in these lesions was largely associated with multifocality of the lesions, the presence of synchronous and metachronous multicentric genital neoplasia, and depressed immunocompetence. These findings indicate that VIN is associated with HPV and may have an infectious etiology.

Original languageEnglish (US)
Pages (from-to)48-55
Number of pages8
JournalInternational Journal of Gynecological Pathology
Volume7
Issue number1
DOIs
StatePublished - Mar 1988

Keywords

  • DNA probes
  • Human papillomavirus
  • Vulvar intraepithelial neoplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology

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