A Clinic-Based, Comprehensive Care Model for Studying Late Effects in Long-Term Survivors of Pediatric Illnesses

Andrea S. Hinkle, Cindy Proukou, Carol A. French, Amy M. Kozlowski, Louis S. Constine, Stuart R. Lipsitz, Tracie L Miller, Steven E Lipshultz

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Objective. Long-term survivors of several childhood illnesses are at risk for multiple late effects of their illness or therapy, and children with documented toxic exposures may also experience long-term health consequences. Clinical studies of these effects are difficult to conduct. The Cardiovascular Status in Childhood Cancer Survivors Study is an established study that highlights the ability to perform comprehensive clinical investigations when patients are cared for in a formal, long-term follow-up clinic. This clinic model facilitates long-term retention and recruitment of patients, allowing comprehensive clinical studies of late effects of illness or exposures, in this case, of cardiovascular complications of cancer treatment during childhood. Methods. The study is funded through the National Institute of Health Office of Cancer Survivorship. Participants are recruited from the Long-Term Survivors Clinic at the University of Rochester. The clinic provides care for all survivors of childhood cancer in the region. The Long-Term Survivors Clinic provides medical care and psychosocial and educational support to patients and facilitates coordination of care. Patients remain in close contact with clinic staff for extended periods. Results. We recruited a representative sample of this long-term survivor population, with a wide range of ages, diagnoses, and time since diagnosis. Longitudinal collection of detailed clinical data will enable us to conduct cohort studies of late effects as well as case-control studies of toxic exposures. Conclusions. The success of this study shows the advantages of formal programs for continued care of patients with chronic illnesses or treatment or toxic exposures. The Long-Term Survivors Clinic provides an excellent model for clinical care and research that is applicable to multiple pediatric and young adult populations.

Original languageEnglish
Pages (from-to)1141-1145
Number of pages5
JournalPediatrics
Volume113
Issue number4 II
StatePublished - Apr 1 2004

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Survivors
Pediatrics
Poisons
Neoplasms
National Institutes of Health (U.S.)
Patient Selection
Population
Case-Control Studies
Young Adult
Patient Care
Chronic Disease
Cohort Studies
Therapeutics
Survival Rate
Health
Research

Keywords

  • Childhood cancer
  • Clinic model
  • Late effects
  • Survivors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Hinkle, A. S., Proukou, C., French, C. A., Kozlowski, A. M., Constine, L. S., Lipsitz, S. R., ... Lipshultz, S. E. (2004). A Clinic-Based, Comprehensive Care Model for Studying Late Effects in Long-Term Survivors of Pediatric Illnesses. Pediatrics, 113(4 II), 1141-1145.

A Clinic-Based, Comprehensive Care Model for Studying Late Effects in Long-Term Survivors of Pediatric Illnesses. / Hinkle, Andrea S.; Proukou, Cindy; French, Carol A.; Kozlowski, Amy M.; Constine, Louis S.; Lipsitz, Stuart R.; Miller, Tracie L; Lipshultz, Steven E.

In: Pediatrics, Vol. 113, No. 4 II, 01.04.2004, p. 1141-1145.

Research output: Contribution to journalArticle

Hinkle, AS, Proukou, C, French, CA, Kozlowski, AM, Constine, LS, Lipsitz, SR, Miller, TL & Lipshultz, SE 2004, 'A Clinic-Based, Comprehensive Care Model for Studying Late Effects in Long-Term Survivors of Pediatric Illnesses', Pediatrics, vol. 113, no. 4 II, pp. 1141-1145.
Hinkle AS, Proukou C, French CA, Kozlowski AM, Constine LS, Lipsitz SR et al. A Clinic-Based, Comprehensive Care Model for Studying Late Effects in Long-Term Survivors of Pediatric Illnesses. Pediatrics. 2004 Apr 1;113(4 II):1141-1145.
Hinkle, Andrea S. ; Proukou, Cindy ; French, Carol A. ; Kozlowski, Amy M. ; Constine, Louis S. ; Lipsitz, Stuart R. ; Miller, Tracie L ; Lipshultz, Steven E. / A Clinic-Based, Comprehensive Care Model for Studying Late Effects in Long-Term Survivors of Pediatric Illnesses. In: Pediatrics. 2004 ; Vol. 113, No. 4 II. pp. 1141-1145.
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