A classification of HTLV-III infection based on 75 cases seen in a suburban community

M. H. Kaplan, S. G. Pahwa, M. Popovic, M. G. Sarngadharan, R. C. Gallo

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6 Scopus citations


Since 1981, 75 patients have been seen at our hospital with human T-cell lymphotropic virus type III (HTLV-III) infection. We have classified their clinical presentation into Groups 0 to 6. Groups 0 to 3 all have antibody to the M(r) 41,000 protein of HTLV-III. Group 0 has no evident disease (9 patients). Group 1 has lymphoadenopathy with or without exaggerated infection (16 patients). Group 2 has persistent lymphadenopathy with chronic hepatitis B surface antigenemia or profound hypergammaglobulinemia (7 patients). Group 3 has oral candidiasis with or without lymphadenopathy (7 patients). In Group 4 are acquired immunodeficiency syndrome (AIDS) adults or children (32 patients). Group 5 is a special classification for immunocompromised patients. Group 6 patients have lymphomas and M(r) 41,000 protein antibody. Four children were classified separately. Three patients in Group 3 developed Group 4 disorders (AIDS). Four patients in Group 4 developed Group 6 disorders. HTLV-III infection spread in families (8 of 36), all from infected mothers to children. In 17 sexual partners, 6 were found to be infected. Five of 6 infected partners were homosexuals. We saw an inordinate number of transfusional AIDS (4 of 29) and 1 of 46 other disorders. Two infants also presented with severe intracranial defects, one with microcephaly and one with cranial calcifications and lucency. HTLV-III is spreading with alarming speed.

Original languageEnglish (US)
Pages (from-to)4655s-4658s
JournalCancer Research
Issue number9 SUPPL.
StatePublished - Dec 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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