A classification of HTLV-III infection based on 75 cases seen in a suburban community

M. H. Kaplan, Savita G Pahwa, M. Popovic, M. G. Sarngadharan, R. C. Gallo

Research output: Contribution to journalArticle

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Abstract

Since 1981, 75 patients have been seen at our hospital with human T-cell lymphotropic virus type III (HTLV-III) infection. We have classified their clinical presentation into Groups 0 to 6. Groups 0 to 3 all have antibody to the M(r) 41,000 protein of HTLV-III. Group 0 has no evident disease (9 patients). Group 1 has lymphoadenopathy with or without exaggerated infection (16 patients). Group 2 has persistent lymphadenopathy with chronic hepatitis B surface antigenemia or profound hypergammaglobulinemia (7 patients). Group 3 has oral candidiasis with or without lymphadenopathy (7 patients). In Group 4 are acquired immunodeficiency syndrome (AIDS) adults or children (32 patients). Group 5 is a special classification for immunocompromised patients. Group 6 patients have lymphomas and M(r) 41,000 protein antibody. Four children were classified separately. Three patients in Group 3 developed Group 4 disorders (AIDS). Four patients in Group 4 developed Group 6 disorders. HTLV-III infection spread in families (8 of 36), all from infected mothers to children. In 17 sexual partners, 6 were found to be infected. Five of 6 infected partners were homosexuals. We saw an inordinate number of transfusional AIDS (4 of 29) and 1 of 46 other disorders. Two infants also presented with severe intracranial defects, one with microcephaly and one with cranial calcifications and lucency. HTLV-III is spreading with alarming speed.

Original languageEnglish
JournalCancer Research
Volume45
Issue number9 SUPPL.
StatePublished - Dec 1 1985
Externally publishedYes

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HIV Infections
HIV
Acquired Immunodeficiency Syndrome
X-Linked Combined Immunodeficiency Diseases
Hypergammaglobulinemia
Oral Candidiasis
Microcephaly
Antibodies
Sexual Partners
Chronic Hepatitis B
Immunocompromised Host
Lymphoma
Proteins
Mothers
Infection

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Kaplan, M. H., Pahwa, S. G., Popovic, M., Sarngadharan, M. G., & Gallo, R. C. (1985). A classification of HTLV-III infection based on 75 cases seen in a suburban community. Cancer Research, 45(9 SUPPL.).

A classification of HTLV-III infection based on 75 cases seen in a suburban community. / Kaplan, M. H.; Pahwa, Savita G; Popovic, M.; Sarngadharan, M. G.; Gallo, R. C.

In: Cancer Research, Vol. 45, No. 9 SUPPL., 01.12.1985.

Research output: Contribution to journalArticle

Kaplan, MH, Pahwa, SG, Popovic, M, Sarngadharan, MG & Gallo, RC 1985, 'A classification of HTLV-III infection based on 75 cases seen in a suburban community', Cancer Research, vol. 45, no. 9 SUPPL..
Kaplan MH, Pahwa SG, Popovic M, Sarngadharan MG, Gallo RC. A classification of HTLV-III infection based on 75 cases seen in a suburban community. Cancer Research. 1985 Dec 1;45(9 SUPPL.).
Kaplan, M. H. ; Pahwa, Savita G ; Popovic, M. ; Sarngadharan, M. G. ; Gallo, R. C. / A classification of HTLV-III infection based on 75 cases seen in a suburban community. In: Cancer Research. 1985 ; Vol. 45, No. 9 SUPPL.
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