A child with BK virus infection: Inadequacy of current therapeutic strategies

Tanya Pereira; Claudia P. Rojas; Monica T. Garcia-Buitrago; Jayanthi Chandar; Carolyn Abitbol; Wacharee Seeherunvong; Paolo Rusconi; Jocelyn H. Bruce; Gaston Zilleruelò

doi:10.1111/j.1399-3046.2011.01602.x

A child with BK virus infection: Inadequacy of current therapeutic strategies

Tanya Pereira, Claudia P. Rojas, Monica T. Garcia-Buitrago, Jayanthi Chandar, Carolyn Abitbol, Wacharee Seeherunvong, Paolo Rusconi, Jocelyn H. Bruce, Gaston Zilleruelò

Research output: Contribution to journal › Article

12 Scopus citations

Abstract

In this report, we describe the development of BKVN in the native kidneys of a child with a cardiac transplant. Elevated BK viral DNA load by PCR necessitated a prolonged course of treatment with escalating doses of cidofovir. Despite a reduction in plasma BK viral load, the infection evolved into an invasive CNS disease, resulting in rhomboencephalitis. This case highlights the need for awareness of the possibility of developing multiorgan complications from BKV infection. The current treatment options for BKV tissue invasive disease are inadequate and need to be improved.

Original language	English (US)
Pages (from-to)	E269-E274
Journal	Pediatric Transplantation
Volume	16
Issue number	7
DOIs	https://doi.org/10.1111/j.1399-3046.2011.01602.x
State	Published - Nov 1 2012

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Keywords

cardiac transplantation
immunocompromised host
renal failure
viral infection

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Transplantation

Cite this

Pereira, T., Rojas, C. P., Garcia-Buitrago, M. T., Chandar, J., Abitbol, C., Seeherunvong, W., Rusconi, P., Bruce, J. H., & Zilleruelò, G. (2012). A child with BK virus infection: Inadequacy of current therapeutic strategies. Pediatric Transplantation, 16(7), E269-E274. https://doi.org/10.1111/j.1399-3046.2011.01602.x

A child with BK virus infection : Inadequacy of current therapeutic strategies. / Pereira, Tanya; Rojas, Claudia P.; Garcia-Buitrago, Monica T.; Chandar, Jayanthi ; Abitbol, Carolyn ; Seeherunvong, Wacharee ; Rusconi, Paolo; Bruce, Jocelyn H.; Zilleruelò, Gaston.

In: Pediatric Transplantation, Vol. 16, No. 7, 01.11.2012, p. E269-E274.

Research output: Contribution to journal › Article

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10.1111/j.1399-3046.2011.01602.x