A child with BK virus infection: Inadequacy of current therapeutic strategies

Tanya Pereira, Claudia P. Rojas, Monica T. Garcia-Buitrago, Jayanthi Chandar, Carolyn Abitbol, Wacharee Seeherunvong, Paolo Rusconi, Jocelyn H. Bruce, Gaston Zilleruelò

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

In this report, we describe the development of BKVN in the native kidneys of a child with a cardiac transplant. Elevated BK viral DNA load by PCR necessitated a prolonged course of treatment with escalating doses of cidofovir. Despite a reduction in plasma BK viral load, the infection evolved into an invasive CNS disease, resulting in rhomboencephalitis. This case highlights the need for awareness of the possibility of developing multiorgan complications from BKV infection. The current treatment options for BKV tissue invasive disease are inadequate and need to be improved.

Original languageEnglish (US)
Pages (from-to)E269-E274
JournalPediatric Transplantation
Volume16
Issue number7
DOIs
StatePublished - Nov 1 2012

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Keywords

  • cardiac transplantation
  • immunocompromised host
  • renal failure
  • viral infection

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

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