A child with BK virus infection: Inadequacy of current therapeutic strategies

Tanya Pereira, Claudia P. Rojas, Monica Garcia-Buitrago, Jayanthi Chandar, Carolyn Abitbol, Wacharee Seeherunvong, Paolo Rusconi, Jocelyn H. Bruce, Gaston E Zilleruelo

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In this report, we describe the development of BKVN in the native kidneys of a child with a cardiac transplant. Elevated BK viral DNA load by PCR necessitated a prolonged course of treatment with escalating doses of cidofovir. Despite a reduction in plasma BK viral load, the infection evolved into an invasive CNS disease, resulting in rhomboencephalitis. This case highlights the need for awareness of the possibility of developing multiorgan complications from BKV infection. The current treatment options for BKV tissue invasive disease are inadequate and need to be improved.

Original languageEnglish
JournalPediatric Transplantation
Volume16
Issue number7
DOIs
StatePublished - Nov 1 2012

Fingerprint

BK Virus
Virus Diseases
Viral Load
Central Nervous System Diseases
Viral DNA
Transplants
Kidney
Polymerase Chain Reaction
Therapeutics
Infection
cidofovir

Keywords

  • cardiac transplantation
  • immunocompromised host
  • renal failure
  • viral infection

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Cite this

A child with BK virus infection : Inadequacy of current therapeutic strategies. / Pereira, Tanya; Rojas, Claudia P.; Garcia-Buitrago, Monica; Chandar, Jayanthi; Abitbol, Carolyn; Seeherunvong, Wacharee; Rusconi, Paolo; Bruce, Jocelyn H.; Zilleruelo, Gaston E.

In: Pediatric Transplantation, Vol. 16, No. 7, 01.11.2012.

Research output: Contribution to journalArticle

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