Abstract
In this report, we describe the development of BKVN in the native kidneys of a child with a cardiac transplant. Elevated BK viral DNA load by PCR necessitated a prolonged course of treatment with escalating doses of cidofovir. Despite a reduction in plasma BK viral load, the infection evolved into an invasive CNS disease, resulting in rhomboencephalitis. This case highlights the need for awareness of the possibility of developing multiorgan complications from BKV infection. The current treatment options for BKV tissue invasive disease are inadequate and need to be improved.
| Original language | English |
|---|---|
| Journal | Pediatric Transplantation |
| Volume | 16 |
| Issue number | 7 |
| DOIs | |
| State | Published - Nov 1 2012 |
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Keywords
- cardiac transplantation
- immunocompromised host
- renal failure
- viral infection
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Transplantation
Cite this
A child with BK virus infection : Inadequacy of current therapeutic strategies. / Pereira, Tanya; Rojas, Claudia P.; Garcia-Buitrago, Monica; Chandar, Jayanthi; Abitbol, Carolyn; Seeherunvong, Wacharee; Rusconi, Paolo; Bruce, Jocelyn H.; Zilleruelo, Gaston E.
In: Pediatric Transplantation, Vol. 16, No. 7, 01.11.2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A child with BK virus infection
T2 - Inadequacy of current therapeutic strategies
AU - Pereira, Tanya
AU - Rojas, Claudia P.
AU - Garcia-Buitrago, Monica
AU - Chandar, Jayanthi
AU - Abitbol, Carolyn
AU - Seeherunvong, Wacharee
AU - Rusconi, Paolo
AU - Bruce, Jocelyn H.
AU - Zilleruelo, Gaston E
PY - 2012/11/1
Y1 - 2012/11/1
N2 - In this report, we describe the development of BKVN in the native kidneys of a child with a cardiac transplant. Elevated BK viral DNA load by PCR necessitated a prolonged course of treatment with escalating doses of cidofovir. Despite a reduction in plasma BK viral load, the infection evolved into an invasive CNS disease, resulting in rhomboencephalitis. This case highlights the need for awareness of the possibility of developing multiorgan complications from BKV infection. The current treatment options for BKV tissue invasive disease are inadequate and need to be improved.
AB - In this report, we describe the development of BKVN in the native kidneys of a child with a cardiac transplant. Elevated BK viral DNA load by PCR necessitated a prolonged course of treatment with escalating doses of cidofovir. Despite a reduction in plasma BK viral load, the infection evolved into an invasive CNS disease, resulting in rhomboencephalitis. This case highlights the need for awareness of the possibility of developing multiorgan complications from BKV infection. The current treatment options for BKV tissue invasive disease are inadequate and need to be improved.
KW - cardiac transplantation
KW - immunocompromised host
KW - renal failure
KW - viral infection
UR - http://www.scopus.com/inward/record.url?scp=84866729883&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866729883&partnerID=8YFLogxK
U2 - 10.1111/j.1399-3046.2011.01602.x
DO - 10.1111/j.1399-3046.2011.01602.x
M3 - Article
C2 - 22129324
AN - SCOPUS:84866729883
VL - 16
JO - Pediatric Transplantation
JF - Pediatric Transplantation
SN - 1397-3142
IS - 7
ER -