A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition

M. D. Mathias, M. V. Ortiz, H. Magnan, S. R. Ambati, E. K. Slotkin, A. J. Chou, M. F. Walsh, K. Offit, Craig Moskowitz, A. Kentsis, L. H. Wexler

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma. Rhabdomyosarcoma, the most common soft tissue sarcoma of childhood. makes up less than 1% of solid malignancies in adults with around 400 new cases each year in the United States. They have not previously been reported concurrently. Case presentation: A 37 year old woman presented with painful enlarging leg mass. Biopsy of the mass was consistent with embryonal rhabdomyosarcoma. Staging imaging revealed a PET avid anterior mediastinal lymph node. Excisional biopsy of this mass was consistent with diffuse large B-cell lymphoma. Hybridization capture-based next-generation DNA sequencing did not reveal shared somatic tumor mutations. Germline analysis did not show identifiable aberrations of TP53 or other heritable cancer susceptibility genes. She was treated with a personalized chemotherapy regimen combining features of R-CHOP and Children's Oncology Group ARST 0331. Conclusions: This case illustrates a unique clinical entity successfully treated with a personalized chemotherapeutic regimen.

Original languageEnglish (US)
Article number7
JournalBiomarker Research
Volume5
Issue number1
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Fingerprint

Embryonal Rhabdomyosarcoma
Lymphoma, Large B-Cell, Diffuse
Biopsy
Cells
Oncology
Chemotherapy
Rhabdomyosarcoma
Neoplasm Genes
Aberrations
DNA Sequence Analysis
Sarcoma
Non-Hodgkin's Lymphoma
Tumors
Neoplasms
Leg
Genes
Lymph Nodes
Tissue
Imaging techniques
Drug Therapy

Keywords

  • Case report
  • Diffuse large B cell lymphoma
  • Molecular analysis
  • Rhabdomyosarcoma

ASJC Scopus subject areas

  • Molecular Medicine
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition. / Mathias, M. D.; Ortiz, M. V.; Magnan, H.; Ambati, S. R.; Slotkin, E. K.; Chou, A. J.; Walsh, M. F.; Offit, K.; Moskowitz, Craig; Kentsis, A.; Wexler, L. H.

In: Biomarker Research, Vol. 5, No. 1, 7, 01.01.2017.

Research output: Contribution to journalArticle

Mathias, MD, Ortiz, MV, Magnan, H, Ambati, SR, Slotkin, EK, Chou, AJ, Walsh, MF, Offit, K, Moskowitz, C, Kentsis, A & Wexler, LH 2017, 'A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition', Biomarker Research, vol. 5, no. 1, 7. https://doi.org/10.1186/s40364-017-0086-7
Mathias, M. D. ; Ortiz, M. V. ; Magnan, H. ; Ambati, S. R. ; Slotkin, E. K. ; Chou, A. J. ; Walsh, M. F. ; Offit, K. ; Moskowitz, Craig ; Kentsis, A. ; Wexler, L. H. / A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition. In: Biomarker Research. 2017 ; Vol. 5, No. 1.
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