A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition

M. D. Mathias, M. V. Ortiz, H. Magnan, S. R. Ambati, E. K. Slotkin, A. J. Chou, M. F. Walsh, K. Offit, C. Moskowitz, A. Kentsis, L. H. Wexler

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background: Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma. Rhabdomyosarcoma, the most common soft tissue sarcoma of childhood. makes up less than 1% of solid malignancies in adults with around 400 new cases each year in the United States. They have not previously been reported concurrently. Case presentation: A 37 year old woman presented with painful enlarging leg mass. Biopsy of the mass was consistent with embryonal rhabdomyosarcoma. Staging imaging revealed a PET avid anterior mediastinal lymph node. Excisional biopsy of this mass was consistent with diffuse large B-cell lymphoma. Hybridization capture-based next-generation DNA sequencing did not reveal shared somatic tumor mutations. Germline analysis did not show identifiable aberrations of TP53 or other heritable cancer susceptibility genes. She was treated with a personalized chemotherapy regimen combining features of R-CHOP and Children's Oncology Group ARST 0331. Conclusions: This case illustrates a unique clinical entity successfully treated with a personalized chemotherapeutic regimen.

Original languageEnglish (US)
Article number7
JournalBiomarker Research
Volume5
Issue number1
DOIs
StatePublished - 2017

Keywords

  • Case report
  • Diffuse large B cell lymphoma
  • Molecular analysis
  • Rhabdomyosarcoma

ASJC Scopus subject areas

  • Molecular Medicine
  • Clinical Biochemistry
  • Biochemistry, medical

Fingerprint Dive into the research topics of 'A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition'. Together they form a unique fingerprint.

  • Cite this

    Mathias, M. D., Ortiz, M. V., Magnan, H., Ambati, S. R., Slotkin, E. K., Chou, A. J., Walsh, M. F., Offit, K., Moskowitz, C., Kentsis, A., & Wexler, L. H. (2017). A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition. Biomarker Research, 5(1), [7]. https://doi.org/10.1186/s40364-017-0086-7