A case of subcutaneous Mycoleptodiscus indicus infection in a liver transplant recipient successfully treated with antifungal therapy

A. P. Garrison, G. W. Procop, V. Vincek, J. Moon, M. I. Morris, S. Doblecki-Lewis, T. J. Cleary, D. Brust, I. Rosa-Cunha

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Mycoleptodiscus indicus, a dematiaceous mold, occurs on the leaves of a number of different host plants and has been only recently described as a cause of human infection. Immunosuppressed individuals are at risk for developing infections with opportunistic fungal pathogens, which are a major cause of morbidity and mortality in this population. In addition, the treatment of infections caused by these fungi is frequently challenging. We report a case of M. indicus subcutaneous infection in a 51-year-old man with human immunodeficiency virus and hepatitis C co-infection, who had a liver transplant. He developed skin nodules with a sporotrichoid lymphangitic distribution. Histopathology demonstrated unusual fungal elements with angioinvasion. Mycology cultures isolated a dematiaceous mold with the characteristic curved hyaline conidia of M. indicus. Initial treatment involved a combination of amphotericin B lipid complex and voriconazole, followed by monotherapy with voriconazole. The subcutaneous lesions resolved completely after 4 months of antifungal therapy.

Original languageEnglish (US)
Pages (from-to)218-220
Number of pages3
JournalTransplant Infectious Disease
Volume10
Issue number3
DOIs
StatePublished - Jun 1 2008

Keywords

  • Amphotericin B lipid complex
  • Hepatitis C
  • HIV
  • Liver transplant
  • Mycoleptodiscus indicus
  • Voriconazole

ASJC Scopus subject areas

  • Transplantation
  • Microbiology (medical)
  • Immunology

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