Abstract
Mycoleptodiscus indicus, a dematiaceous mold, occurs on the leaves of a number of different host plants and has been only recently described as a cause of human infection. Immunosuppressed individuals are at risk for developing infections with opportunistic fungal pathogens, which are a major cause of morbidity and mortality in this population. In addition, the treatment of infections caused by these fungi is frequently challenging. We report a case of M. indicus subcutaneous infection in a 51-year-old man with human immunodeficiency virus and hepatitis C co-infection, who had a liver transplant. He developed skin nodules with a sporotrichoid lymphangitic distribution. Histopathology demonstrated unusual fungal elements with angioinvasion. Mycology cultures isolated a dematiaceous mold with the characteristic curved hyaline conidia of M. indicus. Initial treatment involved a combination of amphotericin B lipid complex and voriconazole, followed by monotherapy with voriconazole. The subcutaneous lesions resolved completely after 4 months of antifungal therapy.
Original language | English (US) |
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Pages (from-to) | 218-220 |
Number of pages | 3 |
Journal | Transplant Infectious Disease |
Volume | 10 |
Issue number | 3 |
DOIs | |
State | Published - Jun 1 2008 |
Keywords
- Amphotericin B lipid complex
- Hepatitis C
- HIV
- Liver transplant
- Mycoleptodiscus indicus
- Voriconazole
ASJC Scopus subject areas
- Transplantation
- Microbiology (medical)
- Immunology