A case of mania following deep brain stimulation for obsessive compulsive disorder

Ihtsham U. Haq, Kelly D. Foote, Wayne K. Goodman, Nicola Ricciuti, Herbert Ward, Atchar Sudhyadhom, Charles E. Jacobson, Mustafa S. Siddiqui, Michael S. Okun

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Deep brain stimulation (DBS) of the basal ganglia is an effective treatment for select movement disorders, including Parkinson's disease, essential tremor and dystonia. Based on these successes, DBS has been explored as an experimental treatment for medication-resistant neuropsychiatric disease. During a multiyear experience employing DBS to treat patients for obsessive compulsive disorder (OCD) we encountered several unanticipated stimulation-induced psychiatric side effects. We present a case of a young woman treated for OCD with DBS of the anterior limb of the internal capsule and nucleus accumbens region, who subsequently manifested a manic episode. We aim to discuss the case details, treatment and potential neuroanatomical underpinnings of this response.

Original languageEnglish (US)
Pages (from-to)322-328
Number of pages7
JournalStereotactic and Functional Neurosurgery
Volume88
Issue number5
DOIs
StatePublished - Sep 2010
Externally publishedYes

Keywords

  • Deep brain stimulation, side effects
  • Neuropsychiatric mania
  • Obsessive compulsive disorder

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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