A case of human intramuscular adrenal gland transplantation as a cure for chronic adrenal insufficiency

E. Grodstein, M. A. Hardy, Michael Goldstein

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Intramuscular endocrine gland transplantation has been well described as it pertains to parathyroid autotransplantation; however, transplantation of the adrenal gland is less well characterized. While adrenal autotransplantation in the setting of Cushing's disease has been described, intramuscular adrenal allotransplantation as a cure for adrenal insufficiency to our knowledge has not been previously carried out. Current treatment for adrenal insufficiency leaves patients without diurnal variation in cortisol release and susceptible to the detrimental effects of chronic hypercortisolism. We describe here the case of a 5-year-old girl with renal failure who had adrenal insufficiency following fulminant meningococcemia that led to requirements for both stress-dose steroid and mineralocorticoid replacement. Ten months after the onset of her disease, she received a simultaneous renal and adrenal gland transplant from her mother. The adrenal gland allograft was morselized into 1 mm3 segments and implanted into three 2 cm pockets created in her rectus abdominis muscle. Three years after surgery, her allograft remains fully functional, responding well to adrenocorticotropin hormone stimulation and the patient does not require any steroid or mineralcorticoid supplementation. We believe this case represents the first description of successful functional intramuscular adrenal allograft transplantation with long-term follow up as a cure for adrenal insufficiency.

Original languageEnglish (US)
Pages (from-to)431-433
Number of pages3
JournalAmerican Journal of Transplantation
Volume10
Issue number2
DOIs
StatePublished - Feb 2010
Externally publishedYes

Fingerprint

Adrenal Insufficiency
Adrenal Glands
Transplantation
Allografts
Autologous Transplantation
Steroids
Endocrine Glands
Pituitary ACTH Hypersecretion
Rectus Abdominis
Mineralocorticoids
Cushing Syndrome
Adrenocorticotropic Hormone
Renal Insufficiency
Hydrocortisone
Mothers
Hormones
Transplants
Kidney
Muscles
Therapeutics

Keywords

  • Adrenal gland
  • Adrenal insufficiency
  • Dual organ transplantation
  • Pediatric transplantation
  • Transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pharmacology (medical)
  • Transplantation

Cite this

A case of human intramuscular adrenal gland transplantation as a cure for chronic adrenal insufficiency. / Grodstein, E.; Hardy, M. A.; Goldstein, Michael.

In: American Journal of Transplantation, Vol. 10, No. 2, 02.2010, p. 431-433.

Research output: Contribution to journalArticle

Grodstein, E. ; Hardy, M. A. ; Goldstein, Michael. / A case of human intramuscular adrenal gland transplantation as a cure for chronic adrenal insufficiency. In: American Journal of Transplantation. 2010 ; Vol. 10, No. 2. pp. 431-433.
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