A carbohydrate-linked cisplatin analogue having antitumor activity

Yongsheng Chen; Mary J. Heeg; Paul G. Braunschweiger; Wenhua Xie; Peng G. Wang

doi:10.1002/(SICI)1521-3773(19990614)38:12<1768::AID-ANIE1768>3.0.CO;2-6

A carbohydrate-linked cisplatin analogue having antitumor activity

Yongsheng Chen, Mary J. Heeg, Paul G. Braunschweiger, Wenhua Xie, Peng G. Wang

Radiation Oncology

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

An unprotected and intact carbohydrate moiety has been observed for the first time in a transition metal complex. The carbohydrate-linked platinum(II) complex cis-dichloro[(2-β-D-glucopyranosidyl)propane-1,3- diamine]platinum (see picture) is an analogue of cisplatin and exhibits comparable antitumor activity along with increased solubility in water.

Original language	English (US)
Pages (from-to)	1768-1769
Number of pages	2
Journal	Angewandte Chemie - International Edition
Volume	38
Issue number	12
DOIs	https://doi.org/10.1002/(SICI)1521-3773(19990614)38:12<1768::AID-ANIE1768>3.0.CO;2-6
State	Published - Jun 14 1999

Keywords

Antitumor agents
Bioinorganic chemistry
Carbohydrates
N ligands
Platinum

ASJC Scopus subject areas

Chemistry(all)

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10.1002/(SICI)1521-3773(19990614)38:12<1768::AID-ANIE1768>3.0.CO;2-6

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