A carbohydrate-linked cisplatin analogue having antitumor activity

Yongsheng Chen, Mary J. Heeg, Paul G. Braunschweiger, Wenhua Xie, Peng G. Wang

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

An unprotected and intact carbohydrate moiety has been observed for the first time in a transition metal complex. The carbohydrate-linked platinum(II) complex cis-dichloro[(2-β-D-glucopyranosidyl)propane-1,3- diamine]platinum (see picture) is an analogue of cisplatin and exhibits comparable antitumor activity along with increased solubility in water.

Original languageEnglish (US)
Pages (from-to)1768-1769
Number of pages2
JournalAngewandte Chemie - International Edition
Volume38
Issue number12
DOIs
StatePublished - Jun 14 1999

Keywords

  • Antitumor agents
  • Bioinorganic chemistry
  • Carbohydrates
  • N ligands
  • Platinum

ASJC Scopus subject areas

  • Chemistry(all)

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