Abstract
An unprotected and intact carbohydrate moiety has been observed for the first time in a transition metal complex. The carbohydrate-linked platinum(II) complex cis-dichloro[(2-β-D-glucopyranosidyl)propane-1,3- diamine]platinum (see picture) is an analogue of cisplatin and exhibits comparable antitumor activity along with increased solubility in water.
| Original language | English |
|---|---|
| Pages (from-to) | 1768-1769 |
| Number of pages | 2 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 38 |
| Issue number | 12 |
| DOIs | |
| State | Published - Jun 14 1999 |
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Keywords
- Antitumor agents
- Bioinorganic chemistry
- Carbohydrates
- N ligands
- Platinum
ASJC Scopus subject areas
- Chemistry(all)
Cite this
A carbohydrate-linked cisplatin analogue having antitumor activity. / Chen, Yongsheng; Heeg, Mary J.; Braunschweiger, Paul G; Xie, Wenhua; Wang, Peng G.
In: Angewandte Chemie - International Edition, Vol. 38, No. 12, 14.06.1999, p. 1768-1769.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A carbohydrate-linked cisplatin analogue having antitumor activity
AU - Chen, Yongsheng
AU - Heeg, Mary J.
AU - Braunschweiger, Paul G
AU - Xie, Wenhua
AU - Wang, Peng G.
PY - 1999/6/14
Y1 - 1999/6/14
N2 - An unprotected and intact carbohydrate moiety has been observed for the first time in a transition metal complex. The carbohydrate-linked platinum(II) complex cis-dichloro[(2-β-D-glucopyranosidyl)propane-1,3- diamine]platinum (see picture) is an analogue of cisplatin and exhibits comparable antitumor activity along with increased solubility in water.
AB - An unprotected and intact carbohydrate moiety has been observed for the first time in a transition metal complex. The carbohydrate-linked platinum(II) complex cis-dichloro[(2-β-D-glucopyranosidyl)propane-1,3- diamine]platinum (see picture) is an analogue of cisplatin and exhibits comparable antitumor activity along with increased solubility in water.
KW - Antitumor agents
KW - Bioinorganic chemistry
KW - Carbohydrates
KW - N ligands
KW - Platinum
UR - http://www.scopus.com/inward/record.url?scp=0033553803&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033553803&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1521-3773(19990614)38:12<1768::AID-ANIE1768>3.0.CO;2-6
DO - 10.1002/(SICI)1521-3773(19990614)38:12<1768::AID-ANIE1768>3.0.CO;2-6
M3 - Article
AN - SCOPUS:0033553803
VL - 38
SP - 1768
EP - 1769
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 12
ER -