A carbohydrate-linked cisplatin analogue having antitumor activity

Yongsheng Chen, Mary J. Heeg, Paul G Braunschweiger, Wenhua Xie, Peng G. Wang

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

An unprotected and intact carbohydrate moiety has been observed for the first time in a transition metal complex. The carbohydrate-linked platinum(II) complex cis-dichloro[(2-β-D-glucopyranosidyl)propane-1,3- diamine]platinum (see picture) is an analogue of cisplatin and exhibits comparable antitumor activity along with increased solubility in water.

Original languageEnglish
Pages (from-to)1768-1769
Number of pages2
JournalAngewandte Chemie - International Edition
Volume38
Issue number12
DOIs
StatePublished - Jun 14 1999

Fingerprint

Carbohydrates
Platinum
Cisplatin
Propane
Diamines
Coordination Complexes
Metal complexes
Transition metals
Solubility
Water

Keywords

  • Antitumor agents
  • Bioinorganic chemistry
  • Carbohydrates
  • N ligands
  • Platinum

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

A carbohydrate-linked cisplatin analogue having antitumor activity. / Chen, Yongsheng; Heeg, Mary J.; Braunschweiger, Paul G; Xie, Wenhua; Wang, Peng G.

In: Angewandte Chemie - International Edition, Vol. 38, No. 12, 14.06.1999, p. 1768-1769.

Research output: Contribution to journalArticle

Chen, Yongsheng ; Heeg, Mary J. ; Braunschweiger, Paul G ; Xie, Wenhua ; Wang, Peng G. / A carbohydrate-linked cisplatin analogue having antitumor activity. In: Angewandte Chemie - International Edition. 1999 ; Vol. 38, No. 12. pp. 1768-1769.
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