A carbohydrate-linked cisplatin analogue having antitumor activity

Yongsheng Chen; Mary J. Heeg; Paul G. Braunschweiger; Wenhua Xie; Peng G. Wang

doi:10.1002/(SICI)1521-3773(19990614)38:12<1768::AID-ANIE1768>3.0.CO;2-6

A carbohydrate-linked cisplatin analogue having antitumor activity

Yongsheng Chen, Mary J. Heeg, Paul G. Braunschweiger, Wenhua Xie, Peng G. Wang

Radiation Oncology

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

An unprotected and intact carbohydrate moiety has been observed for the first time in a transition metal complex. The carbohydrate-linked platinum(II) complex cis-dichloro[(2-β-D-glucopyranosidyl)propane-1,3- diamine]platinum (see picture) is an analogue of cisplatin and exhibits comparable antitumor activity along with increased solubility in water.

Original language	English (US)
Pages (from-to)	1768-1769
Number of pages	2
Journal	Angewandte Chemie - International Edition
Volume	38
Issue number	12
DOIs	https://doi.org/10.1002/(SICI)1521-3773(19990614)38:12<1768::AID-ANIE1768>3.0.CO;2-6
State	Published - Jun 14 1999

Keywords

Antitumor agents
Bioinorganic chemistry
Carbohydrates
N ligands
Platinum

ASJC Scopus subject areas

Chemistry(all)

Access to Document

10.1002/(SICI)1521-3773(19990614)38:12<1768::AID-ANIE1768>3.0.CO;2-6

Cite this

@article{d3a72afa0d5f47dba3377fe2ec77bdaa,

title = "A carbohydrate-linked cisplatin analogue having antitumor activity",

abstract = "An unprotected and intact carbohydrate moiety has been observed for the first time in a transition metal complex. The carbohydrate-linked platinum(II) complex cis-dichloro[(2-β-D-glucopyranosidyl)propane-1,3- diamine]platinum (see picture) is an analogue of cisplatin and exhibits comparable antitumor activity along with increased solubility in water.",

keywords = "Antitumor agents, Bioinorganic chemistry, Carbohydrates, N ligands, Platinum",

author = "Yongsheng Chen and Heeg, {Mary J.} and Braunschweiger, {Paul G.} and Wenhua Xie and Wang, {Peng G.}",

year = "1999",

month = jun,

day = "14",

doi = "10.1002/(SICI)1521-3773(19990614)38:12<1768::AID-ANIE1768>3.0.CO;2-6",

language = "English (US)",

volume = "38",

pages = "1768--1769",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "12",

}

TY - JOUR

T1 - A carbohydrate-linked cisplatin analogue having antitumor activity

AU - Chen, Yongsheng

AU - Heeg, Mary J.

AU - Braunschweiger, Paul G.

AU - Xie, Wenhua

AU - Wang, Peng G.

PY - 1999/6/14

Y1 - 1999/6/14

N2 - An unprotected and intact carbohydrate moiety has been observed for the first time in a transition metal complex. The carbohydrate-linked platinum(II) complex cis-dichloro[(2-β-D-glucopyranosidyl)propane-1,3- diamine]platinum (see picture) is an analogue of cisplatin and exhibits comparable antitumor activity along with increased solubility in water.

AB - An unprotected and intact carbohydrate moiety has been observed for the first time in a transition metal complex. The carbohydrate-linked platinum(II) complex cis-dichloro[(2-β-D-glucopyranosidyl)propane-1,3- diamine]platinum (see picture) is an analogue of cisplatin and exhibits comparable antitumor activity along with increased solubility in water.

KW - Antitumor agents

KW - Bioinorganic chemistry

KW - Carbohydrates

KW - N ligands

KW - Platinum

UR - http://www.scopus.com/inward/record.url?scp=0033553803&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033553803&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1521-3773(19990614)38:12<1768::AID-ANIE1768>3.0.CO;2-6

DO - 10.1002/(SICI)1521-3773(19990614)38:12<1768::AID-ANIE1768>3.0.CO;2-6

M3 - Article

AN - SCOPUS:0033553803

VL - 38

SP - 1768

EP - 1769

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 12

ER -

A carbohydrate-linked cisplatin analogue having antitumor activity

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this