A Cap for Every Occasion: Alternative eIF4F Complexes

J. J David Ho; Stephen Lee

doi:10.1016/j.tibs.2016.05.009

A Cap for Every Occasion: Alternative eIF4F Complexes

J. J David Ho, Stephen Lee

Biochemistry & Molecular Biology

Research output: Contribution to journal › Short survey

14 Scopus citations

Abstract

The eukaryotic translation initiation factor 4F (eIF4F) has become essentially synonymous with 5′ cap-dependent mRNA translation. Recent studies demonstrate that cells assemble variants of eIF4F to produce adaptive, cap-dependent translatomes during physiological conditions that inhibit eIF4F. These findings challenge us to reassess classical perceptions of cellular translational pathways.

Original language	English (US)
Pages (from-to)	821-823
Number of pages	3
Journal	Trends in Biochemical Sciences
Volume	41
Issue number	10
DOIs	https://doi.org/10.1016/j.tibs.2016.05.009
State	Published - Oct 1 2016

Keywords

eIF4E
eIF4E2
eIF4F
eIF4G3
hypoxia
translation

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/j.tibs.2016.05.009

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Ho, J. J. D., & Lee, S. (2016). A Cap for Every Occasion: Alternative eIF4F Complexes. Trends in Biochemical Sciences, 41(10), 821-823. https://doi.org/10.1016/j.tibs.2016.05.009

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