Abstract
The eukaryotic translation initiation factor 4F (eIF4F) has become essentially synonymous with 5′ cap-dependent mRNA translation. Recent studies demonstrate that cells assemble variants of eIF4F to produce adaptive, cap-dependent translatomes during physiological conditions that inhibit eIF4F. These findings challenge us to reassess classical perceptions of cellular translational pathways.
Original language | English (US) |
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Pages (from-to) | 821-823 |
Number of pages | 3 |
Journal | Trends in Biochemical Sciences |
Volume | 41 |
Issue number | 10 |
DOIs | |
State | Published - Oct 1 2016 |
Keywords
- eIF4E
- eIF4E2
- eIF4F
- eIF4G3
- hypoxia
- translation
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology