A Cap for Every Occasion: Alternative eIF4F Complexes

J. J.David Ho; Stephen Lee

doi:10.1016/j.tibs.2016.05.009

A Cap for Every Occasion: Alternative eIF4F Complexes

J. J.David Ho, Stephen Lee

Biochemistry & Molecular Biology

Research output: Contribution to journal › Short survey › peer-review

18 Scopus citations

Abstract

The eukaryotic translation initiation factor 4F (eIF4F) has become essentially synonymous with 5′ cap-dependent mRNA translation. Recent studies demonstrate that cells assemble variants of eIF4F to produce adaptive, cap-dependent translatomes during physiological conditions that inhibit eIF4F. These findings challenge us to reassess classical perceptions of cellular translational pathways.

Original language	English (US)
Pages (from-to)	821-823
Number of pages	3
Journal	Trends in Biochemical Sciences
Volume	41
Issue number	10
DOIs	https://doi.org/10.1016/j.tibs.2016.05.009
State	Published - Oct 1 2016

Keywords

eIF4E
eIF4E2
eIF4F
eIF4G3
hypoxia
translation

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/j.tibs.2016.05.009

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title = "A Cap for Every Occasion: Alternative eIF4F Complexes",

abstract = "The eukaryotic translation initiation factor 4F (eIF4F) has become essentially synonymous with 5′ cap-dependent mRNA translation. Recent studies demonstrate that cells assemble variants of eIF4F to produce adaptive, cap-dependent translatomes during physiological conditions that inhibit eIF4F. These findings challenge us to reassess classical perceptions of cellular translational pathways.",

keywords = "eIF4E, eIF4E2, eIF4F, eIF4G3, hypoxia, translation",

author = "Ho, {J. J.David} and Stephen Lee",

note = "Funding Information: S.L. is funded by the Sylvester Comprehensive Cancer Center and grants from the National Institutes of General Medical Sciences (1R01GM115342) and the National Cancer Institute (1R01CA200676). J.J.D.H. is a recipient of a Canadian Institutes of Health Research (CIHR) Postdoctoral Fellowship.",

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AU - Lee, Stephen

N1 - Funding Information: S.L. is funded by the Sylvester Comprehensive Cancer Center and grants from the National Institutes of General Medical Sciences (1R01GM115342) and the National Cancer Institute (1R01CA200676). J.J.D.H. is a recipient of a Canadian Institutes of Health Research (CIHR) Postdoctoral Fellowship.

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N2 - The eukaryotic translation initiation factor 4F (eIF4F) has become essentially synonymous with 5′ cap-dependent mRNA translation. Recent studies demonstrate that cells assemble variants of eIF4F to produce adaptive, cap-dependent translatomes during physiological conditions that inhibit eIF4F. These findings challenge us to reassess classical perceptions of cellular translational pathways.

AB - The eukaryotic translation initiation factor 4F (eIF4F) has become essentially synonymous with 5′ cap-dependent mRNA translation. Recent studies demonstrate that cells assemble variants of eIF4F to produce adaptive, cap-dependent translatomes during physiological conditions that inhibit eIF4F. These findings challenge us to reassess classical perceptions of cellular translational pathways.

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KW - eIF4F

KW - eIF4G3

KW - hypoxia

KW - translation

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