A Cap for Every Occasion: Alternative eIF4F Complexes

J. J.David Ho, Stephen Lee

Research output: Contribution to journalShort surveypeer-review

25 Scopus citations


The eukaryotic translation initiation factor 4F (eIF4F) has become essentially synonymous with 5′ cap-dependent mRNA translation. Recent studies demonstrate that cells assemble variants of eIF4F to produce adaptive, cap-dependent translatomes during physiological conditions that inhibit eIF4F. These findings challenge us to reassess classical perceptions of cellular translational pathways.

Original languageEnglish (US)
Pages (from-to)821-823
Number of pages3
JournalTrends in Biochemical Sciences
Issue number10
StatePublished - Oct 1 2016


  • eIF4E
  • eIF4E2
  • eIF4F
  • eIF4G3
  • hypoxia
  • translation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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