A canine model to assess the biochemical stress response to laparoscopic and open surgery

Robert Marcovich, Antoinette L. Williams, Brian D. Seifman, J. Stuart Wolf

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Purpose: To develop an animal model to assess the stress response to open laparoscopic surgery. Such a model would allow objective physiologic assessment of the putative benefits of laparoscopy provide a framework in which to compare modifications in operative anesthetic technique that might decrease the stress of surgery. Materials Methods: Mongrel dogs underwent laparoscopic (N = 12) or open surgical (N = 12) left nephrectomy. In 11 control animals after induction of anesthesia line placement the animal underwent either no intervention (open surgery sham; N = 6) or pneumoperitoneum only (laparoscopic sham; N = 5). Serum glucose cortisol were measured preoperatively at skin closure at 4 8 24 hours postoperatively. Values at each time point were compared in the laparoscopic open surgical nephrectomy groups in each of the two nephrectomy groups their respective shams. Results: Compared with baseline there was a sharp rise in serum cortisol at the time of skin closure with a gradual decline to baseline values by 24 hours in all experimental animals. Significantly lower serum cortisol concentrations were seen at 4 8 hours postoperatively in the laparoscopic group than in the open surgery group. Cortisol was significantly higher in the open group than in the sham-open group at all time points whereas cortisol was greater in the laparoscopic group than in the pneumoperitoneum-only group only at the 4-hour time point. No differences were seen in serum glucose between groups. Conclusions: The serum cortisol concentration appears to be a good measure of surgical stress in the canine model. The rapid decline in serum cortisol after laparoscopy compared with open surgery may indicate a lesser degree or quicker resolution of surgical stress in the former. Furthermore the similarity in cortisol curves between laparoscopy pneumoperitoneum only suggests that surgical stress in laparoscopic surgery may be attributable mainly to the effects of pneumoperitoneum.

Original languageEnglish (US)
Pages (from-to)1005-1008
Number of pages4
JournalJournal of Endourology
Volume15
Issue number10
StatePublished - 2001
Externally publishedYes

Fingerprint

Laparoscopy
Hydrocortisone
Canidae
Pneumoperitoneum
Nephrectomy
Serum
Glucose
Skin
Anesthetics
Anesthesia
Animal Models
Dogs

ASJC Scopus subject areas

  • Urology

Cite this

Marcovich, R., Williams, A. L., Seifman, B. D., & Stuart Wolf, J. (2001). A canine model to assess the biochemical stress response to laparoscopic and open surgery. Journal of Endourology, 15(10), 1005-1008.

A canine model to assess the biochemical stress response to laparoscopic and open surgery. / Marcovich, Robert; Williams, Antoinette L.; Seifman, Brian D.; Stuart Wolf, J.

In: Journal of Endourology, Vol. 15, No. 10, 2001, p. 1005-1008.

Research output: Contribution to journalArticle

Marcovich, R, Williams, AL, Seifman, BD & Stuart Wolf, J 2001, 'A canine model to assess the biochemical stress response to laparoscopic and open surgery', Journal of Endourology, vol. 15, no. 10, pp. 1005-1008.
Marcovich, Robert ; Williams, Antoinette L. ; Seifman, Brian D. ; Stuart Wolf, J. / A canine model to assess the biochemical stress response to laparoscopic and open surgery. In: Journal of Endourology. 2001 ; Vol. 15, No. 10. pp. 1005-1008.
@article{6c993c86bc0346bfb9d4079a833fcf08,
title = "A canine model to assess the biochemical stress response to laparoscopic and open surgery",
abstract = "Purpose: To develop an animal model to assess the stress response to open laparoscopic surgery. Such a model would allow objective physiologic assessment of the putative benefits of laparoscopy provide a framework in which to compare modifications in operative anesthetic technique that might decrease the stress of surgery. Materials Methods: Mongrel dogs underwent laparoscopic (N = 12) or open surgical (N = 12) left nephrectomy. In 11 control animals after induction of anesthesia line placement the animal underwent either no intervention (open surgery sham; N = 6) or pneumoperitoneum only (laparoscopic sham; N = 5). Serum glucose cortisol were measured preoperatively at skin closure at 4 8 24 hours postoperatively. Values at each time point were compared in the laparoscopic open surgical nephrectomy groups in each of the two nephrectomy groups their respective shams. Results: Compared with baseline there was a sharp rise in serum cortisol at the time of skin closure with a gradual decline to baseline values by 24 hours in all experimental animals. Significantly lower serum cortisol concentrations were seen at 4 8 hours postoperatively in the laparoscopic group than in the open surgery group. Cortisol was significantly higher in the open group than in the sham-open group at all time points whereas cortisol was greater in the laparoscopic group than in the pneumoperitoneum-only group only at the 4-hour time point. No differences were seen in serum glucose between groups. Conclusions: The serum cortisol concentration appears to be a good measure of surgical stress in the canine model. The rapid decline in serum cortisol after laparoscopy compared with open surgery may indicate a lesser degree or quicker resolution of surgical stress in the former. Furthermore the similarity in cortisol curves between laparoscopy pneumoperitoneum only suggests that surgical stress in laparoscopic surgery may be attributable mainly to the effects of pneumoperitoneum.",
author = "Robert Marcovich and Williams, {Antoinette L.} and Seifman, {Brian D.} and {Stuart Wolf}, J.",
year = "2001",
language = "English (US)",
volume = "15",
pages = "1005--1008",
journal = "Journal of Endourology",
issn = "0892-7790",
publisher = "Mary Ann Liebert Inc.",
number = "10",

}

TY - JOUR

T1 - A canine model to assess the biochemical stress response to laparoscopic and open surgery

AU - Marcovich, Robert

AU - Williams, Antoinette L.

AU - Seifman, Brian D.

AU - Stuart Wolf, J.

PY - 2001

Y1 - 2001

N2 - Purpose: To develop an animal model to assess the stress response to open laparoscopic surgery. Such a model would allow objective physiologic assessment of the putative benefits of laparoscopy provide a framework in which to compare modifications in operative anesthetic technique that might decrease the stress of surgery. Materials Methods: Mongrel dogs underwent laparoscopic (N = 12) or open surgical (N = 12) left nephrectomy. In 11 control animals after induction of anesthesia line placement the animal underwent either no intervention (open surgery sham; N = 6) or pneumoperitoneum only (laparoscopic sham; N = 5). Serum glucose cortisol were measured preoperatively at skin closure at 4 8 24 hours postoperatively. Values at each time point were compared in the laparoscopic open surgical nephrectomy groups in each of the two nephrectomy groups their respective shams. Results: Compared with baseline there was a sharp rise in serum cortisol at the time of skin closure with a gradual decline to baseline values by 24 hours in all experimental animals. Significantly lower serum cortisol concentrations were seen at 4 8 hours postoperatively in the laparoscopic group than in the open surgery group. Cortisol was significantly higher in the open group than in the sham-open group at all time points whereas cortisol was greater in the laparoscopic group than in the pneumoperitoneum-only group only at the 4-hour time point. No differences were seen in serum glucose between groups. Conclusions: The serum cortisol concentration appears to be a good measure of surgical stress in the canine model. The rapid decline in serum cortisol after laparoscopy compared with open surgery may indicate a lesser degree or quicker resolution of surgical stress in the former. Furthermore the similarity in cortisol curves between laparoscopy pneumoperitoneum only suggests that surgical stress in laparoscopic surgery may be attributable mainly to the effects of pneumoperitoneum.

AB - Purpose: To develop an animal model to assess the stress response to open laparoscopic surgery. Such a model would allow objective physiologic assessment of the putative benefits of laparoscopy provide a framework in which to compare modifications in operative anesthetic technique that might decrease the stress of surgery. Materials Methods: Mongrel dogs underwent laparoscopic (N = 12) or open surgical (N = 12) left nephrectomy. In 11 control animals after induction of anesthesia line placement the animal underwent either no intervention (open surgery sham; N = 6) or pneumoperitoneum only (laparoscopic sham; N = 5). Serum glucose cortisol were measured preoperatively at skin closure at 4 8 24 hours postoperatively. Values at each time point were compared in the laparoscopic open surgical nephrectomy groups in each of the two nephrectomy groups their respective shams. Results: Compared with baseline there was a sharp rise in serum cortisol at the time of skin closure with a gradual decline to baseline values by 24 hours in all experimental animals. Significantly lower serum cortisol concentrations were seen at 4 8 hours postoperatively in the laparoscopic group than in the open surgery group. Cortisol was significantly higher in the open group than in the sham-open group at all time points whereas cortisol was greater in the laparoscopic group than in the pneumoperitoneum-only group only at the 4-hour time point. No differences were seen in serum glucose between groups. Conclusions: The serum cortisol concentration appears to be a good measure of surgical stress in the canine model. The rapid decline in serum cortisol after laparoscopy compared with open surgery may indicate a lesser degree or quicker resolution of surgical stress in the former. Furthermore the similarity in cortisol curves between laparoscopy pneumoperitoneum only suggests that surgical stress in laparoscopic surgery may be attributable mainly to the effects of pneumoperitoneum.

UR - http://www.scopus.com/inward/record.url?scp=0035713544&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035713544&partnerID=8YFLogxK

M3 - Article

C2 - 11789976

AN - SCOPUS:0035713544

VL - 15

SP - 1005

EP - 1008

JO - Journal of Endourology

JF - Journal of Endourology

SN - 0892-7790

IS - 10

ER -