A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes

Mohamed Ali Hakimi, Yuanshu Dong, William S. Lane, David W. Speicher, Ramin Shiekhattar

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Eukaryotic genes are under the control of regulatory complexes acting through chromatin structure to control gene expression. Here we report the identification of a family of multiprotein corepressor complexes that function through modifying chromatin structure to keep genes silent. The polypeptide composition of these complexes has in common a core of two subunits, HDAC1,2 and BHC110, an FAD-binding protein. A candidate X-linked mental retardation gene and the transcription initiation factor II-I (TFII-I) are components of a novel member of this family of complexes. Other subunits of these complexes include polypeptides associated with cancer causing chromosomal translocations. These findings not only delineate a novel class of multiprotein complexes involved in transcriptional repression but also reveal an unanticipated role for TFII-I in transcriptional repression.

Original languageEnglish (US)
Pages (from-to)7234-7239
Number of pages6
JournalJournal of Biological Chemistry
Volume278
Issue number9
DOIs
StatePublished - Feb 28 2003
Externally publishedYes

Fingerprint

X-Linked Mental Retardation
Histone Deacetylases
Multiprotein Complexes
Peptide Initiation Factors
Genes
Transcription
Chromatin
Transcription Factors
Co-Repressor Proteins
Genetic Translocation
Peptides
Flavin-Adenine Dinucleotide
Gene expression
Carrier Proteins
Gene Expression
Chemical analysis
Neoplasms

ASJC Scopus subject areas

  • Biochemistry

Cite this

A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. / Hakimi, Mohamed Ali; Dong, Yuanshu; Lane, William S.; Speicher, David W.; Shiekhattar, Ramin.

In: Journal of Biological Chemistry, Vol. 278, No. 9, 28.02.2003, p. 7234-7239.

Research output: Contribution to journalArticle

Hakimi, Mohamed Ali ; Dong, Yuanshu ; Lane, William S. ; Speicher, David W. ; Shiekhattar, Ramin. / A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. In: Journal of Biological Chemistry. 2003 ; Vol. 278, No. 9. pp. 7234-7239.
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