A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes

Mohamed Ali Hakimi, Yuanshu Dong, William S. Lane, David W. Speicher, Ramin Shiekhattar

Research output: Contribution to journalArticle

118 Scopus citations

Abstract

Eukaryotic genes are under the control of regulatory complexes acting through chromatin structure to control gene expression. Here we report the identification of a family of multiprotein corepressor complexes that function through modifying chromatin structure to keep genes silent. The polypeptide composition of these complexes has in common a core of two subunits, HDAC1,2 and BHC110, an FAD-binding protein. A candidate X-linked mental retardation gene and the transcription initiation factor II-I (TFII-I) are components of a novel member of this family of complexes. Other subunits of these complexes include polypeptides associated with cancer causing chromosomal translocations. These findings not only delineate a novel class of multiprotein complexes involved in transcriptional repression but also reveal an unanticipated role for TFII-I in transcriptional repression.

Original languageEnglish (US)
Pages (from-to)7234-7239
Number of pages6
JournalJournal of Biological Chemistry
Volume278
Issue number9
DOIs
StatePublished - Feb 28 2003
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes'. Together they form a unique fingerprint.

  • Cite this