A brief course of cyclosporine A pretransplant reduces posttransplant cyclosporine A requirements in beagles and humans

G. Burke, V. Esquenazi, M. Milgrom, L. Fuller, D. Roth, L. Olson, J. Miller

Research output: Contribution to journalArticle

Abstract

CsA given prior to renal transplantation with or without red blood cell transfusions in DLA haplotype/MLC-reactive beagle dogs, results in prolonged graft survival with lower doses of CsA required posttransplantation. When applied to a human trial, preliminary results show that CsA given in conjunction with transfusion therapy results in: (1) fewer significant rises in PRA (ie, decreased sensitization); (2) lower doses of CsA required over the first 6 months posttransplantation; (3) no difference in patient or graft survival or CMV serology with minimal differences in T4/T8 ratios when compared with red blood cell transfusion therapy alone.

Original languageEnglish (US)
Pages (from-to)478-480
Number of pages3
JournalTransplantation proceedings
Volume20
Issue number2 SUPPL. 2
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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