A brief course of cyclosporine A pretransplant reduces posttransplant cyclosporine A requirements in beagles and humans

George W Burke, V. Esquenazi, M. Milgrom, L. Fuller, David Roth, L. Olson, J. Miller

Research output: Contribution to journalArticle

Abstract

CsA given prior to renal transplantation with or without red blood cell transfusions in DLA haplotype/MLC-reactive beagle dogs, results in prolonged graft survival with lower doses of CsA required posttransplantation. When applied to a human trial, preliminary results show that CsA given in conjunction with transfusion therapy results in: (1) fewer significant rises in PRA (ie, decreased sensitization); (2) lower doses of CsA required over the first 6 months posttransplantation; (3) no difference in patient or graft survival or CMV serology with minimal differences in T4/T8 ratios when compared with red blood cell transfusion therapy alone.

Original languageEnglish
Pages (from-to)478-480
Number of pages3
JournalTransplantation Proceedings
Volume20
Issue number2 SUPPL. 2
StatePublished - Jan 1 1988

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Erythrocyte Transfusion
Graft Survival
Cyclosporine
CD4-CD8 Ratio
Serology
Cell- and Tissue-Based Therapy
Kidney Transplantation
Haplotypes
Dogs
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

A brief course of cyclosporine A pretransplant reduces posttransplant cyclosporine A requirements in beagles and humans. / Burke, George W; Esquenazi, V.; Milgrom, M.; Fuller, L.; Roth, David; Olson, L.; Miller, J.

In: Transplantation Proceedings, Vol. 20, No. 2 SUPPL. 2, 01.01.1988, p. 478-480.

Research output: Contribution to journalArticle

Burke, George W ; Esquenazi, V. ; Milgrom, M. ; Fuller, L. ; Roth, David ; Olson, L. ; Miller, J. / A brief course of cyclosporine A pretransplant reduces posttransplant cyclosporine A requirements in beagles and humans. In: Transplantation Proceedings. 1988 ; Vol. 20, No. 2 SUPPL. 2. pp. 478-480.
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