A bioluminescent molecular switch for glucose

Krystal Teasley Hamorsky; C. Mark Ensor; Yinan Wei; Sylvia Daunert

doi:10.1002/anie.200704440

A bioluminescent molecular switch for glucose

Krystal Teasley Hamorsky, C. Mark Ensor, Yinan Wei, Sylvia Daunert

Research output: Contribution to journal › Article

22 Scopus citations

Abstract

(Figure Presented) Glowing after a sugar rush: A molecular switch is formed by inserting glucose-binding protein (GBP) into aequorin (AEQ; see picture). This switch is triggered by recognition of glucose by the GBP. For the first time, AEQ is rationally split into two fragments that, upon a molecular recognition event, come together and emit bioluminescence.

Original language	English (US)
Pages (from-to)	3718-3721
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	20
DOIs	https://doi.org/10.1002/anie.200704440
State	Published - May 5 2008
Externally published	Yes

Keywords

Binding proteins
Luminescence
Molecular switches
Photoproteins
Protein engineering

ASJC Scopus subject areas

Chemistry(all)
Catalysis
Medicine(all)

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10.1002/anie.200704440

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Teasley Hamorsky, K., Ensor, C. M., Wei, Y., & Daunert, S. (2008). A bioluminescent molecular switch for glucose. Angewandte Chemie - International Edition, 47(20), 3718-3721. https://doi.org/10.1002/anie.200704440

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