Abstract
(Figure Presented) Glowing after a sugar rush: A molecular switch is formed by inserting glucose-binding protein (GBP) into aequorin (AEQ; see picture). This switch is triggered by recognition of glucose by the GBP. For the first time, AEQ is rationally split into two fragments that, upon a molecular recognition event, come together and emit bioluminescence.
Original language | English (US) |
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Pages (from-to) | 3718-3721 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 47 |
Issue number | 20 |
DOIs | |
State | Published - May 5 2008 |
Externally published | Yes |
Keywords
- Binding proteins
- Luminescence
- Molecular switches
- Photoproteins
- Protein engineering
ASJC Scopus subject areas
- Chemistry(all)
- Catalysis
- Medicine(all)