A bioluminescent molecular switch for glucose

Krystal Teasley Hamorsky, C. Mark Ensor, Yinan Wei, Sylvia Daunert

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

(Figure Presented) Glowing after a sugar rush: A molecular switch is formed by inserting glucose-binding protein (GBP) into aequorin (AEQ; see picture). This switch is triggered by recognition of glucose by the GBP. For the first time, AEQ is rationally split into two fragments that, upon a molecular recognition event, come together and emit bioluminescence.

Original languageEnglish (US)
Pages (from-to)3718-3721
Number of pages4
JournalAngewandte Chemie - International Edition
Volume47
Issue number20
DOIs
StatePublished - May 5 2008
Externally publishedYes

Keywords

  • Binding proteins
  • Luminescence
  • Molecular switches
  • Photoproteins
  • Protein engineering

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Medicine(all)

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