A bioluminescent molecular switch for glucose

Krystal Teasley Hamorsky; C. Mark Ensor; Yinan Wei; Sylvia Daunert

doi:10.1002/anie.200704440

A bioluminescent molecular switch for glucose

Krystal Teasley Hamorsky, C. Mark Ensor, Yinan Wei, Sylvia Daunert

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

(Figure Presented) Glowing after a sugar rush: A molecular switch is formed by inserting glucose-binding protein (GBP) into aequorin (AEQ; see picture). This switch is triggered by recognition of glucose by the GBP. For the first time, AEQ is rationally split into two fragments that, upon a molecular recognition event, come together and emit bioluminescence.

Original language	English (US)
Pages (from-to)	3718-3721
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	20
DOIs	https://doi.org/10.1002/anie.200704440
State	Published - May 5 2008
Externally published	Yes

Keywords

Binding proteins
Luminescence
Molecular switches
Photoproteins
Protein engineering

ASJC Scopus subject areas

Chemistry(all)
Catalysis
Medicine(all)

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10.1002/anie.200704440

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title = "A bioluminescent molecular switch for glucose",

abstract = "(Figure Presented) Glowing after a sugar rush: A molecular switch is formed by inserting glucose-binding protein (GBP) into aequorin (AEQ; see picture). This switch is triggered by recognition of glucose by the GBP. For the first time, AEQ is rationally split into two fragments that, upon a molecular recognition event, come together and emit bioluminescence.",

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AU - Teasley Hamorsky, Krystal

AU - Ensor, C. Mark

AU - Wei, Yinan

AU - Daunert, Sylvia

PY - 2008/5/5

Y1 - 2008/5/5

N2 - (Figure Presented) Glowing after a sugar rush: A molecular switch is formed by inserting glucose-binding protein (GBP) into aequorin (AEQ; see picture). This switch is triggered by recognition of glucose by the GBP. For the first time, AEQ is rationally split into two fragments that, upon a molecular recognition event, come together and emit bioluminescence.

AB - (Figure Presented) Glowing after a sugar rush: A molecular switch is formed by inserting glucose-binding protein (GBP) into aequorin (AEQ; see picture). This switch is triggered by recognition of glucose by the GBP. For the first time, AEQ is rationally split into two fragments that, upon a molecular recognition event, come together and emit bioluminescence.

KW - Binding proteins

KW - Luminescence

KW - Molecular switches

KW - Photoproteins

KW - Protein engineering

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A bioluminescent molecular switch for glucose

Abstract

Keywords

ASJC Scopus subject areas

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