Abstract
(Figure Presented) Glowing after a sugar rush: A molecular switch is formed by inserting glucose-binding protein (GBP) into aequorin (AEQ; see picture). This switch is triggered by recognition of glucose by the GBP. For the first time, AEQ is rationally split into two fragments that, upon a molecular recognition event, come together and emit bioluminescence.
| Original language | English |
|---|---|
| Pages (from-to) | 3718-3721 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 47 |
| Issue number | 20 |
| DOIs | |
| State | Published - May 5 2008 |
| Externally published | Yes |
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Keywords
- Binding proteins
- Luminescence
- Molecular switches
- Photoproteins
- Protein engineering
ASJC Scopus subject areas
- Chemistry(all)
- Catalysis
- Medicine(all)
Cite this
A bioluminescent molecular switch for glucose. / Teasley Hamorsky, Krystal; Ensor, C. Mark; Wei, Yinan; Daunert, Sylvia.
In: Angewandte Chemie - International Edition, Vol. 47, No. 20, 05.05.2008, p. 3718-3721.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A bioluminescent molecular switch for glucose
AU - Teasley Hamorsky, Krystal
AU - Ensor, C. Mark
AU - Wei, Yinan
AU - Daunert, Sylvia
PY - 2008/5/5
Y1 - 2008/5/5
N2 - (Figure Presented) Glowing after a sugar rush: A molecular switch is formed by inserting glucose-binding protein (GBP) into aequorin (AEQ; see picture). This switch is triggered by recognition of glucose by the GBP. For the first time, AEQ is rationally split into two fragments that, upon a molecular recognition event, come together and emit bioluminescence.
AB - (Figure Presented) Glowing after a sugar rush: A molecular switch is formed by inserting glucose-binding protein (GBP) into aequorin (AEQ; see picture). This switch is triggered by recognition of glucose by the GBP. For the first time, AEQ is rationally split into two fragments that, upon a molecular recognition event, come together and emit bioluminescence.
KW - Binding proteins
KW - Luminescence
KW - Molecular switches
KW - Photoproteins
KW - Protein engineering
UR - http://www.scopus.com/inward/record.url?scp=45549101342&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=45549101342&partnerID=8YFLogxK
U2 - 10.1002/anie.200704440
DO - 10.1002/anie.200704440
M3 - Article
C2 - 18383457
AN - SCOPUS:45549101342
VL - 47
SP - 3718
EP - 3721
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 20
ER -