A biologic resorbable scaffold for tissue engineering of the endocrine pancreas: Clinical experience of islet transplantation on the omentum

David A. Baidal, Marco Infante, Virginia Fuenmayor, Ana M. Alvarez, Nathalia Padilla, Dora M. Berman, Antonello Pileggi, Elina Linetsky, Gaetano Ciancio, Camillo Ricordi, Rodolfo Alejandro

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Islet transplantation (ITx) is a cellular therapy that has demonstrated efficacy in improving glycemic control and abolishing hypoglycemia in patients affected by type 1 diabetes complicated by hypoglycemia unawareness and episodes of severe hypoglycemia. Although the intrahepatic site is the only clinical site that has shown long-term islet allograft engraftment with achievement of insulin independence, it remains far from being an ideal transplantation site. In this chapter, we have described our clinical experience with ITx within a biodegradable scaffold transplanted onto an extravascular site, the omentum, through laparoscopic surgery. We have provided metabolic data showing efficacy and described the challenges associated with this approach. These encouraging initial results and the unique advantages offered by an extravascular site prompt the need for further evaluation of this transplantation technique. The development of strategies to improve local oxygen delivery, to promote graft neovascularization, and to minimize immunosuppression are required to improve long-term outcomes at this novel transplant site.

Original languageEnglish (US)
Title of host publicationTransplantation, Bioengineering, and Regeneration of the Endocrine Pancreas
Subtitle of host publicationVolume 2
PublisherElsevier
Pages269-276
Number of pages8
ISBN (Electronic)9780128148310
ISBN (Print)9780128148327
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Keywords

  • Biologic resorbable scaffold
  • Extravascular islet transplantation
  • Omentum
  • Omentum islet transplantation
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'A biologic resorbable scaffold for tissue engineering of the endocrine pancreas: Clinical experience of islet transplantation on the omentum'. Together they form a unique fingerprint.

Cite this