A bereavement support group intervention affects plasma burden of human immunodeficiency virus type 1 - Report of a randomized controlled trial

K. Goodkin, T. T. Baldewicz, D. Asthana, I. Khamis, N. T. Blaney, M. Kumar, J. E. Burkhalter, B. Leeds, P. Shapshak

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

This study investigates the potential impact of a bereavement support group on plasma viral load. Methods: A randomly selected subsample of human immunodeficiency virus type 1 (HIV-1)-positive homosexual men participating in a controlled clinical trial of a bereavement support group intervention was studied. The intervention consisted of one 90-minute group session per week for 10 weeks. The plasma HIV-1 RNA copy number was measured at baseline and after intervention (10 weeks) by the Roche AMPLICOR assay. Results: There was a significant effect of the intervention on the change on the plasma HIV-1 RNA copy number (limited control model, β = -0.49, p = 0.02; extended control model, β = -0.37, p = 0.01), independent of antiretroviral therapies; prophylactic therapies against potentially lethal HIV-1 associated conditions; CD4 cell count; viral load; and Centers for Disease Control and Prevention clinical disease stage at baseline. Conclusions: Bereavement support group interventions may prove to be not only a primary therapy for psychologic distress after bereavement but also an adjunctive therapy for sustained control of plasma viral load in conjunction with highly active antiretroviral therapy in this population.

Original languageEnglish (US)
Pages (from-to)44-54
Number of pages11
JournalJournal of Human Virology
Volume4
Issue number1
StatePublished - 2001

Keywords

  • AIDS
  • Behavior
  • Bereavement
  • HAART
  • HIV
  • Stress
  • Support
  • Therapy
  • Viral load

ASJC Scopus subject areas

  • Virology

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