TY - JOUR
T1 - A 10-year prospective study of prodromal patterns for bipolar disorder among Amish youth
AU - Shaw, Jon A.
AU - Egeland, Janice A.
AU - Endicott, Jean
AU - Allen, Cleona R.
AU - Hostetter, Abram M.
N1 - Funding Information:
The CARE (Child and Adolescent Research and Evaluation) program was supported in part by the Stanley Medical Research Institute (1996-2001) and with funding from The Miller School of Medicine, University of Miami (2001-2004). Special thanks to Susan Gravino for her valuable role with the CARE program, Alma Becker, and the CARE families.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2005/11
Y1 - 2005/11
N2 - Objective: Prospective study of well children at risk of bipolarity to identify the frequency and pattern of potentially prodromal symptoms/behaviors for bipolar disorder type I (BPI) disorder. Method: A total of 110 at-risk children with a BPI parent and 112 children with well parents were studied. Ten-year data collection used structured and semistructured annual interviews covering developmental, medical, and behavioral features. Randomized histories for 222 children were submitted blindly for risk rating of bipolarity by a panel of clinicians. Results: Children in the bipolar sample had an overall risk rating of 41% as compared with 16% for control children. Features noted more frequently among the at-risk group were anxious/worried, attention poor/distractible in school, easily excited, hyperalert, mood changes/labile, role impairment in school, somatic complaints, and stubborn/determined. Five additional manic-like behaviors became more evident among at-risk adolescents at the 10-year follow-up: high energy, decreased sleep, problems with thinking/concentration, and excessive and loud talking. Conclusions: The children of a parent with BPI manifested, episodically, miniclusters of potentially prodromal characteristics more frequently than the children of normal controls. None of these children met any of the sets of diagnostic criteria for prepubertal bipolar disorder.
AB - Objective: Prospective study of well children at risk of bipolarity to identify the frequency and pattern of potentially prodromal symptoms/behaviors for bipolar disorder type I (BPI) disorder. Method: A total of 110 at-risk children with a BPI parent and 112 children with well parents were studied. Ten-year data collection used structured and semistructured annual interviews covering developmental, medical, and behavioral features. Randomized histories for 222 children were submitted blindly for risk rating of bipolarity by a panel of clinicians. Results: Children in the bipolar sample had an overall risk rating of 41% as compared with 16% for control children. Features noted more frequently among the at-risk group were anxious/worried, attention poor/distractible in school, easily excited, hyperalert, mood changes/labile, role impairment in school, somatic complaints, and stubborn/determined. Five additional manic-like behaviors became more evident among at-risk adolescents at the 10-year follow-up: high energy, decreased sleep, problems with thinking/concentration, and excessive and loud talking. Conclusions: The children of a parent with BPI manifested, episodically, miniclusters of potentially prodromal characteristics more frequently than the children of normal controls. None of these children met any of the sets of diagnostic criteria for prepubertal bipolar disorder.
KW - Pediatric bipolar
KW - Prodromal features
KW - Prospective study
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U2 - 10.1097/01.chi.0000177052.26476.e5
DO - 10.1097/01.chi.0000177052.26476.e5
M3 - Article
C2 - 16239857
AN - SCOPUS:27144527238
VL - 44
SP - 1104
EP - 1111
JO - Journal of the American Academy of Child Psychiatry
JF - Journal of the American Academy of Child Psychiatry
SN - 0890-8567
IS - 11
ER -
