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  • Stephen D Nimer
2020

Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells

Wesely, J., Kotini, A. G., Izzo, F., Luo, H., Yuan, H., Sun, J., Georgomanoli, M., Zviran, A., Deslauriers, A. G., Dusaj, N., Nimer, S. D., Leslie, C., Landau, D. A., Kharas, M. G. & Papapetrou, E. P., Jun 2 2020, In : Cell Reports. 31, 9, 107688.

Research output: Contribution to journalArticle

Open Access

PRMT5-mediated histone arginine methylation antagonizes transcriptional repression by polycomb complex PRC2

Liu, F., Xu, Y., Lu, X., Hamard, P. J., Karl, D. L., Man, N., Mookhtiar, A. K., Martinez, C., Lossos, I. S., Sun, J. & Nimer, S. D., Apr 6 2020, In : Nucleic acids research. 48, 6, p. 2956-2968 13 p.

Research output: Contribution to journalArticle

Open Access

Targeted chemotherapy overcomes drug resistance in melanoma

Yue, J., Vendramin, R., Liu, F., Lopez, O., Valencia, M. G., Dos Santos, H. G., Gaidosh, G., Beckedorff, F., Blumenthal, E., Speroni, L., Nimer, S. D., Marine, J. C. & Shiekhattar, R., May 1 2020, In : Genes and Development. 34, 9-10, p. 637-649 13 p.

Research output: Contribution to journalArticle

Open Access
2019

ASXL1 alteration cooperates with JAK2V617F to accelerate myelofibrosis

Guo, Y., Zhou, Y., Yamatomo, S., Yang, H., Zhang, P., Chen, S., Nimer, S. D., Zhao, Z. J., Xu, M., Bai, J. & Yang, F. C., May 1 2019, In : Leukemia. 33, 5, p. 1287-1291 5 p.

Research output: Contribution to journalLetter

5 Scopus citations

Destabilization of AETFC through C/EBPα-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation

Zhang, M. M., Liu, N., Zhang, Y. L., Rong, B., Wang, X. L., Xu, C. H., Xie, Y. Y., Shen, S., Zhu, J., Nimer, S. D., Chen, Z., Chen, S. J., Roeder, R. G., Lan, F., Wang, L., Huang, Q. H. & Sun, X. J., Jan 1 2019, In : Leukemia.

Research output: Contribution to journalLetter

Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis

Liu, N., Song, J., Xie, Y., Wang, X. L., Rong, B., Man, N., Zhang, M. M., Zhang, Q., Gao, F. F., Du, M. R., Zhang, Y., Shen, J., Xu, C. H., Hu, C. L., Wu, J. C., Liu, P., Zhang, Y. L., Xie, Y. Y., Liu, P., Huang, J. Y. & 9 others, Huang, Q. H., Lan, F., Shen, S., Nimer, S. D., Chen, Z., Chen, S. J., Roeder, R. G., Wang, L. & Sun, X. J., Jan 15 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 3, p. 890-899 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Erratum: CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis (Cancer Cell (2018) 33(6) (1111–1127.e5), (S1535610818302216), (10.1016/j.ccell.2018.05.007))

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathias, V., Jermakowicz, A. M., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schurer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 others, Yang, F. C., Tenen, D. G., Watts, J., Vega, F. & Nimer, S. D., Jan 14 2019, In : Cancer Cell. 35, 1, 1 p.

Research output: Contribution to journalComment/debate

Risk of disease progression in low-risk MDS is linked to distinct epigenetic subtypes

Qin, T., Sotzen, J., Rampal, R. K., Rapaport, F. T., Levine, R. L., Klimek, V., Nimer, S. D. & Figueroa, M. E., Nov 1 2019, In : Leukemia. 33, 11, p. 2753-2757 5 p.

Research output: Contribution to journalLetter

TAF1 plays a critical role in AML1-ETO driven leukemogenesis

Xu, Y., Man, N., Karl, D., Martinez, C., Liu, F., Sun, J., Martinez, C. J., Martin, G. M., Beckedorff, F., Lai, F., Yue, J., Roisman, A., Greenblatt, S., Duffort, S., Wang, L., Sun, X., Figueroa, M., Shiekhattar, R. & Nimer, S., Dec 1 2019, In : Nature communications. 10, 1, 4925.

Research output: Contribution to journalArticle

Open Access
2017

ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis

Li, Z., Zhang, P., Yan, A., Guo, Z., Ban, Y., Li, J., Chen, S., Yang, H., He, Y., Li, J., Guo, Y., Zhang, W., Hajiramezanali, E., An, H., Fajardo, D., William Harbour, J., Ruan, Y., Nimer, S. D., Yu, P., Chen, X. & 2 others, Xu, M. & Yang, F. C., Jan 2017, In : Science Advances. 3, 1, e1601602.

Research output: Contribution to journalArticle

15 Scopus citations

Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner

Man, N., Tan, Y., Sun, X. J., Liu, F., Cheng, G., Greenblatt, S. M., Martinez, C., Karl, D. L., Ando, K., Sun, M., Hou, D., Chen, B., Xu, M., Yang, F. C., Chen, Z., Chen, S., Nimer, S. D. & Wang, L., May 18 2017, In : Blood. 129, 20, p. 2782-2792 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Clinical characteristics and outcomes according to age in lenalidomide-treated patients with RBC transfusion-dependent lower-risk MDS and del(5q)

Fenaux, P., Giagounidis, A., Selleslag, D., Beyne-Rauzy, O., Mittelman, M., Muus, P., Nimer, S. D., Hellström-Lindberg, E., Powell, B. L., Guerci-Bresler, A., Sekeres, M. A., Deeg, H. J., Del Cañizo, C., Greenberg, P. L., Shammo, J. M., Skikne, B., Yu, X. & List, A. F., Jun 26 2017, In : Journal of Hematology and Oncology. 10, 1, 131.

Research output: Contribution to journalArticle

4 Scopus citations

Covalent modifications of RUNX proteins: Structure affects function

Blumenthal, E., Greenblatt, S., Huang, G., Ando, K., Xu, Y. & Nimer, S. D., 2017, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 962. p. 33-44 12 p. (Advances in Experimental Medicine and Biology; vol. 962).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Histone-binding of DPF2 mediates its repressive role in myeloid differentiation

Huber, F. M., Greenblatt, S. M., Davenport, A. M., Martinez, C., Xu, Y., Vu, L. P., Nimer, S. D. & Hoelz, A., Jun 6 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. 6016-6021 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Loss of Asxl2 leads to myeloid malignancies in mice

Li, J., He, F., Zhang, P., Chen, S., Shi, H., Sun, Y., Guo, Y., Yang, H., Man, N., Greenblatt, S., Li, Z., Guo, Z., Zhou, Y., Wang, L., Morey, L., Williams, S., Chen, X., Wang, Q. T., Nimer, S. D., Yu, P. & 3 others, Wang, Q. F., Xu, M. & Yang, F. C., Jun 8 2017, In : Nature communications. 8, 15456.

Research output: Contribution to journalArticle

10 Scopus citations

Loss of p300 accelerates MDS-associated leukemogenesis

Cheng, G., Liu, F., Asai, T., Lai, F., Man, N., Xu, H., Chen, S., Greenblatt, S., Hamard, P. J., Ando, K., Chen, X., Wang, L., Martinez, C., Tadi, M., Wang, L., Xu, M., Yang, F. C., Shiekhattar, R. & Nimer, S. D., Jan 6 2017, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

11 Scopus citations

Multicenter phase II study of temozolomide and myeloablative chemotherapy with autologous stem cell transplant for newly diagnosed anaplastic oligodendroglioma

Thomas, A. A., Abrey, L. E., Terziev, R., Raizer, J., Martinez, N. L., Forsyth, P., Paleologos, N., Matasar, M., Sauter, C. S., Moskowitz, C., Nimer, S. D., Deangelis, L. M., Kaley, T., Grimm, S., Louis, D. N., Cairncross, J. G., Panageas, K. S., Briggs, S., Faivre, G., Mohile, N. A. & 8 others, Mehta, J., Jonsson, P., Chakravarty, D., Gao, J., Schultz, N., Brennan, C. W., Huse, J. T. & Omuro, A., Oct 1 2017, In : Neuro-Oncology. 19, 10, p. 1380-1390 11 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016

Arginine methyltransferases in normal and malignant hematopoiesis

Greenblatt, S. M., Liu, F. & Nimer, S. D., Jun 1 2016, In : Experimental Hematology. 44, 6, p. 435-441 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Beyond transcription factors: How oncogenic signalling reshapes the epigenetic landscape

Liu, F., Wang, L., Perna, F. & Nimer, S. D., May 25 2016, In : Nature Reviews Cancer. 16, 6, p. 359-372 14 p.

Research output: Contribution to journalReview article

56 Scopus citations

Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin

Man, N., Sun, X. J., Tan, Y., García-Cao, M., Liu, F., Cheng, G., Hatlen, M., Xu, H., Shah, R., Chastain, N., Liu, N., Huang, G., Zhou, Y., Sheng, M., Song, J., Yang, F. C., Benezra, R., Nimer, S. D. & Wang, L., Jan 1 2016, In : Blood. 127, 19, p. 2322-2326 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling

Guryanova, O. A., Shank, K., Spitzer, B., Luciani, L., Koche, R. P., Garrett-Bakelman, F. E., Ganzel, C., Durham, B. H., Mohanty, A., Hoermann, G., Rivera, S. A., Chramiec, A. G., Pronier, E., Bastian, L., Keller, M. D., Tovbin, D., Loizou, E., Weinstein, A. R., Gonzalez, A. R., Lieu, Y. K. & 19 others, Rowe, J. M., Pastore, F., McKenney, A. S., Krivtsov, A. V., Sperr, W. R., Cross, J. R., Mason, C. E., Tallman, M. S., Arcila, M. E., Abdel-Wahab, O., Armstrong, S. A., Kubicek, S., Staber, P. B., Gönen, M., Paietta, E. M., Melnick, A. M., Nimer, S. D., Mukherjee, S. & Levine, R. L., Dec 1 2016, In : Nature medicine. 22, 12, p. 1488-1495 8 p.

Research output: Contribution to journalArticle

78 Scopus citations

Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles

Hatlen, M. A., Arora, K., Vacic, V., Grabowska, E. A., Liao, W., Riley-Gillis, B., Oschwald, D. M., Wang, L., Joergens, J. E., Shih, A. H., Rapaport, F., Gu, S., Voza, F., Asai, T., Neel, B. G., Kharas, M. G., Gonen, M., Levine, R. L. & Nimer, S. D., Jan 1 2016, In : Journal of Experimental Medicine. 213, 1, p. 25-34 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

MSI2 is required for maintaining activated myelodysplastic syndrome stem cells

Taggart, J., Ho, T. C., Amin, E., Xu, H., Barlowe, T. S., Perez, A. R., Durham, B. H., Tivnan, P., Okabe, R., Chow, A., Vu, L., Park, S. M., Prieto, C., Famulare, C., Patel, M., Lengner, C. J., Verma, A., Roboz, G., Guzman, M., Klimek, V. M. & 4 others, Abdel-Wahab, O., Leslie, C., Nimer, S. D. & Kharas, M. G., Feb 22 2016, In : Nature communications. 7, 10739.

Research output: Contribution to journalArticle

17 Scopus citations

Mutational landscape and antiproliferative functions of ELF transcription factors in human cancer

Ando, M., Kawazu, M., Ueno, T., Koinuma, D., Ando, K., Koya, J., Kataoka, K., Yasuda, T., Yamaguchi, H., Fukumura, K., Yamato, A., Soda, M., Sai, E., Yamashita, Y., Asakage, T., Miyazaki, Y., Kurokawa, M., Miyazono, K., Nimer, S. D., Yamasoba, T. & 1 others, Mano, H., Apr 1 2016, In : Cancer Research. 76, 7, p. 1814-1824 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity

Shirakawa, K., Wang, L., Man, N., Maksimoska, J., Sorum, A. W., Lim, H. W., Lee, I. S., Shimazu, T., Newman, J. C., Schröder, S., Ott, M., Marmorstein, R., Meier, J., Nimer, S. & Verdin, E., May 31 2016, In : eLife. 5, MAY2016, e11156.

Research output: Contribution to journalArticle

33 Scopus citations