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  • 2020
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  • Ralf Paus
2020

Adenosine Promotes Human Hair Growth and Inhibits Catagen Transition In Vitro: Role of the Outer Root Sheath Keratinocytes

Lisztes, E., Tóth, B. I., Bertolini, M., Szabó, I. L., Zákány, N., Oláh, A., Szöllősi, A. G., Paus, R. & Bíró, T., May 2020, In : Journal of Investigative Dermatology. 140, 5, p. 1085-1088.e6

Research output: Contribution to journalArticle

1 Scopus citations

Apremilast and tofacitinib exert differential effects in the humanized mouse model of alopecia areata

Laufer Britva, R., Keren, A., Paus, R. & Gilhar, A., Jan 1 2020, In : British Journal of Dermatology. 182, 1, p. 227-229 3 p.

Research output: Contribution to journalLetter

Deciphering the molecular morphology of the human hair cycle: Wnt signalling during the telogen–anagen transformation

Hawkshaw, N. J., Hardman, J. A., Alam, M., Jimenez, F. & Paus, R., May 1 2020, In : British Journal of Dermatology. 182, 5, p. 1184-1193 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Does dysfunctional autophagy contribute to immune privilege collapse and alopecia areata pathogenesis?

Hardman, J. A., Nicu, C., Tai, C., Harries, M., Mironov, A., Purba, T. S. & Paus, R., 2020, (Accepted/In press) In : Journal of dermatological science.

Research output: Contribution to journalLetter

Does mitochondrial dysfunction of hair follicle epithelial stem cells play a role in the pathobiology of lichen planopilaris?

Hardman-Smart, J. A., Purba, T. S., Panicker, S., Farjo, B., Farjo, N., Harries, M. J. & Paus, R., 2020, (Accepted/In press) In : British Journal of Dermatology.

Research output: Contribution to journalLetter

Open Access

Do hair follicles operate as primitive, multifocal kidney-like excretory (mini-) organs?

Carré, J. L., Suzuki, T. & Paus, R., Mar 1 2020, In : Experimental dermatology. 29, 3, p. 357-365 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Fluoxetine promotes human hair follicle pigmentation ex vivo: serotonin reuptake inhibition as a new antigreying strategy?

Chéret, J., Gherardini, J., Bertolini, M. & Paus, R., Jun 1 2020, In : British Journal of Dermatology. 182, 6, p. 1492-1494 3 p.

Research output: Contribution to journalLetter

2 Scopus citations

Frontal fibrosing alopecia shows robust T helper 1 and Janus kinase 3 skewing

Del Duca, E., Ruano Ruiz, J., Pavel, A. B., Dutt Sanyal, R., Song, T., Gay-Mimbrera, J., Zhang, N., Estrada, Y. D., Peng, X., Renert-Yuval, Y., Phelps, R. G., Paus, R., Krueger, J. G. & Guttman-Yassky, E., 2020, (Accepted/In press) In : British Journal of Dermatology.

Research output: Contribution to journalArticle

1 Scopus citations

Hair(y) Matters in Melanoma Biology

Bedogni, B. & Paus, R., May 2020, In : Trends in Molecular Medicine. 26, 5, p. 441-449 9 p.

Research output: Contribution to journalReview article

1 Scopus citations

Hair follicle immune privilege and its collapse in alopecia areata

Bertolini, M., McElwee, K., Gilhar, A., Bulfone-Paus, S. & Paus, R., Aug 1 2020, In : Experimental dermatology. 29, 8, p. 703-725 23 p.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Inhibition of Shh Signaling through MAPK Activation Controls Chemotherapy-Induced Alopecia

Haslam, I. S., Zhou, G. X., Xie, G. J., Teng, X., Ao, X. L., Yan, Z. P., Smart, E., Rutkowski, D., Wierzbicka, J., Zhou, Y. J., Huang, Z., Zhang, Y. D., Farjo, N., Farjo, B., Paus, R. & Yue, Z. C., 2020, (Accepted/In press) In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticle

Mitochondrial energy metabolism is negatively regulated by cannabinoid receptor 1 in intact human epidermis

Oláh, A., Alam, M., Chéret, J., Kis, N. G., Hegyi, Z., Szöllősi, A. G., Vidali, S., Bíró, T. & Paus, R., Jul 1 2020, In : Experimental dermatology. 29, 7, p. 616-622 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Neuroendocrinology and neurobiology of sebaceous glands

Clayton, R. W., Langan, E. A., Ansell, D. M., de Vos, I. J. H. M., Göbel, K., Schneider, M. R., Picardo, M., Lim, X., van Steensel, M. A. M. & Paus, R., Jun 1 2020, In : Biological Reviews. 95, 3, p. 592-624 33 p.

Research output: Contribution to journalArticle

2 Scopus citations
Open Access
1 Scopus citations

Non-neuronal kappa-opioid receptor activation enhances epidermal keratinocyte proliferation, and modulates mast cell functions in human skin ex vivo

Chéret, J., Gherardini, J., Soeberdt, M., Hundt, J. E., Abels, C., Bertolini, M. & Paus, R., Aug 1 2020, In : Journal of Dermatology. 47, 8, p. 917-921 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Preclinical evidence that the PPARγ modulator, N-Acetyl-GED-0507-34-Levo, may protect human hair follicle epithelial stem cells against lichen planopilaris-associated damage

Chéret, J., Piccini, I., Hardman-Smart, J., Ghatak, S., Alam, M., Lehmann, J., Jimenez, F., Erdmann, H., Poblet, E., Botchkareva, N., Paus, R. & Bertolini, M., Apr 1 2020, In : Journal of the European Academy of Dermatology and Venereology. 34, 4, p. e195-e197

Research output: Contribution to journalLetter

Open Access

Profiling the human hair follicle immune system in lichen planopilaris and frontal fibrosing alopecia: can macrophage polarization differentiate these two conditions microscopically?

Harries, M., Hardman, J., Chaudhry, I., Poblet, E. & Paus, R., Sep 1 2020, In : British Journal of Dermatology. 183, 3, p. 537-547 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

The biology of human hair greying

O'Sullivan, J. D. B., Nicu, C., Picard, M., Chéret, J., Bedogni, B., Tobin, D. J. & Paus, R., 2020, (Accepted/In press) In : Biological Reviews.

Research output: Contribution to journalArticle

Open Access

The Hair Follicle as an Interdisciplinary Model for Biomedical Research: An Eclectic Literature Synthesis

Haslam, I. S. & Paus, R., 2020, (Accepted/In press) In : BioEssays.

Research output: Contribution to journalArticle

Open Access

The Phytocannabinoid (–)-Cannabidiol Operates as a Complex, Differential Modulator of Human Hair Growth: Anti-Inflammatory Submicromolar versus Hair Growth Inhibitory Micromolar Effects

Szabó, I. L., Lisztes, E., Béke, G., Tóth, K. F., Paus, R., Oláh, A. & Bíró, T., Feb 2020, In : Journal of Investigative Dermatology. 140, 2, p. 484-488.e5

Research output: Contribution to journalArticle

4 Scopus citations
Open Access
1 Scopus citations

Tissue-resident macrophages can be generated de novo in adult human skin from resident progenitor cells during substance P-mediated neurogenic inflammation ex vivo

Gherardini, J., Uchida, Y., Hardman, J. A., Chéret, J., Mace, K., Bertolini, M. & Paus, R., Jan 1 2020, In : PloS one. 15, 1, e0227817.

Research output: Contribution to journalArticle

Open Access

Topical odorant application of the specific olfactory receptor OR2AT4 agonist, Sandalore®, improves telogen effluvium-associated parameters

Jimenez, F., López, E., Bertolini, M., Alam, M., Chéret, J., Westgate, G., Rinaldi, F., Marzani, B. & Paus, R., 2020, (Accepted/In press) In : Journal of Cosmetic Dermatology.

Research output: Contribution to journalArticle

Toward Predicting the Spatio-Temporal Dynamics of Alopecia Areata Lesions Using Partial Differential Equation Analysis

Dobreva, A., Paus, R. & Cogan, N. G., Mar 1 2020, In : Bulletin of Mathematical Biology. 82, 3, 34.

Research output: Contribution to journalArticle

Translational Neuroendocrinology of Human Skin: Concepts and Perspectives

Ramot, Y., Böhm, M. & Paus, R., 2020, (Accepted/In press) In : Trends in Molecular Medicine.

Research output: Contribution to journalReview article

Vascular endothelial growth factor-A as a promising therapeutic target for the management of psoriasis

Luengas-Martinez, A., Hardman-Smart, J., Paus, R. & Young, H. S., Aug 1 2020, In : Experimental dermatology. 29, 8, p. 687-698 12 p.

Research output: Contribution to journalArticle

Open Access

Vascular Endothelial Growth Factor Blockade Induces Dermal Endothelial Cell Apoptosis in a Clinically Relevant Skin Organ Culture Model

Luengas-Martinez, A., Hardman-Smart, J., Rutkowski, D., Purba, T. S., Paus, R. & Young, H. S., 2020, (Accepted/In press) In : Skin Pharmacology and Physiology.

Research output: Contribution to journalArticle

Open Access
2019

Abstracts

Gkogkolou, P., Sarna, M., Sarna, T., Paus, R., Luger, T. A. & Böhm, M., Apr 1 2019, In : The British journal of dermatology. 180, 4, p. e108-e139

Research output: Contribution to journalArticle

Open Access

An osteopontin-derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor-7 production in outer root sheath keratinocytes

Alam, M., Bertolini, M., Gherardini, J., Keren, A., Ponce, L., Chéret, J., Alenfall, J., Dunér, P., Nilsson, A. H., Gilhar, A. & Paus, R., Jan 1 2019, (Accepted/In press) In : British Journal of Dermatology.

Research output: Contribution to journalArticle

1 Scopus citations

Assessment of Quality of Life and Treatment Outcomes of Patients with Persistent Postchemotherapy Alopecia

Freites-Martinez, A., Chan, D., Sibaud, V., Shapiro, J., Fabbrocini, G., Tosti, A., Cho, J., Goldfarb, S., Modi, S., Gajria, D., Norton, L., Paus, R., Cigler, T. & Lacouture, M. E., Jun 2019, In : JAMA dermatology. 155, 6, p. 724-728 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

CDK4/6 inhibition mitigates stem cell damage in a novel model for taxane-induced alopecia

Purba, T. S., Ng'andu, K., Brunken, L., Smart, E., Mitchell, E., Hassan, N., O'Brien, A., Mellor, C., Jackson, J., Shahmalak, A. & Paus, R., Oct 1 2019, In : EMBO Molecular Medicine. 11, 10, e11031.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Distinct patterns of hair graft survival after transplantation into 2 nonhealing ulcers: Is location everything?

Alam, M., Cooley, J., Plotczyk, M., Martínez-Martín, M. S., Izeta, A., Paus, R. & Jimenez, F., Apr 1 2019, In : Dermatologic Surgery. 45, 4, p. 557-565 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Do human dermal adipocytes switch from lipogenesis in anagen to lipophagy and lipolysis during catagen in the human hair cycle?

Nicu, C., Hardman, J. A., Pople, J. & Paus, R., Apr 2019, In : Experimental dermatology. 28, 4, p. 432-435 4 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Fibrosis and stem cell epithelial-mesenchymal transition in primary cicatricial alopecias

Harries, M., Imanishi, H. & Paus, R., Jun 2019, In : Journal of the American Academy of Dermatology. 80, 6, p. e165-e166

Research output: Contribution to journalLetter

Open Access
3 Scopus citations

Fluorescent cell tracer dye permits real-time assessment of re-epithelialization in a serum-free ex vivo human skin wound assay

Nasir, N. A. M., Paus, R. & Ansell, D. M., Jan 1 2019, In : Wound Repair and Regeneration. 27, 1, p. 126-133 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Frontiers in alopecia areata pathobiology research

Gilhar, A., Laufer-Britva, R., Keren, A. & Paus, R., Dec 2019, In : Journal of Allergy and Clinical Immunology. 144, 6, p. 1478-1489 12 p.

Research output: Contribution to journalReview article

5 Scopus citations

Getting ready for the next decade of Experimental Dermatology

Plikus, M. V. & Paus, R., Nov 1 2019, In : Experimental dermatology. 28, 11, p. 1199-1200 2 p.

Research output: Contribution to journalEditorial

Growth Hormone Operates as a Neuroendocrine Regulator of Human Hair Growth Ex Vivo

Alam, M., Below, D. A., Chéret, J., Langan, E. A., Bertolini, M., Jimenez, F. & Paus, R., Jul 2019, In : Journal of Investigative Dermatology. 139, 7, p. 1593-1596 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Hair disorders in cancer survivors

Freites-Martinez, A., Shapiro, J., van den Hurk, C., Goldfarb, S., Jimenez, J. J., Rossi, A. M., Paus, R. & Lacouture, M. E., May 2019, In : Journal of the American Academy of Dermatology. 80, 5, p. 1199-1213 15 p.

Research output: Contribution to journalReview article

13 Scopus citations

Hair disorders in patients with cancer

Freites-Martinez, A., Shapiro, J., Goldfarb, S., Nangia, J., Jimenez, J. J., Paus, R. & Lacouture, M. E., May 2019, In : Journal of the American Academy of Dermatology. 80, 5, p. 1179-1196 18 p.

Research output: Contribution to journalReview article

13 Scopus citations

Hair growth control by innate immunocytes: Perifollicular macrophages revisited

Muneeb, F., Hardman, J. A. & Paus, R., Apr 2019, In : Experimental dermatology. 28, 4, p. 425-431 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis

Clayton, R. W., Göbel, K., Niessen, C. M., Paus, R., van Steensel, M. A. M. & Lim, X., Jan 1 2019, In : British Journal of Dermatology.

Research output: Contribution to journalReview article

14 Scopus citations

Human Perifollicular Macrophages Undergo Apoptosis, Express Wnt Ligands, and Switch their Polarization during Catagen

Hardman, J. A., Muneeb, F., Pople, J., Bhogal, R., Shahmalak, A. & Paus, R., Dec 2019, In : Journal of Investigative Dermatology. 139, 12, p. 2543-2546.e9

Research output: Contribution to journalArticle

3 Scopus citations

Image Gallery: Optical coherence tomography for intravital human hair follicle analyses ex vivo

Lehmann, J., Kemper, B., Barroso Peña, A., Schnekenburger, J., Paus, R., Bertolini, M. & Chéret, J., May 2019, In : British Journal of Dermatology. 180, 5, p. e141

Research output: Contribution to journalLetter

Open Access

Inhibition of ATP binding cassette transporter B1 sensitizes human hair follicles to chemotherapy-induced damage

Smart, E., Farjo, N., Farjo, B., Haslam, I. S. & Paus, R., Jul 2019, In : Journal of dermatological science. 95, 1, p. 44-47 4 p.

Research output: Contribution to journalLetter

Open Access
2 Scopus citations

Itching for an answer: A review of potential mechanisms of scalp itch in psoriasis

Leon, A., Rosen, J. D., Hashimoto, T., Fostini, A. C., Paus, R. & Yosipovitch, G., Jan 1 2019, In : Experimental dermatology.

Research output: Contribution to journalReview article

Open Access
3 Scopus citations

JAK inhibitors and alopecia areata

Gilhar, A., Keren, A. & Paus, R., Jan 26 2019, In : The Lancet. 393, 10169, p. 318-319 2 p.

Research output: Contribution to journalLetter

15 Scopus citations

Mineralocorticoid Receptor Antagonists Stimulate Human Hair Growth ex vivo

Hundt, J. E., Sass, S., Funk, W., Bíró, T., Farman, N., Langan, E. A. & Paus, R., Nov 1 2019, In : Skin Pharmacology and Physiology. 32, 6, p. 344-348 5 p.

Research output: Contribution to journalArticle

Nestin + progenitor cells isolated from adult human sweat gland stroma promote reepithelialisation and may stimulate angiogenesis in wounded human skin ex vivo

Liao, T., Lehmann, J., Sternstein, S., Yay, A., Zhang, G., Matthießen, A. E., Schumann, S., Siemers, F., Kruse, C., Hundt, J. E., Langan, E. A., Tiede, S. & Paus, R., May 6 2019, In : Archives of Dermatological Research. 311, 4, p. 325-330 6 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations