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    Ronald Charles Desrosiers
2020

A recombinant rhesus monkey rhadinovirus deleted of glycoprotein L establishes persistent infection of rhesus macaques and elicits conventional T cell responses

Hahn, A. S., Bischof, G. F., Großkopf, A. K., Shin, Y. C., Domingues, A., Gonzalez-Nieto, L., Rakasz, E. G., Watkins, D. I., Ensser, A., Martins, M. A. & Desrosiers, R. C., Jan 1 2020, In : Journal of virology. 94, 2, e01093-19.

Research output: Contribution to journalArticle

Rhadinovirus
Macaca mulatta
glycoproteins
Glycoproteins
T-lymphocytes
1 Citation (Scopus)

Liver-Directed but Not Muscle-Directed AAV-Antibody Gene Transfer Limits Humoral Immune Responses in Rhesus Monkeys

Fuchs, S. P., Martinez-Navio, J. M., Rakasz, E. G., Gao, G. & Desrosiers, R. C., Mar 13 2020, In : Molecular Therapy - Methods and Clinical Development. 16, p. 94-102 9 p.

Research output: Contribution to journalArticle

Open Access
Dependovirus
Humoral Immunity
Macaca mulatta
Immunoglobulins
Anti-Idiotypic Antibodies
2019
10 Citations (Scopus)

Adeno-Associated Virus Delivery of Anti-HIV Monoclonal Antibodies Can Drive Long-Term Virologic Suppression

Martinez-Navio, J. M., Fuchs, S. P., Pantry, S. N., Lauer, W. A., Duggan, N. N., Keele, B. F., Rakasz, E. G., Gao, G., Lifson, J. D. & Desrosiers, R. C., Mar 19 2019, In : Immunity. 50, 3, p. 567-575.e5

Research output: Contribution to journalArticle

Dependovirus
HIV Antibodies
Neutralizing Antibodies
Haplorhini
Anti-Idiotypic Antibodies
1 Citation (Scopus)

A highly unusual v1 region of env in an elite controller of HIV infection

Silver, Z. A., Dickinson, G., Seaman, M. S. & Desrosiers, R. C., May 1 2019, In : Journal of Virology. 93, 10, e00094-19.

Research output: Contribution to journalArticle

Open Access
HIV infections
Human immunodeficiency virus 1
HIV Infections
HIV-1
neutralization
7 Citations (Scopus)

Anti-drug Antibody Responses Impair Prophylaxis Mediated by AAV-Delivered HIV-1 Broadly Neutralizing Antibodies

Gardner, M. R., Fetzer, I., Kattenhorn, L. M., Davis-Gardner, M. E., Zhou, A. S., Alfant, B., Weber, J. A., Kondur, H. R., Martinez-Navio, J. M., Fuchs, S. P., Desrosiers, R. C., Gao, G., Lifson, J. D. & Farzan, M., Jan 1 2019, (Accepted/In press) In : Molecular Therapy.

Research output: Contribution to journalArticle

Dependovirus
Neutralizing Antibodies
Antibody Formation
HIV-1
Anti-Idiotypic Antibodies
2 Citations (Scopus)

Circumventing cellular immunity by miR142-mediated regulation sufficiently supports rAAV-delivered OVA expression without activating humoral immunity

Xiao, Y., Muhuri, M., Li, S., Qin, W., Xu, G., Luo, L., Li, J., Letizia, A. J., Wang, S. K., Chan, Y. K., Wang, C., Fuchs, S. P., Wang, D., Su, Q., Abu Nahid, M., Church, G. M., Farzan, M., Yang, L., Wei, Y., Desrosiers, R. C. & 3 others, Mueller, C., Tai, P. W. L. & Gao, G., Jul 11 2019, In : JCI Insight. 4, 13, e99052.

Research output: Contribution to journalArticle

Open Access
Ovalbumin
Antigen-Presenting Cells
Humoral Immunity
Transgenes
Cellular Immunity
4 Citations (Scopus)

EphA7 Functions as Receptor on BJAB Cells for Cell-to-Cell Transmission of the Kaposi's Sarcoma-Associated Herpesvirus and for Cell-Free Infection by the Related Rhesus Monkey Rhadinovirus

Großkopf, A. K., Schlagowski, S., Hörnich, B. F., Fricke, T., Desrosiers, R. C. & Hahn, A. S., Aug 1 2019, In : Journal of virology. 93, 15

Research output: Contribution to journalArticle

Rhadinovirus
Human herpesvirus 8
Human Herpesvirus 8
Macaca mulatta
receptors

The frequency of vaccine-induced T-cell responses does not predict the rate of acquisition after repeated intrarectal SIVmac239 challenges in MAMU-B*08 rhesus macaques

Martins, M., Gonzalez-Nieto, L., Shin, Y. C., Domingues, A., Gutman, M. J., Maxwell, H. S., Magnani, D. M., Ricciardi, M. J., Pedreño-Lopez, N., Bailey, V. K., Altman, J. D., Parks, C. L., Allison, D. B., Ejima, K., Rakasz, E. G., Capuano, S., Desrosiers, R. C., Lifson, J. D. & Watkins, D., Mar 1 2019, In : Journal of Virology. 93, 5, e01626-18.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
Macaca mulatta
Vaccines
T-lymphocytes

Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques

Gonzalez-Nieto, L., Castro, I. M., Bischof, G. F., Shin, Y. C., Ricciardi, M. J., Bailey, V. K., Dang, C. M., Pedreño-Lopez, N., Magnani, D. M., Ejima, K., Allison, D. B., Gil, H. M., Evans, D. T., Rakasz, E. G., Lifson, J. D., Desrosiers, R. C. & Martins, M. A., Jan 1 2019, In : PLoS pathogens. 15, 9, e1008015.

Research output: Contribution to journalArticle

Open Access
Macaca mulatta
Vaccines
Ribosomal DNA
CTLA-4 Antigen
HIV
2 Citations (Scopus)

Vaccine protection against SIVmac239 acquisition

Martins, M., Bischof, G. F., Shin, Y. C., Lauer, W. A., Gonzalez-Nieto, L., Watkins, D., Rakasz, E. G., Lifson, J. D. & Desrosiers, R. C., Jan 29 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1739-1744 6 p.

Research output: Contribution to journalArticle

Vaccines
Immunity
Herpesviridae
Macaca mulatta
Cellular Immunity
2018
8 Citations (Scopus)

A conserved Eph family receptor-binding motif on the gH/gL complex of Kaposi’s sarcoma-associated herpesvirus and rhesus monkey rhadinovirus

Großkopf, A. K., Ensser, A., Neipel, F., Jungnickl, D., Schlagowski, S., Desrosiers, R. C. & Hahn, A. S., Feb 1 2018, In : PLoS Pathogens. 14, 2, e1006912.

Research output: Contribution to journalArticle

Rhadinovirus
Eph Family Receptors
Human Herpesvirus 8
Macaca mulatta
Glycoproteins
4 Citations (Scopus)

A recombinant herpesviral vector containing a near-full-length SIVmac239 genome produces SIV particles and elicits immune responses to all nine SIV gene products

Shin, Y. C., Bischof, G. F., Lauer, W. A., Gonzalez-Nieto, L., Rakasz, E. G., Hendricks, G. M., Watkins, D., Martins, M. & Desrosiers, R. C., Jun 1 2018, In : PLoS Pathogens. 14, 6, e1007143.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Virion
Genome
Genes
Rhadinovirus
18 Citations (Scopus)

Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques

Magnani, D. M., Rogers, T. F., Maness, N. J., Grubaugh, N. D., Beutler, N., Bailey, V. K., Gonzalez-Nieto, L., Gutman, M. J., Pedreño-Lopez, N., Kwal, J. M., Ricciardi, M. J., Myers, T. A., Julander, J. G., Bohm, R. P., Gilbert, M. H., Schiro, F., Aye, P. P., Blair, R. V., Martins, M., Falkenstein, K. P. & 12 others, Kaur, A., Curry, C., Kallas, E. G., Desrosiers, R. C., Goldschmidt-Clermont, P., Whitehead, S. S., Andersen, K. G., Bonaldo, M. C., Lackner, A. A., Panganiban, A. T., Burton, D. R. & Watkins, D., Dec 1 2018, In : Nature Communications. 9, 1, 1624.

Research output: Contribution to journalArticle

Fetal Death
Macaca
viruses
infectious diseases
antibodies
1 Citation (Scopus)

Mamu-B*17+ rhesus macaques vaccinated with env, vif, and nef manifest early control of SIVmac239 replication

Martins, M., Tully, D. C., Pedreño-Lopez, N., Bredow, B. V., Pauthner, M. G., Shin, Y. C., Yuan, M., Lima, N. S., Bean, D. J., Gonzalez-Nieto, L., Domingues, A., Gutman, M. J., Maxwell, H. S., Magnani, D. M., Ricciardi, M. J., Bailey, V. K., Altman, J. D., Burton, D. R., Ejima, K., Allison, D. B. & 9 others, Evans, D. T., Rakasz, E. G., Parks, C. L., Bonaldo, M. C., Capuano, S., Lifson, J. D., Desrosiers, R. C., Allen, T. M. & Watkins, D., Aug 1 2018, In : Journal of Virology. 92, 16, e00690-18.

Research output: Contribution to journalArticle

Macaca mulatta
Simian immunodeficiency virus
Simian Immunodeficiency Virus
virus replication
major histocompatibility complex
1 Citation (Scopus)

With differences in acute viremia in simian immunodeficiency virus δnef-infected animals

Janaka, S. K., Tavakoli-Tameh, A., Neidermyer, W. J., Serra-Moreno, R., Hoxie, J. A., Desrosiers, R. C., Paul Johnson, R., Lifson, J. D., Wolinsky, S. M. & Evans, D. T., Nov 1 2018, In : Journal of Virology. 92, 22, e00542.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
Viremia
viremia
Macaca mulatta
2017
9 Citations (Scopus)

A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus

Magnani, D. M., Silveira, C. G. T., Rosen, B. C., Ricciardi, M. J., Pedreño-Lopez, N., Gutman, M. J., Bailey, V. K., Maxwell, H. S., Domingues, A., Gonzalez-Nieto, L., Avelino-Silva, V. I., Trindade, M., Nogueira, J., Oliveira, C. S., Maestri, A., Felix, A. C., Levi, J. E., Nogueira, M. L., Martins, M., Martinez-Navio, J. M. & 6 others, Fuchs, S. P., Whitehead, S. S., Burton, D. R., Desrosiers, R. C., Kallas, E. G. & Watkins, D., Jun 12 2017, In : PLoS Neglected Tropical Diseases. 11, 6, e0005655.

Research output: Contribution to journalArticle

Immunodominant Epitopes
Antibodies
Immunoglobulin Genes
Dengue Virus
Neutralizing Antibodies
2 Citations (Scopus)

Dengue Virus Evades AAV-Mediated Neutralizing Antibody Prophylaxis in Rhesus Monkeys

Magnani, D. M., Ricciardi, M. J., Bailey, V. K., Gutman, M. J., Pedreño-Lopez, N., Silveira, C. G. T., Maxwell, H. S., Domingues, A., Gonzalez-Nieto, L., Su, Q., Newman, R. M., Pack, M., Martins, M., Martinez-Navio, J. M., Fuchs, S. P., Rakasz, E. G., Allen, T. M., Whitehead, S. S., Burton, D. R., Gao, G. & 3 others, Desrosiers, R. C., Kallas, E. G. & Watkins, D., Oct 4 2017, In : Molecular Therapy. 25, 10, p. 2323-2331 9 p.

Research output: Contribution to journalArticle

Dengue Virus
Neutralizing Antibodies
Macaca mulatta
Dependovirus
Antibody-Dependent Enhancement
3 Citations (Scopus)

HEK293T cell lines defective for O-linked glycosylation

Termini, J. M., Silver, Z. A., Connor, B., Antonopoulos, A., Haslam, S. M., Dell, A. & Desrosiers, R. C., Jun 1 2017, In : PLoS One. 12, 6, e0179949.

Research output: Contribution to journalArticle

Galactokinase
Glycosylation
glycosylation
galactokinase
Galactose
2 Citations (Scopus)

Human immunodeficiency virus and simian immunodeficiency virus maintain high levels of infectivity in the complete absence of mucin-type O-glycosylation

Termini, J. M., Church, E. S., Silver, Z. A., Haslam, S. M., Dell, A. & Desrosiers, R. C., Oct 1 2017, In : Journal of Virology. 91, 19, e01228-17.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
mucins
Human immunodeficiency virus
Mucins
2 Citations (Scopus)

Identification and characterization of a long non-coding RNA up-regulated during HIV-1 infection

Postler, T. S., Pantry, S. N., Desrosiers, R. C. & Ghosh, S., Nov 1 2017, In : Virology. 511, p. 30-39 10 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
HIV Infections
HIV-1
Jurkat Cells
Cytokines
35 Citations (Scopus)

Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques

Magnani, D. M., Rogers, T. F., Beutler, N., Ricciardi, M. J., Bailey, V. K., Gonzalez-Nieto, L., Briney, B., Sok, D., Le, K., Strube, A., Gutman, M. J., Pedreno-Lopez, N., Grubaugh, N. D., Silveira, C. G. T., Maxwell, H. S., Domingues, A., Martins, M., Lee, D. E., Okwuazi, E. E., Jean, S. & 10 others, Strobert, E. A., Chahroudi, A., Silvestri, G., Vanderford, T. H., Kallas, E. G., Desrosiers, R. C., Bonaldo, M. C., Whitehead, S. S., Burton, D. R. & Watkins, D., Oct 4 2017, In : Science Translational Medicine. 9, 410, aan8184.

Research output: Contribution to journalArticle

Macaca
Neutralizing Antibodies
Monoclonal Antibodies
Antibody-Dependent Enhancement
Viremia
7 Citations (Scopus)

Potent plasmablast-derived antibodies elicited by the National Institutes of Health dengue vaccine

Magnani, D. M., Silveira, C. G. T., Ricciardi, M. J., Gonzalez-Nieto, L., Pedreño-Lopez, N., Bailey, V. K., Gutman, M. J., Maxwell, H. S., Domingues, A., Costa, P. R., Ferrari, L., Goulart, R., Martins, M., Martinez-Navio, J. M., Fuchs, S. P., Kalil, J., Timenetsky, M. D. C., Wrammert, J., Whitehead, S. S., Burton, D. R. & 3 others, Desrosiers, R. C., Kallas, E. G. & Watkins, D., Nov 1 2017, In : Journal of Virology. 91, 22, e00867-17.

Research output: Contribution to journalArticle

Dengue Vaccines
National Institutes of Health
Dengue virus
Dengue Virus
dengue
8 Citations (Scopus)

Protection against HIV acquisition in the RV144 trial

Desrosiers, R. C., Sep 1 2017, In : Journal of Virology. 91, 18, e00905-17.

Research output: Contribution to journalArticle

Vaccines
HIV
vaccines
5 Citations (Scopus)

Rare Control of SIVmac239 Infection in a Vaccinated Rhesus Macaque

Martins, M., Tully, D. C., Shin, Y. C., Gonzalez-Nieto, L., Weisgrau, K. L., Bean, D. J., Gadgil, R., Gutman, M. J., Domingues, A., Maxwell, H. S., Magnani, D. M., Ricciardi, M., Pedreño-Lopez, N., Bailey, V., Cruz, M. A., Lima, N. S., Bonaldo, M. C., Altman, J. D., Rakasz, E., Capuano, S. & 6 others, Reimann, K. A., Piatak, M., Lifson, J. D., Desrosiers, R. C., Allen, T. M. & Watkins, D., Aug 1 2017, In : AIDS Research and Human Retroviruses. 33, 8, p. 843-858 16 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Infection Control
Macaca mulatta
T-Lymphocytes
Virus Replication
1 Citation (Scopus)

Simian T lymphotropic virus 1 Infection of Papio anubis: Tax sequence heterogeneity and T cell recognition

Termini, J. M., Magnani, D. M., Maxwell, H. S., Lauer, W., Castro, I., Pecotte, J., Barber, G. N., Watkins, D. & Desrosiers, R. C., Oct 1 2017, In : Journal of Virology. 91, 20, e00950-17.

Research output: Contribution to journalArticle

Simian T-lymphotropic virus 1
Primate T-lymphotropic virus 1
Papio anubis
Papio
taxes

Use of a gamma-2 herpesvirus as a vector to deliver antibodies to rhesus monkeys

Bischof, G. F., Shin, Y. C., Fuchs, S. P., Martinez-Navio, J. M., Lauer, W. A., Rakasz, E. G. & Desrosiers, R. C., Aug 1 2017, In : Gene Therapy. 24, 8, p. 487-492 6 p.

Research output: Contribution to journalArticle

Herpesviridae
Macaca mulatta
Rhadinovirus
Antibodies
Dependovirus
2 Citations (Scopus)

Use of a recombinant gamma-2 herpesvirus vaccine vector against dengue virus in rhesus monkeys

Bischof, G. F., Magnani, D. M., Ricciardi, M., Shin, Y. C., Domingues, A., Bailey, V. K., Gonzalez-Nieto, L., Rakasz, E. G., Watkins, D. & Desrosiers, R. C., Aug 1 2017, In : Journal of Virology. 91, 16, e00525-17.

Research output: Contribution to journalArticle

Herpesvirus Vaccines
vector vaccines
Dengue virus
Dengue Virus
Macaca mulatta
9 Citations (Scopus)

Vaccine-induced immune responses against both Gag and Env improve control of simian immunodeficiency virus replication in rectally challenged rhesus macaques

Martins, M., Shin, Y. C., Gonzalez-Nieto, L., Domingues, A., Gutman, M. J., Maxwell, H. S., Castro, I., Magnani, D. M., Ricciardi, M., Pedreño-Lopez, N., Bailey, V., Betancourt, D., Altman, J. D., Pauthner, M., Burton, D. R., von Bredow, B., Evans, D. T., Yuan, M., Parks, C. L., Ejima, K. & 7 others, Allison, D. B., Rakasz, E., Barber, G. N., Capuano, S., Lifson, J. D., Desrosiers, R. C. & Watkins, D., Jul 1 2017, In : PLoS Pathogens. 13, 7, e1006529.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Virus Replication
Macaca mulatta
AIDS Vaccines
Vaccines
2016
4 Citations (Scopus)

Cellular immune responses against simian T-lymphotropic virus type 1 target Tax in infected baboons

Castro, I., Giret, T. M., Magnani, D. M., Maxwell, H. S., Umland, O., Perry, J. K., Pecotte, J. K., Brasky, K. M., Barber, G. N., Desrosiers, R. C. & Watkins, D., Jun 1 2016, In : Journal of Virology. 90, 11, p. 5280-5291 12 p.

Research output: Contribution to journalArticle

Simian T-lymphotropic virus 1
Human T-lymphotropic virus 1
Papio
taxes
Cellular Immunity
4 Citations (Scopus)

Magnitude and quality of cytokine and chemokine storm during acute infection distinguish nonprogressive and progressive simian immunodeficiency virus infections of nonhuman primates

Keating, S. M., Heitman, J. W., Wu, S., Deng, X., Stacey, A. R., Zahn, R. C., de la Rosa, M., Finstad, S. L., Lifson, J. D., Piatak, M., Gauduin, M. C., Kessler, B. M., Ternette, N., Carville, A., Johnson, R. P., Desrosiers, R. C., Letvin, N. L., Borrow, P., Norris, P. J. & Schmitz, J. E., Jan 1 2016, In : Journal of Virology. 90, 22, p. 10339-10350 12 p.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
Virus Diseases
chemokines
Chemokines
35 Citations (Scopus)

Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding

Panico, M., Bouché, L., Binet, D., O'Connor, M. J., Rahman, D., Pang, P. C., Canis, K., North, S. J., Desrosiers, R. C., Chertova, E., Keele, B. F., Bess, J. W., Lifson, J. D., Haslam, S. M., Dell, A. & Morris, H. R., Sep 8 2016, In : Scientific Reports. 6, 32956.

Research output: Contribution to journalArticle

Neutralizing Antibodies
Glycosylation
Virion
HIV-1
Polysaccharides
15 Citations (Scopus)

Persistent Low-Level Replication of SIVΔnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection

Adnan, S., Reeves, R. K., Gillis, J., Wong, F. E., Yu, Y., Camp, J. V., Li, Q., Connole, M., Li, Y., Piatak, M., Lifson, J. D., Li, W., Keele, B. F., Kozlowski, P. A., Desrosiers, R. C., Haase, A. T. & Johnson, R. P., Dec 13 2016, In : PLoS Pathogens. 12, 12, e1006104.

Research output: Contribution to journalArticle

Immunity
Vaccination
Lymphoid Tissue
T-Lymphocytes
Cellular Immunity
28 Citations (Scopus)
Dependovirus
HIV
Virus Diseases
Antibodies
Haplorhini
9 Citations (Scopus)

Recombinant AAV vectors for enhanced expression of authentic IgG

Fuchs, S. P., Martinez-Navio, J. M., Gao, G. & Desrosiers, R. C., Jun 1 2016, In : PLoS One. 11, 6, e0158009.

Research output: Contribution to journalArticle

Dependovirus
immunoglobulin G
Viruses
Immunoglobulin G
Woodchuck hepatitis virus