Find Research Outputs

Search concepts
Selected Filters
2019

CHAPTER 9: Oligonucleotide Targeting of Long Non-coding RNAs

Blokhin, I., Khorkova, O., Hsiao, J. & Wahlestedt, C. R., Jan 1 2019, Therapies for Retinal Degeneration: Targeting Common Processes. Agrawal, S. & Gait, M. J. (eds.). 68 ed. Royal Society of Chemistry, p. 181-205 25 p. (RSC Drug Discovery Series; vol. 2019-January, no. 68).

Research output: Chapter in Book/Report/Conference proceedingChapter

Long Noncoding RNA
Oligonucleotides
Untranslated RNA
Transcriptome
RNA Transport
1 Citation (Scopus)

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Argemi, J., Latasa, M. U., Atkinson, S. R., Blokhin, I. O., Massey, V., Gue, J. P., Cabezas, J., Lozano, J. J., Van Booven, D., Bell, A., Cao, S., Vernetti, L. A., Arab, J. P., Ventura-Cots, M., Edmunds, L. R., Fondevilla, C., Stärkel, P., Dubuquoy, L., Louvet, A., Odena, G. & 20 others, Gomez, J. L., Aragon, T., Altamirano, J., Caballeria, J., Jurczak, M. J., Taylor, D. L., Berasain, C., Wahlestedt, C. R., Monga, S. P., Morgan, M. Y., Sancho-Bru, P., Mathurin, P., Furuya, S., Lackner, C., Rusyn, I., Shah, V. H., Thursz, M. R., Mann, J., Avila, M. A. & Bataller, R., Dec 1 2019, In : Nature communications. 10, 1, 3126.

Research output: Contribution to journalArticle

Open Access
hepatitis
Alcoholic Hepatitis
gene expression
Gene expression
Liver

Dysregulation of the histone demethylase KDM6B in alcohol dependence is associated with epigenetic regulation of inflammatory signaling pathways

Johnstone, A. L., Andrade, N. S., Barbier, E., Khomtchouk, B. B., Rienas, C. A., Lowe, K., Van Booven, D. J., Domi, E., Esanov, R., Vilca, S., Tapocik, J. D., Rodriguez, K., Maryanski, D., Keogh, M. C., Meinhardt, M. W., Sommer, W. H., Heilig, M., Zeier, Z. R. & Wahlestedt, C. R., Jan 1 2019, (Accepted/In press) In : Addiction Biology. e12816.

Research output: Contribution to journalArticle

Open Access
Histone Demethylases
Epigenomics
Alcoholism
Alcohols
Enzymes
5 Citations (Scopus)

Enhancement of BDNF expression and memory by HDAC inhibition requires BET bromodomain reader proteins

Sartor, G. C., Malvezzi, A. M., Kumar, A., Andrade, N. S., Wiedner, H. J., Vilca, S. J., Janczura, K. J., Bagheri, A., Al-Ali, H., Powell, S. K., Brown, P. T., Volmar, C. H., Foster, T. C., Zeier, Z. R. & Wahlestedt, C. R., Jan 23 2019, In : Journal of Neuroscience. 39, 4, p. 612-626 15 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Brain-Derived Neurotrophic Factor
Proteins
Histone Deacetylase Inhibitors
Messenger RNA

HDAC Inhibitors Induce BDNF Expression and Promote Neurite Outgrowth in Human Neural Progenitor Cells-Derived Neurons

Bagheri, A., Habibzadeh, P., Razavipour, S. F., Volmar, C. H., Chee, N. T., Brothers, S. P., Wahlestedt, C. R., Mowla, S. J. & Faghihi, M. A., Mar 5 2019, In : International journal of molecular sciences. 20, 5

Research output: Contribution to journalArticle

Open Access
Histone Deacetylase Inhibitors
Brain-Derived Neurotrophic Factor
neurons
inhibitors
Neurons
1 Citation (Scopus)

Longevity-related molecular pathways are subject to midlife “switch” in humans

Timmons, J. A., Volmar, C. H., Crossland, H., Phillips, B. E., Sood, S., Janczura, K. J., Törmäkangas, T., Kujala, U. M., Kraus, W. E., Atherton, P. J. & Wahlestedt, C. R., Aug 1 2019, In : Aging Cell. 18, 4, e12970.

Research output: Contribution to journalArticle

Open Access
Long Noncoding RNA
Sirolimus
RNA
Neurons
Skeletal Muscle Fibers

Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells

Cao, H., Salazar-García, L., Gao, F., Wahlestedt, T., Wu, C. L., Han, X., Cai, Y., Xu, D., Wang, F., Tang, L., Ricciardi, N., Cai, D. D., Wang, H., Chin, M. P. S., Timmons, J. A., Wahlestedt, C. & Kapranov, P., Dec 1 2019, In : Nature communications. 10, 1, 5799.

Research output: Contribution to journalArticle

Open Access
Single-Stranded DNA Breaks
nucleotides
strands
Nucleotides
deoxyribonucleic acid

Optimized functional annotation of ChIP-seq data [version 1; peer review: 3 approved with reservations]

Khomtchouk, B. B., Koehler, W. C., Van Booven, D. J. & Wahlestedt, C., Jan 1 2019, In : F1000Research. 8, 612.

Research output: Contribution to journalArticle

Open Access
Peer Review
Genes
Histone Code
Histones
Epigenomics

Ovarian cancer treatment stratification using ex vivo drug sensitivity testing

Lohse, I., Azzam, D. J., Al-Ali, H., Volmar, C. H., Brothers, S. P., Ince, T. A. & Wahlestedt, C., Jan 1 2019, In : Anticancer research. 39, 8, p. 4023-4030 8 p.

Research output: Contribution to journalArticle

Open Access
Ovarian Neoplasms
Pharmaceutical Preparations
Platinum
Therapeutics
Drug Therapy

The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer

Yan, Y., Ma, J., Wang, D., Lin, D., Pang, X., Wang, S., Zhao, Y., Shi, L., Xue, H., Pan, Y., Zhang, J., Wahlestedt, C., Giles, F. J., Chen, Y., Gleave, M. E., Collins, C. C., Ye, D., Wang, Y. & Huang, H., Jan 1 2019, (Accepted/In press) In : EMBO Molecular Medicine. e10659.

Research output: Contribution to journalArticle

Open Access
Prostatic Neoplasms
Organoids
Mutation
Ubiquitin-Protein Ligases
Dimerization
2 Citations (Scopus)

Vitamin C supplementation expands the therapeutic window of BETi for triple negative breast cancer

Mustafi, S., Camarena, V., Qureshi, R., Yoon, H., Volmar, C. H., Huff, T. C., Sant, D. W., Zheng, L., Brothers, S. P., Wahlestedt, C., Slingerland, J. & Wang, G., Jan 1 2019, In : EBioMedicine.

Research output: Contribution to journalArticle

Open Access
Triple Negative Breast Neoplasms
Ascorbic Acid
Therapeutics
Screening
Histone Deacetylase 1
2018
5 Citations (Scopus)

A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease

Timmons, J. A., Atherton, P. J., Larsson, O., Sood, S., Blokhin, I. O., Brogan, R. J., Volmar, C. H., Josse, A. R., Slentz, C., Wahlestedt, C. R., Phillips, S. M., Phillips, B. E., Gallagher, I. J. & Kraus, W. E., Jan 1 2018, In : Nucleic Acids Research. 46, 15, p. 7772-7792 21 p.

Research output: Contribution to journalArticle

Metabolic Diseases
Genomics
Insulin Resistance
Genome-Wide Association Study
RNA
2 Citations (Scopus)

BET Bromodomain Inhibitors Which Permit Treg Function Enable a Combinatorial Strategy to Suppress GVHD in Pre-clinical Allogeneic HSCT

Copsel, S. N., Lightbourn, C. O., Barreras, H., Lohse, I., Wolf, D., Bader, C. S., Manov, J., Kale, B. J., Shah, D., Brothers, S. P., Perez, V. L., Komanduri, K. V., Wahlestedt, C. R. & Levy, R. B., Jan 1 2018, In : Frontiers in immunology. 9, 1 p.

Research output: Contribution to journalArticle

Open Access
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Interleukin-2
Regulatory T-Lymphocytes
Phenotype
7 Citations (Scopus)

Cocaine exposure increases blood pressure and aortic stiffness via the mir-30c-5p-malic enzyme 1-reactive oxygen species pathway

Zhu, W., Wang, H., Wei, J., Sartor, G., Bao, M. M., Pierce, C. T., Wahlestedt, C. R., Dykxhoorn, D. M. & Dong, C., Jan 1 2018, In : Hypertension. 71, 4, p. 752-760 9 p.

Research output: Contribution to journalArticle

malate dehydrogenase (decarboxylating)
Vascular Stiffness
Cocaine
Reactive Oxygen Species
Blood Pressure
4 Citations (Scopus)

Developments in lncRNA drug discovery: where are we heading?

Blokhin, I., Khorkova, O., Hsiao, J. & Wahlestedt, C. R., Sep 2 2018, In : Expert Opinion on Drug Discovery. 13, 9, p. 837-849 13 p.

Research output: Contribution to journalReview article

Long Noncoding RNA
Drug Discovery
Clustered Regularly Interspaced Short Palindromic Repeats
Biodiversity
Expert Testimony
6 Citations (Scopus)

Drug and disease signature integration identifies synergistic combinations in glioblastoma

Stathias, V., Jermakowicz, A. M., Maloof, M. E., Forlin, M., Walters, W., Suter, R. K., Durante, M. A., Williams, S. L., Harbour, J. W., Volmar, C. H., Lyons, N. J., Wahlestedt, C., Graham, R. M., Ivan, M. E., Komotar, R. J., Sarkaria, J. N., Subramanian, A., Golub, T. R., Schürer, S. C. & Ayad, N. G., Dec 1 2018, In : Nature Communications. 9, 1, 5315.

Research output: Contribution to journalArticle

Glioblastoma
drugs
signatures
Gene expression
Genes

Ex vivo drug sensitivity testing as a means for drug repurposing in esophageal adenocarcinoma

Lohse, I., Al-Ali, H., Volmar, C. H., Alvarez Trotta, A. D., Brothers, S. P., Capobianco, A. J. & Wahlestedt, C. R., Sep 1 2018, In : PLoS One. 13, 9, e0203173.

Research output: Contribution to journalArticle

Drug Repositioning
esophageal neoplasms
adenocarcinoma
Adenocarcinoma
Cells
11 Citations (Scopus)

Ex-vivo sensitivity profiling to guide clinical decision making in acute myeloid leukemia: A pilot study

Swords, R. T., Azzam, D., Al-Ali, H., Lohse, I., Volmar, C. H., Watts, J., Perez, A., Rodriguez, A., Vargas, F., Elias, R., Vega, F., Zelent, A. Z., Brothers, S. P., Abbasi, T., Trent, J., Rangwala, S., Deutsch, Y., Conneally, E., Drusbosky, L., Cogle, C. R. & 1 others, Wahlestedt, C. R., Jan 1 2018, In : Leukemia Research. 64, p. 34-41 8 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Pharmaceutical Preparations
Precision Medicine
Therapeutics
Physicians
1 Citation (Scopus)

EZH1 is an antipsychotic-sensitive epigenetic modulator of social and motivational behavior that is dysregulated in schizophrenia

Johnstone, A. L., O'Reilly, J. J., Patel, A. J., Guo, Z., Andrade, N. S., Magistri, M., Nathanson, L., Esanov, R., Miller, B. H., Turecki, G., Brothers, S. P., Zeier, Z. R. & Wahlestedt, C. R., Nov 1 2018, In : Neurobiology of Disease. 119, p. 149-158 10 p.

Research output: Contribution to journalArticle

MicroRNAs
Epigenomics
Antipsychotic Agents
Schizophrenia
Prefrontal Cortex
31 Citations (Scopus)

Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies

Yang, H., Kurtenbach, S., Guo, Y., Lohse, I., Durante, M. A., Li, J., Li, Z., Al-Ali, H., Li, L., Chen, Z., Field, M. G., Zhang, P., Chen, S., Yamamoto, S., Li, Z., Zhou, Y., Nimer, S. D., William Harbour, J., Wahlestedt, C. R., Xu, M. & 1 others, Yang, F-C., Jan 18 2018, In : Blood. 131, 3, p. 328-341 14 p.

Research output: Contribution to journalArticle

Comb and Wattles
Stem cells
Chromatin
Mass spectrometry
Neoplasms
1 Citation (Scopus)

How the strengths of Lisp-family languages facilitate building complex and flexible bioinformatics applications

Khomtchouk, B. B., Weitz, E., Karp, P. D. & Wahlestedt, C. R., May 1 2018, In : Briefings in Bioinformatics. 19, 3, p. 537-543 7 p.

Research output: Contribution to journalComment/debate

Bioinformatics
Computational Biology
Language
Computer programming languages
Artificial intelligence
15 Citations (Scopus)

Inhibition of HDAC3 reverses Alzheimer’s disease-related pathologies in vitro and in the 3xTg-AD mouse model

Janczura, K. J., Volmar, C. H., Sartor, G., Rao, J. S., Ricciardi, N. R., Lambert, G., Brothers, S. P. & Wahlestedt, C. R., Nov 20 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 47, p. E11148-E11157

Research output: Contribution to journalArticle

Alzheimer Disease
Pathology
Acetylation
Phosphorylation
Histones
2 Citations (Scopus)

Precision medicine in the treatment stratification of AML patients: Challenges and progress

Lohse, I., Statz-Geary, K., Brothers, S. P. & Wahlestedt, C. R., Dec 1 2018, In : Oncotarget. 9, 102, p. 37790-37797 8 p.

Research output: Contribution to journalReview article

Precision Medicine
Acute Myeloid Leukemia
Technology
Survival
Neoplasms
1 Citation (Scopus)

Purification of H3 and H4 histone proteins and the quantification of acetylated histone marks in cells and brain tissue

Janczura, K. J., Volmar, C. H. & Wahlestedt, C. R., Nov 1 2018, In : Journal of Visualized Experiments. 2018, 141, e58648.

Research output: Contribution to journalArticle

Histone Code
Histones
Purification
Acetylation
Brain
42 Citations (Scopus)

Serum long noncoding RNA HOTAIR as a novel diagnostic and prognostic biomarker in glioblastoma multiforme

Tan, S. K., Pastori, C., Penas, C., Komotar, R. J., Ivan, M. E., Wahlestedt, C. R. & Ayad, N., Mar 20 2018, In : Molecular Cancer. 17, 1, 74.

Research output: Contribution to journalLetter

Long Noncoding RNA
Glioblastoma
Biomarkers
Serum
Exosomes
14 Citations (Scopus)

Strategies to Annotate and Characterize Long Noncoding RNAs: Advantages and Pitfalls

Cao, H., Wahlestedt, C. R. & Kapranov, P., Jan 1 2018, (Accepted/In press) In : Trends in Genetics.

Research output: Contribution to journalArticle

Long Noncoding RNA
Explosions
Noise
Guidelines
RNA
11 Citations (Scopus)

Vitamin C sensitizes melanoma to BET inhibitors

Mustafi, S., Camarena, V., Volmar, C. H., Huff, T. C., Sant, D. W., Brothers, S. P., Liu, Z-J., Wahlestedt, C. R. & Wang, G., Jan 15 2018, In : Cancer Research. 78, 2, p. 572-583 12 p.

Research output: Contribution to journalArticle

Ascorbic Acid
Melanoma
Epigenomics
Histones
Mustelidae
2017
6 Citations (Scopus)

A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD

Esanov, R., Cabrera, G. T., Andrade, N. S., Gendron, T. F., Brown, R. H., Benatar, M. G., Wahlestedt, C. R., Mueller, C. & Zeier, Z. R., Jun 12 2017, In : Molecular Neurodegeneration. 12, 1, 46.

Research output: Contribution to journalArticle

Bacterial Artificial Chromosomes
Amyotrophic Lateral Sclerosis
Epigenomics
Epigenetic Repression
Induced Pluripotent Stem Cells
3 Citations (Scopus)

Cocaine alters Homer1 natural antisense transcript in the nucleus accumbens

Sartor, G., Powell, S. K., Velmeshev, D., Lin, D. Y., Magistri, M., Wiedner, H. J., Malvezzi, A. M., Andrade, N. S., Faghihi, M. A. & Wahlestedt, C. R., Dec 1 2017, In : Molecular and Cellular Neuroscience. 85, p. 183-189 7 p.

Research output: Contribution to journalArticle

Nucleus Accumbens
Nervous System Diseases
Cocaine
Overlapping Genes
Long Noncoding RNA
1 Citation (Scopus)

Emerging Epigenetic Therapies in Neuroscience: Focus on Bromodomain-Containing Drug Targets

Wahlestedt, C. R., Jan 1 2017, In : Neuropsychopharmacology. 42, 1, p. 374-375 2 p.

Research output: Contribution to journalShort survey

Erratum: How the strengths of Lisp-family languages facilitate building complex and flexible bioinformatics applications (Briefings in bioinformatics (2016))

Khomtchouk, B. B., Weitz, E., Karp, P. D. & Wahlestedt, C., Sep 1 2017, In : Briefings in bioinformatics. 18, 5, 1 p.

Research output: Contribution to journalComment/debate

Open Access
11 Citations (Scopus)

M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory

Volmar, C. H., Salah-Uddin, H., Janczura, K. J., Halley, P., Lambert, G., Wodrich, A., Manoah, S., Patel, N. H., Sartor, G., Mehta, N., Miles, N. T. H., Desse, S., Dorcius, D., Cameron, M. D., Brothers, S. P. & Wahlestedt, C. R., Oct 24 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 43, p. E9135-E9144

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Alzheimer Disease
Genes
Amyloid Precursor Protein Secretases
Gene Expression
1 Citation (Scopus)

Neuropeptide Y Y2 antagonist treated ovariectomized mice exhibit greater bone mineral density

Seldeen, K. L., Halley, P. G., Volmar, C. H., Rodríguez, M. A., Hernandez, M., Pang, M., Carlsson, S. K., Suva, L. J., Wahlestedt, C. R., Troen, B. R. & Brothers, S. P., Jan 1 2017, (Accepted/In press) In : Neuropeptides.

Research output: Contribution to journalArticle

Neuropeptide Y
Bone Density
Bone and Bones
Osteogenesis
Osteoporosis
39 Citations (Scopus)

Oligonucleotide therapies for disorders of the nervous system

Khorkova, O. & Wahlestedt, C. R., Mar 1 2017, In : Nature Biotechnology. 35, 3, p. 249-263 15 p.

Research output: Contribution to journalArticle

Oligonucleotides
Neurology
Nervous System Diseases
Brain
Therapeutics
13 Citations (Scopus)

Oxytocin and social functioning

Jones, C., Barrera, I. G., Brothers, S. P., Ring, R. & Wahlestedt, C. R., 2017, In : Dialogues in Clinical Neuroscience. 19, 2, p. 193-201 9 p.

Research output: Contribution to journalArticle

Oxytocin
Anxiety
Oxytocin Receptors
Intranasal Administration
Anti-Anxiety Agents
19 Citations (Scopus)

Reprogramming of mPFC transcriptome and function in alcohol dependence

Heilig, M., Barbier, E., Johnstone, A. L., Tapocik, J., Meinhardt, M. W., Pfarr, S., Wahlestedt, C. R. & Sommer, W. H., Jan 1 2017, In : Genes, Brain and Behavior. 16, 1, p. 86-100 15 p.

Research output: Contribution to journalReview article

Prefrontal Cortex
Transcriptome
Alcoholism
Epigenomics
Alcohols
18 Citations (Scopus)

Shinyheatmap: Ultra fast low memory heatmap web interface for big data genomics

Khomtchouk, B. B., Hennessy, J. R. & Wahlestedt, C. R., May 1 2017, In : PLoS One. 12, 5, e0176334.

Research output: Contribution to journalArticle

Genomics
Interfaces (computer)
Web browsers
Web Browser
genomics
2016
147 Citations (Scopus)

Altering the course of schizophrenia: progress and perspectives

Millan, M. J., Andrieux, A., Bartzokis, G., Cadenhead, K., Dazzan, P., Fusar-Poli, P., Gallinat, J., Giedd, J., Grayson, D. R., Heinrichs, M., Kahn, R., Krebs, M. O., Leboyer, M., Lewis, D., Marin, O., Marin, P., Meyer-Lindenberg, A., McGorry, P., McGuire, P., Owen, M. J. & 7 others, Patterson, P., Sawa, A., Spedding, M., Uhlhaas, P., Vaccarino, F., Wahlestedt, C. R. & Weinberger, D., Mar 4 2016, (Accepted/In press) In : Nature Reviews Drug Discovery.

Research output: Contribution to journalArticle

Schizophrenia
Psychotic Disorders
Psychiatry
Rodentia
Drug Therapy
8 Citations (Scopus)

C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells

Esanov, R., Belle, K. C., van Blitterswijk, M., Belzil, V. V., Rademakers, R., Dickson, D. W., Petrucelli, L., Boylan, K. B., Dykxhoorn, D. M., Wuu, J., Benatar, M. G., Wahlestedt, C. R. & Zeier, Z. R., Mar 1 2016, In : Experimental Neurology. 277, p. 171-177 7 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Amyotrophic Lateral Sclerosis
5-Methylcytosine
Mutation
Cytosine
15 Citations (Scopus)

Dependence-induced increase of alcohol self-administration and compulsive drinking mediated by the histone methyltransferase PRDM2

Barbier, E., Johnstone, A. L., Khomtchouk, B. B., Tapocik, J. D., Pitcairn, C., Rehman, F., Augier, E., Borich, A., Schank, J. R., Rienas, C. A., van Booven, D. J., Sun, H., Nätt, D., Wahlestedt, C. R. & Heilig, M., Aug 30 2016, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Self Administration
Drinking
Alcohols
Alcoholism
Prefrontal Cortex
5 Citations (Scopus)

Epigenomic and metabolic responses of hypothalamic POMC neurons to gestational nicotine exposure in adult offspring

Silva, J. P., Lambert, G., van Booven, D. & Wahlestedt, C. R., Sep 8 2016, In : Genome Medicine. 8, 1, 93.

Research output: Contribution to journalArticle

Pro-Opiomelanocortin
Nicotine
Epigenomics
Long Noncoding RNA
Neurons
16 Citations (Scopus)

Functional annotation of the vlinc class of non-coding RNAs using systems biology approach

Laurent, G. S., Vyatkin, Y., Antonets, D., Ri, M., Qi, Y., Saik, O., Shtokalo, D., De Hoon, M. J. L., Kawaji, H., Itoh, M., Lassmann, T., Arner, E., Forrest, A. R. R., Nicolas, E., McCaffrey, T. A., Carninci, P., Hayashizaki, Y., Wahlestedt, C. R. & Kapranov, P., Mar 21 2016, In : Nucleic Acids Research. 44, 7, p. 3233-3252 20 p.

Research output: Contribution to journalArticle

Untranslated RNA
Systems Biology
Genes
Genomics
Long Noncoding RNA
41 Citations (Scopus)

Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer

Witt, A. E., Lee, C. W., Lee, T. I., Azzam, D. J., Wang, B., Caslini, C., Petrocca, F., Grosso, J., Jones, M., Cohick, E. B., Gropper, A. B., Wahlestedt, C. R., Richardson, A. L., Shiekhattar, R., Young, R. A. & Ince, T., Oct 3 2016, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Histone Deacetylases
Neoplastic Stem Cells
Ovarian Neoplasms
Breast Neoplasms
Neoplasms
14 Citations (Scopus)

Ischemic Preconditioning Confers Epigenetic Repression of Mtor and Induction of Autophagy Through G9a-Dependent H3K9 Dimethylation

Gidlöf, O., Johnstone, A. L., Bader, K., Khomtchouk, B. B., O'Reilly, J. J., Celik, S., Van Booven, D. J., Wahlestedt, C. R., Metzler, B. & Erlinge, D., Dec 1 2016, In : Journal of the American Heart Association. 5, 12, e004076.

Research output: Contribution to journalArticle

Epigenetic Repression
Ischemic Preconditioning
Autophagy
Sirolimus
Methyltransferases
5 Citations (Scopus)

MicroScope: ChIP-seq and RNA-seq software analysis suite for gene expression heatmaps

Khomtchouk, B. B., Hennessy, J. R. & Wahlestedt, C. R., Sep 22 2016, In : BMC Bioinformatics. 17, 1, 390.

Research output: Contribution to journalArticle

Gene Ontology
Principal Component Analysis
RNA
Gene expression
Microscope
6 Citations (Scopus)

Nociceptin receptor activation does not alter acquisition, expression, extinction and reinstatement of conditioned cocaine preference in mice

Sartor, G., Powell, S. K., Wiedner, H. J., Wahlestedt, C. R. & Brothers, S. P., Feb 1 2016, In : Brain Research. 1632, p. 34-41 8 p.

Research output: Contribution to journalArticle

Cocaine
Cocaine-Related Disorders
Yohimbine
Inbred C57BL Mouse
Opioid Analgesics
4 Citations (Scopus)

Seltene Krankheiten: Aktueller Stand der Pharmaforschung

Translated title of the contribution: Orphan diseases: state of the drug discovery artVolmar, C. H., Wahlestedt, C. R. & Brothers, S. P., Jan 27 2016, (Accepted/In press) In : Wiener Medizinische Wochenschrift. p. 1-8 8 p.

Research output: Contribution to journalArticle

Drug Discovery
Art
Rare Diseases
Pharmaceutical Preparations
Orphan Drug Production
21 Citations (Scopus)

The BET-bromodomain inhibitor JQ1 reduces inflammation and tau phosphorylation at ser396 in the brain of the 3xTg model of Alzheimer’s disease

Magistri, M., Velmeshev, D., Makhmutova, M., Patel, P., Sartor, G., Volmar, C. H., Wahlestedt, C. R. & Faghihi, M. A., Sep 1 2016, In : Current Alzheimer Research. 13, 9, p. 985-995 11 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Phosphorylation
Inflammation
Brain
Learning
9 Citations (Scopus)

The FMR1 promoter is selectively hydroxymethylated in primary neurons of fragile X syndrome patients

Esanov, R., Andrade, N. S., Bennison, S., Wahlestedt, C. R. & Zeier, Z. R., Nov 15 2016, In : Human Molecular Genetics. 25, 22, p. 4870-4880 11 p.

Research output: Contribution to journalArticle

Fragile X Syndrome
Neurons
Epigenomics
Mutation
5-Methylcytosine
17 Citations (Scopus)

The long non-coding RNA FMR4 promotes proliferation of human neural precursor cells and epigenetic regulation of gene expression in trans

Peschansky, V. J., Pastori, C., Zeier, Z. R., Wentzel, K., Velmeshev, D., Magistri, M., Silva, J. P. & Wahlestedt, C. R., Jul 1 2016, In : Molecular and Cellular Neuroscience. 74, p. 49-57 9 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Gene Expression Regulation
Epigenomics
Intellectual Disability
Chromatin