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2020

A new generation of treatments for itch

Fowler, E. & Yosipovitch, G., Jan 2020, In : Acta dermato-venereologica. 100, 1, p. 37-45 9 p., adv00027.

Research output: Contribution to journalReview article

Open Access
Antipruritics
Transient Receptor Potential Channels
Janus Kinases
Therapeutics
Neurokinin-1 Receptors
2019
10 Citations (Scopus)

3-Dimensional Optical Clearing and Imaging of Pruritic Atopic Dermatitis and Psoriasis Skin Reveals Downregulation of Epidermal Innervation

Tan, Y., Ng, W. J., Lee, S. Z. X., Lee, B. T. K., Nattkemper, L. A., Yosipovitch, G., Ng, L. G. & Tey, H. L., Jan 1 2019, In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticle

Optical Imaging
Atopic Dermatitis
Psoriasis
Skin
Down-Regulation
1 Citation (Scopus)

Antipruritic Effects of Janus Kinase Inhibitor Tofacitinib in a Mouse Model of Psoriasis

Hashimoto, T., Sakai, K., Sanders, K. M., Yosipovitch, G. & Akiyama, T., Mar 1 2019, In : Acta dermato-venereologica. 99, 3, p. 298-303 6 p.

Research output: Contribution to journalArticle

Open Access
Antipruritics
imiquimod
Janus Kinases
Nerve Fibers
Psoriasis

Assessing the impact of improvements in PASI and itch scores on patients’ quality of life in the treatment of psoriasis

Yosipovitch, G., Dong, Y., Burge, R., Zhu, B., Shrom, D. & Kimball, A. B., Oct 2019, In : Acta dermato-venereologica. 99, 11, p. 1031-1032 2 p.

Research output: Contribution to journalArticle

Open Access
Psoriasis
Quality of Life
Therapeutics
6 Citations (Scopus)

Chronic itch management: therapies beyond those targeting the immune system

Fowler, E. & Yosipovitch, G., Jan 1 2019, In : Annals of Allergy, Asthma and Immunology.

Research output: Contribution to journalReview article

Immune System
Information Storage and Retrieval
Sensory Receptor Cells
Atopic Dermatitis
Therapeutics
3 Citations (Scopus)
Pruritus
Terminology

Diabetic Skin Changes Can Benefit from Moisturizer and Cleanser Use: A Review

Kirsner, R. S., Yosipovitch, G., Hu, S., Andriessen, A., Hanft, J. R., Kim, P. J., Lavery, L., Meneghini, L. & Ruotsi, L. C., Dec 1 2019, In : Journal of drugs in dermatology : JDD. 18, 12, p. 1211-1217 7 p.

Research output: Contribution to journalArticle

Skin
Diabetes Mellitus
Skin Care
Diabetic Foot
Ceramides

Direct and indirect effects of crisaborole ointment on quality of life in patients with atopic dermatitis: A mediation analysis

Simpson, E. L., Yosipovitch, G., Bushmakin, A. G., Cappelleri, J. C., Luger, T., Ständer, S., Tom, W. L., Ports, W. C., Zielinski, M. A., Tallman, A. M., Tan, H. & Gerber, R. A., Jul 1 2019, In : Acta dermato-venereologica. 99, 9, p. 756-761 6 p.

Research output: Contribution to journalArticle

Open Access
Atopic Dermatitis
Ointments
Pruritus
Quality of Life
Dermatology

Dupilumab use in dermatologic conditions beyond atopic dermatitis–a systematic review

Hendricks, A. J., Yosipovitch, G. & Shi, V. Y., Jan 1 2019, (Accepted/In press) In : Journal of Dermatological Treatment.

Research output: Contribution to journalReview article

Urticaria
Alopecia Areata
Allergic Contact Dermatitis
Eczema
Bullous Pemphigoid

Emerging Methods to Objectively Assess Pruritus in Atopic Dermatitis

Smith, M. P., Ly, K., Thibodeaux, Q., Weerasinghe, T., Wu, J. J., Yosipovitch, G., Bhutani, T. & Liao, W., Jan 1 2019, In : Dermatology and Therapy.

Research output: Contribution to journalReview article

Open Access
Atopic Dermatitis
Pruritus
Actigraphy
Research Personnel
Vibration
1 Citation (Scopus)

Examining the association between pruritus and quality of life in patients with atopic dermatitis treated with crisaborole

Ständer, S., Yosipovitch, G., Bushmakin, A. G., Cappelleri, J. C., Luger, T., Tom, W. L., Ports, W. C., Zielinski, M. A., Tallman, A. M., Tan, H. & Gerber, R. A., Jan 1 2019, In : Journal of the European Academy of Dermatology and Venereology.

Research output: Contribution to journalArticle

Atopic Dermatitis
Pruritus
Quality of Life
AN2728
Dermatology

Itch: an under-recognized problem in psoriasis

Elewski, B., Alexis, A. F., Lebwohl, M., Stein Gold, L., Pariser, D., Del Rosso, J. & Yosipovitch, G., Jan 1 2019, In : Journal of the European Academy of Dermatology and Venereology.

Research output: Contribution to journalReview article

Psoriasis
Antipruritics
Phototherapy
Atopic Dermatitis
Scalp
4 Citations (Scopus)

Itching as a systemic disease

Hashimoto, T. & Yosipovitch, G., Jan 1 2019, In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Pruritus
Skin
Endocrine System Diseases
Hematologic Diseases
Metabolic Diseases
2 Citations (Scopus)

Itching for an answer: A review of potential mechanisms of scalp itch in psoriasis

Leon, A., Rosen, J. D., Hashimoto, T., Fostini, A. C., Paus, R. & Yosipovitch, G., Jan 1 2019, In : Experimental dermatology.

Research output: Contribution to journalReview article

Open Access
Immune system
Neurology
Pruritus
Scalp
Psoriasis

Itch sensitization? A systematic review of studies using quantitative sensory testing in patients with chronic itch

van Laarhoven, A. I. M., Marker, J. B., Elberling, J., Yosipovitch, G., Arendt-Nielsen, L. & Andersen, H. H., Dec 1 2019, In : Pain. 160, 12, p. 2661-2678 18 p.

Research output: Contribution to journalArticle

Skin
Confidence Intervals
Atopic Dermatitis
Meta-Analysis
Central Nervous System Sensitization
1 Citation (Scopus)

Itchy body: Topographical difference of itch and scratching and C Nerve fibres

Hashimoto, T. & Yosipovitch, G., Dec 1 2019, In : Experimental dermatology. 28, 12, p. 1385-1389 5 p.

Research output: Contribution to journalArticle

Nerve Fibers
Unmyelinated Nerve Fibers
Touch
Fibers
Toes

Management of Itch in the Elderly: A Review

Fourzali, K. M. & Yosipovitch, G., Dec 1 2019, In : Dermatology and Therapy. 9, 4, p. 639-653 15 p.

Research output: Contribution to journalReview article

Open Access
Emollients
Polypharmacy
Causality
Health Status
Pharmacokinetics

Mechanisms of Itch in Stasis Dermatitis: Significant Role of IL-31 from Macrophages

Hashimoto, T., Kursewicz, C. D., Fayne, R. A., Nanda, S., Shah, S. M., Nattkemper, L., Yokozeki, H. & Yosipovitch, G., Jan 1 2019, (Accepted/In press) In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticle

Dermatitis
Macrophages
Hemosiderin
Peritoneal Macrophages
Substance P

Neuroimmune interactions in chronic itch of atopic dermatitis

Yosipovitch, G., Berger, T. & Fassett, M. S., Jan 1 2019, (Accepted/In press) In : Journal of the European Academy of Dermatology and Venereology.

Research output: Contribution to journalReview article

Open Access
Atopic Dermatitis
Keratinocytes
Nervous System
Immune System
Therapeutics
4 Citations (Scopus)

Non-Histaminergic Itch Mediators Elevated in the Skin of a Porcine Model of Scabies and of Human Scabies Patients

Sanders, K. M., Nattkemper, L. A., Rosen, J. D., Andersen, H. H., Hsiang, J., Romanelli, P., Bernigaud, C., Guillot, J., Chosidow, O. & Yosipovitch, G., Jan 1 2019, (Accepted/In press) In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticle

Scabies
Skin
Swine
7 Citations (Scopus)

Peak Pruritus Numerical Rating Scale: psychometric validation and responder definition for assessing itch in moderate-to-severe atopic dermatitis

Yosipovitch, G., Reaney, M., Mastey, V., Eckert, L., Abbé, A., Nelson, L., Clark, M., Williams, N., Chen, Z., Ardeleanu, M., Akinlade, B., Graham, N. M. H., Pirozzi, G., Staudinger, H., Plaum, S., Radin, A. & Gadkari, A., Jan 1 2019, In : British Journal of Dermatology.

Research output: Contribution to journalArticle

Open Access
Atopic Dermatitis
Pruritus
Psychometrics
Reproducibility of Results
Interviews
3 Citations (Scopus)

Psoriasiform dermatitis after initiation of treatment with dupilumab for atopic dermatitis

Fowler, E., Silverberg, J. I., Fox, J. D. & Yosipovitch, G., May 1 2019, In : Dermatitis. 30, 3, p. 234-236 3 p.

Research output: Contribution to journalComment/debate

Dermatitis
Atopic Dermatitis
SAR231893

Schwann cells as underestimated, major players in human skin physiology and pathology

Bray, E. R., Chéret, J., Yosipovitch, G. & Paus, R., Jan 1 2019, (Accepted/In press) In : Experimental dermatology.

Research output: Contribution to journalArticle

Open Access
Skin Physiological Phenomena
Schwann Cells
Physiology
Pathology
Skin
1 Citation (Scopus)

Secukinumab provides rapid relief from itching and pain in patients with moderate-to-severe psoriasis: Patient symptom diary data from two phase 3, randomized, placebo-controlled clinical trials

Yosipovitch, G., Soung, J., Weiss, J., Muscianisi, E., Meng, X., Gilloteau, I. & Elewski, B. E., Jul 1 2019, In : Acta dermato-venereologica. 99, 9, p. 820-821 2 p.

Research output: Contribution to journalComment/debate

Open Access
Pruritus
Psoriasis
Randomized Controlled Trials
Placebos
Pain

Signal transducer and activator of transcription 3 in keratinocytes regulates histaminergic itch but not nonhistaminergic itch

Hashimoto, T., Sakai, K., Yosipovitch, G. & Akiyama, T., Jan 1 2019, In : Acta dermato-venereologica. 99, 10, p. 901-902 2 p.

Research output: Contribution to journalComment/debate

Open Access
STAT3 Transcription Factor
Chloroquine
Atopic Dermatitis
Keratinocytes
Serotonin

Skin Barrier Damage and Itch: Review of Mechanisms, Topical Management and Future Directions

Yosipovitch, G., Misery, L., Proksch, E., Metz, M., Ständer, S. & Schmelz, M., Dec 1 2019, In : Acta dermato-venereologica. 99, 13, p. 1201-1209 9 p.

Research output: Contribution to journalArticle

Open Access
Skin
Emollients
Nerve Fibers
Skin Diseases
Direction compound

Skin changes and manifestations associated with the treatment of obesity

Rosen, J., Darwin, E., Tuchayi, S. M., Garibyan, L. & Yosipovitch, G., Nov 2019, In : Journal of the American Academy of Dermatology. 81, 5, p. 1059-1069 11 p.

Research output: Contribution to journalReview article

Skin Manifestations
Weight Loss
Obesity
Skin
Preexisting Condition Coverage

Skin changes in the obese patient

Hirt, P. A., Castillo, D. E., Yosipovitch, G. & Keri, J. E., Nov 2019, In : Journal of the American Academy of Dermatology. 81, 5, p. 1037-1057 21 p.

Research output: Contribution to journalReview article

Obesity
Skin
Skin Manifestations
Skin Diseases
Striae Distensae
5 Citations (Scopus)

Substance P and neurokinin 1 receptor are new targets for the treatment of chronic pruritus

Ständer, S. & Yosipovitch, G., Jan 1 2019, (Accepted/In press) In : British Journal of Dermatology.

Research output: Contribution to journalReview article

Open Access
Neurokinin-1 Receptors
Pruritus
Substance P
Neurokinin-1 Receptor Antagonists
Therapeutics

Switch to Itch—The many novel facets of pruritus research

Ständer, S. & Yosipovitch, G., Dec 1 2019, In : Experimental dermatology. 28, 12, p. 1371-1372 2 p.

Research output: Contribution to journalEditorial

Open Access
1 Citation (Scopus)

The functional network processing acute electrical itch stimuli in humans

Mochizuki, H., Hernandez, L. E., Yosipovitch, G., Sadato, N. & Kakigi, R., Jan 1 2019, In : Frontiers in Physiology. 10, MAY, 555.

Research output: Contribution to journalArticle

Open Access
Brain
Basal Ganglia
Motor Cortex
Neuroimaging
Somatosensory Cortex
2 Citations (Scopus)

The impact of stress on epidermal barrier function: an evidence-based review

Maarouf, M., Maarouf, C. L., Yosipovitch, G. & Shi, V. Y., Dec 1 2019, In : British Journal of Dermatology. 181, 6, p. 1129-1137 9 p.

Research output: Contribution to journalReview article

Hormones
Psychology
Cornea
Skin Physiological Phenomena
Lipids

The NK1 receptor antagonist serlopitant for treatment of chronic pruritus

Ständer, S., Spellman, M. C., Kwon, P. & Yosipovitch, G., Jan 1 2019, In : Expert Opinion on Investigational Drugs.

Research output: Contribution to journalArticle

Open Access
Neurokinin-1 Receptor Antagonists
Pruritus
Therapeutics
Prurigo
Safety
1 Citation (Scopus)

Treatment-induced Delusions of Infestation Associated with Increased Brain Dopamine Levels

Fowler, E., Maderal, A. & Yosipovitch, G., Mar 1 2019, In : Acta dermato-venereologica. 99, 3, p. 327-328 2 p.

Research output: Contribution to journalArticle

Open Access
Delusions
Dopamine
Brain

Two cancer patients receiving dupilumab for treatment of atopic dermatitis

Fowler, E., Rosen, J., Lev-Tov, H. & Yosipovitch, G., Jan 1 2019, In : Acta dermato-venereologica. 99, 10, p. 899-900 2 p.

Research output: Contribution to journalComment/debate

Open Access
Eczema
Atopic Dermatitis
Pruritus
Neoplasms
Therapeutics
1 Citation (Scopus)

Validation of ‘ItchApp©’ in Poland and in the USA: multicentre validation study of an electronical diary for the assessment of pruritus

Schnitzler, C., Rosen, J., Szepietowski, J. C., Reich, A., Yosipovitch, G., Reszke, R., Nattkemper, L. A., Osada, N., Pihan, D., Ständer, S. & Zeidler, C., Feb 1 2019, In : Journal of the European Academy of Dermatology and Venereology. 33, 2, p. 398-404 7 p.

Research output: Contribution to journalArticle

Validation Studies
Poland
Pruritus
Multicenter Studies
Clinical Trials

Why we scratch: Function and dysfunction

Sanders, K. M., Fast, K. & Yosipovitch, G., Jan 1 2019, In : Experimental dermatology.

Research output: Contribution to journalArticle

Open Access
Pleasure
Survival
Therapeutics
Drive

Willingness to pay and quality of life in patients with pruritic skin disorders

Stefanidou, M., Evangelou, G., Kontodimopoulos, N., Koumaki, D., Krueger-Krasagakis, S. E., Yosipovitch, G. & Krasagakis, K., Jan 1 2019, In : Archives of Dermatological Research.

Research output: Contribution to journalArticle

Skin Diseases
Quality of Life
Skin
Demography
Pruritus
2018
16 Citations (Scopus)

Alloknesis and hyperknesis - Mechanisms, assessment methodology, and clinical implications of itch sensitization

Andersen, H. H., Akiyama, T., Nattkemper, L. A., Van Laarhoven, A., Elberling, J., Yosipovitch, G. & Arendt-Nielsen, L., Jul 1 2018, In : Pain. 159, 7, p. 1185-1197 13 p.

Research output: Contribution to journalReview article

Paresthesia
Hyperalgesia
Antipruritics
Pain
Clothing

Anti-pruritic efficacies of doxycycline and erythromycin in the treatment of acne vulgaris: A randomized single-blinded pilot study

Cao, T., Tan, E. S. T., Chan, Y. H., Yosipovitch, G. & Tey, H. L., Jul 1 2018, In : Indian Journal of Dermatology, Venereology and Leprology. 84, 4, p. 458-460 3 p.

Research output: Contribution to journalLetter

Doxycycline
Acne Vulgaris
Erythromycin

Association of psychological stress with skin symptoms among medical students

Bin Saif, G. A., Alotaibi, H. M., Alzolibani, A. A., Almodihesh, N. A., Albraidi, H. F., Alotaibi, N. M. & Yosipovitch, G., Jan 1 2018, In : Saudi Medical Journal. 39, 1, p. 59-66 8 p.

Research output: Contribution to journalArticle

Medical Students
Psychological Stress
Students
Skin
Exanthema
9 Citations (Scopus)

A systematic review of evidence-based treatments for prurigo nodularis

Qureshi, A. A., Abate, L. E., Yosipovitch, G. & Friedman, A. J., Jan 1 2018, (Accepted/In press) In : Journal of the American Academy of Dermatology.

Research output: Contribution to journalArticle

Prurigo
Photochemotherapy
Neurokinin-1 Receptor Antagonists
Fluvoxamine
Paroxetine
6 Citations (Scopus)

Causes, pathophysiology, and treatment of pruritus in the mature patient

Shevchenko, A., Valdes-Rodriguez, R. & Yosipovitch, G., Mar 1 2018, In : Clinics in Dermatology. 36, 2, p. 140-151 12 p.

Research output: Contribution to journalArticle

Pruritus
Dermatitis
Skin
Population
Seborrheic Dermatitis
1 Citation (Scopus)

Characteristics of chronic itch in systemic sclerosis: A cross-sectional survey

Stull, C. M., Weaver, L. A., Valdes-Rodriguez, R., Naramala, S., Lavery, M. J., Chan, Y. H., Mendoza, F. A. & Yosipovitch, G., Jan 1 2018, In : Acta Dermato-Venereologica. 98, 8, p. 793-794 2 p.

Research output: Contribution to journalComment/debate

Systemic Scleroderma
Cross-Sectional Studies

Chronic Itch: A Disease in Its Own Right

Yosipovitch, G., Jul 1 2018, In : Dermatologic Clinics. 36, 3, p. xv-xvi

Research output: Contribution to journalEditorial

18 Citations (Scopus)

Chronic prurigo of nodular type: A review

Zeidler, C., Tsianakas, A., Pereira, M., Ständer, H., Yosipovitch, G. & Ständer, S., Feb 1 2018, In : Acta Dermato-Venereologica. 98, 2, p. 173-179 7 p.

Research output: Contribution to journalReview article

Prurigo
Pruritus
Ultraviolet Therapy
Interleukin Receptors
Art Therapy
1 Citation (Scopus)

Chronic Pruritus in the Geriatric Population

Cao, T., Tey, H. L. & Yosipovitch, G., Jul 1 2018, In : Dermatologic Clinics. 36, 3, p. 199-211 13 p.

Research output: Contribution to journalReview article

Pruritus
Geriatrics
Drug Interactions
Causality
Nervous System
2 Citations (Scopus)

Cross-European validation of the ItchyQoL in pruritic dermatoses

Zeidler, C., Steinke, S., Riepe, C., Bruland, P., Soto-Rey, I., Storck, M., Garcovich, S., Blome, C., Bobko, S., Legat, F. J., Potekaev, N., Lvov, A., Misery, L., Weger, W., Reich, A., Şavk, E., Streit, M., Serra-Baldrich, E., Szepietowski, J. C., Yosipovitch, G. & 3 others, Chen, S. C., Dugas, M. & Ständer, S., Jan 1 2018, (Accepted/In press) In : Journal of the European Academy of Dermatology and Venereology.

Research output: Contribution to journalArticle

Pruritus
Skin Diseases
Quality of Life
Dermatology
Language
1 Citation (Scopus)

Cross-sectional study of clinical distinctions between neuropathic and inflammatory pruritus

Rosen, J. D., Fostini, A. C., Chan, Y. H., Nattkemper, L. A. & Yosipovitch, G., Dec 1 2018, In : Journal of the American Academy of Dermatology. 79, 6, p. 1143-1144 2 p.

Research output: Contribution to journalArticle

Pruritus
Cross-Sectional Studies
1 Citation (Scopus)

Cross-sectional study of psychological stress and skin symptoms in Australian university students

Stewart, T. J., Schut, C., Whitfeld, M. & Yosipovitch, G., Feb 1 2018, In : Australasian Journal of Dermatology. 59, 1, p. e82-e84

Research output: Contribution to journalLetter

Psychological Stress
Cross-Sectional Studies
Students
Skin