Find Research Outputs

Search concepts
Selected Filters

Publication Year

  • 2019
  • 2018
  • 2017
  • 2016

Author

  • Stephen D Nimer
2019

ASXL1 alteration cooperates with JAK2V617F to accelerate myelofibrosis

Guo, Y., Zhou, Y., Yamatomo, S., Yang, H., Zhang, P., Chen, S., Nimer, S. D., Zhao, Z. J., Xu, M., Bai, J. & Yang, F-C., Jan 1 2019, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

4 Scopus citations

Destabilization of AETFC through C/EBPα-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation

Zhang, M. M., Liu, N., Zhang, Y. L., Rong, B., Wang, X. L., Xu, C. H., Xie, Y. Y., Shen, S., Zhu, J., Nimer, S. D., Chen, Z., Chen, S. J., Roeder, R. G., Lan, F., Wang, L., Huang, Q. H. & Sun, X. J., Jan 1 2019, In : Leukemia.

Research output: Contribution to journalLetter

Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis

Liu, N., Song, J., Xie, Y., Wang, X. L., Rong, B., Man, N., Zhang, M. M., Zhang, Q., Gao, F. F., Du, M. R., Zhang, Y., Shen, J., Xu, C. H., Hu, C. L., Wu, J. C., Liu, P., Zhang, Y. L., Xie, Y. Y., Liu, P., Huang, J. Y. & 9 others, Huang, Q. H., Lan, F., Shen, S., Nimer, S. D., Chen, Z., Chen, S. J., Roeder, R. G., Wang, L. & Sun, X. J., Jan 15 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 3, p. 890-899 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Erratum: CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis (Cancer Cell (2018) 33(6) (1111–1127.e5), (S1535610818302216), (10.1016/j.ccell.2018.05.007))

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathias, V., Jermakowicz, A. M., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schurer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 others, Yang, F. C., Tenen, D. G., Watts, J., Vega, F. & Nimer, S. D., Jan 14 2019, In : Cancer Cell. 35, 1, 1 p.

Research output: Contribution to journalComment/debate

Risk of disease progression in low-risk MDS is linked to distinct epigenetic subtypes

Qin, T., Sotzen, J., Rampal, R. K., Rapaport, F. T., Levine, R. L., Klimek, V., Nimer, S. D. & Figueroa, M., Jan 1 2019, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalLetter

TAF1 plays a critical role in AML1-ETO driven leukemogenesis

Xu, Y., Man, N., Karl, D., Martinez, C., Liu, F., Sun, J., Martinez, C. J., Martin, G. M., Beckedorff, F., Lai, F., Yue, J., Roisman, A., Greenblatt, S., Duffort, S., Wang, L., Sun, X., Figueroa, M., Shiekhattar, R. & Nimer, S., Dec 1 2019, In : Nature communications. 10, 1, 4925.

Research output: Contribution to journalArticle

Open Access
2018

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathais, V., McGrew-Jermacowicz, A., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schuerer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 others, Yang, F-C., Tenen, D., Watts, J., Vega, F. & Nimer, S. D., Jun 11 2018, In : Cancer Cell. 33, 6, p. 1111-1127.e5

Research output: Contribution to journalArticle

7 Scopus citations

Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy

Zhang, P., He, F., Bai, J., Yamamoto, S., Chen, S., Zhang, L., Sheng, M., Zhang, L., Guo, Y., Man, N., Yang, H., Wang, S., Cheng, T., Nimer, S. D., Zhou, Y., Xu, M., Wang, Q. F. & Yang, F-C., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5383-5398 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia

Luo, H., Wang, F., Zha, J., Li, H., Yan, B., Du, Q., Yang, F., Sobh, A., Vulpe, C., Drusbosky, L., Cogle, C., Chepelev, I., Xu, B., Nimer, S. D., Licht, J., Qiu, Y., Chen, B., Xu, M. & Huang, S., Aug 23 2018, In : Blood. 132, 8, p. 837-848 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Erratum: CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis (Cancer Cell (2018) 33(6) (1111–1127.e5), (S1535610818302216) (10.1016/j.ccell.2018.05.007))

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathias, V., McGrew-Jermacowicz, A., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schurer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 others, Yang, F. C., Tenen, D., Watts, J., Vega, F. & Nimer, S. D., Nov 12 2018, In : Cancer Cell. 34, 5, 1 p.

Research output: Contribution to journalComment/debate

Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies

Yang, H., Kurtenbach, S., Guo, Y., Lohse, I., Durante, M. A., Li, J., Li, Z., Al-Ali, H., Li, L., Chen, Z., Field, M. G., Zhang, P., Chen, S., Yamamoto, S., Li, Z., Zhou, Y., Nimer, S. D., William Harbour, J., Wahlestedt, C. R., Xu, M. & 1 others, Yang, F-C., Jan 18 2018, In : Blood. 131, 3, p. 328-341 14 p.

Research output: Contribution to journalArticle

34 Scopus citations

Genetic deletion or small-molecule inhibition of the arginine methyltransferase PRMT5 exhibit anti-tumoral activity in mouse models of MLL-rearranged AML

Kaushik, S., Liu, F., Veazey, K. J., Gao, G., Das, P., Neves, L. F., Lin, K., Zhong, Y., Lu, Y., Giuliani, V., Bedford, M. T., Nimer, S. D. & Santos, M. A., Feb 1 2018, In : Leukemia. 32, 2, p. 499-509 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

p300 suppresses leukemia development in NUP98-HOXD13 driven myelodysplastic syndrome

Man, N. & Nimer, S. D., Jun 1 2018, In : Oncotarget. 9, 42, p. 26603-26604 2 p.

Research output: Contribution to journalEditorial

Pathobiological pseudohypoxia as a putative mechanism underlying myelodysplastic syndromes

Hayashi, Y., Zhang, Y., Yokota, A., Yan, X., Liu, J., Choi, K., Li, B., Sashida, G., Peng, Y., Xu, Z., Huang, R., Zhang, L., Freudiger, G. M., Wang, J., Dong, Y., Zhou, Y., Wang, J., Wu, L., Bu, J., Chen, A. & 21 others, Zhao, X., Sun, X., Chetal, K., Olsson, A., Watanabe, M., Romick-Rosendale, L. E., Harada, H., Shih, L. Y., Tse, W., Bridges, J. P., Caligiuri, M. A., Huang, T., Zheng, Y., Witte, D. P., Wang, Q. F., Qu, C. K., Salomonis, N., Grimes, H. L., Nimer, S. D., Xiao, Z. & Huang, G., Nov 1 2018, In : Cancer Discovery. 8, 11, p. 1438-1457 20 p.

Research output: Contribution to journalArticle

6 Scopus citations

PRMT5 interacts with the BCL6 oncoprotein and is required for germinal center formation and lymphoma cell survival

Lu, X., Fernando, T. M., Lossos, C., Yusufova, N., Liu, F., Fontán, L., Durant, M., Geng, H., Melnick, J., Luo, Y., Vega, F., Moy, V. T., Inghirami, G., Nimer, S. D., Melnick, A. M. & Lossos, I., Nov 8 2018, In : Blood. 132, 19, p. 2026-2039 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

PRMT5 Regulates DNA Repair by Controlling the Alternative Splicing of Histone-Modifying Enzymes

Hamard, P. J., Santiago, G. E., Liu, F., Karl, D. L., Martinez, C., Man, N., Mookhtiar, A. K., Duffort, S., Greenblatt, S., Verdun, R. E. & Nimer, S. D., Sep 4 2018, In : Cell Reports. 24, 10, p. 2643-2657 15 p.

Research output: Contribution to journalArticle

20 Scopus citations

Recent advances in the understanding and treatment of acute myeloid leukemia

Watts, J. & Nimer, S. D., Jan 1 2018, In : F1000Research. 7, 1196.

Research output: Contribution to journalReview article

11 Scopus citations

Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo

Guo, Y., Yang, H., Chen, S., Zhang, P., Li, R., Nimer, S. D., William Harbour, J., Xu, M. & Yang, F-C., Apr 2 2018, (Accepted/In press) In : Leukemia. p. 1-4 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine (5hmC)

Chu, Y., Zhao, Z., Sant, D. W., Zhu, G., Greenblatt, S. M., Liu, L., Wang, J., Cao, Z., Tho, J. C., Chen, S., Liu, X., Zhang, P., Maciejewski, J. P., Nimer, S. D., Wang, G., Yuan, W., Yang, F-C. & Xu, M., Jan 1 2018, (Accepted/In press) In : Genomics, Proteomics and Bioinformatics.

Research output: Contribution to journalArticle

5 Scopus citations
2017

ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis

Li, Z., Zhang, P., Yan, A., Guo, Z., Ban, Y., Li, J., Chen, S., Yang, H., He, Y., Li, J., Guo, Y., Zhang, W., Hajiramezanali, E., An, H., Fajardo, D., William Harbour, J., Ruan, Y., Nimer, S. D., Yu, P., Chen, X. & 2 others, Xu, M. & Yang, F-C., Jan 1 2017, In : Science advances. 3, 1, e1601602.

Research output: Contribution to journalArticle

14 Scopus citations

Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner

Man, N., Tan, Y., Sun, X. J., Liu, F., Cheng, G., Greenblatt, S. M., Martinez, C., Karl, D. L., Ando, K., Sun, M., Hou, D., Chen, B., Xu, M., Yang, F-C., Chen, Z., Chen, S., Nimer, S. D. & Wang, L., May 18 2017, In : Blood. 129, 20, p. 2782-2792 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Clinical characteristics and outcomes according to age in lenalidomide-treated patients with RBC transfusion-dependent lower-risk MDS and del(5q)

Fenaux, P., Giagounidis, A., Selleslag, D., Beyne-Rauzy, O., Mittelman, M., Muus, P., Nimer, S. D., Hellström-Lindberg, E., Powell, B. L., Guerci-Bresler, A., Sekeres, M. A., Deeg, H. J., Del Cañizo, C., Greenberg, P. L., Shammo, J. M., Skikne, B., Yu, X. & List, A. F., Jun 26 2017, In : Journal of Hematology and Oncology. 10, 1, 131.

Research output: Contribution to journalArticle

4 Scopus citations

Covalent modifications of RUNX proteins: Structure affects function

Blumenthal, E., Greenblatt, S., Huang, G., Ando, K., Xu, Y. & Nimer, S. D., 2017, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 962. p. 33-44 12 p. (Advances in Experimental Medicine and Biology; vol. 962).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Histone-binding of DPF2 mediates its repressive role in myeloid differentiation

Huber, F. M., Greenblatt, S. M., Davenport, A. M., Martinez, C., Xu, Y., Vu, L. P., Nimer, S. D. & Hoelz, A., Jun 6 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. 6016-6021 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Loss of Asxl2 leads to myeloid malignancies in mice

Li, J., He, F., Zhang, P., Chen, S., Shi, H., Sun, Y., Guo, Y., Yang, H., Man, N., Greenblatt, S., Li, Z., Guo, Z., Zhou, Y., Wang, L., Morey, LL., Williams, S. L., Chen, X., Wang, Q. T., Nimer, S. D., Yu, P. & 3 others, Wang, Q. F., Xu, M. & Yang, F-C., Jun 8 2017, In : Nature Communications. 8, 15456.

Research output: Contribution to journalArticle

9 Scopus citations

Loss of p300 accelerates MDS-associated leukemogenesis

Cheng, G., Liu, F., Asai, T., Lai, F., Man, N., Xu, H., Chen, S., Greenblatt, S., Hamard, P. J., Ando, K., Chen, X., Wang, L., Martinez, C., Tadi, M., Wang, L., Xu, M., Yang, F. C., Shiekhattar, R. & Nimer, S. D., Jan 6 2017, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

11 Scopus citations

Multicenter phase II study of temozolomide and myeloablative chemotherapy with autologous stem cell transplant for newly diagnosed anaplastic oligodendroglioma

Thomas, A. A., Abrey, L. E., Terziev, R., Raizer, J., Martinez, N. L., Forsyth, P., Paleologos, N., Matasar, M., Sauter, C. S., Moskowitz, C., Nimer, S. D., Deangelis, L. M., Kaley, T., Grimm, S., Louis, D. N., Cairncross, J. G., Panageas, K. S., Briggs, S., Faivre, G., Mohile, N. A. & 8 others, Mehta, J., Jonsson, P., Chakravarty, D., Gao, J., Schultz, N., Brennan, C. W., Huse, J. T. & Omuro, A., Oct 1 2017, In : Neuro-Oncology. 19, 10, p. 1380-1390 11 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Arginine methyltransferases in normal and malignant hematopoiesis

Greenblatt, S. M., Liu, F. & Nimer, S. D., Jun 1 2016, In : Experimental Hematology. 44, 6, p. 435-441 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Beyond transcription factors: How oncogenic signalling reshapes the epigenetic landscape

Liu, F., Wang, L., Perna, F. & Nimer, S. D., May 25 2016, In : Nature Reviews Cancer. 16, 6, p. 359-372 14 p.

Research output: Contribution to journalReview article

55 Scopus citations

Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin

Man, N., Sun, X. J., Tan, Y., García-Cao, M., Liu, F., Cheng, G., Hatlen, M., Xu, H., Shah, R., Chastain, N., Liu, N., Huang, G., Zhou, Y., Sheng, M., Song, J., Yang, F-C., Benezra, R., Nimer, S. D. & Wang, L., 2016, In : Blood. 127, 19, p. 2322-2326 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling

Guryanova, O. A., Shank, K., Spitzer, B., Luciani, L., Koche, R. P., Garrett-Bakelman, F. E., Ganzel, C., Durham, B. H., Mohanty, A., Hoermann, G., Rivera, S. A., Chramiec, A. G., Pronier, E., Bastian, L., Keller, M. D., Tovbin, D., Loizou, E., Weinstein, A. R., Gonzalez, A. R., Lieu, Y. K. & 19 others, Rowe, J. M., Pastore, F., McKenney, A. S., Krivtsov, A. V., Sperr, W. R., Cross, J. R., Mason, C. E., Tallman, M. S., Arcila, M. E., Abdel-Wahab, O., Armstrong, S. A., Kubicek, S., Staber, P. B., Gönen, M., Paietta, E. M., Melnick, A. M., Nimer, S. D., Mukherjee, S. & Levine, R. L., Dec 1 2016, In : Nature Medicine. 22, 12, p. 1488-1495 8 p.

Research output: Contribution to journalArticle

68 Scopus citations

Generation of a novel, multi-stage, progressive, and transplantable model of plasma cell neoplasms

Asai, T., Hatlen, M. A., Lossos, C., Ndiaye-Lobry, D., Deblasio, A., Murata, K., Fleisher, M., Cortizas, E. M., Verdun, R. E., Petrini, J. & Nimer, S. D., Mar 10 2016, In : Scientific Reports. 6, 22760.

Research output: Contribution to journalArticle

3 Scopus citations

Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles

Hatlen, M. A., Arora, K., Vacic, V., Grabowska, E. A., Liao, W., Riley-Gillis, B., Oschwald, D. M., Wang, L., Joergens, J. E., Shih, A. H., Rapaport, F., Gu, S., Voza, F., Asai, T., Neel, B. G., Kharas, M. G., Gonen, M., Levine, R. L. & Nimer, S. D., 2016, In : Journal of Experimental Medicine. 213, 1, p. 25-34 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

MSI2 is required for maintaining activated myelodysplastic syndrome stem cells

Taggart, J., Ho, T. C., Amin, E., Xu, H., Barlowe, T. S., Perez, A. R., Durham, B. H., Tivnan, P., Okabe, R., Chow, A., Vu, L., Park, S. M., Prieto, C., Famulare, C., Patel, M., Lengner, C. J., Verma, A., Roboz, G., Guzman, M., Klimek, V. M. & 4 others, Abdel-Wahab, O., Leslie, C., Nimer, S. D. & Kharas, M. G., Feb 22 2016, In : Nature Communications. 7, 10739.

Research output: Contribution to journalArticle

14 Scopus citations

Mutational landscape and antiproliferative functions of ELF transcription factors in human cancer

Ando, M., Kawazu, M., Ueno, T., Koinuma, D., Ando, K., Koya, J., Kataoka, K., Yasuda, T., Yamaguchi, H., Fukumura, K., Yamato, A., Soda, M., Sai, E., Yamashita, Y., Asakage, T., Miyazaki, Y., Kurokawa, M., Miyazono, K., Nimer, S. D., Yamasoba, T. & 1 others, Mano, H., Apr 1 2016, In : Cancer Research. 76, 7, p. 1814-1824 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity

Shirakawa, K., Wang, L., Man, N., Maksimoska, J., Sorum, A. W., Lim, H. W., Lee, I. S., Shimazu, T., Newman, J. C., Schröder, S., Ott, M., Marmorstein, R., Meier, J., Nimer, S. D. & Verdin, E., May 31 2016, In : eLife. 5, MAY2016, e11156.

Research output: Contribution to journalArticle

29 Scopus citations