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  • Ralph L Sacco
2020

Antithrombotic Treatment of Embolic Stroke of Undetermined Source: RE-SPECT ESUS Elderly and Renally Impaired Subgroups

Diener, H. C., Sacco, R. L., Easton, J. D., Granger, C. B., Bar, M., Bernstein, R. A., Brainin, M., Brueckmann, M., Cronin, L., Donnan, G., Gdovinová, Z., Grauer, C., Kleine, E., Kleinig, T. J., Lyrer, P., Martins, S., Meyerhoff, J., Milling, T., Pfeilschifter, W., Poli, S. & 4 others, Reif, M., Rose, D. Z., Šaňák, D. & Schäbitz, W. R., 2020, (Accepted/In press) In : Stroke. p. 1758-1765 8 p.

Research output: Contribution to journalArticle

Open Access

Association between Blood Pressure and Later-Life Cognition among Black and White Individuals

Levine, D. A., Gross, A. L., Briceño, E. M., Tilton, N., Kabeto, M. U., Hingtgen, S. M., Giordani, B. J., Sussman, J. B., Hayward, R. A., Burke, J. F., Elkind, M. S. V., Manly, J. J., Moran, A. E., Kulick, E. R., Gottesman, R. F., Walker, K. A., Yano, Y., Gaskin, D. J., Sidney, S., Yaffe, K. & 5 others, Sacco, R. L., Wright, C. B., Roger, V. L., Allen, N. B. & Galecki, A. T., Jan 1 2020, (Accepted/In press) In : JAMA Neurology.

Research output: Contribution to journalArticle

Association between Central Blood Pressure and Subclinical Cerebrovascular Disease in Older Adults

Matsumoto, K., Jin, Z., Homma, S., Elkind, M. S. V., Rundek, T., Mannina, C., Lee, T. C., Yoshita, M., Decarli, C., Wright, C. B., Sacco, R. L. & Di Tullio, M. R., Feb 1 2020, In : Hypertension. p. 580-587 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Association between PNPLA3 rs738409 G variant and MRI cerebrovascular disease biomarkers

Parikh, N. S., Dueker, N., Varela, D., Del Brutto, V. J., Rundek, T., Wright, C. B., Sacco, R. L., Elkind, M. S. V. & Gutierrez, J., Sep 15 2020, In : Journal of the Neurological Sciences. 416, 116981.

Research output: Contribution to journalArticle

Brain Volume: An Important Determinant of Functional Outcome After Acute Ischemic Stroke

MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium, May 2020, In : Mayo Clinic Proceedings. 95, 5, p. 955-965 11 p.

Research output: Contribution to journalArticle

Classification of Covert Brain Infarct Subtype and Risk of Death and Vascular Events

Gutierrez, J., Gil-Guevara, A., Ramaswamy, S., DeRosa, J., Di Tullio, M. R., Cheung, K., Rundek, T., Sacco, R. L., Wright, C. B. & Elkind, M. S. V., Jan 1 2020, In : Stroke. 51, 1, p. 90-98 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Creatinine versus cystatin C for renal function-based mortality prediction in an elderly cohort: The Northern Manhattan study

Willey, J. Z., Moon, Y. P., Ali Husain, S., Elkind, M. S. V., Sacco, R. L., Wolf, M., Cheung, K., Wright, C. B. & Mohan, S., 2020, In : PloS one. 15, 1, e0226509.

Research output: Contribution to journalArticle

Open Access

De novo EIF2AK1 and EIF2AK2 Variants Are Associated with Developmental Delay, Leukoencephalopathy, and Neurologic Decompensation

Undiagnosed Diseases Network, Apr 2 2020, In : American journal of human genetics. 106, 4, p. 570-583 14 p.

Research output: Contribution to journalArticle

Detailed phenotyping of posterior vs. anterior circulation ischemic stroke: a multi-center MRI study

the Stroke Genetics Network (SiGN), the International Stroke Genetics Consortium (ISGC), and the MRI-Genetics Interface Exploration (MRI-GENIE) Study, Mar 1 2020, In : Journal of Neurology. 267, 3, p. 649-658 10 p.

Research output: Contribution to journalArticle

Open Access

Diastolic Blood Pressure Is Associated with Regional White Matter Lesion Load: The Northern Manhattan Study

Caunca, M. R., Simonetto, M., Cheung, Y. K., Alperin, N., Lee, S. H., Elkind, M. S. V., Sacco, R. L., Rundek, T. & Wright, C. B., Feb 1 2020, In : Stroke. p. 372-378 7 p.

Research output: Contribution to journalArticle

Global Vascular Risk Score and CAIDE Dementia Risk Score Predict Cognitive Function in the Northern Manhattan Study

Rundek, T., Gardener, H., Dias Saporta, A. S., Loewenstein, D. A., Duara, R., Wright, C. B., Dong, C., Levin, B., Elkind, M. S. V. & Sacco, R. L., Jan 1 2020, In : Journal of Alzheimer's disease : JAD. 73, 3, p. 1221-1231 11 p.

Research output: Contribution to journalArticle

Long-term exposure to air pollution and trajectories of cognitive decline among older adults

Kulick, E. R., Wellenius, G. A., Boehme, A. K., Joyce, N. R., Schupf, N., Kaufman, J. D., Mayeux, R., Sacco, R. L., Manly, J. J. & Elkind, M. S. V., Apr 28 2020, In : Neurology. 94, 17, p. E1782-E1792

Research output: Contribution to journalArticle

4 Scopus citations

Multiple Faces of Cerebral Small Vessel Diseases

Gurol, M. E., Sacco, R. L. & McCullough, L. D., Jan 1 2020, In : Stroke. 51, 1, p. 9-11 3 p.

Research output: Contribution to journalArticle

Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium

on behalf of the PROG-IMT study group, Feb 1 2020, In : European Journal of Preventive Cardiology. 27, 3, p. 234-243 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Race and Ethnic Disparities in Stroke Incidence in the Northern Manhattan Study

Gardener, H., Sacco, R. L., Rundek, T., Battistella, V., Cheung, Y. K. & Elkind, M. S. V., Apr 1 2020, In : Stroke. p. 1064-1069 6 p.

Research output: Contribution to journalArticle

Open Access

Randomized Trial of Combined Aerobic, Resistance, and Cognitive Training to Improve Recovery From Stroke: Feasibility and Safety

Koch, S., Tiozzo, E., Simonetto, M., Loewenstein, D., Wright, C. B., Dong, C., Bustillo, A., Perez-Pinzon, M., Dave, K. R., Gutierrez, C. M., Lewis, J. E., Flothmann, M., Mendoza-Puccini, M. C., Junco, B., Rodriguez, Z., Gomes-Osman, J., Rundek, T. & Sacco, R. L., May 18 2020, In : Journal of the American Heart Association. 9, 10, p. e015377

Research output: Contribution to journalArticle

Open Access

Response by Gutierrez et al to Letter Regarding Article, "classification of Covert Brain Infarct Subtype and Risk of Death and Vascular Events"

Gutierrez, J., Di Tullio, M. R., Rundek, T., Sacco, R. L., Wright, C. B. & Elkind, M. S. V., Jan 1 2020, (Accepted/In press) In : Stroke. p. E82

Research output: Contribution to journalLetter

Rising Incidence of Stroke in Pregnancy: A Call for Enhanced Screening and Prevention

Sacco, R. L. & Sur, N. B., Jan 21 2020, In : Journal of the American College of Cardiology. 75, 2, p. 191-193 3 p.

Research output: Contribution to journalEditorial

Sleep quality mediates the relationship between frailty and cognitive dysfunction in non-demented middle aged to older adults

Kaur, S., Banerjee, N., Miranda, M., Slugh, M., Suslow, N. S., McInerney, K. F., Sun, X., Ramos, A., Rundek, T., Sacco, R. L. & Levin, B. E., Jan 1 2020, (Accepted/In press) In : International Psychogeriatrics.

Research output: Contribution to journalLetter

Open Access

Stroke Vision 2020: Creating a roadmap for the next decade

Sacco, R. L., Mar 1 2020, In : Stroke. p. 1040-1046 7 p.

Research output: Contribution to journalReview article

Open Access

The american heart association 2030 impact goal: A presidential advisory from the american heart association

Angell, S. Y., Mcconnell, M. V., Anderson, C. A. M., Bibbins-Domingo, K., Boyle, D. S., Capewell, S., Ezzati, M., De Ferranti, S., Gaskin, D. J., Goetzel, R. Z., Huffman, M. D., Jones, M., Khan, Y. M., Kim, S., Kumanyika, S. K., Mccray, A. T., Merritt, R. K., Milstein, B., Mozaffarian, D., Norris, T. & 7 others, Roth, G. A., Sacco, R. L., Saucedo, J. F., Shay, C. M., Siedzik, D., Saha, S. & Warner, J. J., Mar 3 2020, In : Circulation. p. E120-E138

Research output: Contribution to journalReview article

4 Scopus citations
2019
Open Access
7 Scopus citations

Antibiotic Class and Outcome in Post-stroke Infections: An individual participant data pooled analysis of VISTA-acute

VISTA Collaboration and PISCES Group, 2019, In : Frontiers in Neurology. 10, MAY, 504.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Antiplatelet Therapy after Noncardioembolic Stroke: An Individual Patient Data Network Meta-Analysis

Greving, J. P., Diener, H. C., Reitsma, J. B., Bath, P. M., Csiba, L., Hacke, W., Kappelle, L. J., Koudstaal, P. J., Leys, D., Mas, J. L., Sacco, R. L. & Algra, A., Jul 1 2019, In : Stroke. 50, 7, p. 1812-1818 7 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Antithrombotic Therapy to Prevent Recurrent Strokes in Ischemic Cerebrovascular Disease: JACC Scientific Expert Panel

Del Brutto, V. J., Chaturvedi, S., Diener, H. C., Romano, J. G. & Sacco, R. L., Aug 13 2019, In : Journal of the American College of Cardiology. 74, 6, p. 786-803 18 p.

Research output: Contribution to journalReview article

2 Scopus citations

Association between mortality and implantable cardioverter-defibrillators by aetiology of heart failure: a propensity-matched analysis of the WARCEF trial

for the WARCEF Investigators, Apr 2019, In : ESC Heart Failure. 6, 2, p. 297-307 11 p.

Research output: Contribution to journalArticle

Open Access

Big Data Approaches to Phenotyping Acute Ischemic Stroke Using Automated Lesion Segmentation of Multi-Center Magnetic Resonance Imaging Data

Wu, O., Winzeck, S., Giese, A. K., Hancock, B. L., Etherton, M. R., Bouts, M. J. R. J., Donahue, K., Schirmer, M. D., Irie, R. E., Mocking, S. J. T., McIntosh, E. C., Bezerra, R., Kamnitsas, K., Frid, P., Wasselius, J., Cole, J. W., Xu, H., Holmegaard, L., Jiménez-Conde, J., Lemmens, R. & 22 others, Lorentzen, E., McArdle, P. F., Meschia, J. F., Roquer, J., Rundek, T., Sacco, R. L., Schmidt, R., Sharma, P., Slowik, A., Stanne, T. M., Thijs, V., Vagal, A., Woo, D., Bevan, S., Kittner, S. J., Mitchell, B. D., Rosand, J., Worrall, B. B., Jern, C., Lindgren, A. G., Maguire, J. & Rost, N. S., Jul 1 2019, In : Stroke. 50, 7, p. 1734-1741 8 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Brain arterial dilatation modifies the association between extracranial pulsatile hemodynamics and brain perivascular spaces: the Northern Manhattan Study

Gutierrez, J., DiTullio, M., K Cheung, Y. K., Alperin, N., Bagci, A., L Sacco, R., B Wright, C., SV Elkind, M. & Rundek, T., Jul 1 2019, In : Hypertension Research. 42, 7, p. 1019-1028 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Changes in Left Ventricular Mass and Geometry in the Older Adults: Role of Body Mass and Central Obesity

Lee, T. C., Jin, Z., Homma, S., Nakanishi, K., Elkind, M. S. V., Rundek, T., Tugcu, A., Matsumoto, K., Sacco, R. L. & Di Tullio, M. R., Jan 1 2019, In : Journal of the American Society of Echocardiography.

Research output: Contribution to journalArticle

2 Scopus citations

Cognitive Decline Over Time in Patients With Systolic Heart Failure: Insights From WARCEF

WARCEF Investigators, Dec 2019, In : JACC: Heart Failure. 7, 12, p. 1042-1053 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Dabigatran for prevention of stroke after embolic stroke of undetermined source

Diener, H. C., Sacco, R. L., Donald Easton, J., Granger, C. B., Bernstein, R. A., Uchiyama, S., Kreuzer, J., Cronin, L., Cotton, D., Grauer, C., Brueckmann, M., Chernyatina, M., Donnan, G., Ferro, J. M., Grond, M., Kallmünzer, B., Krupinski, J., Lee, B. C., Lemmens, R., Masjuan, J. & 5 others, Odinak, M., Saver, J. L., Schellinger, P. D., Toni, D. & Toyoda, K., May 16 2019, In : New England Journal of Medicine. 380, 20, p. 1906-1917 12 p.

Research output: Contribution to journalArticle

93 Scopus citations

De Novo Variants in WDR37 Are Associated with Epilepsy, Colobomas, Dysmorphism, Developmental Delay, Intellectual Disability, and Cerebellar Hypoplasia

Undiagnosed Diseases Network, Aug 1 2019, In : American journal of human genetics. 105, 2, p. 413-424 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Disparities and Temporal Trends in the Use of Anticoagulation in Patients with Ischemic Stroke and Atrial Fibrillation

Sur, N. B., Wang, K., Di Tullio, M. R., Gutierrez, C. M., Dong, C., Koch, S., Gardener, H., García-Rivera, E. J., Zevallos, J. C., Burgin, W. S., Rose, D. Z., Goldberger, J. J., Romano, J. G., Sacco, R. L. & Rundek, T., Jan 1 2019, In : Stroke. 50, 6, p. 1452-1459 8 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Effect of hypertension and diabetes on subclinical left ventricular systolic dysfunction in a predominantly elderly population-based cohort

Mannina, C., Jin, Z., Russo, C., Homma, S., Elkind, M. S. V., Rundek, T., Lee, T. C., Matsumoto, K., Shames, S., Sacco, R. L. & Tullio, M. R. D., Jan 1 2019, (Accepted/In press) In : European Journal of Preventive Cardiology.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

Stroke Genetics Network (SiGN), International Stroke Genetics Consortium (ISGC), METASTROKE, Alzheimer’s Disease Genetics Consortium (ADGC) & Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Jan 29 2019, In : Neurology. 92, 5, p. E486-E503

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

GBD 2016 Neurology Collaborators, May 1 2019, In : The Lancet Neurology. 18, 5, p. 459-480 22 p.

Research output: Contribution to journalArticle

Open Access
145 Scopus citations

Guidelines for the early management of patients with acute ischemic stroke 2019 update to the 2018 guidelines for the early management of acute ischemic stroke

Warner, J. J., Harrington, R. A., Sacco, R. L. & Elkind, M. S. V., Dec 1 2019, In : Stroke. 50, 12, p. 3331-3332 2 p.

Research output: Contribution to journalEditorial

Open Access
9 Scopus citations

Interleukin-6 and lipoprotein-associated phospholipase A2 are associated with functional trajectories

Dhamoon, M. S., Cheung, Y. K., Moon, Y. P., Wright, C. B., Sacco, R. L. & Elkind, M. S. V., Apr 2019, In : PloS one. 14, 4, e0214784.

Research output: Contribution to journalArticle

Open Access

Lysosomal Storage and Albinism Due to Effects of a De Novo CLCN7 Variant on Lysosomal Acidification

Undiagnosed Diseases Network, Jun 6 2019, In : American journal of human genetics. 104, 6, p. 1127-1138 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Magnetic Resonance Imaging characteristics in case of TOR1AIP1 muscular dystrophy

Undiagnosed Diseases Network (UDN) & Members of the Undiagnosed Diseases Network, Nov 1 2019, In : Clinical Imaging. 58, p. 108-113 6 p.

Research output: Contribution to journalArticle

Measures of Adiposity and Alzheimer's Disease-Related MRI Markers: The Northern Manhattan Study

Caunca, M. R., Simonetto, M., Alperin, N., Elkind, M. S. V., Sacco, R. L., Wright, C. B. & Rundek, T., Jan 1 2019, In : Journal of Alzheimer's Disease. 70, 4, p. 995-1004 10 p.

Research output: Contribution to journalArticle

Measures of obesity are associated with MRI markers of brain aging: The Northern Manhattan Study

Caunca, M. R., Gardener, H., Simonetto, M., Cheung, Y. K., Alperin, N., Yoshita, M., DeCarli, C., Elkind, M. S. V., Sacco, R. L., Wright, C. B. & Rundek, T., Aug 20 2019, In : Neurology. 93, 8, p. e791-e803

Research output: Contribution to journalArticle

3 Scopus citations

Multi-level community interventions for primary stroke prevention: A conceptual approach by the World Stroke Organization

Brainin, M., Feigin, V., Bath, P. M., Collantes, E., Martins, S., Pandian, J., Sacco, R. & Teuschl, Y., Oct 1 2019, In : International Journal of Stroke. 14, 8, p. 818-825 8 p.

Research output: Contribution to journalReview article

2 Scopus citations

Need to Prioritize Education of the Public Regarding Stroke Symptoms and Faster Activation of the 9-1-1 System: Findings from the Florida–Puerto Rico CReSD Stroke Registry

Gardener, H., Pepe, P. E., Rundek, T., Wang, K., Dong, C., Ciliberti, M., Gutierrez, C., Gandia, A., Antevy, P., Hodges, W., Mueller-Kronast, N., Sand, C., Romano, J. G. & Sacco, R. L., Jul 4 2019, In : Prehospital Emergency Care. 23, 4, p. 439-446 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Neurology: Challenges, opportunities, and the way forward

Sacco, R. L., Nov 19 2019, In : Neurology. 93, 21, p. 911-918 8 p.

Research output: Contribution to journalArticle

Night-time systolic blood pressure and subclinical cerebrovascular disease: The Cardiovascular Abnormalities and Brain Lesions (CABL) study

Nakanishi, K., Jin, Z., Homma, S., Elkind, M. S. V., Rundek, T., Schwartz, J. E., Lee, T. C., Tugcu, A., Yoshita, M., Decarli, C., Wright, C. B., Sacco, R. L. & Di Tullio, M. R., 2019, In : European heart journal cardiovascular Imaging. 20, 7, p. 765-771 7 p., jey221.

Research output: Contribution to journalArticle

6 Scopus citations

Partial Loss of USP9X Function Leads to a Male Neurodevelopmental and Behavioral Disorder Converging on Transforming Growth Factor β Signaling

Undiagnosed Diseases Network, 2019, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to journalArticle

6 Scopus citations

Patterns and Outcomes of Endovascular Therapy in Mild Stroke

Asdaghi, N., Yavagal, D. R., Wang, K., Mueller-Kronast, N., Bhatt, N., Gardener, H. E., Gutierrez, C. M., Marulanda-Londoño, E., Koch, S., Dong, C., Oluwole, S. A., Hanel, R., Mehta, B., Robichaux, M., Nobo, U., Zevallos, J. C., Rundek, T., Sacco, R. L. & Romano, J. G., Aug 1 2019, In : Stroke. 50, 8, p. 2101-2107 7 p.

Research output: Contribution to journalArticle

3 Scopus citations