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  • William K Scott
2020

A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration

International AMD Genomics Consortium (IAMDGC), Dec 1 2020, In : Scientific reports. 10, 1, 1584.

Research output: Contribution to journalArticle

Open Access

Spectrum of genetic variants associated with anterior segment dysgenesis in South Florida

Thanikachalam, S., Hodapp, E., Chang, T. C., Swols, D. M., Cengiz, F. B., Guo, S., Zafeer, M. F., Seyhan, S., Bademci, G., Scott, W. K., Grajewski, A. & Tekin, M., Apr 2020, In : Genes. 11, 4, 350.

Research output: Contribution to journalArticle

Open Access
2018

Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma

Gharahkhani, P., Burdon, K. P., Cooke Bailey, J. N., Hewitt, A. W., Law, M. H., Pasquale, L. R., Kang, J. H., Haines, J. L., Souzeau, E., Zhou, T., Siggs, O. M., Landers, J., Awadalla, M., Sharma, S., Mills, R. A., Ridge, B., Lynn, D., Casson, R., Graham, S. L., Goldberg, I. & 45 others, White, A., Healey, P. R., Grigg, J., Lawlor, M., Mitchell, P., Ruddle, J., Coote, M., Walland, M., Best, S., Vincent, A., Gale, J., Radfordsmith, G., Whiteman, D. C., Montgomery, G. W., Martin, N. G., MacKey, D. A., Wiggs, J. L., MacGregor, S., Craig, J. E., Allingham, R. R., Brilliant, M., Budenz, D. L., Fingert, J. H., Gaasterland, D., Gaasterland, T., Hark, L., Hauser, M., Igo, R. P., Kraft, P., Lee, R. K., Lichter, P. R., Liu, Y., Moroi, S., Pericak-Vance, M., Realini, A., Rhee, D., Richards, J. E., Ritch, R., Schuman, J. S., Scott, W. K., Singh, K., Sit, A. J., Vollrath, D., Wollstein, G. & Zack, D. J., Dec 1 2018, In : Scientific reports. 8, 1, 3124.

Research output: Contribution to journalArticle

9 Scopus citations

Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Iglesias, A. I., Mishra, A., Vitart, V., Bykhovskaya, Y., Höhn, R., Springelkamp, H., Cuellar-Partida, G., Gharahkhani, P., Bailey, J. N. C., Willoughby, C. E., Li, X., Yazar, S., Nag, A., Khawaja, A. P., Polašek, O., Siscovick, D., Mitchell, P., Tham, Y. C., Haines, J. L., Kearns, L. S. & 124 others, Hayward, C., Shi, Y., Van Leeuwen, E. M., Taylor, K. D., Wang, J. J., Rochtchina, E., Attia, J., Scott, R., Holliday, E. G., Baird, P. N., Xie, J., Inouye, M., Viswanathan, A., Sim, X., Bonnemaijer, P., Rotter, J. I., Martin, N. G., Zeller, T., Mills, R. A., Staffieri, S. E., Jonas, J. B., Schmidtmann, I., Boutin, T., Kang, J. H., Lucas, S. E. M., Wong, T. Y., Beutel, M. E., Wilson, J. F., Allingham, R. R., Brilliant, M. H., Budenz, D. L., Christen, W. G., Fingert, J., Friedman, D. S., Gaasterland, D., Gaasterland, T., Hauser, M. A., Kraft, P., Lee, R. K., Lichter, P. R., Liu, Y., Loomis, S. J., Moroi, S. E., Pericak-Vance, M. A., Realini, A., Richards, J. E., Schuman, J. S., Scott, W. K., Singh, K., Sit, A. J., Vollrath, D., Weinreb, R. N., Wollstein, G., Zack, D. J., Zhang, K., Donnelly, P., Barroso, I., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Deloukas, P., Duncanson, A., Jankowski, J., Markus, H. S., Mathew, C. G., Palmer, C. N. A., Plomin, R., Rautanen, A., Sawcer, S. J., Trembath, R. C., Wood, N. W., Spencer, C. C. A., Band, G., Bellenguez, C., Freeman, C., Hellenthal, G., Giannoulatou, E., Pirinen, M., Pearson, R., Strange, A., Su, Z., Vukcevic, D., Langford, C., Hunt, S. E., Edkins, S., Gwilliam, R., Blackburn, H., Bumpstead, S. J., Dronov, S., Gillman, M., Gray, E., Hammond, N., Jayakumar, A., McCann, O. T., Liddle, J., Potter, S. C., Ravindrarajah, R., Ricketts, M., Waller, M., Weston, P., Widaa, S., Whittaker, P., Uitterlinden, A. G., Vithana, E. N., Foster, P. J., Hysi, P. G., Hewitt, A. W., Khor, C. C., Pasquale, L. R., Montgomery, G. W., Klaver, C. C. W., Aung, T., Pfeiffer, N., MacKey, D. A., Hammond, C. J., Cheng, C. Y., Craig, J. E., Rabinowitz, Y. S., Wiggs, J. L., Burdon, K. P., Van Duijn, C. M. & MacGregor, S., Dec 1 2018, In : Nature communications. 9, 1, 1864.

Research output: Contribution to journalArticle

16 Scopus citations

Erratum: Author Correction: A population-specific reference panel empowers genetic studies of Anabaptist populations (Scientific reports (2017) 7 1 (6079))

Hou, L., Kember, R. L., Roach, J. C., O'Connell, J. R., Craig, D. W., Bucan, M., Scott, W. K., Pericak-Vance, M., Haines, J. L., Crawford, M. H., Shuldiner, A. R. & McMahon, F. J., Apr 25 2018, In : Scientific reports. 8, 1, p. 6771 1 p., 6771.

Research output: Contribution to journalComment/debate

Open Access

Family-based genome-wide association study of south Indian pedigrees supports WNT7B as a central corneal thickness locus

Fan, B. J., Chen, X., Sondhi, N., Sharmila, P. F., Soumittra, N., Sripriya, S., Sacikala, S., Asokan, R., Friedman, D. S., Pasquale, L. R., Gao, X. R., Vijaya, L., Bailey, J. C., Vitart, V., Macgregor, S., Hammond, C. J., Khor, C. C., Haines, J. L., George, R., Wiggs, J. L. & 56 others, Allingham, R. R., Gauderman, J., Hauser, M., Rotter, J. I., Varma, R., Aung, T., Burdon, K. P., Cheng, C. Y., Craig, J. E., Cree, A. J., Gharahkhani, P., Hewitt, A. W., Höhn, R., Hysi, P., Iglesias Gonzalez, A. I., Jonas, J., Khawaja, A., Klaver, C. C. W., Pasutto, F., Mackey, D., Mitchell, P., Mishra, A., Pang, C., Springelkamp, H., Thorleifsson, G., Thorsteinsdottir, U., van Duijn, C. M., Viswanathan, A., Wojciechowski, R., Wong, T., Young, T. L., Zeller, T., Brilliant, M., Budenz, D., Fingert, J., Gaasterland, D., Gaasterland, T., Igo, R., Kang, J. H., Kraft, P., Lee, R., Lichter, P., Liu, Y., Moroi, S., Realini, A., Rhee, D., Richards, J. R., Ritch, R., Schuman, J., Scott, W. K., Singh, K., Sit, A., Vollrath, D., Weinreb, R. N., Wollstein, G. & Zack, D., May 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 6, p. 2495-2502 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease

Hui, K. Y., Fernandez-Hernandez, H., Hu, J., Schaffner, A., Pankratz, N., Hsu, N. Y., Chuang, L. S., Carmi, S., Villaverde, N., Li, X., Rivas, M., Levine, A. P., Bao, X., Labrias, P. R., Haritunians, T., Ruane, D., Gettler, K., Chen, E., Li, D., Schiff, E. R. & 31 others, Pontikos, N., Barzilai, N., Brant, S. R., Bressman, S., Cheifetz, A. S., Clark, L. N., Daly, M. J., Desnick, R. J., Duerr, R. H., Katz, S., Lencz, T., Myers, R. H., Ostrer, H., Ozelius, L., Payami, H., Peter, Y., Rioux, J. D., Segal, A. W., Scott, W. K., Silverberg, M. S., Vance, J. M., Ubarretxena-Belandia, I., Foroud, T., Atzmon, G., Pe'er, I., Ioannou, Y., McGovern, D. P. B., Yue, Z., Schadt, E. E., Cho, J. H. & Peter, I., Jan 10 2018, In : Science Translational Medicine. 10, 423, eaai7795.

Research output: Contribution to journalArticle

81 Scopus citations

Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma

International Glaucoma Genetics Consortium & NEIGHBORHOOD Consortium, Jan 1 2018, In : PLoS genetics. 14, 1, e1007145.

Research output: Contribution to journalArticle

8 Scopus citations

Human genetic variation in GLS2 is associated with development of complicated Staphylococcus aureus bacteremia

Scott, W. K., Medie, F. M., Ruffin, F., Sharma-Kuinkel, B. K., Cyr, D. D., Guo, S., Dykxhoorn, D. M., Skov, R. L., Bruun, N. E., Dahl, A., Lerche, C. J., Petersen, A., Larsen, A. R., Lauridsen, T. K., Johansen, H. K., Ullum, H., Sørensen, E., Hassager, C., Bundgaard, H., Schønheyder, H. C. & 9 others, Torp-Pedersen, C., Østergaard, L. B., Arpi, M., Rosenvinge, F., Erikstrup, L. T., Chehri, M., Søgaard, P., Andersen, P. S. & Fowler, V. G., Oct 2018, In : PLoS genetics. 14, 10, e1007667.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Testosterone pathway genetic polymorphisms in relation to primary open-angle glaucoma: An analysis in two large datasets

Australian and New Zealand Registry of Advanced Glaucoma (ANZRAG) Consortium, Feb 2018, In : Investigative Ophthalmology and Visual Science. 59, 2, p. 629-636 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

The carnitine shuttle pathway is altered in patients with neovascular age-related macular degeneration

Mitchell, S. L., Uppal, K., Williamson, S. M., Liu, K., Goodwin Burgess, L., Tran, V., Umfress, A. C., Jarrell, K. L., Cooke Bailey, J. N., Agarwal, A., Pericak-Vance, M., Haines, J. L., Scott, W. K., Jones, D. P. & Brantley, M. A., Oct 2018, In : Investigative Ophthalmology and Visual Science. 59, 12, p. 4978-4985 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016

A common variant in MIR182 is associated with primary open-angle glaucoma in the NEIGHBORHOOD consortium

Liu, Y., Bailey, J. C., Helwa, I., Dismuke, W. M., Cai, J., Drewry, M., Brilliant, M. H., Budenz, D. L., Christen, W. G., Chasman, D. I., Fingert, J. H., Gaasterland, D., Gaasterland, T., Gordon, M. O., Igo, R. P., Kang, J. H., Kass, M. A., Kraft, P., Lee, R. K., Lichter, P. & 25 others, Moroi, S. E., Realini, A., Richards, J. E., Ritch, R., Schuman, J. S., Scott, W. K., Singh, K., Sit, A. J., Song, Y. E., Vollrath, D., Weinreb, R., Medeiros, F., Wollstein, G., Zack, D. J., Zhang, K., Pericak-Vance, M. A., Gonzalez, P., Stamer, W. D., Kuchtey, J., Kuchtey, R. W., Allingham, R. R., Hauser, M. A., Pasquale, L. R., Haines, J. L. & Wiggs, J. L., Aug 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 10, p. 4528-4535 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

Fritsche, L. G., Igl, W., Bailey, J. N. C., Grassmann, F., Sengupta, S., Bragg-Gresham, J. L., Burdon, K. P., Hebbring, S. J., Wen, C., Gorski, M., Kim, I. K., Cho, D., Zack, D., Souied, E., Scholl, H. P. N., Bala, E., ELee, K., Hunter, D. J., Sardell, R. J., Mitchell, P. & 142 others, Merriam, J. E., Cipriani, V., Hoffman, J. D., Schick, T., Lechanteur, Y. T. E., Guymer, R. H., Johnson, M. P., Jiang, Y., Stanton, C. M., Buitendijk, G. H. S., Zhan, X., Kwong, A. M., Boleda, A., Brooks, M., Gieser, L., Ratnapriya, R., Branham, K. E., Foerster, J. R., Heckenlively, J. R., Othman, M. I., Vote, B. J., Liang, H. H., Souzeau, E., McAllister, I. L., Isaacs, T., Hall, J., Lake, S., Mackey, D. A., Constable, I. J., Craig, J. E., Kitchner, T. E., Yang, Z., Su, Z., Luo, H., Chen, D., Ouyang, H., Flagg, K., Lin, D., Mao, G., Ferreyra, H., Stark, K., Von Strachwitz, C. N., Wolf, A., Brandl, C., Rudolph, G., Olden, M., Morrison, M. A., Morgan, D. J., Schu, M., Ahn, J., Silvestri, G., Tsironi, E. E., Park, K. H., Farrer, L. A., Orlin, A., Brucker, A., Li, M., Curcio, C. A., Mohand-Sa'd, S., Sahel, J. A., Audo, I., Benchaboune, M., Cree, A. J., Rennie, C. A., Goverdhan, S. V., Grunin, M., Hagbi-Levi, S., Campochiaro, P., Katsanis, N., Holz, F. G., Blond, F., Blanché, H., Deleuze, J. F. O., Igo, R. P., Truitt, B., Peachey, N. S., Meuer, S. M., Myers, C. E., Moore, E. L., Klein, R., Hauser, M. A., Postel, E. A., Courtenay, M. D., Schwartz, S. G., Kovach, J. L., Scott, W. K., Liew, G., Tan, A. G., Gopinath, B., Merriam, J. C., Smith, R. T., Khan, J. C., Shahid, H., Moore, A. T., McGrath, J. A., Laux, R., Brantley, M. A., Agarwal, A., Ersoy, L., Caramoy, A., Langmann, T., Saksens, N. T. M., Jong, E. K., Hoyng, C. B., Cain, M. S., Richardson, A. J., Martin, T. M., Blangero, J., Weeks, D. E., Dhillon, B., Van Duijn, C. M., Doheny, K. F., Romm, J., Klaver, C. C. W., Hayward, C., Gorin, M. B., Klein, M. L., Baird, P. N., Den Hollander, A. I., Fauser, S., WYates, J. R., Allikmets, R., Wang, J. J., Schaumberg, D. A., Klein, B. E. K., Hagstrom, S. A., Chowers, I., Lotery, A. J., Léveillard, T., Zhang, K., Brilliant, M. H., Hewitt, A. W., Swaroop, A., Chew, E. Y., Pericak-Vance, M. A., DeAngelis, M., Stambolian, D., Haines, J. L., Iyengar, S. K., Weber, B. H. F., Abecasis, G. R. & Heid, I. M., Feb 1 2016, In : Nature genetics. 48, 2, p. 134-143 10 p.

Research output: Contribution to journalArticle

417 Scopus citations

A Locus at 5q33.3 Confers Resistance to Tuberculosis in Highly Susceptible Individuals

Sobota, R. S., Stein, C. M., Kodaman, N., Scheinfeldt, L. B., Maro, I., Wieland-Alter, W., Igo, R. P., Magohe, A., Malone, L. L., Chervenak, K., Hall, N. B., Modongo, C., Zetola, N., Matee, M., Joloba, M., Froment, A., Nyambo, T. B., Moore, J. H., Scott, W. K., Lahey, T. & 5 others, Boom, W. H., Von Reyn, C. F., Tishkoff, S. A., Sirugo, G. & Williams, S. M., Mar 3 2016, In : American journal of human genetics. 98, 3, p. 514-524 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Assessing the association of mitochondrial genetic variation with primary open-angle glaucoma using gene-set analyses

Khawaja, A. P., Cooke Bailey, J. N., Kang, J. H., Rand Allingham, R., Hauser, M. A., Brilliant, M., Budenz, D. L., Christen, W. G., Fingert, J., Gaasterland, D., Gaasterland, T., Kraft, P., Lee, R. K., Lichter, P. R., Liu, Y., Medeiros, F., Moroi, S. E., Richards, J. E., Realini, T., Ritch, R. & 13 others, Schuman, J. S., Scott, W. K., Singh, K., Sit, A. J., Vollrath, D., Wollstein, G., Zack, D. J., Zhang, K., Pericak-Vance, M., Weinreb, R. N., Haines, J. L., Pasquale, L. R. & Wiggs, J. L., Sep 2016, In : Investigative Ophthalmology and Visual Science. 57, 11, p. 5046-5052 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

DNA variants in CACNA1C modify Parkinson disease risk only when Vitamin D level is deficient

Wang, L., Maldonado, L., Beecham, G. W., Martin, E. R., Evatt, M. L., Ritchie, J. C., Haines, J. L., Zabetian, C. P., Payami, H., Pericak-Vance, M. A., Vance, J. M. & Scott, W. K., Jun 1 2016, In : Neurology: Genetics. 2, 3, e72.

Research output: Contribution to journalArticle

6 Scopus citations

Genetic association analysis of drusen progression

Hoffman, J. D., Van Grinsven, M. J. J. P., Li, C., Brantley, M., McGrath, J., Agarwal, A., Scott, W. K., Schwartz, S. G., Kovach, J., Pericak-Vance, M., Sanchez, C. I. & Haines, J. L., Apr 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 4, p. 2225-2231 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma

Bailey, J. N. C., Loomis, S. J., Kang, J. H., Allingham, R. R., Gharahkhani, P., Khor, C. C., Burdon, K. P., Aschard, H., Chasman, D. I., Igo, R. P., Hysi, P. G., Glastonbury, C. A., Ashley-Koch, A., Brilliant, M., Brown, A. A., Budenz, D. L., Buil, A., Cheng, C. Y., Choi, H., Christen, W. G. & 60 others, Curhan, G., De Vivo, I., Fingert, J. H., Foster, P. J., Fuchs, C., Gaasterland, D., Gaasterland, T., Hewitt, A. W., Hu, F., Hunter, D. J., Khawaja, A. P., Lee, R. K., Li, Z., Lichter, P. R., Mackey, D. A., McGuffin, P., Mitchell, P., Moroi, S. E., Perera, S. A., Pepper, K. W., Qi, Q., Realini, T., Richards, J. E., Ridker, P. M., Rimm, E., Ritch, R., Ritchie, M., Schuman, J. S., Scott, W. K., Singh, K., Sit, A. J., Song, Y. E., Tamimi, R. M., Topouzis, F., Viswanathan, A. C., Verma, S. S., Vollrath, D., Wang, J. J., Weisschuh, N., Wissinger, B., Wollstein, G., Wong, T. Y., Yaspan, B. L., Zack, D. J., Zhang, K., Weinreb, R. N., Pericak-Vance, M. A., Small, K., Hammond, C. J., Aung, T., Liu, Y., Vithana, E. N., MacGregor, S., Craig, J. E., Kraft, P., Howell, G., Hauser, M. A., Pasquale, L. R., Haines, J. L. & Wiggs, J. L., Feb 1 2016, In : Nature genetics. 48, 2, p. 189-194 6 p.

Research output: Contribution to journalArticle

106 Scopus citations

Heritability of Choroidal Thickness in the Amish

Sardell, R. J., Nittala, M. G., Adams, L. D., Laux, R. A., Cooke Bailey, J. N., Fuzzell, D., Fuzzell, S., Reinhart-Mercer, L., Caywood, L. J., Horst, V., Mackay, T., Dana, D., Sadda, S. V. R., Scott, W. K., Stambolian, D., Haines, J. L. & Pericak-Vance, M. A., Dec 1 2016, In : Ophthalmology. 123, 12, p. 2537-2544 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Linkage of familial essential tremor to chromosome 5q35

Hicks, J. E., Konidari, I., Scott, B. L., Stajich, J. M., Ashley-Koch, A. E., Gilbert, J. & Scott, W. K., Jul 1 2016, In : Movement Disorders. 31, 7, p. 1059-1062 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Overlap between Parkinson disease and Alzheimer disease in ABCA7 functional variants

Nuytemans, K., Maldonado, L., Ali, A., John-Williams, K., Beecham, G. W., Martin, E., Scott, W. K. & Vance, J. M., Feb 1 2016, In : Neurology: Genetics. 2, 1, e44.

Research output: Contribution to journalArticle

14 Scopus citations

Progression rate from intermediate to advanced age-related macular degeneration is correlated with the number of risk alleles at the CFH locus

Sardell, R. J., Persad, P. J., Pan, S. S., Whitehead, P., Adams, L. D., Laux, R. A., Fortun, J. A., Brantley, M. A., Kovach, J. L., Schwartz, S. G., Agarwal, A., Haines, J. L., Scott, W. K. & Pericak-Vance, M. A., Nov 2016, In : Investigative Ophthalmology and Visual Science. 57, 14, p. 6107-6115 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

The relationship between reticular pseudodrusen and severity of AMD

Kovach, J. L., Schwartz, S. G., Agarwal, A., Brantley, M. A., Pan, S. S., Haines, J. L., Scott, W. K. & Pericak-Vance, M. A., Apr 1 2016, In : Ophthalmology. 123, 4, p. 921-923 3 p.

Research output: Contribution to journalArticle

10 Scopus citations

Whole exome sequencing of extreme age-related macular degeneration phenotypes

Sardell, R. J., Bailey, J. N. C., Courtenay, M. D., Whitehead, P., Laux, R. A., Adams, L. D., Fortun, J., Brantley, M. A., Kovach, J., Schwartz, S., Agarwal, A., Scott, W. K., Haines, J. L. & Pericak-Vance, M. A., Aug 29 2016, In : Molecular Vision. 22, p. 1062-1076 15 p.

Research output: Contribution to journalArticle

9 Scopus citations
2014

Absence of C9ORF72 expanded or intermediate repeats in autopsy-confirmed Parkinson's disease

Nuytemans, K., Inchausti, V., Beecham, G. W., Wang, L., Dickson, D. W., Trojanowski, J. Q., Lee, V. M. Y., Mash, D. C., Frosch, M. P., Foroud, T. M., Honig, L. S., Montine, T. J., Dawson, T. M., Martin, E. R., Scott, W. K. & Vance, J. M., May 2014, In : Movement Disorders. 29, 6, p. 827-830 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

A genome-wide association study of variants associated with acquisition of Staphylococcus aureus bacteremia in a healthcare setting

Nelson, C. L., Pelak, K., Podgoreanu, M. V., Ahn, S. H., Scott, W. K., Allen, A. S., Cowell, L. G., Rude, T. H., Zhang, Y., Tong, A., Ruffin, F., Sharma-Kuinkel, B. K. & Fowler, V. G., Feb 13 2014, In : BMC Infectious Diseases. 14, 1, 83.

Research output: Contribution to journalArticle

24 Scopus citations

Autophagy is redundant for the host defense against systemic Candida albicans infections

Smeekens, S. P., Malireddi, R. K., Plantinga, T. S., Buffen, K., Oosting, M., Joosten, L. A. B., Kullberg, B. J., Perfect, J. R., Scott, W. K., Van De Veerdonk, F. L., Xavier, R. J., Van De Vosse, E., Kanneganti, T. D., Johnson, M. D. & Netea, M. G., May 2014, In : European Journal of Clinical Microbiology and Infectious Diseases. 33, 5, p. 711-722 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Cognitive and motor function in long-duration PARKIN-associated parkinson disease

Alcalay, R. N., Caccappolo, E., Mejia-Santana, H., Tang, M. X., Rosado, L., Reilly, M. O., Ruiz, D., Louis, E. D., Comella, C. L., Nance, M. A., Bressman, S. B., Scott, W. K., Tanner, C. M., Mickel, S. F., Waters, C. H., Fahn, S., Cote, L. J., Frucht, S. J., Ford, B., Rezak, M. & 16 others, Novak, K. E., Friedman, J. H., Pfeiffer, R. F., Marsh, L., Hiner, B., Payami, H., Molho, E., Factor, S. A., Nutt, J. G., Serrano, C., Arroyo, M., Ottman, R., Pauciulo, M. W., Nichols, W. C., Clark, L. N. & Marder, K. S., Jan 2014, In : JAMA Neurology. 71, 1, p. 62-67 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Discovery and Functional Annotation of SIX6 Variants in Primary Open-Angle Glaucoma

Ulmer Carnes, M., Liu, Y. P., Allingham, R. R., Whigham, B. T., Havens, S., Garrett, M. E., Qiao, C., Katsanis, N., Wiggs, J. L., Pasquale, L. R., Ashley-Koch, A., Oh, E. C., Hauser, M. A., Brilliant, M., Budenz, D. L., Chin, H. R., Cooke Bailey, J., Fingert, J., Friedman, D. S., Gaasterland, D. & 22 others, Gaasterland, T., Haines, J., Kang, J. H., Lee, R. K., Lichter, P. R., Liu, Y., Loomis, S., McCarty, C. E., Moroi, S. E., Pericak-Vance, M., Realini, A., Richards, J. E., Schuman, J. S., Scott, W. K., Singh, K., Sit, A., Vollrath, D., Weinreb, R. N., Wollstein, G., Yaspan, B. L., Zack, D. & Zhang, K., May 1 2014, In : PLoS genetics. 10, 5, e1004372.

Research output: Contribution to journalArticle

53 Scopus citations

DNA copy number variants of known glaucoma genes in relation to primary open-angle glaucoma

Liu, Y., Garrett, M. E., Yaspan, B. L., Bailey, J. C., Loomis, S. J., Brilliant, M., Budenz, D. L., Christen, W. G., Fingert, J. H., Gaasterland, D., Gaasterland, T., Kang, J. H., Lee, R. K., Lichter, P., Moroi, S. E., Realini, A., Richards, J. E., Schuman, J. S., Scott, W. K., Singh, K. & 13 others, Sit, A. J., Vollrath, D., Weinreb, R., Wollstein, G., Zack, D. J., Zhang, K., Pericak-Vance, M. A., Haines, J. L., Pasquale, L. R., Wiggs, J. L., Allingham, R. R., Ashley-Koch, A. E. & Hauser, M. A., Nov 20 2014, In : Investigative Ophthalmology and Visual Science. 55, 12, p. 8251-8258 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Dusp3 and Psme3 Are Associated with Murine Susceptibility to Staphylococcus aureus Infection and Human Sepsis

Yan, Q., Sharma-Kuinkel, B. K., Deshmukh, H., Tsalik, E. L., Cyr, D. D., Lucas, J., Woods, C. W., Scott, W. K., Sempowski, G. D., Thaden, J., Rude, T. H., Ahn, S. H. & Fowler, V. G., Jun 2014, In : PLoS pathogens. 10, 6, e1004149.

Research output: Contribution to journalArticle

19 Scopus citations

Epiregulin (EREG) and human V-ATPase (TCIRG1): Genetic variation, ethnicity and pulmonary tuberculosis susceptibility in Guinea-Bissau and The Gambia

White, M. J., Tacconelli, A., Chen, J. S., Wejse, C., Hill, P. C., Gomes, V. F., Velez-Edwards, D. R., Østergaard, L. J., Hu, T., Moore, J. H., Novelli, G., Scott, W. K., Williams, S. M. & Sirugo, G., Sep 21 2014, In : Genes and Immunity. 15, 6, p. 370-377 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma

NEIGHBORHOOD Consortium, BMES GWAS Group & Wellcome Trust Case Control Consortium 2, Jan 1 2014, In : Nature genetics. 46, 10, p. 1126-1130 5 p.

Research output: Contribution to journalArticle

123 Scopus citations

Glutamate Receptor Gene GRIN2A, Coffee, and Parkinson Disease

Hamza, T. H., Hill-Burns, E. M., Scott, W. K., Vance, J. M., Factor, S. A., Zabetian, C. P. & Payami, H., Nov 1 2014, In : PLoS genetics. 10, 11

Research output: Contribution to journalArticle

7 Scopus citations

Hypothesis-independent pathway analysis implicates GABA and Acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma

Bailey, J. N. C., Yaspan, B. L., Pasquale, L. R., Hauser, M. A., Kang, J. H., Loomis, S. J., Brilliant, M., Budenz, D. L., Christen, W. G., Fingert, J., Gaasterland, D., Gaasterland, T., Kraft, P., Lee, R. K., Lichter, P. R., Liu, Y., McCarty, C. A., Moroi, S. E., Richards, J. E., Realini, T. & 13 others, Schuman, J. S., Scott, W. K., Singh, K., Sit, A. J., Vollrath, D., Wollstein, G., Zack, D. J., Zhang, K., Pericak-Vance, M. A., Allingham, R. R., Weinreb, R. N., Haines, J. L. & Wiggs, J. L., 2014, In : Human genetics. 133, 10, p. 1319-1330 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process

Blue Mountains Eye Study-GWAS groupw, NEIGHBORHOOD Consortiumz, Wellcome Trust Case Control Consortium 2 (WTCCC2), Data and Analysis Group, DNA, Genotyping, Data QC and Informatics Group & Publications Committee, 2014, In : Nature communications. 5, 4883.

Research output: Contribution to journalArticle

58 Scopus citations

Rare complement factor H variant associated with age-related macular degeneration in the Amish

Hoffman, J. D., Cooke Bailey, J. N., D'Aoust, L., Cade, W., Ayala-Haedo, J., Fuzzell, D., Laux, R., Adams, L. D., Reinhart-Mercer, L., Caywood, L., Whitehead-Gay, P., Agarwal, A., Wang, G., Scott, W. K., Pericak-Vance, M. A. & Haines, J. L., Jun 6 2014, In : Investigative Ophthalmology and Visual Science. 55, 7, p. 4455-4460 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Rare variant APOC3 R19X is associated with cardio-protective profiles in a diverse population-based survey as part of the epidemiologic architecture for genes linked to environment study

Crawford, D. C., Dumitrescu, L., Goodloe, R., Brown-Gentry, K., Boston, J., McClellan, B., Sutcliffe, C., Wiseman, R., Baker, P., Pericak-Vance, M. A., Scott, W. K., Allen, M., Mayo, P., Schnetz-Boutaud, N., Dilks, H. H., Haines, J. L. & Pollin, T. I., Dec 1 2014, In : Circulation: Cardiovascular Genetics. 7, 6, p. 848-853 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Role of autophagy genetic variants for the risk of Candida infections

Rosentul, D. C., Plantinga, T. S., Farcas, M., Oosting, M., Hamza, O. J. M., Scott, W. K., Alexander, B. D., Yang, J. C., Laird, G. M., Joosten, L. A. B., Van Der Meer, J. W. M., Perfect, J. R., Kullberg, B. J., Van Der Ven, A. J. A. M., Johnson, M. D. & Netea, M. G., May 2014, In : Medical mycology. 52, 4, p. 333-341 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
4 Scopus citations
2013

C9orf72 intermediate repeat copies are a significant risk factor for parkinson disease

Nuytemans, K., Bademci, G., Kohli, M. M., Beecham, G. W., Wang, L., Young, J. I., Nahab, F., Martin, E. R., Gilbert, J. R., Benatar, M., Haines, J. L., Scott, W. K., Züchner, S., Pericak-Vance, M. A. & Vance, J. M., Sep 2013, In : Annals of Human Genetics. 77, 5, p. 351-363 13 p.

Research output: Contribution to journalArticle

46 Scopus citations

Coding variants in ARMS2 and the risk of age-related macular degeneration

Wang, G., Scott, W. K., Agarwal, A., Haines, J. L. & Pericak-Vance, M. A., Jun 2013, In : JAMA ophthalmology. 131, 6, p. 804-805 2 p.

Research output: Contribution to journalLetter

7 Scopus citations

Estrogen pathway polymorphisms in relation to primary open angle glaucoma: An analysis accounting for gender from the United States

Pasquale, L. R., Loomis, S. J., Weinreb, R. N., Kang, J. H., Yaspan, B. L., Cooke Bailey, J., Gaasterland, D., Gaasterland, T., Lee, R. K., Scott, W. K., Lichter, P. R., Budenz, D. L., Liu, Y., Realini, T., Friedman, D. S., McCarty, C. A., Moroi, S. E., Olson, L., Schuman, J. S., Singh, K. & 15 others, Vollrath, D., Wollstein, G., Zack, D. J., Brilliant, M., Sit, A. J., Christen, W. G., Fingert, J., Kraft, P., Zhang, K., Allingham, R. R., Pericak-Vance, M. A., Richards, J. E., Hauser, M. A., Haines, J. L. & Wiggs, J. L., Jul 12 2013, In : Molecular vision. 19, p. 1471-1481 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Evaluating Power and Type 1 Error in Large Pedigree Analyses of Binary Traits

Cummings, A. C., Torstenson, E., Davis, M. F., D'Aoust, L. N., Scott, W. K., Pericak-Vance, M. A., Bush, W. S. & Haines, J. L., May 3 2013, In : PloS one. 8, 5, e62615.

Research output: Contribution to journalArticle

5 Scopus citations

Functional genomics identifies type i interferon pathway as central for host defense against Candida albicans

Smeekens, S. P., Ng, A., Kumar, V., Johnson, M. D., Plantinga, T. S., Van Diemen, C., Arts, P., Verwiel, E. T. P., Gresnigt, M. S., Fransen, K., Van Sommeren, S., Oosting, M., Cheng, S. C., Joosten, L. A. B., Hoischen, A., Kullberg, B. J., Scott, W. K., Perfect, J. R., Van Der Meer, J. W. M., Wijmenga, C. & 2 others, Netea, M. G. & Xavier, R. J., 2013, In : Nature communications. 4, 1342.

Research output: Contribution to journalArticle

94 Scopus citations

Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis

Naj, A. C., Scott, W. K., Courtenay, M. D., Cade, W. H., Schwartz, S. G., Kovach, J. L., Agarwal, A., Wang, G., Haines, J. L. & Pericak-Vance, M. A., May 2013, In : Annals of Human Genetics. 77, 3, p. 215-231 17 p.

Research output: Contribution to journalArticle

29 Scopus citations
12 Scopus citations

Linkage and association of successful aging to the 6q25 region in large Amish kindreds

Edwards, D. R. V., Gilbert, J. R., Hicks, J. E., Myers, J. L., Jiang, L., Cummings, A. C., Guo, S., Gallins, P. J., Konidari, I., Caywood, L., Reinhart-Mercer, L., Fuzzell, D., Knebusch, C., Laux, R., Jackson, C. E., Pericak-Vance, M. A., Haines, J. L. & Scott, W. K., Aug 1 2013, In : AGE. 35, 4, p. 1467-1477 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Parkinson disease loci in the mid-western Amish

Davis, M. F., Cummings, A. C., D'Aoust, L. N., Jiang, L., Velez Edwards, D. R., Laux, R., Reinhart-Mercer, L., Fuzzell, D., Scott, W. K., Pericak-Vance, M. A., Lee, S. L. & Haines, J. L., Nov 2013, In : Human genetics. 132, 11, p. 1213-1221 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Seven new loci associated with age-related macular degeneration

Fritsche, L. G., Chen, W., Schu, M., Yaspan, B. L., Yu, Y., Thorleifsson, G., Zack, D. J., Arakawa, S., Cipriani, V., Ripke, S., Igo, R. P., Buitendijk, G. H. S., Sim, X., Weeks, D. E., Guymer, R. H., Merriam, J. E., Francis, P. J., Hannum, G., Agarwal, A., Armbrecht, A. M. & 136 others, Audo, I., Aung, T., Barile, G. R., Benchaboune, M., Bird, A. C., Bishop, P. N., Branham, K. E., Brooks, M., Brucker, A. J., Cade, W. H., Cain, M. S., Campochiaro, P. A., Chan, C. C., Cheng, C. Y., Chew, E. Y., Chin, K. A., Chowers, I., Clayton, D. G., Cojocaru, R., Conley, Y. P., Cornes, B. K., Daly, M. J., Dhillon, B., Edwards, A. O., Evangelou, E., Fagerness, J., Ferreyra, H. A., Friedman, J. S., Geirsdottir, A., George, R. J., Gieger, C., Gupta, N., Hagstrom, S. A., Harding, S. P., Haritoglou, C., Heckenlively, J. R., Holz, F. G., Hughes, G., Ioannidis, J. P. A., Ishibashi, T., Joseph, P., Jun, G., Kamatani, Y., Katsanis, N., N Keilhauer, C., Khan, J. C., Kim, I. K., Kiyohara, Y., Klein, B. E. K., Klein, R., Kovach, J. L., Kozak, I., Lee, C. J., Lee, K. E., Lichtner, P., Lotery, A. J., Meitinger, T., Mitchell, P., Mohand-Saïd, S., Moore, A. T., Morgan, D. J., Morrison, M. A., Myers, C. E., Naj, A. C., Nakamura, Y., Okada, Y., Orlin, A., Ortube, M. C., Othman, M. I., Pappas, C., Park, K. H., Pauer, G. J. T., Peachey, N. S., Poch, O., Priya, R. R., Reynolds, R., Richardson, A. J., Ripp, R., Rudolph, G., Ryu, E., Sahel, J. A., Schaumberg, D. A., Scholl, H. P. N., Schwartz, S. G., Scott, W. K., Shahid, H., Sigurdsson, H., Silvestri, G., Sivakumaran, T. A., Smith, R. T., Sobrin, L., Souied, E. H., Stambolian, D. E., Stefansson, H., Sturgill-Short, G. M., Takahashi, A., Tosakulwong, N., Truitt, B. J., Tsironi, E. E., Uitterlinden, A. G., Van Duijn, C. M., Vijaya, L., Vingerling, J. R., Vithana, E. N., Webster, A. R., Wichmann, H. E., Winkler, T. W., Wong, T. Y., Wright, A. F., Zelenika, D., Zhang, M., Zhao, L., Zhang, K., Klein, M. L., Hageman, G. S., Lathrop, G. M., Stefansson, K., Allikmets, R., Baird, P. N., Gorin, M. B., Wang, J. J., Klaver, C. C. W., Seddon, J. M., Pericak-Vance, M. A., Iyengar, S. K., Yates, J. R. W., Swaroop, A., Weber, B. H. F., Kubo, M., Deangelis, M. M., Léveillard, T., Thorsteinsdottir, U., Haines, J. L., Farrer, L. A., Heid, I. M. & Abecasis, G. R., Apr 2013, In : Nature genetics. 45, 4, p. 433-439 7 p.

Research output: Contribution to journalArticle

488 Scopus citations