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  • William K Scott
Article

Absence of C9ORF72 expanded or intermediate repeats in autopsy-confirmed Parkinson's disease

Nuytemans, K., Inchausti, V., Beecham, G. W., Wang, L., Dickson, D. W., Trojanowski, J. Q., Lee, V. M. Y., Mash, D. C., Frosch, M. P., Foroud, T. M., Honig, L. S., Montine, T. J., Dawson, T. M., Martin, E. R., Scott, W. K. & Vance, J. M., May 2014, In : Movement Disorders. 29, 6, p. 827-830 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

A chromosome 5q31.1 locus associates with tuberculin skin test reactivity in HIV-positive individuals from tuberculosis hyper-endemic regions in east Africa

Sobota, R. S., Stein, C. M., Kodaman, N., Maro, I., Wieland-Alter, W., Igo, R. P., Magohe, A., Malone, L. S. L., Chervenak, K., Hall, N. B., Matee, M., Mayanja-Kizza, H., Joloba, M., Moore, J. H., Scott, W. K., Lahey, T., Boom, W. H., von Reyn, C. F., Williams, S. M. & Sirugo, G., 2017, In : PLoS genetics. 13, 6, e1006710.

Research output: Contribution to journalArticle

6 Scopus citations

A common variant in MIR182 is associated with primary open-angle glaucoma in the NEIGHBORHOOD consortium

Liu, Y., Bailey, J. C., Helwa, I., Dismuke, W. M., Cai, J., Drewry, M., Brilliant, M. H., Budenz, D. L., Christen, W. G., Chasman, D. I., Fingert, J. H., Gaasterland, D., Gaasterland, T., Gordon, M. O., Igo, R. P., Kang, J. H., Kass, M. A., Kraft, P., Lee, R. K., Lichter, P. & 25 others, Moroi, S. E., Realini, A., Richards, J. E., Ritch, R., Schuman, J. S., Scott, W. K., Singh, K., Sit, A. J., Song, Y. E., Vollrath, D., Weinreb, R., Medeiros, F., Wollstein, G., Zack, D. J., Zhang, K., Pericak-Vance, M. A., Gonzalez, P., Stamer, W. D., Kuchtey, J., Kuchtey, R. W., Allingham, R. R., Hauser, M. A., Pasquale, L. R., Haines, J. L. & Wiggs, J. L., Aug 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 10, p. 4528-4535 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample

Pasquale, L. R., Aschard, H., Kang, J. H., Bailey, J. N. C., Lindström, S., Chasman, D. I., Christen, W. G., Allingham, R. R., Ashley-Koch, A., Lee, R. K., Moroi, S. E., Brilliant, M. H., Wollstein, G., Schuman, J. S., Fingert, J., Budenz, D. L., Realini, T., Gaasterland, T., Gaasterland, D., Scott, W. K. & 21 others, Singh, K., Sit, A. J., Igo, R. P., Song, Y. E., Hark, L., Ritch, R., Rhee, D. J., Gulati, V., Havens, S., Vollrath, D., Zack, D. J., Medeiros, F., Weinreb, R. N., Pericak-Vance, M. A., Liu, Y., Kraft, P., Richards, J. E., Rosner, B. A., Hauser, M. A., Haines, J. L. & Wiggs, J. L., Jan 1 2017, In : Menopause. 24, 2, p. 150-156 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

A genome-wide association study of variants associated with acquisition of Staphylococcus aureus bacteremia in a healthcare setting

Nelson, C. L., Pelak, K., Podgoreanu, M. V., Ahn, S. H., Scott, W. K., Allen, A. S., Cowell, L. G., Rude, T. H., Zhang, Y., Tong, A., Ruffin, F., Sharma-Kuinkel, B. K. & Fowler, V. G., Feb 13 2014, In : BMC Infectious Diseases. 14, 1, 83.

Research output: Contribution to journalArticle

23 Scopus citations

A Genome-Wide Linkage Screen in the Amish with Parkinson Disease Points to Chromosome 6

Cummings, A. C., Lee, S. L., Mccauley, J. L., Jiang, L., Crunk, A., Mcfarland, L. L., Gallins, P. J., Fuzzell, D., Knebusch, C., Jackson, C. E., Scott, W. K., Pericak-Vance, M. A. & Haines, J. L., May 1 2011, In : Annals of Human Genetics. 75, 3, p. 351-358 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

Fritsche, L. G., Igl, W., Bailey, J. N. C., Grassmann, F., Sengupta, S., Bragg-Gresham, J. L., Burdon, K. P., Hebbring, S. J., Wen, C., Gorski, M., Kim, I. K., Cho, D., Zack, D., Souied, E., Scholl, H. P. N., Bala, E., ELee, K., Hunter, D. J., Sardell, R. J., Mitchell, P. & 142 others, Merriam, J. E., Cipriani, V., Hoffman, J. D., Schick, T., Lechanteur, Y. T. E., Guymer, R. H., Johnson, M. P., Jiang, Y., Stanton, C. M., Buitendijk, G. H. S., Zhan, X., Kwong, A. M., Boleda, A., Brooks, M., Gieser, L., Ratnapriya, R., Branham, K. E., Foerster, J. R., Heckenlively, J. R., Othman, M. I., Vote, B. J., Liang, H. H., Souzeau, E., McAllister, I. L., Isaacs, T., Hall, J., Lake, S., Mackey, D. A., Constable, I. J., Craig, J. E., Kitchner, T. E., Yang, Z., Su, Z., Luo, H., Chen, D., Ouyang, H., Flagg, K., Lin, D., Mao, G., Ferreyra, H., Stark, K., Von Strachwitz, C. N., Wolf, A., Brandl, C., Rudolph, G., Olden, M., Morrison, M. A., Morgan, D. J., Schu, M., Ahn, J., Silvestri, G., Tsironi, E. E., Park, K. H., Farrer, L. A., Orlin, A., Brucker, A., Li, M., Curcio, C. A., Mohand-Sa'd, S., Sahel, J. A., Audo, I., Benchaboune, M., Cree, A. J., Rennie, C. A., Goverdhan, S. V., Grunin, M., Hagbi-Levi, S., Campochiaro, P., Katsanis, N., Holz, F. G., Blond, F., Blanché, H., Deleuze, J. F. O., Igo, R. P., Truitt, B., Peachey, N. S., Meuer, S. M., Myers, C. E., Moore, E. L., Klein, R., Hauser, M. A., Postel, E. A., Courtenay, M. D., Schwartz, S. G., Kovach, J. L., Scott, W. K., Liew, G., Tan, A. G., Gopinath, B., Merriam, J. C., Smith, R. T., Khan, J. C., Shahid, H., Moore, A. T., McGrath, J. A., Laux, R., Brantley, M. A., Agarwal, A., Ersoy, L., Caramoy, A., Langmann, T., Saksens, N. T. M., Jong, E. K., Hoyng, C. B., Cain, M. S., Richardson, A. J., Martin, T. M., Blangero, J., Weeks, D. E., Dhillon, B., Van Duijn, C. M., Doheny, K. F., Romm, J., Klaver, C. C. W., Hayward, C., Gorin, M. B., Klein, M. L., Baird, P. N., Den Hollander, A. I., Fauser, S., WYates, J. R., Allikmets, R., Wang, J. J., Schaumberg, D. A., Klein, B. E. K., Hagstrom, S. A., Chowers, I., Lotery, A. J., Léveillard, T., Zhang, K., Brilliant, M. H., Hewitt, A. W., Swaroop, A., Chew, E. Y., Pericak-Vance, M. A., DeAngelis, M., Stambolian, D., Haines, J. L., Iyengar, S. K., Weber, B. H. F., Abecasis, G. R. & Heid, I. M., Feb 1 2016, In : Nature genetics. 48, 2, p. 134-143 10 p.

Research output: Contribution to journalArticle

394 Scopus citations

A Locus at 5q33.3 Confers Resistance to Tuberculosis in Highly Susceptible Individuals

Sobota, R. S., Stein, C. M., Kodaman, N., Scheinfeldt, L. B., Maro, I., Wieland-Alter, W., Igo, R. P., Magohe, A., Malone, L. L., Chervenak, K., Hall, N. B., Modongo, C., Zetola, N., Matee, M., Joloba, M., Froment, A., Nyambo, T. B., Moore, J. H., Scott, W. K., Lahey, T. & 5 others, Boom, W. H., Von Reyn, C. F., Tishkoff, S. A., Sirugo, G. & Williams, S. M., Mar 3 2016, In : American journal of human genetics. 98, 3, p. 514-524 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma

Gharahkhani, P., Burdon, K. P., Cooke Bailey, J. N., Hewitt, A. W., Law, M. H., Pasquale, L. R., Kang, J. H., Haines, J. L., Souzeau, E., Zhou, T., Siggs, O. M., Landers, J., Awadalla, M., Sharma, S., Mills, R. A., Ridge, B., Lynn, D., Casson, R., Graham, S. L., Goldberg, I. & 45 others, White, A., Healey, P. R., Grigg, J., Lawlor, M., Mitchell, P., Ruddle, J., Coote, M., Walland, M., Best, S., Vincent, A., Gale, J., Radfordsmith, G., Whiteman, D. C., Montgomery, G. W., Martin, N. G., MacKey, D. A., Wiggs, J. L., MacGregor, S., Craig, J. E., Allingham, R. R., Brilliant, M., Budenz, D. L., Fingert, J. H., Gaasterland, D., Gaasterland, T., Hark, L., Hauser, M., Igo, R. P., Kraft, P., Lee, R. K., Lichter, P. R., Liu, Y., Moroi, S., Pericak-Vance, M., Realini, A., Rhee, D., Richards, J. E., Ritch, R., Schuman, J. S., Scott, W. K., Singh, K., Sit, A. J., Vollrath, D., Wollstein, G. & Zack, D. J., Dec 1 2018, In : Scientific reports. 8, 1, 3124.

Research output: Contribution to journalArticle

8 Scopus citations

A population-specific reference panel empowers genetic studies of Anabaptist populations

Hou, L., Kember, R. L., Roach, J. C., O'Connell, J. R., Craig, D. W., Bucan, M., Scott, W. K., Pericak-Vance, M. A., Haines, J. L., Crawford, M. H., Shuldiner, A. R. & McMahon, F. J., Dec 1 2017, In : Scientific Reports. 7, 1, 6079.

Research output: Contribution to journalArticle

5 Scopus citations

Assessing the association of mitochondrial genetic variation with primary open-angle glaucoma using gene-set analyses

Khawaja, A. P., Cooke Bailey, J. N., Kang, J. H., Rand Allingham, R., Hauser, M. A., Brilliant, M., Budenz, D. L., Christen, W. G., Fingert, J., Gaasterland, D., Gaasterland, T., Kraft, P., Lee, R. K., Lichter, P. R., Liu, Y., Medeiros, F., Moroi, S. E., Richards, J. E., Realini, T., Ritch, R. & 13 others, Schuman, J. S., Scott, W. K., Singh, K., Sit, A. J., Vollrath, D., Wollstein, G., Zack, D. J., Zhang, K., Pericak-Vance, M., Weinreb, R. N., Haines, J. L., Pasquale, L. R. & Wiggs, J. L., Sep 2016, In : Investigative Ophthalmology and Visual Science. 57, 11, p. 5046-5052 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration

International AMD Genomics Consortium (IAMDGC), Dec 1 2020, In : Scientific reports. 10, 1, 1584.

Research output: Contribution to journalArticle

Open Access

Autophagy is redundant for the host defense against systemic Candida albicans infections

Smeekens, S. P., Malireddi, R. K., Plantinga, T. S., Buffen, K., Oosting, M., Joosten, L. A. B., Kullberg, B. J., Perfect, J. R., Scott, W. K., Van De Veerdonk, F. L., Xavier, R. J., Van De Vosse, E., Kanneganti, T. D., Johnson, M. D. & Netea, M. G., May 2014, In : European Journal of Clinical Microbiology and Infectious Diseases. 33, 5, p. 711-722 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

C9orf72 intermediate repeat copies are a significant risk factor for parkinson disease

Nuytemans, K., Bademci, G., Kohli, M. M., Beecham, G. W., Wang, L., Young, J. I., Nahab, F., Martin, E. R., Gilbert, J. R., Benatar, M., Haines, J. L., Scott, W. K., Züchner, S., Pericak-Vance, M. A. & Vance, J. M., Sep 2013, In : Annals of Human Genetics. 77, 5, p. 351-363 13 p.

Research output: Contribution to journalArticle

46 Scopus citations

Candidate genes on murine chromosome 8 are associated with susceptibility to Staphylococcus aureus infection in mice and are involved with Staphylococcus aureus septicemia in humans

Yan, Q., Ahn, S. H., Medie, F. M., Sharma-Kuinkel, B. K., Park, L. P., Scott, W. K., Deshmukh, H., Tsalik, E. L., Cyr, D. D., Woods, C. W., Yu, C. H. A., Adams, C., Qi, R., Hansen, B. & Fowler, V. G., Jun 2017, In : PloS one. 12, 6, e0179033.

Research output: Contribution to journalArticle

2 Scopus citations

CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from guinea-bissau, West Africa

Hennig, B. J., Velez-Edwards, D. R., Schim Van Der Loeff, M. F., Bisseye, C., Edwards, T. L., Tacconelli, A., Novelli, G., Aaby, P., Kaye, S., Scott, W. K., Jaye, A., Whittle, H. C., Williams, S. M., Hill, A. V. & Sirugo, G., Jan 1 2011, In : Journal of Acquired Immune Deficiency Syndromes. 56, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cognitive and motor function in long-duration PARKIN-associated parkinson disease

Alcalay, R. N., Caccappolo, E., Mejia-Santana, H., Tang, M. X., Rosado, L., Reilly, M. O., Ruiz, D., Louis, E. D., Comella, C. L., Nance, M. A., Bressman, S. B., Scott, W. K., Tanner, C. M., Mickel, S. F., Waters, C. H., Fahn, S., Cote, L. J., Frucht, S. J., Ford, B., Rezak, M. & 16 others, Novak, K. E., Friedman, J. H., Pfeiffer, R. F., Marsh, L., Hiner, B., Payami, H., Molho, E., Factor, S. A., Nutt, J. G., Serrano, C., Arroyo, M., Ottman, R., Pauciulo, M. W., Nichols, W. C., Clark, L. N. & Marder, K. S., Jan 2014, In : JAMA Neurology. 71, 1, p. 62-67 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Iglesias, A. I., Mishra, A., Vitart, V., Bykhovskaya, Y., Höhn, R., Springelkamp, H., Cuellar-Partida, G., Gharahkhani, P., Bailey, J. N. C., Willoughby, C. E., Li, X., Yazar, S., Nag, A., Khawaja, A. P., Polašek, O., Siscovick, D., Mitchell, P., Tham, Y. C., Haines, J. L., Kearns, L. S. & 124 others, Hayward, C., Shi, Y., Van Leeuwen, E. M., Taylor, K. D., Wang, J. J., Rochtchina, E., Attia, J., Scott, R., Holliday, E. G., Baird, P. N., Xie, J., Inouye, M., Viswanathan, A., Sim, X., Bonnemaijer, P., Rotter, J. I., Martin, N. G., Zeller, T., Mills, R. A., Staffieri, S. E., Jonas, J. B., Schmidtmann, I., Boutin, T., Kang, J. H., Lucas, S. E. M., Wong, T. Y., Beutel, M. E., Wilson, J. F., Allingham, R. R., Brilliant, M. H., Budenz, D. L., Christen, W. G., Fingert, J., Friedman, D. S., Gaasterland, D., Gaasterland, T., Hauser, M. A., Kraft, P., Lee, R. K., Lichter, P. R., Liu, Y., Loomis, S. J., Moroi, S. E., Pericak-Vance, M. A., Realini, A., Richards, J. E., Schuman, J. S., Scott, W. K., Singh, K., Sit, A. J., Vollrath, D., Weinreb, R. N., Wollstein, G., Zack, D. J., Zhang, K., Donnelly, P., Barroso, I., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Deloukas, P., Duncanson, A., Jankowski, J., Markus, H. S., Mathew, C. G., Palmer, C. N. A., Plomin, R., Rautanen, A., Sawcer, S. J., Trembath, R. C., Wood, N. W., Spencer, C. C. A., Band, G., Bellenguez, C., Freeman, C., Hellenthal, G., Giannoulatou, E., Pirinen, M., Pearson, R., Strange, A., Su, Z., Vukcevic, D., Langford, C., Hunt, S. E., Edkins, S., Gwilliam, R., Blackburn, H., Bumpstead, S. J., Dronov, S., Gillman, M., Gray, E., Hammond, N., Jayakumar, A., McCann, O. T., Liddle, J., Potter, S. C., Ravindrarajah, R., Ricketts, M., Waller, M., Weston, P., Widaa, S., Whittaker, P., Uitterlinden, A. G., Vithana, E. N., Foster, P. J., Hysi, P. G., Hewitt, A. W., Khor, C. C., Pasquale, L. R., Montgomery, G. W., Klaver, C. C. W., Aung, T., Pfeiffer, N., MacKey, D. A., Hammond, C. J., Cheng, C. Y., Craig, J. E., Rabinowitz, Y. S., Wiggs, J. L., Burdon, K. P., Van Duijn, C. M. & MacGregor, S., Dec 1 2018, In : Nature communications. 9, 1, 1864.

Research output: Contribution to journalArticle

13 Scopus citations

Discovery and Functional Annotation of SIX6 Variants in Primary Open-Angle Glaucoma

Ulmer Carnes, M., Liu, Y. P., Allingham, R. R., Whigham, B. T., Havens, S., Garrett, M. E., Qiao, C., Katsanis, N., Wiggs, J. L., Pasquale, L. R., Ashley-Koch, A., Oh, E. C., Hauser, M. A., Brilliant, M., Budenz, D. L., Chin, H. R., Cooke Bailey, J., Fingert, J., Friedman, D. S., Gaasterland, D. & 22 others, Gaasterland, T., Haines, J., Kang, J. H., Lee, R. K., Lichter, P. R., Liu, Y., Loomis, S., McCarty, C. E., Moroi, S. E., Pericak-Vance, M., Realini, A., Richards, J. E., Schuman, J. S., Scott, W. K., Singh, K., Sit, A., Vollrath, D., Weinreb, R. N., Wollstein, G., Yaspan, B. L., Zack, D. & Zhang, K., May 1 2014, In : PLoS genetics. 10, 5, e1004372.

Research output: Contribution to journalArticle

52 Scopus citations

Dissection of chromosome 16p12 linkage peak suggests a possible role for CACNG3 variants in age-related macular degeneration susceptibility

Spencer, K. L., Olson, L. M., Schnetz-Boutaud, N., Gallins, P., Wang, G., Scott, W. K., Agarwal, A., Jakobsdottir, J., Conley, Y., Weeks, D. E., Gorin, M. B., Pericak-Vance, M. A. & Haines, J. L., Mar 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 3, p. 1748-1754 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

DNA copy number variants of known glaucoma genes in relation to primary open-angle glaucoma

Liu, Y., Garrett, M. E., Yaspan, B. L., Bailey, J. C., Loomis, S. J., Brilliant, M., Budenz, D. L., Christen, W. G., Fingert, J. H., Gaasterland, D., Gaasterland, T., Kang, J. H., Lee, R. K., Lichter, P., Moroi, S. E., Realini, A., Richards, J. E., Schuman, J. S., Scott, W. K., Singh, K. & 13 others, Sit, A. J., Vollrath, D., Weinreb, R., Wollstein, G., Zack, D. J., Zhang, K., Pericak-Vance, M. A., Haines, J. L., Pasquale, L. R., Wiggs, J. L., Allingham, R. R., Ashley-Koch, A. E. & Hauser, M. A., Nov 20 2014, In : Investigative Ophthalmology and Visual Science. 55, 12, p. 8251-8258 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

DNA variants in CACNA1C modify Parkinson disease risk only when Vitamin D level is deficient

Wang, L., Maldonado, L., Beecham, G. W., Martin, E. R., Evatt, M. L., Ritchie, J. C., Haines, J. L., Zabetian, C. P., Payami, H., Pericak-Vance, M. A., Vance, J. M. & Scott, W. K., Jun 1 2016, In : Neurology: Genetics. 2, 3, e72.

Research output: Contribution to journalArticle

5 Scopus citations

Dusp3 and Psme3 Are Associated with Murine Susceptibility to Staphylococcus aureus Infection and Human Sepsis

Yan, Q., Sharma-Kuinkel, B. K., Deshmukh, H., Tsalik, E. L., Cyr, D. D., Lucas, J., Woods, C. W., Scott, W. K., Sempowski, G. D., Thaden, J., Rude, T. H., Ahn, S. H. & Fowler, V. G., Jun 2014, In : PLoS pathogens. 10, 6, e1004149.

Research output: Contribution to journalArticle

19 Scopus citations

Epiregulin (EREG) and human V-ATPase (TCIRG1): Genetic variation, ethnicity and pulmonary tuberculosis susceptibility in Guinea-Bissau and The Gambia

White, M. J., Tacconelli, A., Chen, J. S., Wejse, C., Hill, P. C., Gomes, V. F., Velez-Edwards, D. R., Østergaard, L. J., Hu, T., Moore, J. H., Novelli, G., Scott, W. K., Williams, S. M. & Sirugo, G., Sep 21 2014, In : Genes and Immunity. 15, 6, p. 370-377 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Estimating cumulative pathway effects on risk for age-related macular degeneration using mixed linear models

Hall, J. B., Cooke Bailey, J. N., Hoffman, J. D., Pericak-Vance, M. A., Scott, W. K., Kovach, J. L., Schwartz, S. G., Agarwal, A., Brantley, M. A., Haines, J. L. & Bush, W. S., Oct 14 2015, In : BMC Bioinformatics. 16, 1, 329.

Research output: Contribution to journalArticle

7 Scopus citations

Estrogen pathway polymorphisms in relation to primary open angle glaucoma: An analysis accounting for gender from the United States

Pasquale, L. R., Loomis, S. J., Weinreb, R. N., Kang, J. H., Yaspan, B. L., Cooke Bailey, J., Gaasterland, D., Gaasterland, T., Lee, R. K., Scott, W. K., Lichter, P. R., Budenz, D. L., Liu, Y., Realini, T., Friedman, D. S., McCarty, C. A., Moroi, S. E., Olson, L., Schuman, J. S., Singh, K. & 15 others, Vollrath, D., Wollstein, G., Zack, D. J., Brilliant, M., Sit, A. J., Christen, W. G., Fingert, J., Kraft, P., Zhang, K., Allingham, R. R., Pericak-Vance, M. A., Richards, J. E., Hauser, M. A., Haines, J. L. & Wiggs, J. L., Jul 12 2013, In : Molecular vision. 19, p. 1471-1481 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Evaluating genetic susceptibility to Staphylococcus aureus bacteremia in African Americans using admixture mapping

Cyr, D. D., Allen, A. S., Du, G. J., Ruffin, F., Adams, C., Thaden, J. T., Maskarinec, S. A., Souli, M., Guo, S., Dykxhoorn, D. M., Scott, W. K. & Fowler, V. G., Mar 23 2017, (Accepted/In press) In : Genes and Immunity.

Research output: Contribution to journalArticle

11 Scopus citations

Evaluating Power and Type 1 Error in Large Pedigree Analyses of Binary Traits

Cummings, A. C., Torstenson, E., Davis, M. F., D'Aoust, L. N., Scott, W. K., Pericak-Vance, M. A., Bush, W. S. & Haines, J. L., May 3 2013, In : PloS one. 8, 5, e62615.

Research output: Contribution to journalArticle

4 Scopus citations

Examination of candidate exonic variants for association to alzheimer disease in the Amish

D'Aoust, L. N., Cummings, A. C., Laux, R., Fuzzell, D., Caywood, L., Reinhart-Mercer, L., Scott, W. K., Pericak-Vance, M. A. & Haines, J. L., Feb 10 2015, In : PloS one. 10, 2, e0118043.

Research output: Contribution to journalArticle

4 Scopus citations

Family-based genome-wide association study of south Indian pedigrees supports WNT7B as a central corneal thickness locus

Fan, B. J., Chen, X., Sondhi, N., Sharmila, P. F., Soumittra, N., Sripriya, S., Sacikala, S., Asokan, R., Friedman, D. S., Pasquale, L. R., Gao, X. R., Vijaya, L., Bailey, J. C., Vitart, V., Macgregor, S., Hammond, C. J., Khor, C. C., Haines, J. L., George, R., Wiggs, J. L. & 56 others, Allingham, R. R., Gauderman, J., Hauser, M., Rotter, J. I., Varma, R., Aung, T., Burdon, K. P., Cheng, C. Y., Craig, J. E., Cree, A. J., Gharahkhani, P., Hewitt, A. W., Höhn, R., Hysi, P., Iglesias Gonzalez, A. I., Jonas, J., Khawaja, A., Klaver, C. C. W., Pasutto, F., Mackey, D., Mitchell, P., Mishra, A., Pang, C., Springelkamp, H., Thorleifsson, G., Thorsteinsdottir, U., van Duijn, C. M., Viswanathan, A., Wojciechowski, R., Wong, T., Young, T. L., Zeller, T., Brilliant, M., Budenz, D., Fingert, J., Gaasterland, D., Gaasterland, T., Igo, R., Kang, J. H., Kraft, P., Lee, R., Lichter, P., Liu, Y., Moroi, S., Realini, A., Rhee, D., Richards, J. R., Ritch, R., Schuman, J., Scott, W. K., Singh, K., Sit, A., Vollrath, D., Weinreb, R. N., Wollstein, G. & Zack, D., May 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 6, p. 2495-2502 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Functional genomics identifies type i interferon pathway as central for host defense against Candida albicans

Smeekens, S. P., Ng, A., Kumar, V., Johnson, M. D., Plantinga, T. S., Van Diemen, C., Arts, P., Verwiel, E. T. P., Gresnigt, M. S., Fransen, K., Van Sommeren, S., Oosting, M., Cheng, S. C., Joosten, L. A. B., Hoischen, A., Kullberg, B. J., Scott, W. K., Perfect, J. R., Van Der Meer, J. W. M., Wijmenga, C. & 2 others, Netea, M. G. & Xavier, R. J., 2013, In : Nature communications. 4, 1342.

Research output: Contribution to journalArticle

93 Scopus citations

Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease

Hui, K. Y., Fernandez-Hernandez, H., Hu, J., Schaffner, A., Pankratz, N., Hsu, N. Y., Chuang, L. S., Carmi, S., Villaverde, N., Li, X., Rivas, M., Levine, A. P., Bao, X., Labrias, P. R., Haritunians, T., Ruane, D., Gettler, K., Chen, E., Li, D., Schiff, E. R. & 31 others, Pontikos, N., Barzilai, N., Brant, S. R., Bressman, S., Cheifetz, A. S., Clark, L. N., Daly, M. J., Desnick, R. J., Duerr, R. H., Katz, S., Lencz, T., Myers, R. H., Ostrer, H., Ozelius, L., Payami, H., Peter, Y., Rioux, J. D., Segal, A. W., Scott, W. K., Silverberg, M. S., Vance, J. M., Ubarretxena-Belandia, I., Foroud, T., Atzmon, G., Pe'er, I., Ioannou, Y., McGovern, D. P. B., Yue, Z., Schadt, E. E., Cho, J. H. & Peter, I., Jan 10 2018, In : Science Translational Medicine. 10, 423, eaai7795.

Research output: Contribution to journalArticle

74 Scopus citations

Generation of disease-specific autopsy-confirmed iPSCs lines from postmortem isolated Peripheral Blood Mononuclear Cells

Belle, K., Shabazz, F. S., Nuytemans, K., Davis, D. A., Ali, A., Young, J., Scott, W. K., Mash, D. C., Vance, J. M. & Dykxhoorn, D. M., Jan 10 2017, In : Neuroscience Letters. 637, p. 201-206 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Genetic association analysis of drusen progression

Hoffman, J. D., Van Grinsven, M. J. J. P., Li, C., Brantley, M., McGrath, J., Agarwal, A., Scott, W. K., Schwartz, S. G., Kovach, J., Pericak-Vance, M., Sanchez, C. I. & Haines, J. L., Apr 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 4, p. 2225-2231 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: A multi-cohort analysis

Aschard, H., Kang, J. H., Iglesias, A. I., Hysi, P., Cooke Bailey, J. N., Khawaja, A. P., Allingham, R. R., Ashley-Koch, A., Lee, R. K., Moroi, S. E., Brilliant, M. H., Wollstein, G., Schuman, J. S., Fingert, J. H., Budenz, D. L., Realini, T., Gaasterland, T., Scott, W. K., Singh, K., Sit, A. J. & 25 others, Igo, R. P., Song, Y. E., Hark, L., Ritch, R., Rhee, D. J., Gulati, V., Haven, S., Vollrath, D., Zack, D. J., Medeiros, F., Weinreb, R. N., Cheng, C. Y., Chasman, D. I., Christen, W. G., Pericak-Vance, M. A., Liu, Y., Kraft, P., Richards, J. E., Rosner, B. A., Hauser, M. A., Klaver, C. C. W., Vanduijn, C. M., Haines, J., Wiggs, J. L. & Pasquale, L. R., Nov 1 2017, In : European Journal of Human Genetics. 25, 11, p. 1261-1267 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis

Naj, A. C., Scott, W. K., Courtenay, M. D., Cade, W. H., Schwartz, S. G., Kovach, J. L., Agarwal, A., Wang, G., Haines, J. L. & Pericak-Vance, M. A., May 1 2013, In : Annals of Human Genetics. 77, 3, p. 215-231 17 p.

Research output: Contribution to journalArticle

29 Scopus citations

Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits

International AMD Genomics Consortium (IAMDGC), Mar 27 2017, In : Genome Medicine. 9, 1, 29.

Research output: Contribution to journalArticle

27 Scopus citations

Genetic variation in the dectin-1/CARD9 recognition pathway and susceptibility to candidemia

Rosentul, D. C., Plantinga, T. S., Oosting, M., Scott, W. K., Velez Edwards, D. R., Smith, P. B., Alexander, B. D., Yang, J. C., Laird, G. M., Joosten, L. A. B., Van Der Meer, J. W. M., Perfect, J. R., Kullberg, B. J., Netea, M. G. & Johnson, M. D., Oct 1 2011, In : Journal of Infectious Diseases. 204, 7, p. 1138-1145 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma

NEIGHBORHOOD Consortium, BMES GWAS Group & Wellcome Trust Case Control Consortium 2, Jan 1 2014, In : Nature genetics. 46, 10, p. 1126-1130 5 p.

Research output: Contribution to journalArticle

119 Scopus citations

Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma

Bailey, J. N. C., Loomis, S. J., Kang, J. H., Allingham, R. R., Gharahkhani, P., Khor, C. C., Burdon, K. P., Aschard, H., Chasman, D. I., Igo, R. P., Hysi, P. G., Glastonbury, C. A., Ashley-Koch, A., Brilliant, M., Brown, A. A., Budenz, D. L., Buil, A., Cheng, C. Y., Choi, H., Christen, W. G. & 60 others, Curhan, G., De Vivo, I., Fingert, J. H., Foster, P. J., Fuchs, C., Gaasterland, D., Gaasterland, T., Hewitt, A. W., Hu, F., Hunter, D. J., Khawaja, A. P., Lee, R. K., Li, Z., Lichter, P. R., Mackey, D. A., McGuffin, P., Mitchell, P., Moroi, S. E., Perera, S. A., Pepper, K. W., Qi, Q., Realini, T., Richards, J. E., Ridker, P. M., Rimm, E., Ritch, R., Ritchie, M., Schuman, J. S., Scott, W. K., Singh, K., Sit, A. J., Song, Y. E., Tamimi, R. M., Topouzis, F., Viswanathan, A. C., Verma, S. S., Vollrath, D., Wang, J. J., Weisschuh, N., Wissinger, B., Wollstein, G., Wong, T. Y., Yaspan, B. L., Zack, D. J., Zhang, K., Weinreb, R. N., Pericak-Vance, M. A., Small, K., Hammond, C. J., Aung, T., Liu, Y., Vithana, E. N., MacGregor, S., Craig, J. E., Kraft, P., Howell, G., Hauser, M. A., Pasquale, L. R., Haines, J. L. & Wiggs, J. L., Feb 1 2016, In : Nature genetics. 48, 2, p. 189-194 6 p.

Research output: Contribution to journalArticle

105 Scopus citations

Genome-wide gene-environment study identifies glutamate receptor gene grin2a as a parkinson's disease modifier gene via interaction with coffee

Hamza, T. H., Chen, H., Hill-Burns, E. M., Rhodes, S. L., Montimurro, J., Kay, D. M., Tenesa, A., Kusel, V. I., Sheehan, P., Eaaswarkhanth, M., Yearout, D., Samii, A., Roberts, J. W., Agarwal, P., Bordelon, Y., Park, Y., Wang, L., Gao, J., Vance, J. M., Kendler, K. S. & 7 others, Bacanu, S. A., Scott, W. K., Ritz, B., Nutt, J., Factor, S. A., Zabetian, C. P. & Payami, H., Aug 2011, In : PLoS genetics. 7, 8, e1002237.

Research output: Contribution to journalArticle

137 Scopus citations

Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma

International Glaucoma Genetics Consortium & NEIGHBORHOOD Consortium, Jan 1 2018, In : PLoS genetics. 14, 1, e1007145.

Research output: Contribution to journalArticle

8 Scopus citations

Glutamate Receptor Gene GRIN2A, Coffee, and Parkinson Disease

Hamza, T. H., Hill-Burns, E. M., Scott, W. K., Vance, J. M., Factor, S. A., Zabetian, C. P. & Payami, H., Nov 1 2014, In : PLoS genetics. 10, 11

Research output: Contribution to journalArticle

7 Scopus citations

Heritability of Choroidal Thickness in the Amish

Sardell, R. J., Nittala, M. G., Adams, L. D., Laux, R. A., Cooke Bailey, J. N., Fuzzell, D., Fuzzell, S., Reinhart-Mercer, L., Caywood, L. J., Horst, V., Mackay, T., Dana, D., Sadda, S. V. R., Scott, W. K., Stambolian, D., Haines, J. L. & Pericak-Vance, M. A., Dec 1 2016, In : Ophthalmology. 123, 12, p. 2537-2544 8 p.

Research output: Contribution to journalArticle

10 Scopus citations
12 Scopus citations

Human genetic variation in GLS2 is associated with development of complicated Staphylococcus aureus bacteremia

Scott, W. K., Medie, F. M., Ruffin, F., Sharma-Kuinkel, B. K., Cyr, D. D., Guo, S., Dykxhoorn, D. M., Skov, R. L., Bruun, N. E., Dahl, A., Lerche, C. J., Petersen, A., Larsen, A. R., Lauridsen, T. K., Johansen, H. K., Ullum, H., Sørensen, E., Hassager, C., Bundgaard, H., Schønheyder, H. C. & 9 others, Torp-Pedersen, C., Østergaard, L. B., Arpi, M., Rosenvinge, F., Erikstrup, L. T., Chehri, M., Søgaard, P., Andersen, P. S. & Fowler, V. G., Oct 2018, In : PLoS genetics. 14, 10, e1007667.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Hypothesis-independent pathway analysis implicates GABA and Acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma

Bailey, J. N. C., Yaspan, B. L., Pasquale, L. R., Hauser, M. A., Kang, J. H., Loomis, S. J., Brilliant, M., Budenz, D. L., Christen, W. G., Fingert, J., Gaasterland, D., Gaasterland, T., Kraft, P., Lee, R. K., Lichter, P. R., Liu, Y., McCarty, C. A., Moroi, S. E., Richards, J. E., Realini, T. & 13 others, Schuman, J. S., Scott, W. K., Singh, K., Sit, A. J., Vollrath, D., Wollstein, G., Zack, D. J., Zhang, K., Pericak-Vance, M. A., Allingham, R. R., Weinreb, R. N., Haines, J. L. & Wiggs, J. L., Jan 1 2014, In : Human genetics. 133, 10, p. 1319-1330 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Identifying consensus disease pathways in Parkinson's disease using an integrative systems biology approach

Edwards, Y. J. K., Beecham, G. W., Scott, W. K., Khuri, S., Bademci, G., Tekin, D., Martin, E. R., Jiang, Z., Mash, D. C., ffrench-Mullen, J., Pericak-Vance, M. A., Tsinoremas, N. & Vance, J. M., 2011, In : PloS one. 6, 2, e16917.

Research output: Contribution to journalArticle

50 Scopus citations

Interleukin 12B (IL12B) genetic variation and pulmonary tuberculosis: A study of cohorts from the Gambia, Guinea-Bissau, United States and Argentina

Morris, G. A. J., Edwards, D. R. V., Hill, P. C., Wejse, C., Bisseye, C., Olesen, R., Edwards, T. L., Gilbert, J. R., Myers, J. L., Stryjewski, M. E., Abbate, E., Estevan, R., Hamilton, C. D., Tacconelli, A., Novelli, G., Brunetti, E., Aaby, P., Sodemann, M., Østergaard, L., Adegbola, R. & 3 others, Williams, S. M., Scott, W. K. & Sirugo, G., 2011, In : PloS one. 6, 2, e16656.

Research output: Contribution to journalArticle

31 Scopus citations

Joint Analysis of Nuclear and Mitochondrial Variants in Age-Related Macular Degeneration Identifies Novel Loci TRPM1 and ABHD2/RLBP1

for the International Age-Related Macular Degeneration Genomics Consortium (IAMDGC), Aug 1 2017, In : Investigative ophthalmology & visual science. 58, 10, p. 4027-4038 12 p.

Research output: Contribution to journalArticle

7 Scopus citations