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  • Marjana Tomic-Canic
2020

A bioengineered living cell construct activates metallothionein/zinc/MMP8 and inhibits TGFβ to stimulate remodeling of fibrotic venous leg ulcers

Stone, R. C., Stojadinovic, O., Sawaya, A. P., Glinos, G. D., Lindley, L. E., Pastar, I., Badiavas, E. & Tomic-Canic, M., Mar 1 2020, In : Wound Repair and Regeneration. 28, 2, p. 164-176 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Multimodal, in Situ Imaging of Ex Vivo Human Skin Reveals Decrease of Cholesterol Sulfate in the Neoepithelium during Acute Wound Healing

Castellanos, A., Hernandez, M. G., Tomic-Canic, M., Jozic, I. & Fernandez-Lima, F., Jan 7 2020, In : Analytical Chemistry. 92, 1, p. 1386-1394 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

The Potential Impact of Social Genomics on Wound Healing

Fayne, R. A., Borda, L. J., Egger, A. N. & Tomic-Canic, M., Jun 2020, In : Advances in Wound Care. 9, 6, p. 325-331 7 p.

Research output: Contribution to journalReview article

1 Scopus citations
2019

A tractable, simplified ex vivo human skin model of wound infection

Yoon, D. J., Fregoso, D. R., Nguyen, D., Chen, V., Strbo, N., Fuentes, J. J., Tomic-Canic, M., Crawford, R., Pastar, I. & Isseroff, R. R., Jul 1 2019, In : Wound Repair and Regeneration. 27, 4, p. 421-425 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Cellular Senescence in Diabetic Wounds: When Too Many Retirees Stress the System

Tomic-Canic, M. & DiPietro, L. A., May 2019, In : Journal of Investigative Dermatology. 139, 5, p. 997-999 3 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

Differentiation of diabetic foot ulcer-derived induced pluripotent stem cells reveals distinct cellular and tissue phenotypes

Kashpur, O., Smith, A., Gerami-Naini, B., Maione, A. G., Calabrese, R., Tellechea, A., Theocharidis, G., Liang, L., Pastar, I., Tomic-Canic, M., Mooney, D., Veves, A. & Garlick, J. A., Jan 2019, In : FASEB Journal. 33, 1, p. 1262-1277 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

Mevastatin promotes healing by targeting caveolin-1 to restore EGFR signaling

Sawaya, A. P., Jozic, I., Stone, R. C., Pastar, I., Egger, A. N., Stojadinovic, O., Glinos, G. D., Kirsner, R. S. & Tomic-Canic, M., Dec 5 2019, In : JCI Insight. 4, 23, e129320.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Pharmacological and Genetic Inhibition of Caveolin-1 Promotes Epithelialization and Wound Closure

Jozic, I., Sawaya, A. P., Pastar, I., Head, C. R., Wong, L. L., Glinos, G. D., Wikramanayake, T. C., Brem, H., Kirsner, R. S. & Tomic-Canic, M., Nov 6 2019, In : Molecular Therapy. 27, 11, p. 1992-2004 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Single cell analyses reveal specific distribution of anti-bacterial molecule Perforin-2 in human skin and its modulation by wounding and Staphylococcus aureus infection

Strbo, N., Pastar, I., Romero, L., Chen, V., Vujanac, M., Sawaya, A. P., Jozic, I., Ferreira, A. D. F., Wong, L. L., Head, C., Stojadinovic, O., Garcia, D., O'Neill, K., Drakulich, S., Taller, S., Kirsner, R. S. & Tomic-Canic, M., Mar 2019, In : Experimental dermatology. 28, 3, p. 225-232 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2018

A Modeling Conundrum: Murine Models for Cutaneous Wound Healing

Elliot, S., Wikramanayake, T. C., Jozic, I. & Tomic-Canic, M., Apr 2018, In : Journal of Investigative Dermatology. 138, 4, p. 736-740 5 p.

Research output: Contribution to journalComment/debate

17 Scopus citations
24 Scopus citations

Healing Chronic Wounds: Current Challenges and Potential Solutions

Darwin, E. & Tomic-Canic, M., Dec 1 2018, In : Current Dermatology Reports. 7, 4, p. 296-302 7 p.

Research output: Contribution to journalReview article

6 Scopus citations

Increased IL-17-expressing γδ T cells in seborrhoeic dermatitis-like lesions of the Mpzl3 knockout mice

Wikramanayake, T., Hirt, P., Almastadi, M., Mitchell, H., Tomic-Canic, M., Romero, L., Garcia, D. & Strbo, N., Dec 1 2018, In : Experimental Dermatology. 27, 12, p. 1408-1411 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Mesenchymal stromal cells prevent bleomycin-induced lung and skin fibrosis in aged mice and restore wound healing

Rubio, G. A., Elliot, S. J., Wikramanayake, T. C., Xia, X., Pereira-Simon, S., Thaller, S. R., Glinos, G. D., Jozic, I., Hirt, P., Pastar, I., Tomic-Canic, M. & Glassberg, M. K., Aug 2018, In : Journal of Cellular Physiology. 233, 8, p. 5503-5512 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Novel mevalonate kinase missense mutation in a patient with disseminated superficial actinic porokeratosis

Glinos, G. D., Pastar, I., Giubellino, A., Tomic-Canic, M., Miteva, M. & Stone, R. C., May 2018, In : JAAD Case Reports. 4, 4, p. 340-343 4 p.

Research output: Contribution to journalArticle

Staphylococcus aureus Triggers Induction of miR-15B-5P to Diminish DNA Repair and Deregulate Inflammatory Response in Diabetic Foot Ulcers

Ramirez, H. A., Pastar, I., Jozic, I., Stojadinovic, O., Stone, R. C., Ojeh, N., Gil, J., Davis, S. C., Kirsner, R. S. & Tomic-Canic, M., May 2018, In : Journal of Investigative Dermatology. 138, 5, p. 1187-1196 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

The epithelialisation phase in wound healing: Options to enhance wound closure

Tomic-Canic, M., Wong, L. L. & Smola, H., Oct 1 2018, In : Journal of Wound Care. 27, 10, p. 646-658 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Topical mevastatin promotes wound healing by inhibiting the transcription factor c-Myc via the glucocorticoid receptor and the long non-coding RNA Gas5

Sawaya, A. P., Pastar, I., Stojadinovic, O., Lazovic, S., Davis, S. C., Gil, J., Kirsner, R. S. & Tomic-Canic, M., Jan 26 2018, In : Journal of Biological Chemistry. 293, 4, p. 1439-1449 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2017

A bioengineered living cell construct activates an acute wound healing response in venous leg ulcers

Stone, R. C., Stojadinovic, O., Rosa, A. M., Ramirez, H. A., Badiavas, E., Blumenberg, M. & Tomic-Canic, M., Jan 4 2017, In : Science Translational Medicine. 9, 371, eaaf8611.

Research output: Contribution to journalArticle

35 Scopus citations

In vitro skin models to study epithelial regeneration from the hair follicle

Ojeh, N., Akgül, B., Tomic-Canic, M., Philpott, M. & Navsaria, H., Mar 2017, In : PloS one. 12, 3, e0174389.

Research output: Contribution to journalArticle

9 Scopus citations

MiR-21 and miR-205 are induced in invasive cutaneous squamous cell carcinomas

Stojadinovic, O., Ramirez, H., Pastar, I., Gordon, K. A., Stone, R., Choudhary, S., Badiavas, E. V., Nouri, K. & Tomic-Canic, M., Mar 1 2017, In : Archives of Dermatological Research. 309, 2, p. 133-139 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Nanotechnology-Driven Therapeutic Interventions in Wound Healing: Potential Uses and Applications

Hamdan, S., Pastar, I., Drakulich, S., Dikici, E., Tomic-Canic, M., Deo, S. & Daunert, S., Mar 22 2017, In : ACS Central Science. 3, 3, p. 163-175 13 p.

Research output: Contribution to journalArticle

90 Scopus citations

Optical coherence tomography for assessment of epithelialization in a human ex vivo wound model

Glinos, G. D., Verne, S. H., Aldahan, A. S., Liang, L., Nouri, K., Elliot, S., Glassberg, M., Cabrera DeBuc, D., Koru-Sengul, T., Tomic-Canic, M. & Pastar, I., Nov 1 2017, In : Wound Repair and Regeneration. 25, 6, p. 1017-1026 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Preclinical models for wound-healing studies

Pastar, I., Liang, L., Sawaya, A. P., Wikramanayake, T., Glinos, G. D., Drakulich, S., Chen, V., Stojadinovic, O., Davis, S. C. & Tomic-Canic, M., Nov 15 2017, Skin Tissue Models. Elsevier Inc., p. 223-251 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Probiotics or pro-healers: the role of beneficial bacteria in tissue repair

Lukic, J., Chen, V., Strahinic, I., Begovic, J., Lev-Tov, H., Davis, S. C., Tomic-Canic, M. & Pastar, I., Nov 1 2017, In : Wound Repair and Regeneration. 25, 6, p. 912-922 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Stress Signals, Mediated by Membranous Glucocorticoid Receptor, Activate PLC/PKC/GSK-3β/β-catenin Pathway to Inhibit Wound Closure

Jozic, I., Vukelic, S., Stojadinovic, O., Liang, L., Ramirez, H. A., Pastar, I. & Tomic Canic, M., May 2017, In : Journal of Investigative Dermatology. 137, 5, p. 1144-1154 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Updates in wound healing: Mechanisms and translation

Eming, S. A. & Tomic-Canic, M., Feb 1 2017, In : Experimental Dermatology. 26, 2, p. 97-98 2 p.

Research output: Contribution to journalEditorial

10 Scopus citations

Wound healing protects against chemotherapy-induced alopecia in young rats via up-regulating interleukin-1β-mediated signaling

Stojadinovic, O., Wikramanayake, T. C., Villasante Fricke, A. C., Yin, N. C., Liang, L., Hinde, E., Escandon, J., Tomic-Canic, M., Ansell, D. M., Paus, R. & Jimenez, J. J., May 2017, In : Heliyon. 3, 5, e00309.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Altered ECM deposition by diabetic foot ulcer-derived fibroblasts implicates fibronectin in chronic wound repair

Maione, A. G., Smith, A., Kashpur, O., Yanez, V., Knight, E., Mooney, D. J., Veves, A., Tomic-Canic, M. & Garlick, J. A., Jul 1 2016, In : Wound Repair and Regeneration. 24, 4, p. 630-643 14 p.

Research output: Contribution to journalArticle

23 Scopus citations

Biology and biomarkers for wound healing

Lindley, L. E., Stojadinovic, O., Pastar, I. & Tomic-Canic, M., 2016, In : Plastic and reconstructive surgery. 138, 3, p. 18S-28S

Research output: Contribution to journalArticle

55 Scopus citations

Epithelial-mesenchymal transition in tissue repair and fibrosis

Stone, R. C., Pastar, I., Ojeh, N., Chen, V., Liu, S., Garzon, K. I. & Tomic-Canic, M., Sep 1 2016, In : Cell and Tissue Research. 365, 3, p. 495-506 12 p.

Research output: Contribution to journalReview article

148 Scopus citations

Integrative analysis of miRNA and mRNA paired expression profiling of primary fibroblast derived from diabetic foot ulcers reveals multiple impaired cellular functions

Liang, L., Stone, R. C., Stojadinovic, O., Ramirez, H., Pastar, I., Maione, A. G., Smith, A., Yanez, V., Veves, A., Kirsner, R. S., Garlick, J. A. & Tomic-Canic, M., Nov 1 2016, In : Wound Repair and Regeneration. 24, 6, p. 943-953 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Mineralocorticoid Receptor Antagonists—A New Sprinkle of Salt and Youth

Stojadinovic, O., Lindley, L. E., Jozic, I. & Tomic-Canic, M., Oct 1 2016, In : Journal of Investigative Dermatology. 136, 10, p. 1938-1941 4 p.

Research output: Contribution to journalComment/debate

4 Scopus citations

Modalities to treat venous ulcers: Compression, surgery, and bioengineered tissue

Gould, L. J., Dosi, G., Couch, K., Gibbons, G. W., Howell, R. S., Brem, H. & Tomic-Canic, M., 2016, In : Plastic and reconstructive surgery. 138, 3, p. 199S-208S

Research output: Contribution to journalArticle

8 Scopus citations

Skin Metabolite, Farnesyl Pyrophosphate, Regulates Epidermal Response to Inflammation, Oxidative Stress, and Migration

Pastar, I., Stojadinovic, O., Sawaya, A. P., Stone, R. C., Lindley, L. E., Ojeh, N., Vukelic, S., Samuels, H. H. & Tomic-Canic, M., Nov 1 2016, In : Journal of Cellular Physiology. 231, 11, p. 2452-2463 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

The effects of caffeine on wound healing

Ojeh, N., Stojadinovic, O., Pastar, I., Sawaya, A., Yin, N. & Tomic-Canic, M., Oct 1 2016, In : International Wound Journal. 13, 5, p. 605-613 9 p.

Research output: Contribution to journalArticle

13 Scopus citations
2015

Chronic wound repair and healing in older adults: Current status and future research

Gould, L., Abadir, P., Brem, H., Carter, M., Conner-Kerr, T., Davidson, J., Dipietro, L., Falanga, V., Fife, C., Gardner, S., Grice, E., Harmon, J., Hazzard, W. R., High, K. P., Houghton, P., Jacobson, N., Kirsner, R. S., Kovacs, E. J., Margolis, D., McFarland Horne, F. & 9 others, Reed, M. J., Sullivan, D. H., Thom, S., Tomic-Canic, M., Walston, J., Whitney, J. A., Williams, J., Zieman, S. & Schmader, K., Mar 1 2015, In : Journal of the American Geriatrics Society. 63, 3, p. 427-438 12 p.

Research output: Contribution to journalArticle

99 Scopus citations

Chronic wound repair and healing in older adults: Current status and future research

Gould, L., Abadir, P., Brem, H., Carter, M., Conner-Kerr, T., Davidson, J., Dipietro, L., Falanga, V., Fife, C., Gardner, S., Grice, E., Harmon, J., Hazzard, W. R., High, K. P., Houghton, P., Jacobson, N., Kirsner, R. S., Kovacs, E. J., Margolis, D., McFarland Horne, F. & 9 others, Reed, M. J., Sullivan, D. H., Thom, S., Tomic-Canic, M., Walston, J., Whitney, J., Williams, J., Zieman, S. & Schmader, K., Jan 1 2015, In : Wound Repair and Regeneration. 23, 1, p. 1-13 13 p.

Research output: Contribution to journalReview article

68 Scopus citations

Comparative genomic, microRNA, and tissue analyses reveal subtle differences between non-diabetic and diabetic foot skin

Ramirez, H. A., Liang, L., Pastar, I., Rosa, A. M., Stojadinovic, O., Zwick, T. G., Kirsner, R. S., Maione, A. G., Garlick, J. A. & Tomic-Canic, M., Aug 28 2015, In : PloS one. 10, 8, e0137133.

Research output: Contribution to journalArticle

25 Scopus citations

Effect of physical therapy on wound healing and quality of life in patients with venous leg ulcers a systematic review

Yim, E., Kirsner, R. S., Gailey, R. S., Mandel, D. W., Chen, S. C. & Tomic-Canic, M., Mar 1 2015, In : JAMA Dermatology. 151, 3, p. 320-327 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Nanoparticles for Fidgety Cell Movement and Enhanced Wound Healing

Jozic, I., Daunert, S., Tomic-Canic, M. & Pastar, I., Sep 18 2015, In : Journal of Investigative Dermatology. 135, 9, p. 2151-2153 3 p.

Research output: Contribution to journalArticle

6 Scopus citations

Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria

McCormack, R. M., de Armas, L. R., Shiratsuchi, M., Fiorentino, D. G., Olsson, M. L., Lichtenheld, M. G., Morales, A., Lyapichev, K., Gonzalez, L. E., Strbo, N., Sukumar, N., Stojadinovic, O., Plano, G. V., Munson, G. P., Tomic-Canic, M., Kirsner, R. S., Russell, D. G. & Podack, E. R., Sep 24 2015, In : eLife. 4, September2015, e06508.

Research output: Contribution to journalArticle

28 Scopus citations

Skin: An essential organ

Baranoski, S., Ayello, E. A., Levine, J. M., LeBlanc, K. & Tomic-Canic, M., Jul 29 2015, Wound Care Essentials: Practice Principles: Fourth Edition. Wolters Kluwer Health

Research output: Chapter in Book/Report/Conference proceedingChapter

Skin under the (Spot)-Light: Cross-Talk with the Central Hypothalamic-Pituitary-Adrenal (HPA) Axis

Jozic, I., Stojadinovic, O., Kirsner, R. & Tomic-Canic, M., Jun 1 2015, In : The Journal of investigative dermatology. 135, 6, p. 1469-1471 3 p.

Research output: Contribution to journalArticle

10 Scopus citations

Stem cells in skin regeneration, wound healing, and their clinical applications

Ojeh, N., Pastar, I., Tomic-Canic, M. & Stojadinovic, O., Oct 23 2015, In : International journal of molecular sciences. 16, 10, p. 25476-25501 26 p.

Research output: Contribution to journalReview article

110 Scopus citations

Three-dimensional human tissue models that incorporate diabetic foot ulcer-derived fibroblasts mimic in vivo features of chronic wounds

Maione, A. G., Brudno, Y., Stojadinovic, O., Park, L. K., Smith, A., Tellechea, A., Leal, E. C., Kearney, C. J., Veves, A., Tomic-Canic, M., Mooney, D. J. & Garlick, J. A., May 1 2015, In : Tissue Engineering - Part C: Methods. 21, 5, p. 499-508 10 p.

Research output: Contribution to journalArticle

29 Scopus citations
2014

Analysis and meta-analysis of transcriptional profiling in human epidermis

Mimoso, C., Lee, D. D., Zavadil, J., Tomic-Canic, M. & Blumenberg, M., 2014, In : Methods in molecular biology (Clifton, N.J.). 1195, p. 61-97 37 p.

Research output: Contribution to journalArticle

Analysis and meta-analysis of transcriptional profiling in human epidermis

Mimoso, C., Lee, D. D., Zavadil, J., Tomic-Canic, M. & Blumenberg, M., 2014, Epidermal Cells: Methods and Protocols. Humana Press Inc., p. 61-97 37 p. (Methods in Molecular Biology; vol. 1195).

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations