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  • William K Scott
2013

Parkinson disease loci in the mid-western Amish

Davis, M. F., Cummings, A. C., D'Aoust, L. N., Jiang, L., Velez Edwards, D. R., Laux, R., Reinhart-Mercer, L., Fuzzell, D., Scott, W. K., Pericak-Vance, M. A., Lee, S. L. & Haines, J. L., Nov 1 2013, In : Human genetics. 132, 11, p. 1213-1221 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Seven new loci associated with age-related macular degeneration

Fritsche, L. G., Chen, W., Schu, M., Yaspan, B. L., Yu, Y., Thorleifsson, G., Zack, D. J., Arakawa, S., Cipriani, V., Ripke, S., Igo, R. P., Buitendijk, G. H. S., Sim, X., Weeks, D. E., Guymer, R. H., Merriam, J. E., Francis, P. J., Hannum, G., Agarwal, A., Armbrecht, A. M. & 136 others, Audo, I., Aung, T., Barile, G. R., Benchaboune, M., Bird, A. C., Bishop, P. N., Branham, K. E., Brooks, M., Brucker, A. J., Cade, W. H., Cain, M. S., Campochiaro, P. A., Chan, C. C., Cheng, C. Y., Chew, E. Y., Chin, K. A., Chowers, I., Clayton, D. G., Cojocaru, R., Conley, Y. P., Cornes, B. K., Daly, M. J., Dhillon, B., Edwards, A. O., Evangelou, E., Fagerness, J., Ferreyra, H. A., Friedman, J. S., Geirsdottir, A., George, R. J., Gieger, C., Gupta, N., Hagstrom, S. A., Harding, S. P., Haritoglou, C., Heckenlively, J. R., Holz, F. G., Hughes, G., Ioannidis, J. P. A., Ishibashi, T., Joseph, P., Jun, G., Kamatani, Y., Katsanis, N., N Keilhauer, C., Khan, J. C., Kim, I. K., Kiyohara, Y., Klein, B. E. K., Klein, R., Kovach, J. L., Kozak, I., Lee, C. J., Lee, K. E., Lichtner, P., Lotery, A. J., Meitinger, T., Mitchell, P., Mohand-Saïd, S., Moore, A. T., Morgan, D. J., Morrison, M. A., Myers, C. E., Naj, A. C., Nakamura, Y., Okada, Y., Orlin, A., Ortube, M. C., Othman, M. I., Pappas, C., Park, K. H., Pauer, G. J. T., Peachey, N. S., Poch, O., Priya, R. R., Reynolds, R., Richardson, A. J., Ripp, R., Rudolph, G., Ryu, E., Sahel, J. A., Schaumberg, D. A., Scholl, H. P. N., Schwartz, S. G., Scott, W. K., Shahid, H., Sigurdsson, H., Silvestri, G., Sivakumaran, T. A., Smith, R. T., Sobrin, L., Souied, E. H., Stambolian, D. E., Stefansson, H., Sturgill-Short, G. M., Takahashi, A., Tosakulwong, N., Truitt, B. J., Tsironi, E. E., Uitterlinden, A. G., Van Duijn, C. M., Vijaya, L., Vingerling, J. R., Vithana, E. N., Webster, A. R., Wichmann, H. E., Winkler, T. W., Wong, T. Y., Wright, A. F., Zelenika, D., Zhang, M., Zhao, L., Zhang, K., Klein, M. L., Hageman, G. S., Lathrop, G. M., Stefansson, K., Allikmets, R., Baird, P. N., Gorin, M. B., Wang, J. J., Klaver, C. C. W., Seddon, J. M., Pericak-Vance, M. A., Iyengar, S. K., Yates, J. R. W., Swaroop, A., Weber, B. H. F., Kubo, M., Deangelis, M. M., Léveillard, T., Thorsteinsdottir, U., Haines, J. L., Farrer, L. A., Heid, I. M. & Abecasis, G. R., Apr 2013, In : Nature genetics. 45, 4, p. 433-439 7 p.

Research output: Contribution to journalArticle

483 Scopus citations

Variants at chromosome 10q26 locus and the expression of HTRA1 in the retina

Wang, G., Dubovy, S. R., Kovach, J. L., Schwartz, S. G., Agarwal, A., Scott, W. K., Haines, J. L. & Pericak-Vance, M. A., Jul 1 2013, In : Experimental Eye Research. 112, p. 102-105 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

Whole exome sequencing of rare variants in EIF4G1 and VPS35 in Parkinson disease

Nuytemans, K., Bademci, G., Inchausti, V., Dressen, A., Kinnamon, D. D., Mehta, A., Wang, L., Züchner, S., Beecham, G. W., Martin, E. R., Scott, W. K. & Vance, J. M., Mar 12 2013, In : Neurology. 80, 11, p. 982-989 8 p.

Research output: Contribution to journalArticle

51 Scopus citations
2012

A novel ARMS2 splice variant is identified in human retina

Wang, G., Scott, W. K., Whitehead, P., Court, B. L., Kovach, J. L., Schwartz, S. G., Agarwal, A., Dubovy, S., Haines, J. L. & Pericak-Vance, M. A., Jan 1 2012, In : Experimental Eye Research. 94, 1, p. 187-191 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Cognitive performance of GBA mutation carriers with early-onset PD The CORE-PD study

Alcalay, R. N., Caccappolo, E., Mejia-Santana, H., Tang, M. X., Rosado, L., Reilly, M. O., Ruiz, D., Ross, B., Verbitsky, M., Kisselev, S., Louis, E., Comella, C., Colcher, A., Jennings, D., Nance, M., Bressman, S., Scott, W. K., Tanner, C., Mickel, S., Andrews, H. & 18 others, Waters, C., Fahn, S., Cote, L., Frucht, S., Ford, B., Rezak, M., Novak, K., Friedman, J. H., Pfeiffer, R., Marsh, L., Hiner, B., Siderowf, A., Payami, H., Molho, E., Factor, S., Ottman, R., Clark, L. N. & Marder, K., May 1 2012, In : Neurology. 78, 18, p. 1434-1440 7 p.

Research output: Contribution to journalArticle

140 Scopus citations

Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDgene database

Lill, C. M., Roehr, J. T., McQueen, M. B., Kavvoura, F. K., Bagade, S., Schjeide, B. M. M., Schjeide, L. M., Meissner, E., Zauft, U., Allen, N. C., Liu, T., Schilling, M., Anderson, K. J., Beecham, G., Berg, D., Biernacka, J. M., Brice, A., DeStefano, A. L., Do, C. B., Eriksson, N. & 34 others, Factor, S. A., Farrer, M. J., Foroud, T., Gasser, T., Hamza, T., Hardy, J. A., Heutink, P., Hill-Burns, E. M., Klein, C., Latourelle, J. C., Maraganore, D. M., Martin, E. R., Martinez, M., Myers, R. H., Nalls, M. A., Pankratz, N., Payami, H., Satake, W., Scott, W. K., Sharma, M., Singleton, A. B., Stefansson, K., Toda, T., Tung, J. Y., Vance, J., Wood, N. W., Zabetian, C. P., Young, P., Tanzi, R. E., Khoury, M. J., Zipp, F., Lehrach, H., Ioannidis, J. P. A. & Bertram, L., Mar 2012, In : PLoS genetics. 8, 3, e1002548.

Research output: Contribution to journalArticle

367 Scopus citations

Cytokine gene polymorphisms and the outcome of invasive candidiasis: A prospective cohort study

Johnson, M. D., Plantinga, T. S., Van De Vosse, E., Velez Edwards, D. R., Smith, P. B., Alexander, B. D., Yang, J. C., Kremer, D., Laird, G. M., Oosting, M., Joosten, L. A. B., Van Der Meer, J. W. M., Van Dissel, J. T., Walsh, T. J., Perfect, J. R., Kullberg, B. J., Scott, W. K. & Netea, M. G., Feb 15 2012, In : Clinical Infectious Diseases. 54, 4, p. 502-510 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

Genome-Wide Association and Linkage Study in the Amish Detects a Novel Candidate Late-Onset Alzheimer Disease Gene

Cummings, A. C., Jiang, L., Velez Edwards, D. R., Mccauley, J. L., Laux, R., Mcfarland, L. L., Fuzzell, D., Knebusch, C., Caywood, L., Reinhart-Mercer, L., Nations, L., Gilbert, J. R., Konidari, I., Tramontana, M., Cuccaro, M. L., Scott, W. K., Pericak-Vance, M. A. & Haines, J. L., Sep 1 2012, In : Annals of Human Genetics. 76, 5, p. 342-351 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Haplotype association mapping identifies a candidate gene region in mice infected with staphylococcus aureus

Johnson, N. V., Ahn, S. H., Deshmukh, H., Levin, M. K., Nelson, C. L., Scott, W. K., Allen, A., Fowler, V. G. & Cowell, L. G., Jun 2012, In : G3: Genes, Genomes, Genetics. 2, 6, p. 693-700 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Human genetic susceptibility to Candida infections

Plantinga, T. S., Johnson, M. D., Scott, W. K., Joosten, L. A. B., Van Der Meer, J. W. M., Perfect, J. R., Kullberg, B. J. & Netea, M. G., Nov 1 2012, In : Medical mycology. 87, 8, p. 785-794 10 p.

Research output: Contribution to journalReview article

23 Scopus citations

MCP1 SNPS and pulmonary tuberculosis in cohorts from west africa, the USA and argentina: Lack of association or epistasis with IL12B polymorphisms

Edwards, D. R., Tacconelli, A., Wejse, C., Hill, P. C., Morris, G. A. J., Edwards, T. L., Gilbert, J. R., Myers, J. L., Park, Y. S., Stryjewski, M. E., Abbate, E., Estevan, R., Rabna, P., Novelli, G., Hamilton, C. D., Adegbola, R., Østergaard, L., Williams, S. M., Scott, W. K. & Sirugo, G., Feb 27 2012, In : PloS one. 7, 2, e32275.

Research output: Contribution to journalArticle

17 Scopus citations

Meta-analysis of Parkinson's Disease: Identification of a novel locus, RIT2

Pankratz, N., Beecham, G. W., Destefano, A. L., Dawson, T. M., Doheny, K. F., Factor, S. A., Hamza, T. H., Hung, A. Y., Hyman, B. T., Ivinson, A. J., Krainc, D., Latourelle, J. C., Clark, L. N., Marder, K., Martin, E. R., Mayeux, R., Ross, O. A., Scherzer, C. R., Simon, D. K., Tanner, C. & 7 others, Vance, J. M., Wszolek, Z. K., Zabetian, C. P., Myers, R. H., Payami, H., Scott, W. K. & Foroud, T., Mar 1 2012, In : Annals of neurology. 71, 3, p. 370-384 15 p.

Research output: Contribution to journalArticle

156 Scopus citations

Mitochondrial Haplogroup X is associated with successful aging in the Amish

Courtenay, M. D., Gilbert, J. R., Jiang, L., Cummings, A. C., Gallins, P. J., Caywood, L., Reinhart-Mercer, L., Fuzzell, D., Knebusch, C., Laux, R., McCauley, J. L., Jackson, C. E., Pericak-Vance, M. A., Haines, J. L. & Scott, W. K., Feb 1 2012, In : Human genetics. 131, 2, p. 201-208 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Population-based case-control association studies

Hancock, D. B. & Scott, W. K., Jul 1 2012, In : Current protocols in human genetics. SUPPL.74, 1.17.

Research output: Contribution to journalArticle

7 Scopus citations

Retinoblastoma treatment: Impact of the glycolytic inhibitor 2-deoxy-d-glucose on molecular genomics expression in LH BETAT AG retinal tumors

Piña, Y., Houston, S. K., Murray, T. G., Koru-Sengul, T., Decatur, C., Scott, W. K., Nathanson, L., Clarke, J. & Lampidis, T. J., May 27 2012, In : Clinical Ophthalmology. 6, 1, p. 817-830 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

The ARMS2 A69S variant and bilateral advanced age-related macular degeneration

Schwartz, S. G., Agarwal, A., Kovach, J. L., Gallins, P. J., Cade, W., Postel, E. A., Wang, G., Ayala-Haedo, J., Spencer, K. M., Haines, J. L., Pericak-Vance, M. A. & Scott, W. K., Sep 1 2012, In : Retina. 32, 8, p. 1486-1491 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

The impact of caspase-12 on susceptibility to candidemia

Rosentul, D. C., Plantinga, T. S., Scott, W. K., Alexander, B. D., Van De Geer, N. M. D., Perfect, J. R., Kullberg, B. J., Johnson, M. D. & Netea, M. G., Mar 1 2012, In : European Journal of Clinical Microbiology and Infectious Diseases. 31, 3, p. 277-280 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

Toll-like receptor 1 polymorphisms increase susceptibility to candidemia

Plantinga, T. S., Johnson, M. D., Scott, W. K., Van De Vosse, E., Velez Edwards, D. R., Smith, P. B., Alexander, B. D., Yang, J. C., Kremer, D., Laird, G. M., Oosting, M., Joosten, L. A. B., Van Der Meer, J. W. M., Van Dissel, J. T., Walsh, T. J., Perfect, J. R., Kullberg, B. J. & Netea, M. G., Mar 15 2012, In : Journal of Infectious Diseases. 205, 6, p. 934-943 10 p.

Research output: Contribution to journalArticle

86 Scopus citations
2011

A Genome-Wide Linkage Screen in the Amish with Parkinson Disease Points to Chromosome 6

Cummings, A. C., Lee, S. L., Mccauley, J. L., Jiang, L., Crunk, A., Mcfarland, L. L., Gallins, P. J., Fuzzell, D., Knebusch, C., Jackson, C. E., Scott, W. K., Pericak-Vance, M. A. & Haines, J. L., May 1 2011, In : Annals of Human Genetics. 75, 3, p. 351-358 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from guinea-bissau, West Africa

Hennig, B. J., Velez-Edwards, D. R., Schim Van Der Loeff, M. F., Bisseye, C., Edwards, T. L., Tacconelli, A., Novelli, G., Aaby, P., Kaye, S., Scott, W. K., Jaye, A., Whittle, H. C., Williams, S. M., Hill, A. V. & Sirugo, G., Jan 1 2011, In : Journal of Acquired Immune Deficiency Syndromes. 56, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Dissection of chromosome 16p12 linkage peak suggests a possible role for CACNG3 variants in age-related macular degeneration susceptibility

Spencer, K. L., Olson, L. M., Schnetz-Boutaud, N., Gallins, P., Wang, G., Scott, W. K., Agarwal, A., Jakobsdottir, J., Conley, Y., Weeks, D. E., Gorin, M. B., Pericak-Vance, M. A. & Haines, J. L., Mar 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 3, p. 1748-1754 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Genetic variation in the dectin-1/CARD9 recognition pathway and susceptibility to candidemia

Rosentul, D. C., Plantinga, T. S., Oosting, M., Scott, W. K., Velez Edwards, D. R., Smith, P. B., Alexander, B. D., Yang, J. C., Laird, G. M., Joosten, L. A. B., Van Der Meer, J. W. M., Perfect, J. R., Kullberg, B. J., Netea, M. G. & Johnson, M. D., Oct 1 2011, In : Journal of Infectious Diseases. 204, 7, p. 1138-1145 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Genome-wide gene-environment study identifies glutamate receptor gene grin2a as a parkinson's disease modifier gene via interaction with coffee

Hamza, T. H., Chen, H., Hill-Burns, E. M., Rhodes, S. L., Montimurro, J., Kay, D. M., Tenesa, A., Kusel, V. I., Sheehan, P., Eaaswarkhanth, M., Yearout, D., Samii, A., Roberts, J. W., Agarwal, P., Bordelon, Y., Park, Y., Wang, L., Gao, J., Vance, J. M., Kendler, K. S. & 7 others, Bacanu, S. A., Scott, W. K., Ritz, B., Nutt, J., Factor, S. A., Zabetian, C. P. & Payami, H., Aug 2011, In : PLoS genetics. 7, 8, e1002237.

Research output: Contribution to journalArticle

137 Scopus citations

Identifying consensus disease pathways in Parkinson's disease using an integrative systems biology approach

Edwards, Y. J. K., Beecham, G. W., Scott, W. K., Khuri, S., Bademci, G., Tekin, D., Martin, E. R., Jiang, Z., Mash, D. C., ffrench-Mullen, J., Pericak-Vance, M. A., Tsinoremas, N. & Vance, J. M., 2011, In : PloS one. 6, 2, e16917.

Research output: Contribution to journalArticle

50 Scopus citations

Interleukin 12B (IL12B) genetic variation and pulmonary tuberculosis: A study of cohorts from the Gambia, Guinea-Bissau, United States and Argentina

Morris, G. A. J., Edwards, D. R. V., Hill, P. C., Wejse, C., Bisseye, C., Olesen, R., Edwards, T. L., Gilbert, J. R., Myers, J. L., Stryjewski, M. E., Abbate, E., Estevan, R., Hamilton, C. D., Tacconelli, A., Novelli, G., Brunetti, E., Aaby, P., Sodemann, M., Østergaard, L., Adegbola, R. & 3 others, Williams, S. M., Scott, W. K. & Sirugo, G., 2011, In : PloS one. 6, 2, e16656.

Research output: Contribution to journalArticle

31 Scopus citations

Neuropsychological profile of parkin mutation carriers with and without parkinson disease: The CORE-PD study

Caccappolo, E., Alcalay, R. N., Mejia-Santana, H., Tang, M. X., Rakitin, B., Rosado, L., Louis, E. D., Comella, C. L., Colcher, A., Jennings, D., Nance, M. A., Bressman, S., Scott, W. K., Tanner, C. M., Mickel, S. F., Andrews, H. F., Waters, C., Fahn, S., Cote, L. J., Frucht, S. & 14 others, Ford, B., Rezak, M., Novak, K., Friedman, J. H., Pfeiffer, R. F., Marsh, L., Hiner, B., Siderowf, A. D., Ross, B. M., Verbitsky, M., Kisselev, S., Ottman, R., Clark, L. N. & Marder, K. S., Jan 1 2011, In : Journal of the International Neuropsychological Society. 17, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Olfaction in Parkin heterozygotes and compound heterozygotes: The CORE-PD study

Alcalay, R. N., Siderowf, A., Ottman, R., Caccappolo, E., Mejia-Santana, H., Tang, M. X., Rosado, L., Louis, E., Ruiz, D., Waters, C., Fahn, S., Cote, L., Frucht, S., Ford, B., Orbe-Reilly, M., Ross, B., Verbitsky, M., Kisselev, S., Comella, C., Colcher, A. & 14 others, Jennings, D., Nance, M., Bressman, S., Scott, W. K., Tanner, C., Mickel, S., Rezak, M., Novak, K. E., Friedman, J. H., Pfeiffer, R., Marsh, L., Hiner, B., Clark, L. N. & Marder, K., Jan 25 2011, In : Neurology. 76, 4, p. 319-326 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Regional and temporal differences in gene expression of LH BETAT AG retinoblastoma tumors

Houston, S. K., Pina, Y., Clarke, J., Koru-Sengul, T., Scott, W. K., Nathanson, L., Schefler, A. C. & Murray, T. G., Jul 2011, In : Investigative Ophthalmology and Visual Science. 52, 8, p. 5359-5368 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Successful Aging Shows Linkage to Chromosomes 6, 7, and 14 in the Amish

Edwards, D. R. V., Gilbert, J. R., Jiang, L., Gallins, P. J., Caywood, L., Creason, M., Fuzzell, D., Knebusch, C., Jackson, C. E., Pericak-Vance, M. A., Haines, J. L. & Scott, W. K., Jul 1 2011, In : Annals of Human Genetics. 75, 4, p. 516-528 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

The relation between depression and parkin genotype: The CORE-PD study

Srivastava, A., Tang, M. X., Mejia-Santana, H., Rosado, L., Louis, E. D., Caccappolo, E., Comella, C., Colcher, A., Siderowf, A., Jennings, D., Nance, M., Bressman, S., Scott, W. K., Tanner, C., Mickel, S., Andrews, H., Waters, C., Fahn, S., Cote, L., Frucht, S. & 14 others, Ford, B., Alcalay, R. N., Ross, B., Orbe Reilly, M., Rezak, M., Novak, K., Friedman, J. H., Pfeiffer, R. D., Marsh, L., Hiner, B., Merle, D., Ottman, R., Clark, L. N. & Marder, K., Dec 1 2011, In : Parkinsonism and Related Disorders. 17, 10, p. 740-744 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Using genetic variation and environmental risk factor data to identify individuals at high risk for age-related macular degeneration

Spencer, K. L., Olson, L. M., Schnetz-Boutaud, N., Gallins, P., Agarwal, A., Iannaccone, A., Kritchevsky, S. B., Garcia, M., Nalls, M. A., Newman, A. B., Scott, W. K., Pericak-Vance, M. A. & Haines, J. L., 2011, In : PloS one. 6, 3, e17784.

Research output: Contribution to journalArticle

34 Scopus citations

Vitamin D Receptor Gene as a Candidate Gene for Parkinson Disease

Butler, M. W., Burt, A., Edwards, T. L., Zuchner, S., Scott, W. K., Martin, E. R., Vance, J. M. & Wang, L., Mar 1 2011, In : Annals of Human Genetics. 75, 2, p. 201-210 10 p.

Research output: Contribution to journalArticle

79 Scopus citations