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Author

  • Tasuku Akiyama
2020

New insights into the mechanisms behind mechanical itch

Sakai, K. & Akiyama, T., Aug 1 2020, In : Experimental dermatology. 29, 8, p. 680-686 7 p.

Research output: Contribution to journalArticle

Open Access
2019

Antipruritic effects of janus kinase inhibitor tofacitinib in a mouse model of psoriasis

Hashimoto, T., Sakai, K., Sanders, K. M., Yosipovitch, G. & Akiyama, T., 2019, In : Acta dermato-venereologica. 99, 3, p. 298-303 6 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

A subpopulation of amygdala neurons mediates the affective component of itch

Sanders, K. M., Sakai, K., Henry, T. D., Hashimoto, T. & Akiyama, T., Apr 24 2019, In : Journal of Neuroscience. 39, 17, p. 3345-3356 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Disinhibition of Touch-Evoked Itch in a Mouse Model of Psoriasis

Sakai, K. & Akiyama, T., Jun 2019, In : Journal of Investigative Dermatology. 139, 6, p. 1407-1410 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Signal transducer and activator of transcription 3 in keratinocytes regulates histaminergic itch but not nonhistaminergic itch

Hashimoto, T., Sakai, K., Yosipovitch, G. & Akiyama, T., Jan 1 2019, In : Acta dermato-venereologica. 99, 10, p. 901-902 2 p.

Research output: Contribution to journalComment/debate

Open Access

Why does stress aggravate itch? A possible role of the amygdala

Pavlenko, D. & Akiyama, T., Jan 1 2019, In : Experimental dermatology.

Research output: Contribution to journalLetter

Open Access
1 Scopus citations
2018

Alloknesis and hyperknesis - Mechanisms, assessment methodology, and clinical implications of itch sensitization

Andersen, H. H., Akiyama, T., Nattkemper, L. A., Van Laarhoven, A., Elberling, J., Yosipovitch, G. & Arendt-Nielsen, L., Jul 1 2018, In : Pain. 159, 7, p. 1185-1197 13 p.

Research output: Contribution to journalReview article

23 Scopus citations

Effects of pruritogens and algogens on rostral ventromedial medullary on and off cells

Follansbee, T., Akiyama, T., Fujii, M., Davoodi, A., Nagamine, M., Iodi Carstens, M. & Carstens, E., Nov 2018, In : Journal of neurophysiology. 120, 5, p. 2156-2163 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Modulation of itch by localized skin warming and cooling

Sanders, K. M., Hashimoto, T., Sakai, K. & Akiyama, T., 2018, In : Acta dermato-venereologica. 98, 9, p. 855-861 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Peripheral gabapentin regulates mosquito allergy-induced itch in mice

Akiyama, T., Andoh, T., Ohtsuka, E., Nojima, H., Ouchi, H., Takahata, H. & Kuraishi, Y., Aug 15 2018, In : European Journal of Pharmacology. 833, p. 44-49 6 p.

Research output: Contribution to journalArticle

The vicious cycle of itch and anxiety

Sanders, K. M. & Akiyama, T., Apr 2018, In : Neuroscience and Biobehavioral Reviews. 87, p. 17-26 10 p.

Research output: Contribution to journalReview article

18 Scopus citations
2016

Anatomical evidence of pruriceptive trigeminothalamic and trigeminoparabrachial projection neurons in mice

Akiyama, T., Curtis, E., Nguyen, T., Carstens, M. I. & Carstens, E., Feb 1 2016, In : Journal of Comparative Neurology. 524, 2, p. 244-256 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Central Mechanisms of Itch

Carstens, E. & Akiyama, T., 2016, In : Current Problems in Dermatology (Switzerland). 50, p. 11-17 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Involvement of TRPV4 in serotonin-evoked scratching

Akiyama, T., Ivanov, M., Nagamine, M., Davoodi, A., Carstens, M. I., Ikoma, A., Cevikbas, F., Kempkes, C., Buddenkotte, J., Steinhoff, M. & Carstens, E., Jan 2016, In : Journal of Investigative Dermatology. 136, 1, p. 154-160 7 p.

Research output: Contribution to journalArticle

57 Scopus citations

Mouse model of imiquimod-induced psoriatic itch

Sakai, K., Sanders, K. M., Youssef, M. R., Yanushefski, K. M., Jensen, L., Yosipovitch, G. & Akiyama, T., Aug 19 2016, In : Pain. 157, 11, p. 2536-2543 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Neural processing of itch

Akiyama, T. & Carstens, E., Jan 1 2016, Pruritus: Second Edition. Springer International Publishing, p. 3-11 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2015

A central role for spinal dorsal horn neurons that express neurokinin-1 receptors in chronic itch

Akiyama, T., Nguyen, T., Curtis, E., Nishida, K., Devireddy, J., Delahanty, J., Carstens, M. I. & Carstens, E., Jul 2015, In : Pain. 156, 7, p. 1240-1246 7 p.

Research output: Contribution to journalArticle

45 Scopus citations

Assessment of chemically evoked itch in rodents

Akiyama, T. & Carstens, E., Jun 1 2015, Pain Models: Translational Relevance and Applications. Wolters Kluwer Health

Research output: Chapter in Book/Report/Conference proceedingChapter

Evaluation of the synuclein-γ (sncg) gene as a PPARγ target in murine adipocytes, dorsal root ganglia somatosensory neurons, and human adipose tissue

Dunn, T. N., Akiyama, T., Lee, H. W., Kim, J. B., Knotts, T. A., Smith, S. R., Sears, D. D., Carstens, E. & Adams, S. H., Mar 1 2015, In : PloS one. 10, 3, e0115830.

Research output: Contribution to journalArticle

6 Scopus citations

Intradermal endothelin-1 excites bombesin-responsive superficial dorsal horn neurons in the mouse

Akiyama, T., Nagamine, M., Davoodi, A., Iodi Carstens, M., Cevikbas, F., Steinhoff, M. & Carstens, E., Oct 2015, In : Journal of neurophysiology. 114, 4, p. 2528-2534 7 p., A042.

Research output: Contribution to journalArticle

3 Scopus citations

Nalfurafine suppresses pruritogen- and touch-evoked scratching behavior in models of acute and chronic itch in mice

Akiyama, T., Carstens, M. I., Piecha, D., Steppan, S. & Carstens, E., 2015, In : Acta dermato-venereologica. 95, 2, p. 147-150 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

Protease-activated receptors and itch

Akiyama, T., Lerner, E. A. & Carstens, E., 2015, In : Handbook of experimental pharmacology. 226, p. 219-235 17 p.

Research output: Contribution to journalArticle

16 Scopus citations
2014

A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1

Cevikbas, F., Wang, X., Akiyama, T., Kempkes, C., Savinko, T., Antal, A., Kukova, G., Buhl, T., Ikoma, A., Buddenkotte, J., Soumelis, V., Feld, M., Alenius, H., Dillon, S. R., Carstens, E., Homey, B., Basbaum, A. & Steinhoff, M., Feb 2014, In : Journal of Allergy and Clinical Immunology. 133, 2, p. 448-460.e7

Research output: Contribution to journalArticle

266 Scopus citations

Behavioral model of itch, alloknesis, pain and allodynia in the lower hindlimb and correlative responses of lumbar dorsal horn neurons in the mouse

Akiyama, T., Nagamine, M., Carstens, M. I. & Carstens, E., Apr 25 2014, In : Neuroscience. 266, p. 38-46 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus

Kido-Nakahara, M., Buddenkotte, J., Kempkes, C., Ikoma, A., Cevikbas, F., Akiyama, T., Nunes, F., Seeliger, S., Hasdemir, B., Mess, C., Buhl, T., Sulk, M., Müller, F. U., Metze, D., Bunnett, N. W., Bhargava, A., Carstens, E., Furue, M. & Steinhoff, M., Jun 2 2014, In : Journal of Clinical Investigation. 124, 6, p. 2683-2695 13 p.

Research output: Contribution to journalArticle

40 Scopus citations

Role of spinal bombesin-responsive neurons in nonhistaminergic itch

Akiyama, T., Tominaga, M., Takamori, K., Carstens, M. I. & Carstens, E., Nov 1 2014, In : Journal of neurophysiology. 112, 9, p. 2283-2289 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Roles of glutamate, substance P, and gastrin-releasing peptide as spinal neurotransmitters of histaminergic and nonhistaminergic itch

Akiyama, T., Tominaga, M., Takamori, K., Carstens, M. I. & Carstens, E., Jan 2014, In : Pain. 155, 1, p. 80-92 13 p.

Research output: Contribution to journalArticle

59 Scopus citations
2013

Frataxin deficiency leads to defects in expression of antioxidants and Nrf2 expression in dorsal root ganglia of the Friedreich's Ataxia YG8R mouse model

Shan, Y., Schoenfeld, R. A., Hayashi, G., Napoli, E., Akiyama, T., Iodi Carstens, M., Carstens, E. E., Pook, M. A. & Cortopassi, G. A., Nov 1 2013, In : Antioxidants and Redox Signaling. 19, 13, p. 1481-1493 13 p.

Research output: Contribution to journalArticle

71 Scopus citations

Neural processing of itch

Akiyama, T. & Carstens, E., Oct 10 2013, In : Neuroscience. 250, p. 697-714 18 p.

Research output: Contribution to journalReview article

144 Scopus citations

Roles for substance P and gastrin-releasing peptide as neurotransmitters released by primary afferent pruriceptors

Akiyama, T., Tominaga, M., Davoodi, A., Nagamine, M., Blansit, K., Horwitz, A., Carstens, M. I. & Carstens, E., 2013, In : Journal of neurophysiology. 109, 3, p. 742-748 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

Scratching inhibits serotonin-evoked responses of rat dorsal horn neurons in a site- and state-dependent manner

Nishida, K., Takechi, K., Akiyama, T., Carstens, M. I. & Carstens, E., Oct 1 2013, In : Neuroscience. 250, p. 275-281 7 p.

Research output: Contribution to journalArticle

7 Scopus citations
2012

Cross-sensitization of histamine-independent itch in mouse primary sensory neurons

Akiyama, T., Tominaga, M., Davoodi, A., Nagamine, M., Blansit, K., Horwitz, A., Carstens, M. I. & Carstens, E., Dec 13 2012, In : Neuroscience. 226, p. 305-312 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Mouse model of touch-evoked itch (alloknesis)

Akiyama, T., Carstens, M. I., Ikoma, A., Cevikbas, F., Steinhoff, M. & Carstens, E., Jul 2012, In : Journal of Investigative Dermatology. 132, 7, p. 1886-1891 6 p.

Research output: Contribution to journalArticle

57 Scopus citations

Site-dependent and state-dependent inhibition of pruritogen-responsive spinal neurons by scratching

Akiyama, T., Tominaga, M., Carstens, M. I. & Carstens, E. E., Aug 2012, In : European Journal of Neuroscience. 36, 3, p. 2311-2316 6 p.

Research output: Contribution to journalArticle

17 Scopus citations
2011

Enhanced responses of lumbar superficial dorsal horn neurons to intradermal PAR-2 agonist but not histamine in a mouse hindpaw dry skin itch model

Akiyama, T., Carstens, M. I. & Carstens, E., Jun 2011, In : Journal of neurophysiology. 105, 6, p. 2811-2817 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Transmitters and pathways mediating inhibition of spinal Itch-Signaling neurons by scratching and other counterstimuli

Akiyama, T., Carstens, M. & Carstens, E., 2011, In : PloS one. 6, 7, e22665.

Research output: Contribution to journalArticle

67 Scopus citations