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Author

  • Nagi Ayad
2020

Bromodomain Protein BRD4 Is Essential for Hair Cell Function and Survival

Kannan-Sundhari, A., Abad, C., Maloof, M. E., Ayad, N., Young, J. I., Liu, X. Z. & Walz, K., Sep 8 2020, In : Frontiers in Cell and Developmental Biology. 8, 576654.

Research output: Contribution to journalArticle

Open Access
2019

A CK1a Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma

Rodriguez-Blanco, J., Li, B., Long, J., Shen, C., Yang, F., Orton, D., Collins, S., Kasahara, N., Ayad, N. G., McCrea, H. J., Roussel, M. F., Weiss, W. A., Capobianco, A. J. & Robbins, D. J., Feb 15 2019, In : Clinical Cancer Research. 25, 4, p. 1379-1388 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Prenatal arsenic exposure alters the placental expression of multiple epigenetic regulators in a sex-dependent manner

Winterbottom, E. F., Moroishi, Y., Halchenko, Y., Armstrong, D. A., Beach, P. J., Nguyen, Q. P., Capobianco, A. J., Ayad, N. G., Marsit, C. J., Li, Z., Karagas, M. R. & Robbins, D. J., Feb 28 2019, In : Environmental Health: A Global Access Science Source. 18, 1, 18.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis

Penas, C., Maloof, M. E., Stathias, V., Long, J., Tan, S. K., Mier, J., Fang, Y., Valdes, C., Rodriguez-Blanco, J., Chiang, C. M., Robbins, D. J., Liebl, D. J., Lee, J. K., Hatten, M. E., Clarke, J. & Ayad, N. G., Dec 1 2019, In : Nature communications. 10, 1, 3028.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2017

A cell based screening approach for identifying protein degradation regulators

Simanski, S., Maloof, M. E., Sato, T. K., Cavett, V., Caldwell Busby, J. & Ayad, N. G., May 19 2017, In : Cell Cycle. 16, 10, p. 940-946 7 p.

Research output: Contribution to journalArticle

Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations

Allen, B. K., Mehta, S., Ember, S. W. J., Zhu, J. Y., Schönbrunn, E., Ayad, N. G. & Schürer, S. C., 2017, In : ACS Omega. 2, 8, p. 4760-4771 12 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma

Rodriguez-Blanco, J., Pednekar, L., Penas, C., Li, B., Martin, V., Long, J., Lee, E., Weiss, W. A., Rodriguez, C., Mehrdad, N., Nguyen, D. M., Ayad, N. G., Rai, P., Capobianco, A. J. & Robbins, D. J., Nov 9 2017, In : Oncogene. 36, 45, p. 6306-6314 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Casein kinase signaling in axon regeneration

Ayad, N. G., Lee, J. K. & Lemmon, V. P., Feb 2016, In : Neural Regeneration Research. 11, 2, p. 210-211 2 p.

Research output: Contribution to journalComment/debate

2015

Casein kinase 1δ is an APC/CCdh1 substrate that regulates cerebellar granule cell neurogenesis

Penas, C., Govek, E. E., Fang, Y., Ramachandran, V., Daniel, M., Wang, W., Maloof, M. E., Rahaim, R. J., Bibian, M., Kawauchi, D., Finkelstein, D., Han, J. L., Long, J., Li, B., Robbins, D. J., Malumbres, M., Roussel, M. F., Roush, W. R., Hatten, M. E. & Ayad, N. G., 2015, In : Cell Reports. 11, 2, p. 249-260 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Editor's Choice: Epigenetic Pathways and Glioblastoma Treatment: Insights from Signaling Cascades

Allen, B. K., Stathias, V., Maloof, M. E., Vidovic, D., Winterbottom, E. F., Capobianco, A. J., Clarke, J., Schurer, S., Robbins, D. J. & Ayad, N. G., Mar 1 2015, In : Journal of cellular biochemistry. 116, 3, p. iii

Research output: Contribution to journalEditorial

Epigenetic Pathways and Glioblastoma Treatment: Insights from Signaling Cascades

Allen, B. K., Stathias, V., Maloof, M. E., Vidovic, D., Winterbottom, E. F., Capobianco, A. J., Clarke, J., Schurer, S., Robbins, D. J. & Ayad, N. G., Mar 1 2015, In : Journal of cellular biochemistry. 116, 3, p. 351-363 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation

Penas, C., Mishra, J. K., Wood, S. D., Schürer, S. C., Roush, W. R. & Ayad, N. G., Feb 1 2015, In : Cell Cycle. 14, 3, p. 417-424 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4

Allen, B. K., Mehta, S., Ember, S. W. J., Schonbrunn, E., Ayad, N. & Schürer, S. C., Nov 24 2015, In : Scientific reports. 5, 16924.

Research output: Contribution to journalArticle

31 Scopus citations

Screening of cell cycle fusion proteins to identify kinase signaling networks

Trojanowsky, M., Vidovic, D., Simanski, S., Penas, C., Schurer, S. & Ayad, N. G., Apr 15 2015, In : Cell Cycle. 14, 8, p. 1274-1281 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

The APC/C and CK1 in the developing brain

Penas, C., Hatten, M. E. & Ayad, N. G., 2015, In : Oncotarget. 6, 19, p. 16792-16793 2 p.

Research output: Contribution to journalEditorial

Open Access

The bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation

Pastori, C., Kapranov, P., Penas, C., Peschansky, V., Volmar, C. H., Sarkaria, J. N., Bregy, A., Komotar, R., Laurent, G. S., Ayad, N. G., Wahlestedt, C. & Roberts, T. C., Jul 7 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 27, p. 8326-8331 6 p.

Research output: Contribution to journalArticle

115 Scopus citations

The Epigenetics of Medulloblastoma

Penas, C., Stathias, V., Allen, B. K. & Ayad, N., Jul 22 2015, Epigenetic Cancer Therapy. Elsevier Inc., p. 317-337 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

BET bromodomain proteins are required for glioblastoma cell proliferation

Pastori, C., Daniel, M., Penas, C., Volmar, C. H., Johnstone, A. L., Brothers, S. P., Graham, R. M., Allen, B., Sarkaria, J. N., Komotar, R. J., Wahlestedt, C. & Ayad, N. G., Feb 19 2014, In : Epigenetics. 9, 4, p. 611-620 10 p.

Research output: Contribution to journalArticle

81 Scopus citations

Casein kinase 1-dependent wee1 protein degradation

Penas, L., Ramachandran, V., Simanski, S., Lee, C., Madoux, F., Rahaim, R. J., Chauhan, R., Barnaby, O., Schurer, S., Hodder, P., Steen, J., Roush, W. R. & Ayad, N. G., Jul 4 2014, In : Journal of Biological Chemistry. 289, 27, p. 18893-18903 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Identifying glioblastoma gene networks based on hypergeometric test analysis

Stathias, V., Pastori, C., Griffin, T. Z., Komotar, R., Clarke, J., Zhang, M. & Ayad, N. G. A., Dec 31 2014, In : PloS one. 9, 12, e115842.

Research output: Contribution to journalArticle

7 Scopus citations

The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers

Long, J., Li, B., Rodriguez-Blanco, J., Pastori, C., Volmar, C. H., Wahlestedt, C., Capobianco, A., Bai, F., Pei, X. H., Ayad, N. G. & Robbins, D. J., Dec 19 2014, In : Journal of Biological Chemistry. 289, 51, p. 35494-35502 9 p., A32.

Research output: Contribution to journalArticle

66 Scopus citations

Transcriptional repression of ER through hMAPK dependent histone deacetylation by class I HDACs

Plotkin, A., Volmar, C. H., Wahlestedt, C. R., Ayad, N. & El-Ashry, D., Sep 1 2014, In : Breast Cancer Research and Treatment. 147, 2, p. 249-263 15 p.

Research output: Contribution to journalArticle

10 Scopus citations
2013

Epigenetic pathways and glioblastoma treatment

Clarke, J., Penas, C., Pastori, C., Komotar, R. J., Bregy, A., Shah, A. H., Wahlestedt, C. & Ayad, N. G., 2013, In : Epigenetics. 8, 8, p. 785-795 11 p.

Research output: Contribution to journalReview article

36 Scopus citations
2012

The APC/C ubiquitin ligase: From cell biology to tumorigenesis

Penas, C., Ramachandran, V. & Ayad, N. G., 2012, In : Frontiers in Oncology. 1, JAN, 00060.

Research output: Contribution to journalReview article

29 Scopus citations