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  • Camillo Ricordi
2020

Conformal Coating of Stem Cell-Derived Islets for β Cell Replacement in Type 1 Diabetes

Stock, A. A., Manzoli, V., De Toni, T., Abreu, M. M., Poh, Y. C., Ye, L., Roose, A., Pagliuca, F. W., Thanos, C., Ricordi, C. & Tomei, A. A., Jan 14 2020, In : Stem Cell Reports. 14, 1, p. 91-104 14 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
6 Scopus citations
Open Access

Long-term culture of human pancreatic slices as a model to study real-time islet regeneration

Qadir, M. M. F., Álvarez-Cubela, S., Weitz, J., Panzer, J. K., Klein, D., Moreno-Hernández, Y., Cechin, S., Tamayo, A., Almaça, J., Hiller, H., Beery, M., Kusmartseva, I., Atkinson, M., Speier, S., Ricordi, C., Pugliese, A., Caicedo, A., Fraker, C. A., Pastori, R. L. & Domínguez-Bendala, J., Dec 1 2020, In : Nature communications. 11, 1, 3265.

Research output: Contribution to journalArticle

Open Access

Mesenchymal stem cells ameliorate β cell dysfunction of human type 2 diabetic islets by reversing β cell dedifferentiation

Wang, L., Liu, T., Liang, R., Wang, G., Liu, Y., Zou, J., Liu, N., Zhang, B., Liu, Y., Ding, X., Cai, X., Wang, Z., Xu, X., Ricordi, C., Wang, S. & Shen, Z., Jan 2020, In : EBioMedicine. 51, 102615.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

"Old School" Islet Purification Based on the Unit Gravity Sedimentation as a Rescue Technique for Intraportal Islet Transplantation-A Case Report

Gołębiewska, J. E., Gołąb, K., Gorycki, T., Śledziński, M., Gulczyński, J., Żygowska, I., Wolnik, B., Hoffmann, M., Witkowski, P., Ricordi, C., Szurowska, E., Śledziński, Z. & Dębska-Ślizień, A., Jan 1 2020, In : Cell transplantation. 29, p. 963689720947098

Research output: Contribution to journalArticle

Open Access

Publisher Correction: Long-term culture of human pancreatic slices as a model to study real-time islet regeneration (Nature Communications, (2020), 11, 1, (3265), 10.1038/s41467-020-17040-8)

Qadir, M. M. F., Álvarez-Cubela, S., Weitz, J., Panzer, J. K., Klein, D., Moreno-Hernández, Y., Cechin, S., Tamayo, A., Almaça, J., Hiller, H., Beery, M., Kusmartseva, I., Atkinson, M., Speier, S., Ricordi, C., Pugliese, A., Caicedo, A., Fraker, C. A., Pastori, R. L. & Domínguez-Bendala, J., Dec 1 2020, In : Nature communications. 11, 1, 3742.

Research output: Contribution to journalComment/debate

Open Access

Single-cell resolution analysis of the human pancreatic ductal progenitor cell niche

Qadir, M. M. F., Álvarez-Cubela, S., Klein, D., van Dijk, J., Muñiz-Anquela, R., Moreno-Hernández, Y. B., Lanzoni, G., Sadiq, S., Navarro-Rubio, B., García, M. T., Díaz, Á., Johnson, K., Sant, D., Ricordi, C., Griswold, A., Pastori, R. L. & Domínguez-Bendala, J., May 19 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 20, p. 10876-10887 12 p.

Research output: Contribution to journalArticle

Open Access

The Effect of Recovery Warm-up Time Following Cold Storage on the Dynamic Glucose-stimulated Insulin Secretion of Isolated Human Islets

Alcazar, O., Alvarez, A., Ricordi, C., Linetsky, E. & Buchwald, P., Jan 1 2020, In : Cell transplantation. 29, p. 963689720908278

Research output: Contribution to journalArticle

Open Access

在新冠肺炎大流行期间, 羟基氯喹对糖尿病患者降糖作用的风险和益处

Translated title of the contribution: Antihyperglycemic properties of hydroxychloroquine in patients with diabetes: Risks and benefits at the time of COVID-19 pandemicInfante, M., Ricordi, C. & Fabbri, A., Sep 1 2020, In : Journal of Diabetes. 12, 9, p. 659-667 9 p.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations
2018

Administration of Vitamin D and high dose of omega 3 to sustain remission of type 1 diabetes

Cadario, F., Savastio, S., Ricotti, R., Rizzo, A. M., Carrera, D., Maiuri, L. & Ricordi, C., Jan 1 2018, In : European review for medical and pharmacological sciences. 22, 2, p. 512-515 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Carnosine protects pancreatic beta cells and islets against oxidative stress damage

Miceli, V., Pampalone, M., Frazziano, G., Grasso, G., Rizzarelli, E., Ricordi, C., Casu, A., Iannolo, G. & Conaldi, P. G., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Endocrinology.

Research output: Contribution to journalArticle

12 Scopus citations

Chronic Liraglutide Administration Fails to Suppress Postprandial Glucagon Levels in Type 1 Diabetic Islet Allograft Recipients with Graft Dysfunction

Vendrame, F., Padilla, N., Peixoto, E., Baidal, D., Lagari, V., Gil, A. A., Mantero, A., Messinger, S., Ricordi, C. & Alejandro, R., Jan 1 2018, In : Transplantation. 102, 1, p. e39-e40

Research output: Contribution to journalLetter

Divergent antioxidant capacity of human islet cell subsets: A potential cause of beta-cell vulnerability in diabetes and islet transplantation

Miki, A., Ricordi, C., Sakuma, Y., Yamamoto, T., Misawa, R., Mita, A., Molano, R. D., Vaziri, N. D., Pileggi, A. & Ichii, H., May 2018, In : PloS one. 13, 5, e0196570.

Research output: Contribution to journalArticle

15 Scopus citations

Immunoisolation of murine islet allografts in vascularized sites through conformal coating with polyethylene glycol

Manzoli, V., Villa, C., Bayer, A. L., Morales, L. C., Molano, R. D., Torrente, Y., Ricordi, C., Hubbell, J. A. & Tomei, A. A., Mar 2018, In : American Journal of Transplantation. 18, 3, p. 590-603 14 p.

Research output: Contribution to journalArticle

21 Scopus citations

Inflammasome Proteins in Serum and Serum-Derived Extracellular Vesicles as Biomarkers of Stroke

Kerr, N., García-Contreras, M., Abbassi, S., Mejias, N. H., Desousa, B. R., Ricordi, C., Dietrich, W. D., Keane, R. W. & de Rivero Vaccari, J. P., Sep 4 2018, In : Frontiers in Molecular Neuroscience. 11, 309.

Research output: Contribution to journalArticle

16 Scopus citations

Insulin-mimetic effects of short-term rapamycin in type 1 diabetic patients prior to islet transplantation

Benedini, S., Ermetici, F., Briganti, S., Codella, R., Terruzzi, I., Maffi, P., Caldara, R., Secchi, A., Nano, R., Piemonti, L., Alejandro, R., Ricordi, C. & Luzi, L., Apr 13 2018, (Accepted/In press) In : Acta Diabetologica. p. 1-8 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Islet-derived EATP fuels autoreactive CD8+ T cells and facilitates the onset of type 1 diabetes

Tezza, S., Nasr, M. B., D'Addio, F., Vergani, A., Usuelli, V., Falzoni, S., Bassi, R., Dellepiane, S., Fotino, C., Rossi, C., Maestroni, A., Solini, A., Corradi, D., Giani, E., Mameli, C., Bertuzzi, F., Pezzolesi, M. G., Wasserfall, C. H., Atkinson, M. A., Füchtbauer, E. M. & 7 others, Ricordi, C., Folli, F., Virgilio, F. D., Pileggi, A., Dhe-Paganon, S., Zuccotti, G. V. & Fiorina, P., Oct 2018, In : Diabetes. 67, 10, p. 2038-2053 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

Metabolomic changes in human adipose tissue derived products following non-enzymatic microfacturing

Garcia-Contreras, M., Messaggio, F., Mendez, A. J. & Ricordi, C., Jan 1 2018, In : European Review for Medical and Pharmacological Sciences. 22, 10, p. 3249-3260 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Microencapsulated adult porcine islets transplanted intraperitoneally in streptozotocin-diabetic non-human primates

Safley, S. A., Kenyon, N. S., Berman, D. M., Barber, G. F., Willman, M., Duncanson, S., Iwakoshi, N., Holdcraft, R., Gazda, L., Thompson, P., Badell, I. R., Sambanis, A., Ricordi, C. & Weber, C. J., Nov 1 2018, In : Xenotransplantation. 25, 6, e12450.

Research output: Contribution to journalArticle

19 Scopus citations

Omega-3 PUFAs and vitamin D co-supplementation as a safe-effective therapeutic approach for core symptoms of autism spectrum disorder: case report and literature review

Infante, M., Sears, B., Rizzo, A. M., Mariani Cerati, D., Caprio, M., Ricordi, C. & Fabbri, A., 2018, (Accepted/In press) In : Nutritional Neuroscience.

Research output: Contribution to journalArticle

8 Scopus citations

P2RY1/ALK3-Expressing Cells within the Adult Human Exocrine Pancreas Are BMP-7 Expandable and Exhibit Progenitor-like Characteristics

Qadir, M. M. F., Álvarez-Cubela, S., Klein, D., Lanzoni, G., García-Santana, C., Montalvo, A., Pláceres-Uray, F., Mazza, E. M. C., Ricordi, C., Inverardi, L. A., Pastori, R. L. & Domínguez-Bendala, J., Feb 27 2018, In : Cell Reports. 22, 9, p. 2408-2420 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point

Rodriguez-Diaz, R., Molano, R. D., Weitz, J. R., Abdulreda, M. H., Berman, D. M., Leibiger, B., Leibiger, I. B., Kenyon, N. S., Ricordi, C., Pileggi, A., Caicedo, A. & Berggren, P. O., Mar 6 2018, In : Cell Metabolism. 27, 3, p. 549-558.e4

Research output: Contribution to journalArticle

38 Scopus citations

Regenerative Medicine in the State of Florida: Letter Outlining the Florida Organization for Regenerative Medicine

Bruce, C. J., Bu, G., Centanni, J. M., Davis, M. D., Dobson, J., Hare, J. M., Fields, G. B., Jove, R., Kenyon, N., Khan, A., March, K., Matosevic, S., Mahmood, A., Pepine, C. J., Ricordi, C., Shapiro, S. A., Zylberberg, C. & Zylberberg, E., Jul 1 2018, In : Stem Cells Translational Medicine. 7, 7, p. 511-512 2 p.

Research output: Contribution to journalLetter

Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells

Odorico, J., Markmann, J., Melton, D., Greenstein, J., Hwa, A., Nostro, C., Rezania, A., Oberholzer, J., Pipeleers, D., Yang, L., Cowan, C., Huangfu, D., Egli, D., Ben-David, U., Vallier, L., Grey, S. T., Tang, Q., Roep, B., Ricordi, C., Naji, A. & 16 others, Orlando, G., Anderson, D. G., Poznansky, M., Ludwig, B., Tomei, A., Greiner, D. L., Graham, M., Carpenter, M., Migliaccio, G., D'Amour, K., Hering, B., Piemonti, L., Berney, T., Rickels, M., Kay, T. & Adams, A., Aug 1 2018, In : Transplantation. 102, 8, p. 1223-1229 7 p.

Research output: Contribution to journalReview article

17 Scopus citations
2017

Active subjects with autoimmune type 1 diabetes have better metabolic profiles than sedentary controls

Adamo, M., Codella, R., Casiraghi, F., Ferrulli, A., Macrì, C., Bazzigaluppi, E., Terruzzi, I., Inverardi, L., Ricordi, C. & Luzi, L., 2017, In : Cell transplantation. 26, 1, p. 23-32 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Bioengineering of an intraabdominal endocrine pancreas

Baidal, D. A., Ricordi, C., Berman, D. M., Alvarez, A., Padilla, N., Ciancio, G., Linetsky, E., Pileggi, A. & Alejandro, R., May 11 2017, In : New England Journal of Medicine. 376, 19, 19.

Research output: Contribution to journalLetter

49 Scopus citations

Can Type 1 diabetes progression be halted? Possible role of high dose vitamin D and omega 3 fatty acids

Cadario, F., Savastio, S., Rizzo, A. M., Carrera, D., Bona, G. & Ricordi, C., Apr 1 2017, In : European Review for Medical and Pharmacological Sciences. 21, 7, p. 1604-1609 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Comprehensive metabolomics study to assess longitudinal biochemical changes and potential early biomarkers in nonobese diabetic mice that progress to diabetes

Buchwald, P., Tamayo-Garcia, A., Ramamoorthy, S., Garcia-Contreras, M., Mendez, A. J. & Ricordi, C., Oct 6 2017, In : Journal of Proteome Research. 16, 10, p. 3873-3890 18 p.

Research output: Contribution to journalArticle

5 Scopus citations

Diabetes and Alzheimer's Disease: Can Elevated Free Copper Predict the Risk of the Disease?

Squitti, R., Mendez, A. J., Simonelli, I. & Ricordi, C., 2017, In : Journal of Alzheimer's Disease. 56, 3, p. 1055-1064 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Does the Mesenchymal Stem Cell Source Influence Smooth Muscle Regeneration in Tissue-Engineered Urinary Bladders?

Pokrywczynska, M., Jundzill, A., Warda, K., Buchholz, L., Rasmus, M., Adamowicz, J., Bodnar, M., Marszalek, A., Helmin-Basa, A., Michalkiewicz, J., Gagat, M., Grzanka, A., Frontczak-Baniewicz, M., Gastecka, A. M., Kloskowski, T., Nowacki, M., Ricordi, C. & Drewa, T., Nov 1 2017, In : Cell transplantation. 26, 11, p. 1780-1791 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Effects of composition of alginate-polyethylene glycol microcapsules and transplant site on encapsulated islet graft outcomes in mice

Villa, C., Manzoli, V., Abreu, M. M., Verheyen, C. A., Seskin, M., Najjar, M., Molano, R. D., Torrente, Y., Ricordi, C. & Tomei, A. A., May 2017, In : Transplantation. 101, 5, p. 1025-1035 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Engineering human renal epithelial cells for transplantation in regenerative medicine

Manzoli, V., Colter, D. C., Dhanaraj, S., Fornoni, A., Ricordi, C., Pileggi, A. & Tomei, A. A., Oct 2017, In : Medical Engineering and Physics. 48, p. 3-13 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Exosomes as biomarkers and therapeutic tools for type 1 diabetes mellitus

Garcia-Contreras, M., Brooks, R. W., Boccuzzi, L., Robbins, P. D. & Ricordi, C., Jun 1 2017, In : European Review for Medical and Pharmacological Sciences. 21, 12, p. 2940-2956 17 p.

Research output: Contribution to journalReview article

33 Scopus citations

Islet transplantation for hypoglycemia unawareness/severe hypoglycemia: Caveat emptor

Hering, B. J., Bridges, N. D., Eggerman, T. L. & Ricordi, C., Aug 1 2017, In : Diabetes Care. 40, 8, p. e111-e112

Research output: Contribution to journalLetter

Metabolomics Study of the Effects of Inflammation, Hypoxia, and High Glucose on Isolated Human Pancreatic Islets

Garcia-Contreras, M., Tamayo-Garcia, A., Pappan, K. L., Michelotti, G. A., Stabler, C. L., Ricordi, C. & Buchwald, P., Jun 2 2017, In : Journal of Proteome Research. 16, 6, p. 2294-2306 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes

Garcia-Contreras, M., Shah, S. H., Tamayo, A., Robbins, P. D., Golberg, R. B., Mendez, A. J. & Ricordi, C., Dec 1 2017, In : Scientific reports. 7, 1, 5998.

Research output: Contribution to journalArticle

40 Scopus citations
2016

A multicenter study: North american islet donor score in donor pancreas selection for human islet isolation for transplantation

Wang, L. J., Kin, T., O’Gorman, D., Shapiro, A. M. J., Naziruddin, B., Takita, M., Levy, M. F., Posselt, A. M., Szot, G. L., Savari, O., Barbaro, B., McGarrigle, J., Yeh, C., Oberholzer, J., Lei, J., Chen, T., Lian, M., Markmann, J. F., Alvarez, A., Linetsky, E. & 16 others, Ricordi, C., Balamurugan, A. N., Loganathan, G., Wilhelm, J. J., Hering, B. J., Bottino, R., Trucco, M., Liu, C., Min, Z., Li, Y., Naji, A., Fernandez, L. A., Ziemelis, M., Danobeitia, J. S., Millis, J. M. & Witkowski, P., 2016, In : Cell transplantation. 25, 8, p. 1515-1523 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Bioengineering the endocrine pancreas: Intraomental islet transplantation within a biologic resorbable scaffold

Berman, D. M., Molano, R., Fotino, C., Ulissi, U., Gimeno, J., Mendez, A. J., Kenyon, N. M., Kenyon, N. S., Andrews, D. M., Ricordi, C. & Pileggi, A., May 1 2016, In : Diabetes. 65, 5, p. 1350-1361 12 p.

Research output: Contribution to journalArticle

57 Scopus citations

CD52-negative NK cells are abundant in the liver and less susceptible to alemtuzumab treatment

Hotta, R., Ohira, M., Matsuura, T., Muraoka, I., Tryphonopoulos, P., Fan, J., Tekin, A., Selvaggi, G., Levi, D., Ruiz, P., Ricordi, C., Vianna, R., Ohdan, H., Waldmann, H., Tzakis, A. G. & Nishida, S., Aug 2016, In : PloS one. 11, 8, e0161618.

Research output: Contribution to journalArticle

4 Scopus citations

Clinical pancreatic islet transplantation

Shapiro, A. M. J., Pokrywczynska, M. & Ricordi, C., Nov 11 2016, (Accepted/In press) In : Nature Reviews Endocrinology.

Research output: Contribution to journalArticle

184 Scopus citations
18 Scopus citations

Executive summary of IPITA-TTS opinion leaders report on the future of b-cell replacement

Markmann, J. F., Bartlett, S. T., Johnson, P., Korsgren, O., Hering, B. J., Scharp, D., Kay, T. W. H., Bromberg, J., Odorico, J. S., Weir, G. C., Bridges, N., Kandaswamy, R., Stock, P., Friend, P., Gotoh, M., Cooper, D. K. C., Park, C. G., O'Connell, P. J., Stabler, C., Matsumoto, S. & 14 others, Ludwig, B., Choudhary, P., Khovatchev, B., Rickels, M. R., Sykes, M., Wood, K., Kraemer, K., Hwa, A., Stanley, E., Ricordi, C., Zimmerman, M., Greenstein, J., Montanya, E. & Otonkoski, T., Jun 21 2016, In : Transplantation. 100, 7, p. e25-e31

Research output: Contribution to journalArticle

19 Scopus citations

Fully automated islet cell counter (ICC) for the assessment of islet mass, purity, and size distribution by digital image analysis

Buchwald, P., Bernal, A., Echeverri, F., Tamayo-Garcia, A., Linetsky, E. & Ricordi, C., 2016, In : Cell Transplantation. 25, 10, p. 1747-1761 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

G-CSF and exenatide might be associated with increased long-term survival of allogeneic pancreatic islet grafts

Zoso, A., Serafini, P., Lanzoni, G., Peixoto, E., Messinger, S., Mantero, A., Padilla-Téllez, N. D., Baidal, D. A., Alejandro, R., Ricordi, C. & Inverardi, L., Jun 2016, In : PloS one. 11, 6, e0157245.

Research output: Contribution to journalArticle

4 Scopus citations

Mesenchymal stem cells in Lipogems, a reverse story: From clinical practice to basic science

Tremolada, C., Ricordi, C., Caplan, A. I. & Ventura, C., 2016, Methods in Molecular Biology. Humana Press Inc., Vol. 1416. p. 109-122 14 p. (Methods in Molecular Biology; vol. 1416).

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Metformin restrains pancreatic duodenal homeobox-1 (PDX-1) function by inhibiting ERK signaling in pancreatic ductal adenocarcinoma

Zhou, G., Yu, J., Wang, A., Liu, S. H., Sinnett-Smith, J., Wu, J., Sanchez, R., Nemunaitis, J., Ricordi, C., Rozengurt, E. & Brunicardi, F. C., Jan 1 2016, In : Current Molecular Medicine. 16, 1, p. 83-90 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

National institutes of health-sponsored clinical islet transplantation consortium phase 3 trial: Manufacture of a complex cellular product at eight processing facilities

Ricordi, C., Goldstein, J. S., Balamurugan, A. N., Szot, G. L., Kin, T., Liu, C., Czarniecki, C. W., Barbaro, B., Bridges, N. D., Cano, J., Clarke, W. R., Eggerman, T. L., Hunsicker, L. G., Kaufman, D. B., Khan, A., Lafontant, D. E., Linetsky, E., Luo, X., Markmann, J. F., Naji, A. & 14 others, Korsgren, O., Oberholzer, J., Turgeon, N. A., Brandhorst, D., Friberg, A. S., Lei, J., Wang, L. J., Wilhelm, J. J., Willits, J., Zhang, X., Hering, B. J., Posselt, A. M., Stock, P. G. & Shapiro, A. M. J., Nov 2016, In : Diabetes. 65, 11, p. 3418-3428 11 p.

Research output: Contribution to journalArticle

58 Scopus citations

Phase 3 trial of transplantation of human islets in type 1 diabetes complicated by severe hypoglycemia

Hering, B. J., Clarke, W. R., Bridges, N. D., Eggerman, T. L., Alejandro, R., Bellin, M. D., Chaloner, K., Czarniecki, C. W., Goldstein, J. S., Hunsicker, L. G., Kaufman, D. B., Korsgren, O., Larsen, C. P., Luo, X., Markmann, J. F., Naji, A., Oberholzer, J., Posselt, A. M., Rickels, M. R., Ricordi, C. & 5 others, Robien, M. A., Senior, P. A., James Shapiro, A. M., Stock, P. G. & Turgeon, N. A., Jul 1 2016, In : Diabetes care. 39, 7, p. 1230-1240 11 p.

Research output: Contribution to journalArticle

204 Scopus citations

Report from IPITA-TTS opinion leaders meeting on the future of β-cell replacement

Bartlett, S. T., Markmann, J. F., Johnson, P., Korsgren, O., Hering, B. J., Scharp, D., Kay, T. W. H., Bromberg, J., Odorico, J. S., Weir, G. C., Bridges, N., Kandaswamy, R., Stock, P., Friend, P., Gotoh, M., Cooper, D. K. C., Park, C. G., O'Connell, P., Stabler, C., Matsumoto, S. & 14 others, Ludwig, B., Choudhary, P., Kovatchev, B., Rickels, M. R., Sykes, M., Wood, K., Kraemer, K., Hwa, A., Stanley, E., Ricordi, C., Zimmerman, M., Greenstein, J., Montanya, E. & Otonkoski, T., 2016, In : Transplantation. 100, p. S1-S44

Research output: Contribution to journalArticle

37 Scopus citations